Recent advancements in mechanistic Research, therapeutic Potential, and Structure-Activity relationships of Aurora kinase inhibitors in cancer therapies DOI
Ghanshyam Teli, Lalmohan Maji, Rohit Pal

et al.

Bioorganic Chemistry, Journal Year: 2024, Volume and Issue: 154, P. 107976 - 107976

Published: Nov. 16, 2024

Language: Английский

Development of 1,2,3-triazole hybrids as multi-faced anticancer agents co-targeting EGFR/mTOR pathway and tubulin depolymerization DOI
Mennatallah A. Shaheen, Khaled M. Darwish, Safaa M. Kishk

et al.

Bioorganic Chemistry, Journal Year: 2025, Volume and Issue: 156, P. 108153 - 108153

Published: Jan. 11, 2025

Language: Английский

Citations

3
A comprehensive review on role of Aurora kinase inhibitors (AKIs) in cancer therapeutics DOI
Deepali Gupta, Mukesh Kumar, Sana Saifi

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 265, P. 130913 - 130913

Published: March 18, 2024

Language: Английский

Citations

13
Synthesis, antitumor activity, antimicrobial evaluation and molecular docking studies of some hydrazone, 1,3,4-oxadiazole, 1,2,4-triazole and pyrazole derivatives bearing nicotinoyl moiety DOI Creative Commons
Abdel‐Rahman Farghaly, Saleh A. Ahmed, Khatib Sayeed Ismail

et al.

Results in Chemistry, Journal Year: 2024, Volume and Issue: 7, P. 101474 - 101474

Published: Jan. 1, 2024

In this study, we synthesized a number of new intriguing azoles bearing nicotinoyl moiety, their antimicrobial and antitumor activities were investigated as well. We succeeded to prepare sequence hydrazones 2,4, 1,3,4-oxadiazoles 5, 6, 11, 12, 1,2,4-triazole 8, pyrazoles 9, 10, 13, 14, 16, 18, 20, 22, 25 pyrazolo[3,4-d]pyrimidines 15, 23, 24. Most the compounds tested against strains fungus bacteria. Some that demonstrated significant biological activity selected test for cancer cells. It is interesting note that, some showed moderate potent antibacterial activity. Strong was by 16 23 (MIC = 2.5–5 µg/mL) most microorganisms. Compounds 24 4a reasonable response Compound 2 explained weak towards one Also, it found at given concentration (3.16 amino nitrile 9 exhibited strong cell-growth inhibiting action (>50 %). Based on these findings, compound seems like good lead candidates investigate further potential anticancer agent respectively.

Language: Английский

Citations

8
PI3Kδ and mTOR dual inhibitors: Design, synthesis and anticancer evaluation of 3-substituted aminomethylquinoline analogues DOI

Digambar Yevale,

Nishith Teraiya,

Twinkle Lalwani

et al.

Bioorganic Chemistry, Journal Year: 2024, Volume and Issue: 147, P. 107323 - 107323

Published: March 30, 2024

Language: Английский

Citations

8
Research progress on the relationship between AURKA and tumorigenesis: the neglected nuclear function of AURKA DOI Creative Commons
Menghua Chen, Huijun Zhu, Jian Li

et al.

Annals of Medicine, Journal Year: 2024, Volume and Issue: 56(1)

Published: May 13, 2024

AURKA is a threonine or serine kinase that needs to be activated by TPX2, Bora and other factors. located on chromosome 20 amplified overexpressed in many human cancers, such as breast cancer. regulates some basic cellular processes, this regulation realized

Language: Английский

Citations

4
Discovery of new pyrazole-4-carboxamide analogues as potential anticancer agents targeting dual Aurora kinase A and B DOI

Digambar Yevale,

Nishith Teraiya,

Twinkle Lalwani

et al.

European Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 280, P. 116917 - 116917

Published: Oct. 4, 2024

Language: Английский

Citations

4
Advances in the Design, Discovery, and optimization of aurora kinase inhibitors as anticancer agents DOI
Anita Verma,

Pradhuman Bharatiya,

Aashish Jaitak

et al.

Expert Opinion on Drug Discovery, Journal Year: 2025, Volume and Issue: unknown

Published: March 17, 2025

Introduction Aurora kinases (AKs) play key roles during carcinogenesis and show a close relationship with many cellular effects including mitotic entry, spindle assembly chromosomal alignment biorientation. Indeed, elevated levels of AKs have been reported in several different tumor types, leading research scientists to investigate ways that we can target for the purpose developing new anticancer therapeutics.

Language: Английский

Citations

0
First-in-class Dual Inhibitors of MASTL and Aurora A Kinase: Discovery of Selective Cyclohexa[b]thiophenes with Potent Anticancer Activity DOI

Somaya A. Abdel‐Rahman,

Hossam Nada, Moustafa T. Gabr

et al.

European Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 117729 - 117729

Published: May 1, 2025

Language: Английский

Citations

0
Imidazole Hybrids: A Privileged Class of Heterocycles in Medicinal Chemistry with New Insights into Anticancer Activity DOI Creative Commons

Zarifa Murtazaeva,

Azizbek Nasrullaev,

Anvarjon Buronov

et al.

Molecules, Journal Year: 2025, Volume and Issue: 30(10), P. 2245 - 2245

Published: May 21, 2025

Imidazole is a five-membered heterocyclic system featuring two nitrogen heteroatoms at the 1- and 3-positions of ring. The imidazole scaffold particularly suited for kinase inhibition concepts. This further confirms that this privileged structure in development anticancer drugs. Considering these key factors recent focus scientists on compounds, we discuss activities imidazole-containing hybrids related highlighting articles published 2023 serve as basis medicinal chemistry leads. From chemical perspective, present review emphasizes hybrid molecules with an ring side chain, imidazole-centered molecules, condensed hybrids, compounds containing or more rings, polycyclic metal complexes, benzimidazole hybrids.

Language: Английский

Citations

0
Computational Design, Synthesis, and Bioevaluation of 2-(Pyrimidin-4-yl)oxazole-4-carboxamide Derivatives: Dual Inhibition of EGFRWT and EGFRT790M with ADMET Profiling DOI
Nilesh Raghunath Khedkar, Milind Sindkhedkar, Alex Joseph

et al.

Bioorganic Chemistry, Journal Year: 2023, Volume and Issue: 143, P. 107027 - 107027

Published: Dec. 9, 2023

Language: Английский

Citations

6