Propolis and its potential against SARS-CoV-2 infection mechanisms and COVID-19 disease

Biomedicine & Pharmacotherapy, Journal Year: 2020, Volume and Issue: 131, P. 110622 - 110622

Published: Aug. 17, 2020

Propolis, a resinous material produced by honey bees from plant exudates, has long been used in traditional herbal medicine and is widely consumed as health aid immune system booster. The COVID-19 pandemic renewed interest propolis products worldwide; fortunately, various aspects of the SARS-CoV-2 infection mechanism are potential targets for compounds. entry into host cells characterized viral spike protein interaction with cellular angiotensin-converting enzyme 2 (ACE2) serine protease TMPRSS2. This involves PAK1 overexpression, which kinase that mediates coronavirus-induced lung inflammation, fibrosis, suppression. Propolis components have inhibitory effects on ACE2, TMPRSS2 signaling pathways; addition, antiviral activity proven vitro vivo. In pre-clinical studies, promoted immunoregulation pro-inflammatory cytokines, including reduction IL-6, IL-1 beta TNF-α. monocytes macrophages, well Jak2/STAT3, NF-kB, inflammasome pathways, reducing risk cytokine storm syndrome, major mortality factor advanced disease. also shown promise an treatment comorbidities particularly dangerous patients, respiratory diseases, hypertension, diabetes, cancer. Standardized consistent bioactive properties now available. Given current emergency caused limited therapeutic options, presented promising relevant option safe, easy to administrate orally readily available natural supplement functional food.

Language: Английский

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Active packaging films and edible coatings based on polyphenol‐rich propolis extract: A review

Comprehensive Reviews in Food Science and Food Safety, Journal Year: 2021, Volume and Issue: 20(2), P. 2106 - 2145

Published: Jan. 23, 2021

Abstract The development of active packaging films and edible coatings based on biopolymers natural bioactive substances has received increasing attention in recent years. Propolis, also called bee glue, is a resin substance collected by worker‐bees from the mucilage, gum, several plants. In food industry, propolis commonly extracted solvents to afford polyphenol‐rich extract with potent antimicrobial antioxidant activities. prepared can be mixed biopolymers, plasticizers, emulsifiers, reinforcing agents develop coatings. functionality closely related type, harvesting method, geographic origin, extraction method conditions propolis, content composition polyphenolic compounds extract, presence other substances. Active impact physical, biochemical, sensory properties (e.g., fruits, vegetables, meat, fish) during storage. This review focuses advances extract. structural characterization, functionality, potential applications summarized.

Language: Английский

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Anticancer Activity of Propolis and Its Compounds

Nutrients, Journal Year: 2021, Volume and Issue: 13(8), P. 2594 - 2594

Published: July 28, 2021

Propolis is a natural material that honey bees (Apis mellifera) produce from various botanical sources. The therapeutic activity of propolis, including antibacterial, antifungal, and anti-inflammatory effects, have been known since antiquity. Cancer one the major burdens disease worldwide, therefore, numerous studies are being conducted to develop new chemotherapeutic agents treatments for cancer. rich source biologically active compounds, which affect signaling pathways regulating crucial cellular processes. results latest research show propolis can inhibit proliferation, angiogenesis, metastasis cancer cells stimulate apoptosis. Moreover, it may influence tumor microenvironment multidrug resistance cancers. This review briefly summarizes molecular mechanisms anticancer its compounds highlights potential benefits reduce side effects chemotherapy radiotherapy.

Language: Английский

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Chemical Variability and Pharmacological Potential of Propolis as a Source for the Development of New Pharmaceutical Products

Molecules, Journal Year: 2022, Volume and Issue: 27(5), P. 1600 - 1600

Published: Feb. 28, 2022

This review aims to analyze propolis as a potential raw material for the development and manufacture of new health-promoting products. Many scientific publications were retrieved from Scopus, PubMed, Google Scholar databases via searching word "propolis". The different extraction procedures, key biologically active compounds, biological properties, therapeutic analyzed. It was concluded that possesses variety properties because very complex chemical composition mainly depends on plant species visited by bees bees. Numerous studies found versatile pharmacological activities propolis: antimicrobial, antifungal, antiviral, antioxidant, anticancer, anti-inflammatory, immunomodulatory, etc. In this review, are presented point view origin standardization purpose pharmaceutical products its base. revealed some types propolis, especially European contain flavonoids phenolic acids, which could be markers quality evaluation preparations. One more focus paper overview microorganisms' sensitivity further antimicrobial antioxidant treatment various infectious diseases with an emphasis illnesses oral cavity. established activity is quite significant, Gram-negative bacteria lipophilic viruses. present study also interest industry appropriate design standardized preparations such mouthwashes, toothpastes, drops, sprays, creams, ointments, suppositories, tablets, capsules, Moreover, regarded source isolation substances. Furthermore, can facilitate partially overcoming problem preparations, principal obstacle broader use in industry. Finally, area food nutritionally well-balanced results indicate deserves better studied promising effects connection locality collection, vegetation, methods, standardization.

