Decoding the “Fingerprint” of Implant Materials: Insights into the Foreign Body Reaction

Small, Journal Year: 2024, Volume and Issue: 20(23)

Published: Jan. 8, 2024

Abstract Foreign body reaction (FBR) is a prevalent yet often overlooked pathological phenomenon, particularly within the field of biomedical implantation. The presence FBR poses heavy burden on both medical and socioeconomic systems. This review seeks to elucidate protein “fingerprint” implant materials, which generated by physiochemical properties materials themselves. In this review, activity macrophages, formation foreign giant cells (FBGCs), development fibrosis capsules in context are introduced. Additionally, relationship between various elucidated detail, as an overview existing approaches technologies employed alleviate FBR. Finally, significance components (metallic non‐metallic materials), surface CHEMISTRY (charge wettability), physical characteristics (topography, roughness, stiffness) establishing also well documented. conclusion, aims emphasize importance provides current perspectives developing with anti‐FBR properties.

Language: Английский

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A Fused Membrane‐Camouflaged Biomimetic Nanosystem for Dual‐Targeted Therapy of Septic Arthritis

Small, Journal Year: 2025, Volume and Issue: 21(9)

Published: Jan. 19, 2025

Abstract Due to the inherent aseptic and enclosed characteristics of joint cavity, septic arthritis (SA) almost inevitably leads intractable infections rapidly progressing complex pathological environments. Presently, SA faces not only deficient effectiveness gold‐standard systemic antibiotic therapy but also scarcity effective localized targeted approaches standardized animal models. Herein, an ingenious multifunctional nanosystem is designed, which involves methylation hyaluronic acid (HA), copolymerization with DEGDA, loading vancomycin (VAN), then coating fused macrophage‐platelet membrane (denoted as FM@HA@VAN). Upon intra‐articular administration, FM@HA@VAN nanoparticles exhibit sustained retention selectively targeting infected sites, leveraging macrophage‐mediated inflammation homing platelet‐directed bacteria targeting. The acidic microenvironment triggers responsive release vancomycin, leading potent bactericidal effects. Subsequently, exposed HA@VAN are efficiently internalized by activated macrophages, releasing HA alleviate oxidative stress achieve chondroprotection inhibiting pro‐inflammatory cytokines, neutralizing ROS upregulating macrophage M2 polarization. In vivo model experiments confirm efficacy this dual‐targeting antibacterial approach, demonstrating its precision in eradicating bacterial alleviating associated processes, including synovial hyperplasia cartilage erosion. therapeutic nanosystem, coordinated fused‐membranes, holds promise for enhancing treatment SA.

Language: Английский

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Latest advancements and trends in biomedical polymers for disease prevention, diagnosis, treatment, and clinical application

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: 380, P. 138 - 174

Published: Feb. 5, 2025

Language: Английский

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Metabolic reprogramming of macrophages by a nano-sized opsonization strategy to restore M1/M2 balance for osteoarthritis therapy

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: 380, P. 469 - 489

Published: Feb. 11, 2025

Language: Английский

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Osteoarthritis year in review 2023: Biology

Osteoarthritis and Cartilage, Journal Year: 2023, Volume and Issue: 32(2), P. 148 - 158

Published: Nov. 7, 2023

Great progress continues to be made in our understanding of the multiple facets osteoarthritis (OA) biology. Here, we review major advances this field and towards therapy development over past year, highlighting a selection relevant published literature from PubMed search covering year end April 2022 2023. The selected articles have been arranged themes. These include 1) molecular regulation articular cartilage implications for OA, 2) mechanisms subchondral bone remodelling, 3) role synovium inflammation, 4) age-related changes including matrix stiffening, cellular senescence, mitochondrial dysfunction, metabolic impaired autophagy, 5) peripheral OA pain. Progress responsible aspects biology is unravelling novel therapeutic targets disease modification.

