The role of turmeric and black pepper oil nanoemulsion in attenuating cytokine storm triggered by duck hepatitis A virus type I (DHAV-I)-induced infection in ducklings DOI Creative Commons
Hemat S. El-Sayed,

Aalaa Saad,

Wesam A. Tawfik

et al.

Poultry Science, Journal Year: 2023, Volume and Issue: 103(3), P. 103404 - 103404

Published: Dec. 27, 2023

The cytokine storm induced by duck hepatitis A virus type 1 (DHAV-1) infection significantly contributes to severe, rapid deaths and economic losses in the industry Egypt. This study aimed investigate potential inhibitory effect of a nano-emulsion containing turmeric black pepper oil on immune response pathogenesis DHAV-1 ducklings. total 105 ducklings from non-vaccinated breeders were divided into 5 experimental groups, each comprising 21 birds. negative control group (G1) remained non-infected with non-treated nano-emulsion, while positive (G2) was infected but not treated nano-emulsion. other two groups (G3, supplemented which DHAV-1), 4 (the prophylactic G4) DHAV-1, both received throughout experiment. Group 5, (G5, therapeutic group) hand only onset clinical signs. At days old, (G2), (G4), (G5) DHAV-1. All exhibited depression, anorexia, opisthotonos, their livers displayed various degrees ecchymotic hemorrhage, liver enlargement, microscopic pathological lesions. Notably, experienced most severe pronounced effects compared Meanwhile, viral RNA loads lower tissues G4, G5) G2. Additionally, effectively modulated pro-inflammatory expression, antioxidant enzymes, lipid profile In conclusion, has be agent for regulating modulating response, decreasing DHAV-1-induced storms, minimizing mortality business. More research is needed understand how alleviates DHVA-1-induced storms lowers duckling mortality.

Language: Английский

Innovative Delivery Systems for Curcumin: Exploring Nanosized and Conventional Formulations DOI Creative Commons
Jibira Yakubu, Amit V. Pandey

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(5), P. 637 - 637

Published: May 9, 2024

Curcumin, a polyphenol with rich history spanning two centuries, has emerged as promising therapeutic agent targeting multiple signaling pathways and exhibiting cellular-level activities that contribute to its diverse health benefits. Extensive preclinical clinical studies have demonstrated ability enhance the potential of various bioactive compounds. While reported advantages are manifold, predominantly attributed antioxidant anti-inflammatory properties, efficacy is hindered by poor bioavailability stemming from inadequate absorption, rapid metabolism, elimination. To address this challenge, nanodelivery systems approach, offering enhanced solubility, biocompatibility, effects for curcumin. We analyzed knowledge on curcumin nanoencapsulation synergistic other compounds, extracted electronic databases. discuss pharmacokinetic profile curcumin, current advancements in techniques, combined agents across disorders. By unifying existing knowledge, analysis intends provide insights into technologies overcome constraints associated treatments, emphasizing importance combinatorial approaches improving efficacy. Finally, compilation study data aims inform inspire future research encapsulating drugs characteristics investigating innovative drug combinations improve outcomes.

Language: Английский

Citations

11
Nanoparticles of Natural Product-derived Medicines: Beyond the Pandemic DOI Creative Commons
Yedi Herdiana

Heliyon, Journal Year: 2025, Volume and Issue: 11(4), P. e42739 - e42739

Published: Feb. 1, 2025

This review explores the synergistic potential of natural products and nanotechnology for viral infections, highlighting key antiviral, immunomodulatory, antioxidant properties to combat pandemics caused by highly infectious viruses. These often result in severe public health crises, particularly affecting vulnerable populations due respiratory complications increased mortality rates. A cytokine storm is initiated when an overload pro-inflammatory cytokines chemokines released, leading a systemic inflammatory response. Viral mutations limited availability effective drugs, vaccines, therapies contribute continuous transmission virus. The coronavirus disease-19 (COVID-19) pandemic has sparked renewed interest product-derived antivirals. efficacy traditional medicines against infections examined. Their anti-inflammatory, are highlighted. discusses how enhances herbal combating infections.

Language: Английский

Citations

1
Plant-derived molecules in monkeypox management: insight and alternative therapeutic strategies DOI Creative Commons
Martin Ndayambaje, Emmanuel Munyeshyaka,

Olive Dieumerci

et al.

Beni-Suef University Journal of Basic and Applied Sciences, Journal Year: 2025, Volume and Issue: 14(1)

Published: Feb. 19, 2025

Abstract The WHO and CDC recently declared monkeypox virus (MPXV) a zoonotic disease known as (Mpox) Public Health Emergency of International Concern. According to the CDC, no treatment is specifically approved for Mpox infections. Medicinal plants are crucial in healthcare economic development, particularly low- middle-income countries. This review offers valuable insights into pathogenesis management through therapeutic approaches vaccination strategies using plant-based molecules. Core structural proteins necessary both viral entry immune response, including A29, H3L, L1R, involved MPXV. Potential targets vaccines include like A35R B6R, which essential propagation viruses. MPXV evades system by concealing its DNA, suppressing interferon limiting T NK cell activation, preventing apoptosis, complicating vaccine development. Antivirals (tecovirimat, brincidofovir) vaccinations (JYNNEOS, ACAM2000) manage Mpox. A recent study revealed early clinical trial results, indicating that antiviral drug tecovirimat, well-known conventional treatment, more effective than placebo against clade I type Research gaps, low effectiveness, availability challenges. novel perspective on combating global threat investigating alternative centered plant-derived compounds. Graphical

Language: Английский

Citations

1
Fenpropathrin provoked kidney damage via controlling the NLRP3/Caspase-1/GSDMD–mediated pyroptosis: The palliative role of curcumin-loaded chitosan nanoparticles DOI
Yasmina M. Abd‐Elhakim, Amany Abdel-Rahman Mohamed, Ahmed E. Noreldin

et al.

