Molecular Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
21(9), P. 4476 - 4489
Published: Aug. 6, 2024
In
this
study,
we
prepared
bionic
selenium-baicalein
nanoparticles
(ACM-SSe-BE)
for
the
targeted
treatment
of
nonsmall
cell
lung
cancer.
Due
to
coating
A549
membrane,
system
has
homologous
targeting
capabilities,
allowing
preparation
target
tumor
cells.
The
borate
ester
bond
between
selenium
(SSe)
and
baicalein
(BE)
is
pH-sensitive
can
break
under
acidic
conditions
in
microenvironment
achieve
release
BE
at
site.
Moreover,
SSe
further
enhances
antitumor
effect
by
increasing
production
ROS
Transmission
electron
microscopy
(TEM)
images
dynamic
light
scattering
(DLS)
showed
that
ACM-SSe-BE
had
a
particle
size
approximately
155
±
2
nm.
FTIR
verified
successful
coupling
BE.
vitro
experiments
indicated
cumulative
pH
5.5
after
24
h
was
69.39
1.07%,
which
less
than
20%
7.4,
confirming
ACM-SSe-BE.
Cell
uptake
vivo
imaging
good
ability.
results
MTT,
flow
cytometry,
Western
blot,
immunofluorescence
staining
demonstrated
promoted
apoptosis
inhibited
proliferation.
were
consistent
with
those
experiments.
These
clearly
suggested
will
be
promising
nanosystem
Small Methods,
Journal Year:
2023,
Volume and Issue:
8(7)
Published: Nov. 30, 2023
Abstract
Inflammation‐associated
diseases
are
very
common
clinically
with
a
high
incidence;
however,
there
is
still
lack
of
effective
treatments.
Cell‐biomimetic
nanoplatforms
have
led
to
many
breakthroughs
in
the
field
biomedicine,
significantly
improving
efficiency
drug
delivery
and
its
therapeutic
implications
especially
for
inflammation‐associated
diseases.
Macrophages
an
important
component
immune
cells
play
critical
role
occurrence
progression
while
simultaneously
maintaining
homeostasis
modulating
responses.
Therefore,
macrophage‐biomimetic
not
only
inherit
functions
macrophages
including
inflammation
tropism
effect
targeted
drugs
neutralization
pro‐inflammatory
cytokines
toxins
via
membrane
surface
receptors
or
proteins,
but
also
maintain
inner
nanoparticles.
Macrophage‐biomimetic
shown
remarkable
efficacy
excellent
application
potential
In
this
review,
diseases,
physiological
macrophages,
classification
construction
first
introduced.
Next,
latest
applications
different
treatment
summarized.
Finally,
challenges
opportunities
future
biomedical
discussed.
It
hoped
that
review
will
provide
new
ideas
further
development
nanoplatforms.
Engineered Regeneration,
Journal Year:
2023,
Volume and Issue:
5(1), P. 92 - 110
Published: Dec. 14, 2023
Osteoarthritis
(OA)
represents
an
enduring
and
widespread
global
burden,
causing
significant
morbidity
disability,
whose
pathology
is
characterized
by
persistent
inflammation,
progressive
cartilage
degeneration,
abnormal
bone
homeostasis,
excessive
synovial
hyperplasia,
resulting
from
its
complex
microenvironment.
Unfortunately,
current
therapeutic
approaches
for
OA
remain
suboptimal,
prompting
increased
interest
in
advanced
nanotechnology
as
a
means
to
enhance
effects.
In
recent
years,
progress
has
been
made
the
development
of
versatile
nanoplatforms
designed
specific
microenvironment
OA,
promising
results
introducing
concept
"OA
nanomedicine".
Compared
conventional
therapies
like
non-steroidal
anti-inflammatory
drugs
(NSAIDs),
nanomedicine
offers
precise
targeted,
controllable
personalized
ways
therapy,
contributing
better
outcomes.
However,
comprehensive
review
consolidating
nanomedicine"
currently
absent
literature.
Therefore,
this
review,
we
aim
unravel
key
pathological
microenvironmental
characteristics
while
summarizing
properties
advantages
nanosystems
possessing
microenvironment-reprogramming
capabilities
therapy.
