Molecules,
Journal Year:
2024,
Volume and Issue:
29(17), P. 4193 - 4193
Published: Sept. 4, 2024
The
emergence
of
natural
products
has
provided
extremely
valuable
references
for
the
treatment
various
diseases.
Cucurbitacin
B,
a
tetracyclic
triterpenoid
compound
isolated
from
cucurbitaceae
and
other
plants,
is
most
abundant
member
cucurbitin
family
exhibits
wide
range
biological
activities,
including
anti-inflammatory,
anti-cancer,
even
agricultural
applications.
Due
to
its
high
toxicity
narrow
therapeutic
window,
structural
modification
dosage
form
development
are
necessary
address
these
issues
with
cucurbitacin
B.
This
paper
reviews
recent
research
progress
in
pharmacological
action,
modification,
application
review
aims
enhance
understanding
advancements
this
field
provide
constructive
suggestions
further
on
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(10), P. 5222 - 5222
Published: May 10, 2024
Flavonoids,
a
variety
of
plant
secondary
metabolites,
are
known
for
their
diverse
biological
activities.
Isoflavones
subgroup
flavonoids
that
have
gained
attention
potential
health
benefits.
Puerarin
is
one
the
bioactive
isoflavones
found
in
Kudzu
root
and
Pueraria
genus,
which
widely
used
alternative
Chinese
medicine,
has
been
to
be
effective
treating
chronic
conditions
like
cardiovascular
diseases,
liver
gastric
respiratory
diabetes,
Alzheimer’s
disease,
cancer.
extensively
researched
both
scientific
clinical
studies
over
past
few
years.
The
purpose
this
review
provide
an
up-to-date
exploration
puerarin
biosynthesis,
most
common
extraction
methods,
analytical
techniques,
effects,
new
perspective
medical
pharmaceutical
research
development.
Discover Oncology,
Journal Year:
2025,
Volume and Issue:
16(1)
Published: Jan. 8, 2025
Vanillic
Acid
(VA)
is
an
aromatic
acid
extracted
from
traditional
Chinese
medicine
such
as
Angelica
sinensis
and
Panax
ginseng,
which
has
demonstrated
potent
anti-cancer
activity,
inhibiting
the
onset
progression
of
various
malignant
tumors.
This
review
highlights
principal
mechanism
by
VA
exerts
its
anticancer
including
apoptosis
induction,
specifically
promoting
generation
intracellular
reactive
oxygen
species
(ROS),
in
turn
triggers
mitochondrial
apoptosis.
Furthermore,
disrupts
cancer
cell
cycle,
arresting
most
cells
at
G1
phase,
curtails
migration,
invasion,
angiogenesis,
potentiates
therapeutic
efficacy
chemotherapeutic
drugs,
all
while
minimizing
adverse
reactions.
paper
offers
a
comprehensive
VA's
anti-tumor
effects
underlying
mechanisms,
aiming
to
provide
some
references
for
scientists
clinical
physicians
research
strategies.
Mycology: An International Journal on Fungal Biology,
Journal Year:
2024,
Volume and Issue:
15(3), P. 283 - 321
Published: June 11, 2024
Fungi
have
been
identified
as
a
prolific
source
of
structurally
unique
secondary
metabolites,
many
which
display
promising
biological
and
pharmacological
properties.
This
review
provides
an
overview
the
structures
new
natural
products
derived
from
fungi
their
activities
along
with
research
strategies,
focuses
on
literature
published
in
representative
journals
2023.
In
this
review,
total
553
including
219
polyketides,
145
terpenoids,
35
steroids,
106
alkaloids,
48
peptides
are
presented.
By
summarising
latest
findings,
aims
to
provide
guide
inspire
further
innovation
fields
discovery
fungal
pharmaceutical
development.
Journal of Advanced Research,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Aug. 1, 2024
Traditional
Chinese
Medicine
(TCM)
has
gained
global
attention,
particularly
after
Professor
Youyou
Tu
was
awarded
the
Nobel
Prize
for
her
discovery
of
artemisinin
as
a
treatment
malaria.
However,
theory
behind
TCM
is
often
perceived
"black-box"
with
complex
components
and
an
unclear
structure
mechanism
action.
This
had
hindered
development
within
framework
modern
medicine.
The
molecular
compatibility
proposed
by
Tian
Xie's
team
integrates
Western
medicine
in
clinical
practice,
provide
feasible
direction
modernization.
It
necessary
to
summarize
popularize
this
theory.
review
aims
systematically
introduce
some
new
insight
TCM.
According
theory,
desired
effects
can
be
achieved
organically
combining
multiple
active
molecules
from
These
compounds
have
specific
ingredients,
precise
mechanisms,
controllable
quality
that
meet
standards
guided
antitumor
drug
elemene
emulsions,
also
revealed
extensive
between
TCM-derived
other
TCM,
medicine,
or
biomaterials.
opens
up
potential
TCM-based
options.
In
conclusion,
holds
promise
strategy
modernizing
Frontiers in Pharmacology,
Journal Year:
2024,
Volume and Issue:
15
Published: Nov. 29, 2024
The
role
of
computational
tools
in
drug
discovery
and
development
is
becoming
increasingly
important
due
to
the
rapid
computing
power
advancements
chemistry
biology,
improving
research
efficiency
reducing
costs
potential
risks
preclinical
clinical
trials.
Machine
learning,
especially
deep
a
subfield
artificial
intelligence
(AI),
has
demonstrated
significant
advantages
development,
including
high-throughput
virtual
screening,
