Two birds with one stone: Natural polyphenols boosted periodontitis treatment of chlorhexidine via reducing toxicity and regulating microenvironments DOI

Zhiyuan Sun,

Tianyou Wang,

Enni Chen

et al.

Materials Horizons, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Chlorhexidine (CHX) is considered the gold standard for controlling periodontal plaque and has been extensively used as a topical agent in treating periodontitis. Nevertheless, practical clinical application of CHX still constrained by inherent limitations its properties, including toxicity, inadequate biofilm scavenging capacity, single biological effect. In this study, polyphenolic epigallocatechin gallate (EGCG) employed to integrate with form an EGCG-CHX nanoplatform

Language: Английский

Microenvironment-responsive metal-phenolic network release platform with ROS scavenging, anti-pyroptosis, and ECM regeneration for intervertebral disc degeneration DOI Creative Commons
Hao Zhou, Jinpeng He, Renfeng Liu

et al.

Bioactive Materials, Journal Year: 2024, Volume and Issue: 37, P. 51 - 71

Published: March 15, 2024

Intervertebral disc degeneration (IVDD) can be caused by aging, injury, and genetic factors. The pathological changes associated with IVDD include the excessive accumulation of reactive oxygen species (ROS), cellular pyroptosis, extracellular matrix (ECM) degradation. There are currently no approved specific molecular therapies for IVDD. In this study, we developed a multifunctional microenvironment-responsive metal-phenolic network release platform, termed TMP@Alg-PBA/PVA, which could treat (IL-1β)-induced (TA-Mn-PVP, TMP) released from platform targeted mitochondria to efficiently scavenge ROS reduce ECM Pyroptosis was suppressed through inhibition IL-17/ERK signaling pathway. These findings demonstrate versatility platform. And in rat model IVDD, TMP@Alg-PBA/PVA exhibited excellent therapeutic effects reducing progression disease. therefore, presents clinical potential treatment

Language: Английский

Citations

22
Design of pH-Responsive Nanomaterials Based on the Tumor Microenvironment DOI Creative Commons

Yunheng Liu,

Lei Si, Yuxuan Jiang

et al.

International Journal of Nanomedicine, Journal Year: 2025, Volume and Issue: Volume 20, P. 705 - 721

Published: Jan. 1, 2025

The metabolic activity of tumor cells leads to the acidification surrounding microenvironment, which provides new strategies for application nanotechnology in cancer therapy.Researchers have developed various types pH-responsive nanomaterials based on acidic microenvironment.This review an in-depth discussion design mechanisms, drug-loading strategies, and pathways microenvironment-responsive nanodrug delivery systems.These materials trigger drug release upon reaching enhancing therapeutic targeting reducing toxicity healthy cells.pH-responsive include organic nanomaterials, inorganic composite nanomaterials.Additionally, this outlines prospects, challenges aiming promote development clinical translation field.

Language: Английский

Citations

3
Components, Formulations, Deliveries, and Combinations of Tumor Vaccines DOI
Tengfei Liu,

Wenyan Yao,

Wenyu Sun

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: 18(29), P. 18801 - 18833

Published: July 9, 2024

Tumor vaccines, an important part of immunotherapy, prevent cancer or kill existing tumor cells by activating restoring the body's own immune system. Currently, various formulations vaccines have been developed, including cell membrane DNA mRNA polypeptide virus-vectored and tumor-in-situ vaccines. There are also multiple delivery systems for such as liposomes, vesicles, viruses, exosomes, emulsions. In addition, to decrease risk escape tolerance that may exist with a single vaccine, combination therapy radiotherapy, chemotherapy, checkpoint inhibitors, cytokines, CAR-T therapy, photoimmunotherapy is effective strategy. Given critical role in here, we look back history discuss antigens, adjuvants, formulations, systems, mechanisms, future directions

Language: Английский

Citations

17
Engineering Versatile Bacteria‐Derived Outer Membrane Vesicles: An Adaptable Platform for Advancing Cancer Immunotherapy DOI Creative Commons

Ziheng Luo,

Cheng Xiang, Bin Feng

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: 11(33)

Published: July 1, 2024

In recent years, cancer immunotherapy has undergone a transformative shift toward personalized and targeted therapeutic strategies. Bacteria-derived outer membrane vesicles (OMVs) have emerged as promising adaptable platform for due to their unique properties, including natural immunogenicity the ability be engineered specific purposes. this review, comprehensive overview is provided of state-of-the-art techniques methodologies employed in engineering versatile OMVs immunotherapy. Beginning by exploring biogenesis composition OMVs, unveiling intrinsic immunogenic properties appeal. Subsequently, innovative approaches engineer are delved into, ranging from genetic parent bacteria incorporation functional molecules. The importance rational design strategies highlighted enhance specificity allowing tailoring diverse types. Furthermore, insights into clinical studies potential challenges utilizing vaccines or adjuvants also provided, offering assessment current landscape future prospects. Overall, review provides valuable researchers involved rapidly evolving field immunotherapy, roadmap harnessing full treatment.

Language: Английский

Citations

13
Extracellular Vesicle‐Based Antitumor Nanomedicines DOI Open Access
Mingfeng Li, Yanfei Liu, Fei Liu

et al.

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 11, 2025

Abstract Extracellular vesicles (EVs) have emerged as promising bioactive carriers for delivering therapeutic agents, including nucleic acids, proteins, and small‐molecule drugs, owing to their excellent physicochemical stability biocompatibility. However, comprehensive reviews on the various types of EV‐based nanomedicines cancer therapy remain scarce. This review explores potential EVs antitumor nanomedicines. Methods EV extraction, drug loading, engineering modifications are systematically examined, strengths limitations these technical approaches critically assessed. Additionally, key strategies developing therapies highlighted. Finally, opportunities challenges associated with advancing toward clinical translation discussed. With integration multiple disciplines, robust platforms expected be manufactured provide more personalized effective solutions oncology patients.

