Frontiers in Pharmacology,
Journal Year:
2024,
Volume and Issue:
15
Published: Oct. 1, 2024
Uveal
melanoma
(UM)
is
the
most
common
primary
intraocular
tumour
in
adults.
Local
resection,
radiation
therapy,
and
enucleation
are
current
first-line,
UM
treatments.
However,
regardless
of
treatment
received,
around
50%
patients
will
develop
metastatic
disease
within
five
to
7
years.
In
largest
published
series
unselected
with
(mUM),
median
survival
time
after
diagnosis
metastasis
was
3.6
months,
less
than
1%
surviving
beyond
5
Approved
drugs
for
mUM
include
systemic
tebentafusp-tebn
or
isolated
hepatic
perfusion
(IHP)
melphalan.
these
only
available
a
subset
improve
by
few
highlighting
urgent
need
new
Accurately
predicting
which
at
high
risk
metastases
also
crucial.
Researchers
developing
gene
expression
signatures
create
reliable
prognostic
models
aimed
improving
patient
follow-up
strategies.
this
review
we
discuss
evidence
supporting
ferroptosis,
non-apoptotic
form
cell
death,
as
potential
novel
target
prognosticator
UM.
Chemical Reviews,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 14, 2025
Ferroptosis,
an
iron-dependent
form
of
regulatory
cell
death,
has
garnered
significant
interest
as
a
therapeutic
target
in
cancer
treatment
due
to
its
distinct
characteristics,
including
lipid
peroxide
generation
and
redox
imbalance.
However,
clinical
application
oncology
is
currently
limited
by
issues
such
suboptimal
efficacy
potential
off-target
effects.
The
advent
nanotechnology
provided
new
way
for
overcoming
these
challenges
through
the
development
activatable
magnetic
nanoparticles
(MNPs).
These
innovative
MNPs
are
designed
improve
specificity
ferroptosis
induction.
This
Review
delves
into
chemical
biological
principles
guiding
design
ferroptosis-based
therapies
imaging-guided
therapies.
It
discusses
mechanisms
attributes
ferroptosis,
composition
MNPs,
their
mechanism
action
inducers,
integration
with
advanced
imaging
techniques
monitoring.
Additionally,
we
examine
convergence
other
strategies,
chemodynamic
therapy,
photothermal
photodynamic
sonodynamic
immunotherapy,
within
context
nanomedicine
strategies
utilizing
MNPs.
highlights
multifunctional
surpass
limitations
conventional
treatments,
envisioning
future
drug-resistance-free,
precision
diagnostics
treating
recalcitrant
cancers.
Journal of Nanobiotechnology,
Journal Year:
2025,
Volume and Issue:
23(1)
Published: Feb. 25, 2025
The
human
retina
is
a
fragile
and
sophisticated
light-sensitive
tissue
in
the
central
nervous
system.
Unhealthy
retinas
can
cause
irreversible
visual
deterioration
permanent
vision
loss.
Effective
therapeutic
strategies
are
restricted
to
treatment
or
reversal
of
these
conditions.
In
recent
years,
nanoscience
nanotechnology
have
revolutionized
targeted
management
retinal
diseases.
Pharmaceuticals,
theranostics,
regenerative
medicine,
gene
therapy,
prostheses
indispensable
for
interventions
been
significantly
advanced
by
nanomedical
innovations.
Hence,
this
review
presents
novel
insights
into
use
versatile
nanomaterial-based
nanocomposites
frontier
applications,
including
non-invasive
drug
delivery,
theranostic
contrast
agents,
nanoagents,
stem
cell-based
optogenetics
prostheses,
which
mainly
reported
within
last
5
years.
Furthermore,
progress,
potential
challenges,
future
perspectives
field
highlighted
discussed
detail,
may
shed
light
on
clinical
translations
ultimately,
benefit
patients
with
disorders.
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
34(44)
Published: July 16, 2024
Abstract
Despite
its
effectiveness
in
exterminating
tumor
cells,
ferroptosis
is
seriously
hampered
by
the
high
expression
of
antioxidant
glutathione
(GSH)
and
inadequacy
endogenous
H
2
O
tumors.
