Gliricidia sepium (Jacq.) Kunth. ex. Walp. Leaves-Derived Biogenic Nanohydrogel Accelerates Diabetic Wound Healing in Rats Over 21 Days DOI
Aya A. Wafaey, Seham S. El‐Hawary, Mohamed A. El Raey

et al.

Burns, Journal Year: 2024, Volume and Issue: 51(2), P. 107368 - 107368

Published: Dec. 28, 2024

Language: Английский

Protective effects of Euphorbia heterophylla against testicular degeneration in streptozotocin-induced diabetic rats in relation to phytochemical profile DOI Creative Commons
Ahmed M. Nagy, Heba A. Fahmy, Mohamed F. Abdelhameed

et al.

PLoS ONE, Journal Year: 2025, Volume and Issue: 20(1), P. e0314781 - e0314781

Published: Jan. 16, 2025

Background Diabetes mellitus (DM) poses a major risk to human health due an array of implications, one which is detrimental effect on the testicular and reproductive functions. Euphorbia heterophylla widely recognized for its medicinal properties worldwide. Methods findings The objective this study was profile E . ethanol extract (EH-EtOH) elucidate protective role in oxidative stress, relieving inflammatory action hyperglycemia-induced degeneration restoring normal histological structure with physiological tissue streptozotocin (STZ)-induced DM. High-resolution ultra-performance liquid chromatography-mass spectrometry (UHPLC-ESI-Orbitrap-MS) analysis employed analyze compounds present EH-EtOH. EH-EtOH against rat model DM evaluated by measuring improvements blood glucose levels, body weight, inflammation, damage, microcirculation impairment, apoptosis cells induced STZ. chemical profiling revealed presence 52 compounds, including phenolic acids, flavonoids, coumarins, phloroglucinols, triterpenes. Notably, identified isovitexin- C -hexoside, isorhamnetin- O diosmetin, halfordin first time species. Treatment effectively mitigated damage caused STZ, as evidenced restored testosterone (T4) levels antioxidant capacity, reduced expression pro-inflammatory cytokines, improved microcirculation, inhibition testes. Conclusions These results emphasize potential therapeutic related male infertility dysfunctions via antioxidant/angiogenetic /anti-apoptotic effect.

Language: Английский

Citations

1
The effects of nanoparticle based drugs on Helicobacter pylori infection and gastric cancer DOI
Zahra Ebrahimi, H Hamid, Parisa Salari

et al.

Gene Reports, Journal Year: 2025, Volume and Issue: unknown, P. 102223 - 102223

Published: April 1, 2025

Language: Английский

Citations

0
Role of Phytochemical Mediated Zinc Oxide Nanoparticles on Biomedical and Industrial Wastewater Treatment: A Green Approach by Experimental and Molecular Docking Exploration DOI

Praveen Kumar Muchinthala,

Venkatramana Losetty

Journal of environmental chemical engineering, Journal Year: 2025, Volume and Issue: unknown, P. 115333 - 115333

Published: Jan. 1, 2025

Language: Английский

Citations

0
UHPLC-QTOF-MS/MS profiling, molecular networking, and molecular docking analysis of Gliricidia sepium (Jacq.) Kunth. ex. Walp. stem ethanolic extract and its gastroprotective effect on gastritis in rats DOI Creative Commons
Aya A. Wafaey, Seham S. El‐Hawary, Osama G. Mohamed

et al.

Toxicology Reports, Journal Year: 2025, Volume and Issue: 14, P. 101944 - 101944

Published: Feb. 4, 2025

Metabolic profiling of the crude ethanolic extract Gliricidia sepium (Jacq.) Kunth. ex. Walp. stem (GSS) was conducted using ultra-high performance quadrupole time flight mass spectrometry/mass spectrometry (UHPLC-QTOF-MS/MS) in negative mode, resulting identification 23 compounds belonging to various classes such as flavonoids, fatty acids, triterpenoid saponins, and phenolic acids. Notably, eight flavonoids including kaempferol-3-O-robinoside-7-O-rhamnoside, isoquercitrin, kaempferol-3-O-rutinoside, apigenin-7-glucoside, kaempeferol-7-O-rhamnoside, luteolin, apigenin, liquiritigenin, along with two acids (4-hydroxycinnamic acid 2-hydroxyhydrocinnamic acid) four saponins (soyasaponin I, soyasaponin II, III, kaikasaponin III) were dereplicated. Additionally, nine derivatives identified, azelaic 2-isopropyl malic acid. Molecular networking analysis revealed formation clusters among while others do not form clusters. Further indicated that GSS exhibited a total content 38.78 ± 1.609 µg gallic equivalent/mg flavonoid 5.62 0.50 rutin equivalent/mg. Biological evaluations showed mitigated gastric tissue injury induced by pyloric ligation, notable reduction oxidative stress marker reactive oxygen species levels inflammatory cytokines interleukin-6 tumor necrosis factor-alpha levels. it enhanced superoxide dismutase inhibitor nuclear factor kappa B alpha levels, lowering expression inducible nitric oxide synthase. Histopathological examination significant improvements morphology GSS-treated groups compared control group. docking studies potential interactions between target proteins involved stress, inflammation, protection gastritis. This study aims investigate gastroprotective activity against gastritis via ligation.

