Journal of Food Process Engineering,
Journal Year:
2024,
Volume and Issue:
47(11)
Published: Nov. 1, 2024
ABSTRACT
Turmeric
is
a
medicinal
herb
that
can
be
used
in
wide
range
of
applications,
such
as
food
ingredients,
cosmetics,
and
traditional
medicine.
The
active
ingredients
found
turmeric
are
curcumin
(CUR),
desmethoxycurcumin
(DMC),
bisdesmethoxycurcumin
(BMDC).
aim
this
research
was
to
precipitate
the
from
extract
using
gas
anti‐solvent
process
with
carbon
dioxide
anti‐solvent.
effects
solvent
type
(ethanol,
methanol,
acetonitrile),
precipitation
temperature
(25°C–45°C),
CO
2
flow
rate
(4–12
mL/min)
on
amount
precipitates
were
investigated
Box–Behnken
design
experiments.
analyzed
for
curcuminoids
CUR
content
HPLC
tested
antioxidant
activity.
It
significant
variables
at
5%
significance
level
precipitates.
Using
mixture
ethanol
methanol
(77.5%
v/v
ethanol)
polarity
index
4.48
solvent,
25.40°C,
7.56
mL/min
optimal
conditions
achieving
highest
At
conditions,
amounts
27.33
±
0.23
13.30
0.12
mg/5
mL
extracted
solution,
respectively.
In
studies,
Trolox
equivalents
products
DPPH
ABTS
assays
38.19
0.17
65.96
2.36
total
phenolic
30.84
1.80
solution.
Advanced Science,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 22, 2025
Abstract
Osteoarthritis
(OA)
is
increasingly
recognized
as
a
whole‐organ
disease
predominantly
affecting
the
elderly,
characterized
by
typical
alterations
in
subchondral
bone
and
cartilage,
along
with
recurrent
synovial
inflammation.
Despite
availability
of
various
therapeutics
medications,
complete
resolution
OA
remains
elusive.
In
this
study,
novel
functional
hydrogels
are
developed
integrating
natural
bioactive
molecules
for
treatment.
Specifically,
baicalin
(Bai)
combined
2‐hydroxyethyl
acrylate
(HEA)
to
form
polymerizable
monomer
(HEA‐Bai)
through
esterification,
which
subjected
reversible
addition‐fragmentation
chain
transfer
(RAFT)
polymerization
produce
Bai‐based
polymer
(P
m
).
These
macromolecules
incorporated
into
Schiff‐base
hydrogels,
demonstrate
excellent
mechanical
properties
self‐healing
performance.
Notably,
formulations
taken
up
fibroblast‐like
synoviocytes
(FLSs),
where
they
regulate
glycolysis.
Mechanistically,
inhibition
yes‐associated
protein
1
(YAP1)
suppressed
FLSs
glycolysis
reduced
secretion
inflammatory
factors,
including
interleukin
1β
(IL‐1β),
IL‐6,
IL‐8.
Furthermore,
hydrogel
(AG‐P
)‐OC,
severing
lubricant
nutrient,
prolonged
joint
retention
Bai,
thereby
reducing
cartilage
degradation
Meanwhile,
)‐OC
alleviated
pain
targeting
YAP1
signaling
inhibiting
macrophage
recruitment
polarization.
Taken
together,
flavonoid‐based
injectable
exhibits
enhanced
biocompatibility
efficacy
against
OA.
Frontiers in Pharmacology,
Journal Year:
2024,
Volume and Issue:
15
Published: Sept. 25, 2024
Notable
progress
has
been
made
in
"ferroptosis-based
nano
drug
delivery
systems
(NDDSs)"
over
the
past
11
years.
Despite
ongoing
absence
of
a
comprehensive
scientometric
overview
and
up-to-date
scientific
mapping
research,
especially
regarding
evolution,
critical
research
pathways,
current
landscape,
central
investigative
themes,
future
directions.
Small Methods,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 30, 2025
Osteoarthritis
(OA)
is
the
most
prevalent
degenerative
joint
disorder,
characterized
by
progressive
degradation,
pain,
and
diminished
mobility,
all
of
which
collectively
impair
patients'
quality
life
escalate
healthcare
expenditures.
Current
treatment
options
are
often
inadequate
due
to
limited
efficacy,
adverse
side
effects,
temporary
symptom
relief,
underscoring
urgent
need
for
more
effective
therapeutic
strategies.
Recent
advancements
in
nanomaterials
nanomedicines
offer
promising
solutions
improving
drug
bioavailability,
reducing
effects
providing
targeted
benefits.
This
review
critically
examines
pathogenesis
OA,
highlights
limitations
existing
treatments,
explores
latest
innovations
intelligent
design
OA
therapy,
with
an
emphasis
on
their
engineered
properties,
mechanisms,
translational
potential
clinical
application.
By
compiling
recent
findings,
this
work
aims
inspire
further
exploration
innovation
nanomedicine,
ultimately
advancing
development
personalized
therapies.
Advanced Functional Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 27, 2025
Abstract
Abnormal
friction
forces,
compact
matrix
structure,
and
dynamic
acidic
microenvironment
in
osteoarthritis
(OA)
make
it
difficult
to
remodel
cartilage
regeneration
by
integrating
prominent
inflammatory
responses
anabolism.
Here,
pH‐responsive
PSBMA‐
b
‐PColBP@KGN
nanoparticles
(PSPK
NPs)
are
developed
a
simple
supramolecular
assembly
process.
PSPK
NPs
found
reduce
the
coefficient
of
(0.028)
under
high
loading
pressure
(10.41
MPa).
The
synergistic
effect
KGN
release
coupling
deep
penetration
promotes
generation
microenvironment.
Further,
vivo
studies
confirm
potential
restoring
homeostasis,
as
evidenced
reduced
osteophyte
volume,
aligned
structures,
abundant
matrix.
This
study
provides
novel
insights
into
effects
release,
penetration,
hydration
lubrication
on
OA
treatment,
offering
strategy
for
design
tissue‐adaptive
promote
tissue
inflammation‐related
diseases.
Macromolecular Rapid Communications,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 18, 2024
Osteoarthritis
(OA)
is
a
chronic
degenerative
joint
disease
characterized
by
the
degradation
of
articular
cartilage.
Recent
studies
have
demonstrated
that
chondrocyte
ferroptosis
plays
crucial
role
in
progression
OA.
Consequently,
developing
nanomedicines
suppress
promising
strategy
for
OA
treatment.
However,
there
are
few
reports
on
specifically
targeting
therapy.
In
this
study,
Curcumin-loaded
nanoparticles
(Cur-NPs)
fabricated
to
regulating
reactive
oxygen
species
(ROS),
ferrous
ion
(Fe