Toxicology and Applied Pharmacology, Journal Year: 2024, Volume and Issue: 484, P. 116869 - 116869

Published: Feb. 19, 2024

Language: Английский

Citations

7
Photodynamic Action of Curcumin and Methylene Blue against Bacteria and SARS-CoV-2—A Review DOI Creative Commons
Siukan Law, Albert Wingnang Leung, Chuanshan Xu

et al.

Pharmaceuticals, Journal Year: 2023, Volume and Issue: 17(1), P. 34 - 34

Published: Dec. 25, 2023

Coronavirus disease 19 (COVID-19) has occurred for more than four years, and the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing COVID-19 is a strain of coronavirus, which presents high rates morbidity around world. Up to present date, there are no therapeutics that can avert this form illness, photodynamic therapy (PDT) may be an alternative approach against SARS-CoV-2. Curcumin methylene blue have been approved used in clinical practices as photosensitizer PDT long time with their anti-viral properties disinfection through photo-inactivated Previously, curcumin antibacterial Gram-positive bacteria, Staphylococcus aureus (S. aureus), Gram-negative Escherichia coli (E. coli), Enterococcus faecalis faecalis), Pseudomonas aeruginosa (P. aeruginosa). Methods: To conduct literature review, nine electronic databases were researched, such WanFang Data, PubMed, Science Direct, Scopus, Web Science, Springer Link, SciFinder, China National Knowledge Infrastructure (CNKI), without any regard language constraints. In vitro vivo studies included evaluated effect mediated via or combat bacteria All eligible analyzed summarized review. Results: inhibited replication The reactive oxygen species (ROS) generated during treatment prevent attachment SARS-CoV-2 on ACE2 receptor damage nucleic acids either DNA RNA. It also modulates pro-inflammatory cytokines attenuates clotting effects host response. Conclusion: action provides possible infection because they act non-toxic photosensitizers effect, properties, functions.

Language: Английский

Citations

9
Clinical Trial Findings and Drug Development Challenges for Curcumin in Infectious Disease Prevention and Treatment DOI Creative Commons
Mohamed El Oirdi, Mohd Farhan

Life, Journal Year: 2024, Volume and Issue: 14(9), P. 1138 - 1138

Published: Sept. 9, 2024

Since ancient times, turmeric, scientifically known as Curcuma longa, has been renowned for its therapeutic properties. Recently, extensive documentation highlighted the prevalence of microbial diseases without effective treatments, increased expense certain antimicrobial medications, and growing occurrence drug resistance. Experts predict that resistance will emerge a significant global cause death by middle this century, thereby necessitating intervention. Curcumin, major curcuminoid molecule, shown action. Improving altering use natural agents is most approach to addressing issues targeted specificity in chemically synthesized medicines. Further research required explore efficacy curcumin other substances combating infections. The solubility bioavailability impede capability. To enhance curcumin’s effectiveness, researchers have recently employed several methods, including development curcumin-based nanoformulations. This review seeks compile latest available literature assess advantages agent (particularly antiviral antibacterial) strategies medical efficacy. future application help alleviate infections, promoting sustainability world’s population.

Language: Английский

Citations

2
The role of turmeric and black pepper oil nanoemulsion in attenuating cytokine storm triggered by duck hepatitis A virus type I (DHAV-I)-induced infection in ducklings DOI Creative Commons
Hemat S. El-Sayed,

Aalaa Saad,

Wesam A. Tawfik

et al.

Poultry Science, Journal Year: 2023, Volume and Issue: 103(3), P. 103404 - 103404

Published: Dec. 27, 2023

The cytokine storm induced by duck hepatitis A virus type 1 (DHAV-1) infection significantly contributes to severe, rapid deaths and economic losses in the industry Egypt. This study aimed investigate potential inhibitory effect of a nano-emulsion containing turmeric black pepper oil on immune response pathogenesis DHAV-1 ducklings. total 105 ducklings from non-vaccinated breeders were divided into 5 experimental groups, each comprising 21 birds. negative control group (G1) remained non-infected with non-treated nano-emulsion, while positive (G2) was infected but not treated nano-emulsion. other two groups (G3, supplemented which DHAV-1), 4 (the prophylactic G4) DHAV-1, both received throughout experiment. Group 5, (G5, therapeutic group) hand only onset clinical signs. At days old, (G2), (G4), (G5) DHAV-1. All exhibited depression, anorexia, opisthotonos, their livers displayed various degrees ecchymotic hemorrhage, liver enlargement, microscopic pathological lesions. Notably, experienced most severe pronounced effects compared Meanwhile, viral RNA loads lower tissues G4, G5) G2. Additionally, effectively modulated pro-inflammatory expression, antioxidant enzymes, lipid profile In conclusion, has be agent for regulating modulating response, decreasing DHAV-1-induced storms, minimizing mortality business. More research is needed understand how alleviates DHVA-1-induced storms lowers duckling mortality.

Language: Английский

Citations

4