Applied Surface Science, Journal Year: 2024, Volume and Issue: 675, P. 160949 - 160949
Published: Aug. 14, 2024
Biomaterials Advances, Journal Year: 2025, Volume and Issue: 169, P. 214193 - 214193
Published: Jan. 18, 2025
Language: Английский
Citations
2
International Journal of Nanomedicine, Journal Year: 2025, Volume and Issue: Volume 20, P. 125 - 139
Published: Jan. 1, 2025
Photo-immunotherapy faces challenges from poor immunogenicity and low response rate due to hypoxic microenvironment. This study presents Rh-PTZ, a small organic molecule with D-π-A structure, that simultaneously amplifies mitochondria-targeted type-I PDT-dependent immune stimulation for the treatment of cancer. The hydrophobic Rh-PTZ was encapsulated into F127 prepare nanoparticles (Rh-PTZ NPs). ROS generation ability, mitochondrial targeting capacity, ICD triggering effect mediated by NPs under LED light irradiation were investigated. Based on 4T1 subcutaneous tumor model, in vivo biological safety assessment, NIR fluorescent imaging, efficacy PDT assessed. could efficiently accumulate site induce O2 •- •OH burst situ irradiation, thereby causing severe dysfunction. can amplify stress-caused immunogenic cell death (ICD) stimulate response, promote maturation sufficient dendritic cells (DCs), enhance infiltration cells, alleviate immunosuppressive mitochondria-targeting holds promise photo-immunotherapy hypoxia overcoming limitations traditional immunotherapy.
Language: Английский
Citations
1
Bone Research, Journal Year: 2025, Volume and Issue: 13(1)
Published: March 14, 2025
Language: Английский
Citations
1
Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(25), P. 6242 - 6256
Published: Jan. 1, 2024
An artificial nano-enzyme-enhanced hydrogel was developed to treat OA through a ternary synergistic strategy of efficiently driving O 2 production from endogenous ROS in chondrocytes and maintaining lubrication at the articular cartilage interface.
Language: Английский
Citations
6
Theranostics, Journal Year: 2024, Volume and Issue: 14(11), P. 4375 - 4392
Published: Jan. 1, 2024
Rationale: Autism spectrum disorder (ASD) represents a complex neurodevelopmental condition lacking specific pharmacological interventions.Given the multifaced etiology of ASD, there exist no effective treatment for ASD.Rapamycin (RAPA) can activate autophagy by inhibiting mTOR pathway and has exhibited promising effects in treating central nervous system disorders; however, its limited ability to cross blood-brain barrier (BBB) hindered clinical efficacy, leading substantial side effects.Methods: To address this challenge, we designed drug delivery utilizing red blood cell membrane (CM) vesicles modified with SS31 peptides enhance brain penetration RAPA autism.Results: The fabricated SCM@RAPA nanoparticles, an average diameter 110 nm, exhibit rapid release pathological environment characterized oxidative stress.In vitro results demonstrate that effectively cellular autophagy, reduce intracellular ROS levels, improve mitochondrial function, thereby ameliorating neuronal damage.SS31 peptide modification significantly enhances BBB accumulation [email protected], nanoparticles potential ameliorate social deficits, cognitive reverse impairments valproic acid (VPA)-induced ASD models.Conclusions: therapeutic managing signifies paradigm shift autism treatment, holding promise interventions diverse neurological conditions.
Language: Английский
Citations
4
Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)
Published: Sept. 16, 2024
Nanozymes, a category of nanomaterials with enzyme-like activity, have garnered growing interest in various biomedical contexts. Notably, nanozymes that are capable regulating reactive oxygen species levels by emulating antioxidant or prooxidant enzymes within cells hold significant therapeutic potential for range disorders. Herein, we overview the catalytic mechanisms four exemplary orthopedic domain. Subsequently, emphasize recent groundbreaking advancements nanozyme applications orthopaedics, encompassing osteoarthritis, osteoporosis, intervertebral disc degeneration, bone defects, spinal cord injury, gout, rheumatoid arthritis, osteosarcoma and infection. Furthermore, discuss emerging area's future prospects several noteworthy challenges application. This review not only fosters ongoing development research but also emergence more potent treatment orthopaedical diseases future.
Language: Английский
Citations
4
Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)
Published: Nov. 23, 2024
Oxidative stress (OS) and neuroinflammation are critical pathological processes in secondary brain injury (SBI) after intracerebral hemorrhage(ICH), their intimate interactions initiate aggravate damage. Thus, targeting oxidative could be a promising therapeutic strategy for ICH treatment. Here, we report high-performance platform using polydopamine (PDA)-coated diselenide bridged mesoporous silica nanoparticle (PDA-DSeMSN) as smart ROS scavenger ROS-responsive drug delivery system. Caffeic acid phenethyl ester (CAPE) was blocked the pore of DSeMSN by covering with PDA gatekeeper. PDA-DSeMSN @CAPE maintained high stability underwent reactive oxygen species (ROS)-responsive degradation release. The intelligent nanomaterial effectively eliminated ROS, promoted M1 to M2 microglial conversion suppressed vitro vivo. Importantly, intravenous administration PDA-DSeMSN@CAPE specifically accumulated perihematomal sites demonstrated robust neuroprotection an mouse model biological safety. Taking together, synergistic effect ability scavenging makes it powerful provided new considerations into action improve ICH-induce injury.
Language: Английский
Citations
4
Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 160620 - 160620
Published: Feb. 1, 2025
Language: Английский
Citations
0
Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown
Published: March 3, 2025
Abstract Imbalanced mitochondrial quality control is strongly linked to the onset and development of osteoarthritis (OA). However, current research primarily focuses on local cartilage repair phenotype maintenance, lacking a systematic approach subcellular control. To address this, present study proposes strategy based nanozyme hydrogel microspheres (“mitochondrial inspector”), constructed through electrostatic self‐assembly, incorporation dynamic diselenide bonds, microfluidic technology. The oxidative stress microenvironment improved by cerium dioxide nanoparticles combined with metformin activate autophagy clear persistently dysfunctional mitochondria, thereby inhibiting OA progression. In vitro results showed that “mitochondrial inspector” not only significantly chondrocytes, but also efficiently scavenged damaged increased membrane potential over 20‐fold, notably function chondrocyte homeostasis. rat model, minimally invasive intra‐articular injection effectively regulated quality, alleviated matrix degradation, reduced osteophyte formation ≈80%, Mankin score for damage 70%. summary, this presents novel microsphere‐based treatment OA, providing new insights therapies other aging‐related diseases.
Language: Английский
Citations
0
Colloids and Surfaces B Biointerfaces, Journal Year: 2025, Volume and Issue: 251, P. 114608 - 114608
Published: March 12, 2025
Language: Английский
Citations
0