Development of Polymer‐Based Piezoelectric Materials for the Bone Tissue Regeneration DOI Open Access

Madappa C Maridevaru,

Honglang Lu,

Shubham Roy

et al.

Macromolecular Bioscience, Journal Year: 2025, Volume and Issue: unknown

Published: March 25, 2025

With the aging population, fitness issues, poor bone healing, and high infection rates are associated with fractures other diseases. Nevertheless, traditional approaches materials struggle to treat orthopedic diseases by loading exogenous stem cells, growth factors, or merely structurally simulating periosteum. The advancement of biomedical has become critical in addressing challenges tissue regeneration, encompassing a range conditions including wounds, inflammation, infections, fractures, degenerative effects metabolic disorders. Recently, polymer-based piezoelectric have emerged as promising avenue for enhancing regenerative processes. These possess unique electrical properties that can stimulate cellular activities promote making them particularly suitable engineering applications. This review aims delineate multifaceted role treating various bone-related ailments, highlighting their potential active regeneration actively pointing out future research directions medicine engineering. By integrating insights from science develop more effective strategies managing injuries disorders, ultimately promoting osseointegration, accelerating regeneration.

Language: Английский

Piezoelectric Biomaterials Inspired by Nature for Applications in Biomedicine and Nanotechnology DOI
Siying Chen,

Xiaoyu Tong,

Yehong Huo

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(35)

Published: June 22, 2024

Bioelectricity provides electrostimulation to regulate cell/tissue behaviors and functions. In the human body, bioelectricity can be generated in electromechanically responsive tissues organs, as well biomolecular building blocks that exhibit piezoelectricity, with a phenomenon known piezoelectric effect. Inspired by natural bio-piezoelectric phenomenon, efforts have been devoted exploiting high-performance synthetic biomaterials, including molecular materials, polymeric ceramic composite materials. Notably, biomaterials polarize under mechanical strain generate electrical potentials, which used fabricate electronic devices. Herein, review article is proposed summarize design research progress of devices toward bionanotechnology. First, functions regulating electrophysiological activity from cellular tissue level are introduced. Next, recent advances structure-property relationship various provided detail. following part, applications engineering, drug delivery, biosensing, energy harvesting, catalysis systematically classified discussed. Finally, challenges future prospects presented. It believed this will provide inspiration for development innovative fields biomedicine nanotechnology.

Language: Английский

Citations

39
Degradable piezoelectric biomaterials for medical applications DOI Creative Commons
Yuan Bai, Hongyu Meng, Zhou Li

et al.

MedMat., Journal Year: 2024, Volume and Issue: 1(1), P. 40 - 49

Published: May 13, 2024

The energy harvesting technology based on piezoelectricity promises to achieve a self-powered mode for portable medical electronic devices. Piezoelectric materials, as crucial components in electromechanical applications, have extensively been utilized Especially, degradable piezoelectric biomaterials received much attention the field due their excellent biocompatibility and biosafety. This mini-review mainly summarizes types structural characteristics of from small-molecule crystals polymers. Afterward, applications are briefly introduced, including harvester sensor, actuator transducer, tissue engineering scaffold. Finally, material perspective, some challenges currently faced by proposed.

Language: Английский

Citations

18
The potential application of electrical stimulation in tendon repair: a review DOI Creative Commons
Xiao Yu,

Yihong Shen,

Jie Cui

et al.

Med-X, Journal Year: 2025, Volume and Issue: 3(1)

Published: March 4, 2025

Language: Английский

Citations

2
Biodegradable Piezoelectric Janus Membrane with Enhanced Antibacterial and Osteoinductive Properties for Periodontitis Therapy DOI Open Access
Jingrong Cheng,

Liping Wu,

Hongying Fu

et al.

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 26, 2025

An ideal guided bone regeneration (GBR) membrane for periodontitis treatment should incorporate biocompatibility, biodegradability, mechanical strength, antibacterial properties, and osteoconductivity. However, no commercially available GBR meets all these criteria simultaneously. In this study, a novel biodegradable piezoelectric double-layered is developed, with non-piezoelectric Poly-L-lactic acid (PLLA) side facing the gingiva PLLA-ZnO alveolar bone. This asymmetric membrane, distinct fiber orientations charge distribution, combines synergizes degradability, barrier function, activity osteogenic potential to enhance efficacy. The can effectively prevent fibroblast migration, inhibits bacterial infection, promotes both in vitro vivo. testing shows good rate against Porphyromonas gingivalis (P. gingivalis) Staphylococcus aureus (S. aureus) after 10 min of ultrasound stimulation. Expression levels genes Bone morphogenetic Protein 2 (BMP2), Runt-related transcription factor (RUNX2), Osteopontin (OPN) Osteocalcin (OCN) are over twice that control. mouse P. gingivalis-mediated model, our composite demonstrates effective antimicrobial effects promote 2- 4-weeks implantation, facilitated by mechanisms such as physical isolation, zinc ion release, effects, enhanced expression through activation osteogenesis-related signaling pathways, underscoring its strong applications.

