Heliyon,
Journal Year:
2023,
Volume and Issue:
9(11), P. e21648 - e21648
Published: Nov. 1, 2023
Reports
regarding
the
antiviral
activity
of
curcumin
have
surfaced.
However,
to
date
there
has
been
no
scientometric
analysis
relationship
between
and
Coronavirus
Disease
2019
(COVID-19).
To
comprehensively
understand
studies
involving
in
context
COVID-19,
we
conducted
a
provide
an
exhaustive
review
these
studies.We
systematically
searched
Web
Science
core
collection
database
for
bibliographic
data
indexed
from
January
1,
2020,
December
31,
2022,
using
keywords
such
as
'curcumin',
'COVID-19',
their
synonyms.
clarify
research
content
trends
related
utilized
VOSviewer,
Origin
2023,
Charticulator
analysis,
supplemented
by
external
data.The
final
count
publications
included
this
study
was
252.
These
originated
63
countries
or
territories,
with
India
contributing
highest
number
publications.
They
were
published
across
170
journals.
Notably,
Egyptian
Knowledge
Bank
(EKB)
emerged
most
important
institution
that
carried
out
study.
The
cited
publication
had
referenced
166
times.
main
elements
involved
keyword
reflected
immuno-inflammatory
modulation
inflammatory
cytokine
storm.
Furthermore,
pharmacological
mechanisms
treating
COVID-19
prominent
area
research.
Simultaneously,
exists
direct
evidence
clinical
usage
enhance
outcomes.The
underscores
burgeoning
professional
domain
curcumin-based
treatment
COVID-19.
Ongoing
focused
on
its
immunomodulatory
effects
storms.
On
other
hand,
mechanism
is
hot
spot
field
at
present,
which
may
become
trend
future.
While
maintaining
focus
foundational
research,
application
infection
developing
parallel,
highlighting
obvious
guiding
value
practice.
insights
offer
researchers
snapshot
present
state
guide
further
mechanistic
validation
efforts
Pharmaceuticals,
Journal Year:
2023,
Volume and Issue:
16(6), P. 862 - 862
Published: June 9, 2023
Chronic
inflammation
and
tissue
damage
can
result
from
uncontrolled
during
SARS-CoV-2
or
COVID-19
infections,
leading
to
post-acute
COVID
conditions
long
COVID.
Curcumin,
found
in
turmeric,
has
potent
anti-inflammatory
properties
but
limited
effectiveness.
This
study
developed
nanocurcumin,
a
curcumin
nanoparticle,
enhance
its
physical
chemical
stability
investigate
vitro
upon
CoV2-SP
induction
lung
epithelial
cells.
Nanocurcumin
was
prepared
by
encapsulating
extract
phospholipids.
The
particle
size,
polydispersity
index,
zeta
potential
of
nanocurcumin
were
measured
using
dynamic
light
scattering.
encapsulated
content
determined
HPLC
analysis.
encapsulation
efficiency
90.74
±
5.35%
as
HPLC.
Regarding
the
release
curcumin,
displayed
higher
than
non-nanoparticle
curcumin.
further
investigated
for
A549
cell
line.
As
ELISA,
showed
inhibitory
effects
on
inflammatory
cytokine
releases
CoV2-SP-stimulated
conditions,
evidenced
significant
decrease
IL-6,
IL-1β
IL-18
secretions
compared
with
spike-stimulated
control
group
(p
<
0.05).
Additionally,
RT-PCR,
significantly
inhibited
expression
genes
(IL-6,
IL-1β,
IL-18,
NLRP3)
inhibition
NLRP3
inflammasome
machinery
proteins
Western
blot,
decreased
expressions
including
NLRP3,
ASC,
pro-caspase-1,
active
form
caspase-1
cells
Overall,
nanoparticle
formulation
improved
solubility
bioavailability,
demonstrating
CoV2-SP-induced
scenario
inhibiting
mediators
machinery.
shows
promise
an
product
preventing
COVID-19-related
airway
inflammation.
Frontiers in Chemistry,
Journal Year:
2022,
Volume and Issue:
10
Published: Feb. 10, 2022
Coronavirus
disease
2019
(COVID-19)
is
a
new
and
severe
infectious
global
disaster
spreading
rapidly
worldwide.
Natural
products
have
long
history
been
widely
used
to
treat
various
acute,
chronic,
even
life-threatening
diseases
However,
the
natural
reduced
bioavailability
availability
as
they
poor
kinetic
properties,
such
large
molecular
weight,
inability
cross
lipid
membranes,
weak
absorption
ability.