First,
make
retrospection
features
Furthermore,
provide
overview
advances
nanomedicine.
Eventually,
discuss
present
challenges
associated
with
insights
into
future
prospects
clinical-translational
lens.
By
doing
so,
can
foster
propel
successful
nanomedicine,
addressing
unmet
needs
Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
13(16)
Published: Feb. 23, 2024
Although
the
pathogenesis
of
osteoarthritis
(OA)
is
unclear,
inflammatory
cytokines
are
related
to
its
occurrence.
However,
few
studies
focused
on
therapeutic
strategies
regulating
joint
homeostasis
by
simultaneously
remodeling
anti-inflammatory
and
immunomodulatory
microenvironments.
Fibroblast
growth
factor
18
(FGF18)
only
disease-modifying
OA
drug
(DMOAD)
with
a
potent
ability
high
efficiency
in
maintaining
phenotype
chondrocytes
within
cell
culture
models.
potential
role
immune
microenvironment
remains
unknown.
Besides,
information
an
optimal
carrier,
whose
interface
chondral-biomimetic
mimic
native
articular
tissue,
still
lacking,
which
substantially
limits
clinical
efficacy
FGF18.
Herein,
simulate
cartilage
matrix,
chondroitin
sulfate
(ChS)-based
nanoparticles
(NPs)
integrated
into
poly(D,
L-lactide)-poly(ethylene
glycol)-poly(D,
L-lactide)
(PLEL)
hydrogels
develop
bionic
thermosensitive
sustainable
delivery
system.
Electrostatically
self-assembled
ChS
ε-poly-l-lysine
(EPL)
NPs
prepared
for
bioencapsulation
This
system
suppressed
response
interleukin-1β
(IL-1β)-mediated
chondrocytes,
promoted
macrophage
M2
polarization,
inhibited
M1
thereby
ameliorating
degeneration
synovitis
OA.
Thus,
ChS-based
hydrogel
offers
strategy
regulate
chondrocyte-macrophage
crosstalk,
thus
re-establishing
therapy.
International Journal of Biological Sciences,
Journal Year:
2024,
Volume and Issue:
20(8), P. 2994 - 3007
Published: Jan. 1, 2024
Osteoarthritis
(OA)
is
a
challenging
degenerative
joint
disease
to
manage.
Previous
research
has
indicated
that
cell-free
fat
extract
(CEFFE)
may
hold
potential
for
OA
treatment.
This
study
investigated
the
role
of
Annexin
A5
(AnxA5)
within
CEFFE
in
regulating
macrophage
polarization
and
protecting
chondrocytes.
Molecular Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
21(9), P. 4476 - 4489
Published: Aug. 6, 2024
In
this
study,
we
prepared
bionic
selenium-baicalein
nanoparticles
(ACM-SSe-BE)
for
the
targeted
treatment
of
nonsmall
cell
lung
cancer.
Due
to
coating
A549
membrane,
system
has
homologous
targeting
capabilities,
allowing
preparation
target
tumor
cells.
The
borate
ester
bond
between
selenium
(SSe)
and
baicalein
(BE)
is
pH-sensitive
can
break
under
acidic
conditions
in
microenvironment
achieve
release
BE
at
site.
Moreover,
SSe
further
enhances
antitumor
effect
by
increasing
production
ROS
Transmission
electron
microscopy
(TEM)
images
dynamic
light
scattering
(DLS)
showed
that
ACM-SSe-BE
had
a
particle
size
approximately
155
±
2
nm.
FTIR
verified
successful
coupling
BE.
vitro
experiments
indicated
cumulative
pH
5.5
after
24
h
was
69.39
1.07%,
which
less
than
20%
7.4,
confirming
ACM-SSe-BE.
Cell
uptake
vivo
imaging
good
ability.
results
MTT,
flow
cytometry,
Western
blot,
immunofluorescence
staining
demonstrated
promoted
apoptosis
inhibited
proliferation.
were
consistent
with
those
experiments.
These
clearly
suggested
will
be
promising
nanosystem
