APL Bioengineering,
Journal Year:
2018,
Volume and Issue:
2(2)
Published: June 1, 2018
Wound
healing
is
a
highly
complex
process
of
tissue
repair
that
relies
on
the
synergistic
effect
number
different
cells,
cytokines,
enzymes,
and
growth
factors.
A
deregulation
in
this
can
lead
to
formation
non-healing
chronic
ulcer.
Current
treatment
options,
such
as
collagen
wound
dressings,
are
unable
meet
demand
set
by
environment.
Therefore,
multifaceted
bioactive
dressing
needed
elicit
targeted
affect.
strategies
seek
develop
through
delivery
molecule
hydrogel
or
polymeric
scaffold.
This
review
examines
current
biomaterial
small
molecule-based
approaches
material
for
therapy
accepted
models
testing
efficacy.
Biomedicine & Pharmacotherapy,
Journal Year:
2020,
Volume and Issue:
131, P. 110622 - 110622
Published: Aug. 17, 2020
Propolis,
a
resinous
material
produced
by
honey
bees
from
plant
exudates,
has
long
been
used
in
traditional
herbal
medicine
and
is
widely
consumed
as
health
aid
immune
system
booster.
The
COVID-19
pandemic
renewed
interest
propolis
products
worldwide;
fortunately,
various
aspects
of
the
SARS-CoV-2
infection
mechanism
are
potential
targets
for
compounds.
entry
into
host
cells
characterized
viral
spike
protein
interaction
with
cellular
angiotensin-converting
enzyme
2
(ACE2)
serine
protease
TMPRSS2.
This
involves
PAK1
overexpression,
which
kinase
that
mediates
coronavirus-induced
lung
inflammation,
fibrosis,
suppression.
Propolis
components
have
inhibitory
effects
on
ACE2,
TMPRSS2
signaling
pathways;
addition,
antiviral
activity
proven
vitro
vivo.
In
pre-clinical
studies,
promoted
immunoregulation
pro-inflammatory
cytokines,
including
reduction
IL-6,
IL-1
beta
TNF-α.
monocytes
macrophages,
well
Jak2/STAT3,
NF-kB,
inflammasome
pathways,
reducing
risk
cytokine
storm
syndrome,
major
mortality
factor
advanced
disease.
also
shown
promise
an
treatment
comorbidities
particularly
dangerous
patients,
respiratory
diseases,
hypertension,
diabetes,
cancer.
Standardized
consistent
bioactive
properties
now
available.
Given
current
emergency
caused
limited
therapeutic
options,
presented
promising
relevant
option
safe,
easy
to
administrate
orally
readily
available
natural
supplement
functional
food.
Saudi Journal of Biological Sciences,
Journal Year:
2020,
Volume and Issue:
27(11), P. 3079 - 3086
Published: Sept. 14, 2020
Propolis
(bee
glue)
is
a
bee
glue,
sticky
resinous
material
released
from
various
plant
sources
such
as
bud
exudates,
flowers,
and
leaves
modified
by
secretions
wax
propolis
composed
of
resins,
waxes,
polyphenols,
polysaccharides,
volatile
materials,
secondary
metabolites
that
are
responsible
for
bioactivity
antibacterial,
anti-angiogenic,
antiulcer,
anti-inflammatory,
antioxidant,
anti-viral
activities.
The
physico-chemical
characteristics
the
natural
properties
kinds
have
been
studied
past
decade.
Novel
active
anti-microbial
compounds
identified
in
propolis.
Those
positively
modulated
antimicrobial
resistance
multidrug
resistant
bacteria.
Published
research
has
indicated
its
derivatives
many
with
broad
spectrum
against
different
types
bacteria
it
enhanced
efficacy
conventional
antibiotics.
Besides,
combination
other
honey
whereby,
combinations
synergistic
effect
bacterial
strains
Escherichia
coli
Staphylococcus
aureus.
activity
very
much
dependent
on
seasonal
regional
factors,
Middle
Eastern
shown
best
antibacterial
efficacy.
main
flavonoids
ingredients
should
not
be
overlooked
evaluated
clinical
trials
to
better
elucidate
their
potential
application
fields
medicine.
Clinical
use
new
drugs
biotechnological
products
conducted.
