Small,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 13, 2024
Abstract
Heart
failure
(HF)
represents
a
cardiovascular
disease
that
significantly
threatens
global
well‐being
and
quality
of
life.
Electroactive
nanomaterials,
characterized
by
their
distinctive
physical
chemical
properties,
emerge
as
promising
candidates
for
HF
prevention
management.
This
review
comprehensively
examines
electroactive
nanomaterials
applications
in
intervention.
It
presents
the
definition,
classification,
intrinsic
characteristics
conductive,
piezoelectric,
triboelectric
emphasizing
mechanical
robustness,
electrical
conductivity,
piezoelectric
coefficients.
The
elucidates
mechanisms:
1)
early
detection
diagnosis,
employing
nanomaterial‐based
sensors
real‐time
cardiac
health
monitoring;
2)
tissue
repair
regeneration,
providing
mechanical,
chemical,
stimuli
restoration;
3)
localized
administration
bioactive
biomolecules,
genes,
or
pharmacotherapeutic
agents,
using
advanced
drug
delivery
systems;
4)
stimulation
therapies,
leveraging
properties
innovative
pacemaker
neurostimulation
technologies.
Challenges
clinical
translation,
such
biocompatibility,
stability,
scalability,
are
discussed,
along
with
future
prospects
potential
innovations,
including
multifunctional
stimuli‐responsive
precise
therapies.
encapsulates
current
research
directions
concerning
use
management,
highlighting
to
innovating
medicine.
Materials Today Bio,
Journal Year:
2024,
Volume and Issue:
25, P. 100978 - 100978
Published: Feb. 13, 2024
A
life-threatening
illness
that
poses
a
serious
threat
to
human
health
is
myocardial
infarction.
It
may
result
in
significant
number
of
cells
dying,
dilated
left
ventricles,
dysfunctional
heart
function,
and
ultimately
cardiac
failure.
Based
on
the
development
emerging
biomaterials
lack
clinical
treatment
methods
donors
for
infarction,
hydrogels
with
good
compatibility
have
been
gradually
applied
Specifically,
based
three
processes
pathophysiology
we
summarized
various
types
designed
tissue
engineering
recent
years,
including
natural
hydrogels,
intelligent
growth
factors,
stem
cells,
microRNA-loaded
hydrogels.
In
addition,
also
describe
patch
preparation
techniques
promote
repair
MI
function.
Although
most
these
are
still
preclinical
research
stage
trials,
they
great
potential
further
application
future.
expected
this
review
will
improve
our
knowledge
offer
fresh
approaches
treating
Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
16(4), P. 469 - 469
Published: March 27, 2024
With
its
exceptional
biocompatibility,
alginate
emerged
as
a
highly
promising
biomaterial
for
large
range
of
applications
in
regenerative
medicine.
Whether
the
form
microparticles,
injectable
hydrogels,
rigid
scaffolds,
or
bioinks,
provides
versatile
platform
encapsulating
cells
and
fostering
an
optimal
environment
to
enhance
cell
viability.
This
review
aims
highlight
recent
studies
utilizing
diverse
formulations
transplantation,
offering
insights
into
efficacy
treating
various
diseases
injuries
within
field
Deleted Journal,
Journal Year:
2023,
Volume and Issue:
2(1), P. 288 - 306
Published: July 26, 2023
Polysaccharides
are
inspiring
and
valuable
molecules
to
the
development
of
novel
drug
delivery
systems
owing
their
natural
availability,
non-toxicity,
biocompatibility,
good
biological
performance,
chemical
similarity
physiological
environment,
besides
noticeable
use
for
tailored-materials
assembly.
Biodegradable
hydrogels
based
on
polysaccharides
have
been
widely
studied
as
potential
pharmaceutical
forms
due
controlled
release
properties,
which
improve
bioavailability,
therapeutic
efficacy,
patient
compliance.
Despite
these
advantages,
polysaccharide
materials
present
insufficient
mechanical
properties
or
processability,
thus,
overcome
drawbacks,
feasible
suitable
crosslinking
methods
employed
strength
stability.
Therefore,
this
review
presents
recent
advances
in
hydrogels,
including
chitosan,
cellulose,
hyaluronic
acid,
alginate,
providing
examples
manufacturing
processes
with
emphasis
carriers
delivery.
Polysaccharide-based
represent
a
sustainable,
biocompatible,
appreciable
alternative
obtain
systems.
Journal of Materials Chemistry B,
Journal Year:
2024,
Volume and Issue:
12(25), P. 6242 - 6256
Published: Jan. 1, 2024
An
artificial
nano-enzyme-enhanced
hydrogel
was
developed
to
treat
OA
through
a
ternary
synergistic
strategy
of
efficiently
driving
O
2
production
from
endogenous
ROS
in
chondrocytes
and
maintaining
lubrication
at
the
articular
cartilage
interface.
Expert Opinion on Drug Delivery,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 25, 2024
Myocardial
infarction
(MI)
causes
extensive
structural
and
functional
damage
to
the
cardiac
tissue
due
significant
loss
of
cardiomyocytes.
Early
reperfusion
is
standard
treatment
strategy
for
acute
MI,
but
it
associated
with
adverse
effects.
Additionally,
current
therapies
alleviate
pathological
changes
post-MI
are
not
effective.
Subsequent
remodeling
damaged
myocardium
often
results
in
heart
failure.
Oral
drugs
aimed
at
reducing
myocardial
require
repeated
administration
high
doses
maintain
therapeutic
levels.