Language: Английский

Citations

1
Bacterial-Mediated In Situ Engineering of Tumour-Associated Macrophages for Cancer Immunotherapy DOI Open Access

Gabriela Christina Kuhl,

Mark Tangney

Cancers, Journal Year: 2025, Volume and Issue: 17(5), P. 723 - 723

Published: Feb. 20, 2025

Background/Objectives: Tumour-associated macrophages (TAMs) are critical components of the tumour microenvironment (TME), significantly influencing cancer progression and treatment resistance. This review aims to explore innovative use engineered bacteria reprogram TAMs, enhancing their anti-tumour functions improving therapeutic outcomes. Methods: We conducted a systematic following predefined protocol. Multiple databases were searched identify relevant studies on phenotypic plasticity, for reprogramming. Inclusion exclusion criteria applied select studies, data extracted using standardised forms. Data synthesis was performed summarise findings, focusing mechanisms benefits non-pathogenic modify TAMs. Results: The summarises findings that can selectively target promoting shift from tumour-promoting M2 phenotype tumour-fighting M1 phenotype. reprogramming enhances pro-inflammatory responses activity within TME. Evidence various indicates significant regression improved immune bacterial therapy. Conclusions: Reprogramming TAMs presents promising strategy approach leverages natural targeting abilities directly tumour, potentially patient outcomes offering new insights into immune-based treatments. Further research is needed optimise these methods assess clinical applicability.

Language: Английский

Citations

1
Harnessing Bacterial Membrane Components for Tumor Vaccines: Strategies and Perspectives DOI

Zhenxin Bai,

Xuanyu Wang,

Tianming Liang

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: June 27, 2024

Tumor vaccines stand at the vanguard of tumor immunotherapy, demonstrating significant potential and promise in recent years. While have achieved breakthroughs treatment cancer, they still encounter numerous challenges, including improving immunogenicity expanding scope vaccine application. As natural immune activators, bacterial components offer inherent advantages vaccines. Bacterial membrane components, with their safer profile, easy extraction, purification, engineering, along diverse array activate system improve efficacy. This review systematically summarizes mechanism action therapeutic effects membranes its derivatives (including vesicles hybrid biomaterials) Subsequently, authors delve into preparation based on biomaterials. Following this, outer are elucidated, mechanisms explained. Moreover, combination therapy analyzed. Last, challenges trends this field discussed. comprehensive analysis aims to a more informed reference scientific foundation for design implementation membrane-based

Language: Английский

Citations

6
Nano-photosensitizers with gallic acid-involved Fe–O–Cu “electronic storage station” bridging ligand-to-metal charge transfer for efficient catalytic theranostics DOI

Yunlong Li,

Chunsheng Li, Shuang Liu

et al.

Journal of Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 676, P. 974 - 988

Published: July 24, 2024

Language: Английский

Citations

5
Metal ions-anchored bacterial outer membrane vesicles for enhanced ferroptosis induction and immune stimulation in targeted antitumor therapy DOI Creative Commons
Ying Sun, Yanyan Ma,

Shijie Shangguan

et al.

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Aug. 9, 2024

The activation of ferroptosis presents a versatile strategy for enhancing the antitumor immune responses in cancer therapy. However, developing inducers that combine high biocompatibility and therapeutic efficiency remains challenging. In this study, we propose novel approach using biological nanoparticles derived from outer membrane vesicles (OMVs) Escherichia coli tumor treatment, aiming to activate stimulate responses. Specifically, functionalize OMVs by anchoring them with ferrous ions via electrostatic interactions loading STING agonist-4, followed tumor-targeting DSPE-PEG-FA decoration, henceforth referred as OMV/SaFeFA. endows peroxidase-like activity, capable inducing cellular lipid peroxidation catalyzing H

Language: Английский

Citations

4
Polyphenol Mediated Assembly: Tailored Nano‐Dredger Unblocks Axonal Autophagosomes Retrograde Transport Traffic Jam for Accelerated Alzheimer's Waste Clearance DOI Open Access
Ran Meng, Yixian Li,

Xiyu Yang

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 17, 2024

Clear-cut evidence has linked defective autophagy to Alzheimer's disease (AD). Recent studies underscore a unique hurdle in AD neuronal autophagy: impaired retrograde axonal transport of autophagosomes, potent enough induce autophagic stress and neurodegeneration. Nonetheless, pertinent therapy is unavailable. Here, novel combinational composed siROCK2 lithospermic acid B (LA) introduced, tailored dredge blocked by multi-mitigating microtubule disruption, ATP depletion, oxidative stress, initiation impediments AD. Leveraging the recent discovery multi-interactions between polyphenol LA siRNA, ε-Poly-L-lysine, anionic lipid nanovacuoles, are successfully co-loaded into fresh nano-drug delivery system, LIP@PL-LA/siRC, via ratio-flexible straightforward fabrication process. Further modification with TPL peptide onto LIP@PL-LA/siRC creates brain-neuron targeted, biocompatible, pluripotent nanomedicine, named "Nano-dredger" (T-LIP@PL-LA/siRC). Nano-dredger efficiently accelerates lysosomal degradation thereby facilitating clearance neurotoxic proteins, improving complexity, alleviating memory defects 3×Tg-AD transgenic mice. This study provides flexible polyphenol/siRNA co-delivery paradigm furnishes conceptual proof that dredging represents promising therapeutic avenue.

Language: Английский

Citations

3