Language: Английский

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Targeting YAP1‐regulated Glycolysis in Fibroblast‐Like Synoviocytes Impairs Macrophage Infiltration to Ameliorate Diabetic Osteoarthritis Progression

Advanced Science, Journal Year: 2023, Volume and Issue: 11(5)

Published: Dec. 3, 2023

Abstract The interplay between immune cells/macrophages and fibroblast‐like synoviocytes (FLSs) plays a pivotal role in initiating synovitis; however, their involvement metabolic disorders, including diabetic osteoarthritis (DOA), is largely unknown. In this study, single‐cell RNA sequencing (scRNA‐seq) employed to investigate the synovial cell composition of DOA. A significant enrichment activated macrophages within eight distinct clusters found DOA synovium. Moreover, it demonstrated that increased glycolysis FLSs key driver for patients’ macrophage infiltration polarization. addition, yes‐associated protein 1 (YAP1)/thioredoxin‐interacting (TXNIP) signaling axis play crucial regulating glucose transporter (GLUT1)‐dependent FLSs, thereby controlling expression series adhesion molecules such as intercellular molecule‐1 (ICAM‐1) which may subsequently fine‐tune M1‐polarized patients db/db OA mice. For treatment, M1 membrane‐camouflaged Verteporfin (Vt)‐loaded PLGA nanoparticles (MVPs) are developed ameliorate progression by YAP1/TXNIP axis, thus suppressing macrophages. results provide several novel insights into pathogenesis offer promising treatment approach

Language: Английский

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Nanoparticle-Mediated Multiple Modulation of Bone Microenvironment To Tackle Osteoarthritis

ACS Nano, Journal Year: 2024, Volume and Issue: 18(15), P. 10625 - 10641

Published: April 2, 2024

Development of nanomedicines that can collaboratively scavenge reactive oxygen species (ROS) and inhibit inflammatory cytokines, along with osteogenesis promotion, is essential for efficient osteoarthritis (OA) treatment. Herein, we report the design a ROS-responsive nanomedicine formulation based on fibronectin (FN)-coated polymer nanoparticles (NPs) loaded azabisdimethylphoaphonate-terminated phosphorus dendrimers (G4-TBP). The constructed G4-TBP NPs-FN size 268 nm are stable under physiological conditions, be specifically taken up by macrophages through FN-mediated targeting, dissociated in oxidative microenvironment. dendrimer having intrinsic anti-inflammatory property FN both antioxidative properties display integrated functions ROS scavenging, hypoxia attenuation, macrophage M2 polarization, thus protecting from apoptosis creating designed bone immune microenvironment stem cell osteogenic differentiation. These characteristics lead to their effective treatment an OA model vivo reduce pathological changes joints including synovitis inhibition cartilage matrix degradation simultaneously promote differentiation repair. developed combining advantages bioactive treat may immunomodulatory therapy different diseases.

Language: Английский

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Harnessing Nanomedicine for Cartilage Repair: Design Considerations and Recent Advances in Biomaterials

ACS Nano, Journal Year: 2024, Volume and Issue: 18(16), P. 10667 - 10687

Published: April 9, 2024

Cartilage injuries are escalating worldwide, particularly in aging society. Given its limited self-healing ability, the repair and regeneration of damaged articular cartilage remain formidable challenges. To address this issue, nanomaterials leveraged to achieve desirable outcomes by enhancing mechanical properties, optimizing drug loading bioavailability, enabling site-specific targeted delivery, orchestrating cell activities at nanoscale. This review presents a comprehensive survey recent research nanomedicine for repair, with primary focus on biomaterial design considerations advances. The commences an introductory overview intricate microenvironment further delves into key parameters crucial treating damage, including microstructure, surface charge, active targeting. focal point lies advances nano delivery systems nanotechnology-enabled 3D matrices repair. We discuss compositions properties these elucidate how materials impact cartilage. underscores pivotal role nanotechnology improving efficacy biomaterials utilized treatment damage.

Language: Английский

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Hyaluronic Acid Receptor‐Mediated Nanomedicines and Targeted Therapy

Small Methods, Journal Year: 2024, Volume and Issue: unknown

Published: July 23, 2024

Abstract Hyaluronic acid (HA) is a naturally occurring polysaccharide found in the extracellular matrix with broad applications disease treatment. HA possesses good biocompatibility, biodegradability, and ability to interact various cell surface receptors. Its wide range of molecular weights modifiable chemical groups make it an effective drug carrier for delivery. Additionally, overexpression specific receptors on surfaces many states enhances accumulation drugs at pathological sites through receptor binding. In this review, modification drugs, major proteins, latest advances receptor‐targeted nano delivery systems (DDS) treatment tumors inflammatory diseases are summarized. Furthermore, functions varying vivo selection methods different discussed.

Language: Английский

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Curcumin-loaded biomimetic nanosponges for osteoarthritis alleviation by synergistically suppressing inflammation and ferroptosis

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 491, P. 152132 - 152132

Published: May 10, 2024

Language: Английский

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