Language: Английский

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Alternatives to Antimicrobial Treatment in Bovine Mastitis Therapy: A Review

Antibiotics, Journal Year: 2023, Volume and Issue: 12(4), P. 683 - 683

Published: March 30, 2023

Despite preventive and therapeutic measures, mastitis continues to be the most prevalent health problem in dairy herds. Considering risks associated with antibiotic therapy, such as compromised effectiveness due emergence of resistant bacteria, food safety issues, environmental impact, an increasing number scientific studies have referred new procedures that could serve alternatives conventional therapy. Therefore, aim this review was provide insight into currently available literature data investigation non-antibiotic alternative approaches. In general, a vast vitro vivo offer comprehension novel, effective, safe agents potential reduce current use antibiotics increase animal productivity protection. Constant progress field overcome treatment difficulties bovine considerable global pressure being applied on reducing antimicrobial therapy animals.

Language: Английский

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Propolis: Encapsulation and application in the food and pharmaceutical industries

Trends in Food Science & Technology, Journal Year: 2022, Volume and Issue: 127, P. 169 - 180

Published: June 7, 2022

Language: Английский

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Is Propolis a Potential Anti-Obesogenic Agent for Obesity?

Current Nutrition Reports, Journal Year: 2024, Volume and Issue: 13(2), P. 186 - 193

Published: March 4, 2024

Abstract Purpose of Review Propolis is a bee product that has been used for thousands years. The chemical composition and biological activity propolis, which investigated in the twentieth century, may vary according to location. polyphenols can induce thermogenesis brown beige fat tissue via uncoupled protein-1 creatinine kinase metabolic pathways. This review provides comprehensive investigation structural properties propolis insights into their promising potential strategies body weight management. Recent Findings By raising overall energy expenditure, it might lead Furthermore, phenolic components artepillin C, quercetin, catechin, chlorogenic acid found its have anti-obesogenic effect by stimulating sympathetic nervous system, enhancing browning white adipose tissue, triggering AMP-activated protein activation mitochondrial biogenesis. Summary Propolis, natural product, effective preventing obesity contemporary pandemic.

Language: Английский

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Antifungal Properties of Chemically Defined Propolis from Various Geographical Regions

Microorganisms, Journal Year: 2022, Volume and Issue: 10(2), P. 364 - 364

Published: Feb. 4, 2022

Long-term fungal infections that are difficult to treat require new substances for their prevention, treatment, or as adjuvants during antibiotic therapy. Propolis is a very promising source of natural show wide range pharmacological properties, including antifungal activity against various strains. The purpose the literature review was summarize recent studies (PubMed, Scopus) on progress in evaluating chemically defined propolis extracts. During selection studies, only those with results expressed minimal inhibitory concentration (MIC) and/or fungicidal (MFC) were analyzed. Moreover, plant, animal and environmental factors influencing chemical composition discussed. Mechanisms extracts research trends aspect developing therapies assessment drug interactions indicated. shows there great definition After comparing MIC/MFC values, it assessed offer not pathogenic Candida strains but also risky molds; however, strength this varied.

Language: Английский

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Stingless bee propolis: composition, biological activities and its applications in the food industry

Food Production Processing and Nutrition, Journal Year: 2023, Volume and Issue: 5(1)

Published: May 4, 2023

Abstract The breeding of stingless bees, known as meliponiculture, can be found throughout the world, and is closely linked to history first human communities in Americas. This activity provides products industrial interest (food, cosmetics, pharmaceuticals), among them propolis stands out. matrix a resinous material but being difficult classify conceptualize due its variability according environment producing species. produced by these bees source compounds with nutritional functional potential, main focused on phenolic compounds. potential makes product that used prospection new molecules antimicrobial antioxidant activity. Thus, scientific literature describes (generally extracts) against bacteria fungi, higher microbicidal gram-positive bacteria. high this bee consequence presence several use from SBP (Stingless propolis) still quite limited, generally restricted studies application other sectors benefit productive sector, Apis mellifera . work presents discusses composition consequent biological activities, well applications food industry. Graphical

Language: Английский

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Honey as a Functional Food for Apis mellifera

Annual Review of Entomology, Journal Year: 2020, Volume and Issue: 66(1), P. 185 - 208

Published: Aug. 18, 2020

Although nectar is consumed, primarily as a supplemental food, by broad range of insects spanning at least five orders, it processed and stored only small number species, most which are bees wasps in the superfamily Apoidea. Within this group, Apis mellifera has evolved remarkable adaptations facilitating processing storage; doing so, species utilizes end product, honey, for diverse functions with few if any equivalents other phytophagous insects. Honey its phytochemical constituents, some likely derive from propolis, have functional significance protecting honey against microbial pathogens, toxins, cold stress, well regulating development adult longevity. The distinctive properties A. appear to arisen multiple ways, including genome modification; partnerships symbionts; evolution specialized behaviors, foraging substances than nectar. That making involves incorporation exogenous material nectar, endogenous products such antimicrobial peptides royal jelly, suggests that regarding little more source carbohydrates concept need revision.

Language: Английский

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