Language: Английский

Citations

2
Recent advances in TENGs collecting acoustic energy: From low-frequency sound to ultrasound DOI

Siqian Zhou,

Conger Jia,

Guolv Shu

et al.

Nano Energy, Journal Year: 2024, Volume and Issue: 129, P. 109951 - 109951

Published: July 9, 2024

Language: Английский

Citations

14
Extracellular Matrix‐Surrogate Advanced Functional Composite Biomaterials for Tissue Repair and Regeneration DOI Creative Commons

Milad Vahidi,

Amin S. Rizkalla, Kibret Mequanint

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(27)

Published: July 22, 2024

Abstract Native tissues, comprising multiple cell types and extracellular matrix components, are inherently composites. Mimicking the intricate structure, functionality, dynamic properties of native composite tissues represents a significant frontier in biomaterials science tissue engineering research. Biomimetic combine benefits different such as polymers, ceramics, metals, biomolecules, to create tissue‐template materials that closely simulate structure functionality tissues. While design their vitro testing frequently reviewed, there is considerable gap whole animal studies provides insight into progress toward clinical translation. Herein, we provide an insightful critical review advanced applicable several The incorporation bioactive cues signaling molecules mimic microenvironment discussed. Strategies for spatiotemporal release growth factors, cytokines, proteins elucidated, highlighting role guiding cellular behavior, promoting regeneration, modulating immune responses. Advanced challenges, achieving optimal mechanical properties, improving long‐term stability, integrating multifunctionality future directions, We believe this manuscript reader with timely perspective on biomaterials.

Language: Английский

Citations

11
Ultrasound-triggered piezoelectric polyetheretherketone with boosted osteogenesis via regulating Akt/GSK3β/β-catenin pathway DOI Creative Commons
Yue Li, Yingying Fan, Siyu Zhao

et al.

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Sept. 5, 2024

Language: Английский

Citations

10
A bioabsorbable mechanoelectric fiber as electrical stimulation suture DOI Creative Commons

Zhouquan Sun,

Yuefan Jin,

Jiabei Luo

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Oct. 8, 2024

In surgical medicine, suturing is the standard treatment for large incisions, yet traditional sutures are limited in functionality. Electrical stimulation a non-pharmacological therapy that promotes wound healing. this context, we designed passive and biodegradable mechanoelectric suture. The suture consists of multi-layer coaxial structure composed (poly(lactic-co-glycolic acid), polycaprolactone) magnesium to allow safe degradation. addition excellent mechanical properties, mechanoelectrical nature grants generation electric fields response movement stretching. This shown speed up healing by 50% reduce risk infection. work presents an evolution conventional closure procedures, using degradable device ready be translated into clinical practice.

Language: Английский

Citations

10
Breaking piezoelectric limits of molecules for biodegradable implants DOI Creative Commons
Jianhua Hao, Nik Ahmad Nizam Nik Malek,

Wan Hairul Anuar Kamaruddin

et al.

BMEMat, Journal Year: 2024, Volume and Issue: 2(2)

Published: May 11, 2024

Abstract In the quest for optimizing biodegradable implants, exploration of piezoelectric materials stands at forefront biomedical engineering research. Traditional often suffer from limitations in biocompatibility and biodegradability, significantly impeding their vivo study further application. By leveraging molecular structural design, a recent innovative approach transcends conventional limits molecules designed implants. The implants may open new avenues applications bioenergy harvesting/sensing, implanted electronics, transient medical devices tissue regeneration.

Language: Английский

Citations

9
Ingenious Structure Engineering to Enhance Piezoelectricity in Poly(vinylidene fluoride) for Biomedical Applications DOI
Jiwei Cui,

Lijun Du,

Zhiheng Meng

et al.

Biomacromolecules, Journal Year: 2024, Volume and Issue: 25(9), P. 5541 - 5591

Published: Aug. 12, 2024

The future development of wearable/implantable sensing and medical devices relies on substrates with excellent flexibility, stability, biocompatibility, self-powered capabilities. Enhancing the energy efficiency convenience is crucial, converting external mechanical into electrical a promising strategy for long-term advancement. Poly(vinylidene fluoride) (PVDF), known its piezoelectricity, an outstanding representative electroactive polymer. Ingeniously designed PVDF-based polymers have been fabricated as piezoelectric various applications. Notably, performance platforms determined by their structural characteristics at different scales. This Review highlights how researchers can strategically engineer structures microscopic, mesoscopic, macroscopic We discuss advanced research diverse designs in biomedical sensing, disease diagnosis, treatment. Ultimately, we try to give perspectives trends biomedicine, providing valuable insights further research.

Language: Английский

Citations

8