With
rapid
development
of
nanotechnology,
using
novel
nanotechnology
in
conjunction
with
can
effectively
eliminate
restriction
entry
nanoproducts
into
body
be
diagnose
diseases,
including
COVID-19,
bringing
strategies
directions
for
medicine.
This
article
reviews
role
implementation
against
COVID-19
based
on
nanotechnology.
International Journal of Nanomedicine,
Journal Year:
2023,
Volume and Issue:
Volume 18, P. 5831 - 5869
Published: Oct. 1, 2023
Purpose:
Immunomodulatory
and
broad-spectrum
antiviral
activities
have
motivated
the
evaluation
of
curcumin
for
Coronavirus
infection
2019
(COVID-19)
management.
Inadequate
bioavailability
is
main
impediment
to
therapeutic
effects
oral
Cur.
This
study
aimed
develop
an
optimal
transferosome-loaded
thermosensitive
in
situ
gel
improve
its
delivery
lungs.
Methods:
Transferosomes
were
developed
by
using
3
screening
layouts.
The
phospholipid
concentration
as
well
type
surfactant
considered
independent
variables.
entrapment
efficiency
(EE%),
size,
surface
charge,
polydispersity
index
(PDI)
regarded
dependent
factors.
A
cold
technique
was
employed
in-situ
gels.
Optimized
transferosomes
loaded
onto
selected
produced
assessed
based
on
shape
attributes,
ex
vivo
permeability
enhancement,
safety
nasal
mucosa.
vitro
cytotoxicity,
cytopathic
effect,
plaque
assay
(CV/CPE/Plaque
activity),
performance
evaluated
after
intranasal
administration
experimental
rabbits.
Results:
optimized
preparation
displayed
a
particle
size
664.3
±
69.3
nm,
EE%
82.8
0.02%,
ZP
−
11.23
2.5
mV,
PDI
0.6
0.03.
release
from
transferosomal
markedly
improved
compared
with
that
free
drug-loaded
gel.
An
permeation
revealed
significant
improvement
(2.58-fold)
drug
across
tissues
sheep.
Histopathological
confirmed
these
preparations.
formulation
showed
high
activity
against
SARS-CoV-2
at
reduced
concentrations.
High
relative
(226.45%)
attained
formula
intranasally
administered
rabbits
transferosome
relatively
lung
accumulation
administration.
Conclusion:
provides
promising
treatment
COVID-19
patients,
which
can
be
further
preclinical
clinical
studies.
Keywords:
transferosomes,
curcumin,
gels,
coronavirus
2,
SARS-CoV-2,
Heliyon,
Journal Year:
2023,
Volume and Issue:
9(11), P. e21648 - e21648
Published: Nov. 1, 2023
Reports
regarding
the
antiviral
activity
of
curcumin
have
surfaced.
However,
to
date
there
has
been
no
scientometric
analysis
relationship
between
and
Coronavirus
Disease
2019
(COVID-19).
To
comprehensively
understand
studies
involving
in
context
COVID-19,
we
conducted
a
provide
an
exhaustive
review
these
studies.We
systematically
searched
Web
Science
core
collection
database
for
bibliographic
data
indexed
from
January
1,
2020,
December
31,
2022,
using
keywords
such
as
'curcumin',
'COVID-19',
their
synonyms.
clarify
research
content
trends
related
utilized
VOSviewer,
Origin
2023,
Charticulator
analysis,
supplemented
by
external
data.The
final
count
publications
included
this
study
was
252.
These
originated
63
countries
or
territories,
with
India
contributing
highest
number
publications.
They
were
published
across
170
journals.
Notably,
Egyptian
Knowledge
Bank
(EKB)
emerged
most
important
institution
that
carried
out
study.
The
cited
publication
had
referenced
166
times.
main
elements
involved
keyword
reflected
immuno-inflammatory
modulation
inflammatory
cytokine
storm.
Furthermore,
pharmacological
mechanisms
treating
COVID-19
prominent
area
research.
Simultaneously,
exists
direct
evidence
clinical
usage
enhance
outcomes.The
underscores
burgeoning
professional
domain
curcumin-based
treatment
COVID-19.
Ongoing
focused
on
its
immunomodulatory
effects
storms.
On
other
hand,
mechanism
is
hot
spot
field
at
present,
which
may
become
trend
future.
While
maintaining
focus
foundational
research,
application
infection
developing
parallel,
highlighting
obvious
guiding
value
practice.
insights
offer
researchers
snapshot
present
state
guide
further
mechanistic
validation
efforts