This
review
aims
at
highlighting
some
recent
scientific
findings
associated
components.
Scientific Reports,
Journal Year:
2020,
Volume and Issue:
10(1)
Published: Feb. 20, 2020
One-layer
wound
dressings
cannot
meet
all
the
clinical
needs
due
to
their
individual
characteristics
and
shortcomings.
Therefore,
bilayer
which
are
composed
of
two
layers
with
different
properties
have
gained
lots
attention.
In
present
study,
polycaprolactone/gelatin
(PCL/Gel)
scaffold
was
electrospun
on
a
dense
membrane
polyurethane
ethanolic
extract
propolis
(PU/EEP).
The
PU/EEP
used
as
top
layer
protect
area
from
external
contamination
dehydration,
while
PCL/Gel
sublayer
facilitate
cells'
adhesion
proliferation.
dressing
investigated
regarding
its
microstructure,
mechanical
properties,
surface
wettability,
anti-bacterial
activity,
biodegradability,
biocompatibility,
efficacy
in
animal
model
histopathological
analyzes.
Scanning
electron
micrographs
exhibited
uniform
morphology
bead-free
structure
average
fibers'
diameter
237.3
±
65.1
nm.
Significant
activity
observed
against
Staphylococcal
aureus
(5.4
0.3
mm),
Escherichia
coli
(1.9
0.4
mm)
Staphylococcus
epidermidis
(1.0
0.2
according
inhibition
zone
test.
high
hydrophilicity
(51.1
4.9°),
biocompatibility.
could
significantly
accelerate
closure
collagen
deposition
Wistar
rats'
skin
model.
Taking
together,
PU/EEP-PCL/Gel
can
be
potential
candidate
for
biomedical
applications
remarkable
antibacterial
features,
healing
activities.
Journal of Functional Biomaterials,
Journal Year:
2023,
Volume and Issue:
14(9), P. 455 - 455
Published: Sept. 3, 2023
Biomaterials
are
at
the
forefront
of
future,
finding
a
variety
applications
in
biomedical
field,
especially
wound
healing,
thanks
to
their
biocompatible
and
biodegradable
properties.
Wounds
spontaneously
try
heal
through
series
interconnected
processes
involving
several
initiators
mediators
such
as
cytokines,
macrophages,
fibroblasts.
The
combination
biopolymers
with
healing
properties
may
provide
opportunities
synthesize
matrices
that
stimulate
trigger
target
cell
responses
crucial
process.
This
review
outlines
optimal
management
care
required
for
treatment
special
focus
on
biopolymers,
drug-delivery
systems,
nanotechnologies
used
enhanced
applications.
Researchers
have
utilized
range
techniques
produce
dressings,
leading
products
different
characteristics.
Each
method
comes
its
unique
strengths
limitations,
which
important
consider.
future
trajectory
dressing
advancement
should
prioritize
economical
eco-friendly
methodologies,
along
improving
efficacy
constituent
materials.
aim
this
work
is
give
researchers
possibility
evaluate
proper
materials
preparation
better
understand
synthesis
conditions
well
most
effective
bioactive
molecules
load.
Journal of Nanobiotechnology,
Journal Year:
2025,
Volume and Issue:
23(1)
Published: Jan. 31, 2025
Hydrogel,
a
polymer
material
with
three-dimensional
structure,
has
considerably
expanded
in
research
across
multiple
fields
lately.
However,
the
lack
of
comprehensive
review
integrating
status
hydrogel
diverse
hindered
development
hydrogel.
This
bibliometric
analysis
reviewed
hydrogel-related
over
past
decades,
emphasizing
evolution,
status,
and
future
directions
within
multitude
fields,
such
as
materials
science,
chemistry,
engineering,
physics,
biochemistry
molecular
biology,
pharmacology
pharmacy,
cell
biotechnology
applied
microbiology,
etc.
We
encapsulated
applications
potential
wound
healing,
drug
delivery,
encapsulation,
bioprinting,
tissue
electronic
products,
environment
applications,
disease
treatment.
study
integrated
current
matrix
system
characteristics
hydrogels,
aiming
to
offer
cross-field
reference
for
researchers
promote
advancement
research.
Furthermore,
we
proposed
novel
reproducible
paradigm,
which
can
provide
more
trends
trajectory
field.