Language: Английский

Citations

0
Biosynthesis of non-toxic TiO2 nanoparticles using polysaccharide rich ⁠marine algae Caulerpa racemose for inhibition of biofilm-producing bacteria and brine shrimp Artemia DOI
Govindan Rajivgandhi, Mudaliar Mahesh Margoni,

Malathi Mathiazhagan

et al.

Colloids and Surfaces A Physicochemical and Engineering Aspects, Journal Year: 2025, Volume and Issue: unknown, P. 136483 - 136483

Published: Feb. 1, 2025

Language: Английский

Citations

0
Advances in Green Synthesis and Application of Nanoparticles from Crop Residues: A Comprehensive Review DOI Creative Commons
Olawale Festus Olaniyan,

Chinenye Agnes Ariwaodo,

Sulyman Olalekan Ibrahim

et al.

Scientific African, Journal Year: 2025, Volume and Issue: unknown, P. e02654 - e02654

Published: March 1, 2025

Language: Английский

Citations

0
Assessing anticancer, antidiabetic, and antioxidant capacities in green-synthesized zinc oxide nanoparticles and solvent-based plant extracts DOI Creative Commons
Muhammad Azeem, Muhammad Hussnain Siddique, Muhammad Imran

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(14), P. e34073 - e34073

Published: July 1, 2024

Cancer and diabetes represent significant challenges in the field of biomedicine, with major global impacts on public health. Acacia nilotica, commonly called 'gum arabic tree,' is recognized for its unique biomedical properties. The current study aimed to investigate pharmacological potential A. nilotica-based zinc-oxide nanoparticles (ZnO-NPs) comparison ethanol methanol-based extracts against cancer, diabetes, oxidative stress. Green synthesis ZnO-NPs was performed using barks nilotica. Different techniques characterization ZnO-NPs, including UV–Visible spectroscopy, Scanning Electron Microscopy, Fourier Transmission Infrared (FT-IR) X-ray Diffraction (XRD), were utilized. morphological analysis revealed that fine NPs have mean particle sizes 15 ± 1.5 nm. For solvent based-extraction, leaves utilized dissolved into methanol further processing. MTT assay optimum concentration inhibit proliferation liver cancer cell line HepG2 100 μg/mL where 67.0 % inhibition observed; both ethanol- showed at μg/mL. DPPH demonstrated 250 1000 extracts, as antioxidant activity (with 73.1 %, 68.9 68.2 respectively). α-Glucosidase 10 antidiabetic 95 93.7 93.4 provided interesting insights efficacy reliability application. Further research should be focused examining specific pathways safety solvent-based extracts.

Language: Английский

Citations

2
Biogenic Nanoparticles as Safer Alternatives for Gastric Ulcers: An Update on Green Synthesis Methods, Toxicity, and Their Efficacy in Controlling Inflammation DOI

Susmita Yadav,

Suraj N. Mali, Anima Pandey

et al.

Biological Trace Element Research, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 21, 2024

Language: Английский

Citations

2
Eco-friendly synthesis of Co3O4 nanoparticles using Millettia pinnata towards increased anti-oxidant, anti-biofilm and cytocompatibility properties against biofilm producing bacteria and human pulmonary alveolar basal cells DOI
Mudaliar Mahesh Margoni, Govindan Rajivgandhi,

Chackaravarthi Gnanasekaran

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 100, P. 106124 - 106124

Published: Aug. 28, 2024

Language: Английский

Citations

1
Gliricidia sepium (Jacq.) Kunth. ex. Walp. Leaves-Derived Biogenic Nanohydrogel Accelerates Diabetic Wound Healing in Rats Over 21 Days DOI
Aya A. Wafaey, Seham S. El‐Hawary, Mohamed A. El Raey

et al.

Burns, Journal Year: 2024, Volume and Issue: 51(2), P. 107368 - 107368

Published: Dec. 28, 2024

Language: Английский

Citations

1