Herein,
metal‐phenolic
nanoformulations
(FNCP
NFs)
composed
sonosensitizer
Chlorin
e6
(Ce6),
phenolic
GSH
consumer
naphthazarin,
Fe
3+
,
followed
modification
PEG2000,
are
strategically
designed
fabricated
for
ultrasound‐boosted
cells
through
triple
regulatory
pathways.
The
carrier‐free
FNCP
NFs
can
rapidly
dissociate
under
microenvironment
response
with
assistance
ultrasound,
releasing
2+
Ce6,
naphthazarin.
Ce6
capable
producing
singlet
oxygen
(
1
)
hydroxyl
radicals
·
OH)
ultrasound‐activated
sonodynamic
therapy
Fenton
reaction‐mediated
chemodynamic
(CDT),
respectively,
which
not
only
induce
apoptotic
cell
death
but
also
lead
to
effective
accumulation
lipid
peroxidation
(LPO),
resulting
ferroptosis.
Meanwhile,
released
naphthazarin
self‐cycling
valence
alternations
/Fe
promote
significant
decrease
intracellular
contents,
further
inducing
inactivation
peroxidase
4
(GPX4)
up‐regulation
LPO
levels,
eventually
realizing
synergistically
enhanced
This
facile
feasible
design
versatile
offers
a
new
strategy
effectively
improving
efficiency
multimodal
cancer
therapies.
International Journal of Nanomedicine,
Journal Year:
2024,
Volume and Issue:
Volume 19, P. 9549 - 9574
Published: Sept. 1, 2024
Molecular
imaging
is
an
advanced
technology
that
utilizes
specific
probes
or
markers
in
conjunction
with
cutting-edge
techniques
to
observe
and
analyze
the
localization,
distribution,
activity,
interactions
of
biomolecules
within
living
organisms.
Tumor
molecular
imaging,
by
enabling
visualization
quantification
characteristics
tumor
cells,
facilitates
a
deeper
more
comprehensive
understanding
tumors,
providing
valuable
insights
for
early
diagnosis,
treatment
monitoring,
cancer
biology
research.
However,
image
quality
still
requires
improvement,
nanotechnology
has
significantly
propelled
advancement
imaging.
Currently,
nanoparticle-based
technologies
encompass
radionuclide
fluorescence
magnetic
resonance
ultrasound
photoacoustic
multimodal
among
others.
As
our
microenvironment
deepens,
design
nanoparticle
also
evolved,
offering
new
perspectives
expanding
applications
Beyond
diagnostics,
there
marked
trend
towards
integrated
diagnosis
therapy,
image-guided
playing
pivotal
role.
This
includes
surgery,
photodynamic
chemodynamic
therapy.
Despite
continuous
advancements
innovative
developments
many
these
remain
experimental
stage
require
breakthroughs
before
they
can
be
fully
into
clinical
practice.
Journal of Materials Chemistry B,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
10B
agents
are
critical
components
in
the
application
of
boron
neutron
capture
therapy
(BNCT)
for
tumor
treatment.
The
development
a
multi-functional
agent
plays
an
important
role
BNCT.
This
study
presents
pioneering
lyophilized-tumour-cell-based
approach
enhanced
accumulation
10B-doped
carbon
dots
(10B-CDs)
within
tumour
tissue,
irradiating
thermal
neutrons
to
treat
prostate
cancer.
In
this
platform,
lyophilized
RM-1
cells
function
as
both
cell
antigens
and
delivery
vehicles
10B-CDs.
design
facilitates
co-delivery
10B,
thereby
changing
immune
status
from
"cold"
"hot"
prolonging
retention
time
10B-CDs
vivo.
Prostate
cancer
killed
by
BNCT
mediated
not
only
damage
DNA,
but
ferroptosis
is
also
underlying
mechanism.
powerful
binary
system
offers
novel
strategy
combining
with
immunotherapy
treatment
cancer,
providing
promising
BNCT-based
combination
immunotherapy.