This
compromises
efficacy
patient
adherence
may
cause
effects,
such
as
hypotension
liver
and/or
kidney
dysfunction.
Hydrogels
have
emerged
an
effective
delivery
platform
orthotopic
MI
their
water
content
excellent
compatibility.
Nanoscale,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Jan. 1, 2024
With
exceptional
biocompatibility
and
biodegradability,
plant-derived
materials
have
garnered
significant
interest
for
a
myriad
of
biomedical
applications.
This
mini-review
presents
concise
overview
prevalent
materials,
encompassing
polysaccharide-based
polymers,
protein-based
extracellular
vesicles,
mucilage,
decellularized
scaffolds,
whole
plant-based
biomass.
Through
different
processing
techniques,
these
can
be
tailored
into
variety
forms,
such
as
nanoparticles,
nanofibers,
hydrogels,
to
address
the
nuanced
requirements
emphasis
on
wound
healing,
tissue
engineering,
drug
delivery,
this
review
underscores
unique
advantages
lower
risk
endotoxin
virus
contamination,
reduced
ethical
concerns,
scalability,
eco-friendly
attributes.
However,
challenges
need
development
standardized
isolation
methods
further
transition
from
preclinical
clinical
applications
still
remain
solved.
Macromolecular Rapid Communications,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 13, 2025
Abstract
Myocardial
infarction
(MI)
is
a
leading
cause
of
mortality
among
cardiovascular
diseases.
Following
MI,
the
damaged
myocardium
progressively
being
replaced
by
fibrous
scar
tissue,
which
exhibits
poor
electrical
conductivity,
ultimately
resulting
in
arrhythmias
and
adverse
cardiac
remodeling.
Due
to
their
extracellular
matrix‐like
structure
excellent
biocompatibility,
hydrogels
are
emerging
as
focal
point
tissue
engineering.
However,
traditional
lack
necessary
conductivity
restore
signal
transmission
infarcted
regions.
Imparting
while
also
enhancing
adhesive
properties
enables
them
adhere
closely
myocardial
establish
stable
connections,
facilitate
synchronized
contraction
repair
within
area.
This
paper
reviews
strategies
for
constructing
conductive
hydrogels,
focusing
on
application
MI
repair.
Furthermore,
challenges
future
directions
developing
discussed.
Advanced Functional Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 23, 2025
Abstract
Developing
network‐remodeling,
electroactive
and
antibacterial
cryogel
with
tissue
sealing
pro‐coagulant
activity
for
wound
repair
hemostasis
remains
challenging.
Here,
quaternized
chitosan‐graft‐polyaniline
(QCSP),
oxidized
dextran
(OD),
benzaldehyde‐terminated
Pluronic
F127
are
used
to
prepare
dressings
(QP/OD/PF)
network
remodeling,
electroactivity,
antibacterial,
antioxidation,
blood
concentration
effect
via
in
situ
dual
Schiff
base
crosslinking.
The
exhibits
conductivity
remodeling
after
water
absorption
demonstrates
degradation,
rapid
swelling,
excellent
adhesion,
biocompatibility,
photothermal
property.
Besides,
the
hemostatic
property
of
is
confirmed
mouse
liver
puncture
bleeding
model,
rat
cruciate
incision
perforation
model.
effect,
as
well
activation
platelets
cells
by
cryogel,
confirmed.
This
functionality
successfully
utilized
biologically
active
clot/cryogel
composite
dressing
(B‐QP/OD/PF)
further
promote
skin
healing.
All
results
closure
ratio,
histological
examination,
immunofluorescence
staining,
collagen
deposition
confirm
that
B‐QP/OD/PF
superior
QP/OD/PF
other
groups
promoting
full‐thickness
defect
opens
up
a
new
direction
development
International Journal of Nanomedicine,
Journal Year:
2025,
Volume and Issue:
Volume 20, P. 1747 - 1768
Published: Feb. 1, 2025
Abstract:
Myocardial
infarction
(MI)
is
the
leading
cause
of
mortality
from
cardiovascular
diseases.
Rapid
diagnosis
and
effective
treatment
are
critical
for
improving
patient
prognosis.
Although
current
diagnostic
therapeutic
approaches
have
made
significant
progress,
they
still
face
challenges
such
as
ischemia-reperfusion
injury,
microcirculatory
disorders,
adverse
cardiac
remodeling,
inflammatory
responses.
These
issues
highlight
urgent
need
innovative
solutions.
Nanomaterials,
with
their
diverse
types,
excellent
physicochemical
properties,
biocompatibility,
targeting
capabilities,
offer
promising
potential
in
addressing
these
challenges.
Advances
nanotechnology
increasingly
drawn
attention
to
application
nanomaterials
both
diagnosing
treating
myocardial
infarction.
We
summarize
pathophysiological
mechanisms
staging
systematically
review
applications
MI
diagnosis,
including
detection
biomarkers
imaging
techniques,
well
treatment,
encompassing
anti-inflammatory
effects,
antioxidant
stress,
inhibition
fibrosis,
promotion
angiogenesis,
conduction
repair.
analyze
existing
provide
insights
into
future
research
directions
Specifically,
we
discuss
rigorous
safety
assessments,
long-term
efficacy
studies,
development
robust
strategies
translating
laboratory
findings
clinical
practice.
In
conclusion,
holds
promise
a
new
strategy
Its
enhance
outcomes
revolutionize
care
makes
it
an
exciting
area
practical
real-world
settings.
Keywords:
infarction,
nanomaterials,
nanoparticles,
