Development of a Microbial-Assisted Process for Enhanced Astaxanthin Recovery from Crab Exoskeleton Waste DOI Creative Commons
Mohamed N. Abd El-Ghany,

Salwa A.H. Hamdi,

Reham M. Elbaz

et al.

Fermentation, Journal Year: 2023, Volume and Issue: 9(6), P. 505 - 505

Published: May 24, 2023

Astaxanthin is a xanthophyll carotenoid possessing impressive nutraceutical, antioxidant, and bioactive merits. Traditionally, astaxanthin extracted from crustacean wastes via solvent extraction methods. However, the rigid structure of shells that comprise complex proteins chitin challenges process. This investigation addressed an efficient microbial-assisted method to facilitate recovery crab exoskeleton waste utilizing chitinolytic proteolytic microorganisms. Herein, we evaluated effect pretreatment with newly isolated probiotic strain, Bacillus amyloliquefaciens CPFD8, showing remarkable protease chitinase activity Saccharomyces cerevisiae 006-001 before extraction, using acetone/hexane, on recovery. Furthermore, antioxidant anti-inflammatory activities recovered were inspected. Results revealed both strains boosted yield (Callinectes sapidus) compared acetone/hexane. Under optimum conditions, was 217 91 µg/g in samples treated B. CPFD8 S. 006-001, respectively. Interestingly, yielded more than 6-fold just 35 µg/g. increase could be attributed rendered deproteinized shell accessible chitinase, facilitating penetration solvents astaxanthin. The exhibited excellent scavenging DPPH or ABTS free radicals IC50 values 50.93 17.56 µg/mL, In addition, showed impact LPS-induced murine macrophage RAW264.7 cells significantly inhibited production nitric oxide, TNF-α, IL-6 untreated control. These findings suggest potential use developed maximize (C. waste.

Language: Английский

Carotenoids: Dietary Sources, Extraction, Encapsulation, Bioavailability, and Health Benefits—A Review of Recent Advancements DOI Creative Commons
Ramesh Kumar Saini,

Prasad Parchuri,

Veeresh Lokesh

et al.

Antioxidants, Journal Year: 2022, Volume and Issue: 11(4), P. 795 - 795

Published: April 18, 2022

Natural carotenoids (CARs), viz. β-carotene, lutein, astaxanthin, bixin, norbixin, capsanthin, lycopene, canthaxanthin, β-Apo-8-carotenal, zeaxanthin, and β-apo-8-carotenal-ester, are being studied as potential candidates in fields such food, feed, nutraceuticals, cosmeceuticals. CAR research is advancing the following three major fields: (1) production from natural sources optimization of its downstream processing; (2) encapsulation for enhanced physical chemical properties; (3) preclinical, clinical, epidemiological studies CARs’ health benefits. This review critically discusses recent developments chemistry antioxidant activity, marketing trends, dietary sources, extraction, bioaccessibility bioavailability, methods, intake, benefits CARs. Preclinical, on cancer, obesity, type 2 diabetes (T2D), cardiovascular diseases (CVD), osteoporosis, neurodegenerative disease, mental health, eye, skin also discussed.

Language: Английский

Citations

173
Recent advancements in astaxanthin production from microalgae: A review DOI
Anil Kumar Patel,

Vaibhav Sunil Tambat,

Chiu‐Wen Chen

et al.

Bioresource Technology, Journal Year: 2022, Volume and Issue: 364, P. 128030 - 128030

Published: Sept. 26, 2022

Language: Английский

Citations

107
Technological advances in the production of carotenoids and their applications– A critical review DOI
Veeramuthu Ashokkumar,

G. Flora,

Murugan Sevanan

et al.

Bioresource Technology, Journal Year: 2022, Volume and Issue: 367, P. 128215 - 128215

Published: Nov. 1, 2022

Language: Английский

Citations

82
Astaxanthin from Crustaceans and Their Byproducts: A Bioactive Metabolite Candidate for Therapeutic Application DOI Creative Commons
Vida Šimat, Nikheel Bhojraj Rathod, Martina Čagalj

et al.

Marine Drugs, Journal Year: 2022, Volume and Issue: 20(3), P. 206 - 206

Published: March 12, 2022

In recent years, the food, pharma, and cosmetic industries have shown considerable interest in bioactive molecules of marine origin that show high potential for application as nutraceuticals therapeutic agents. Astaxanthin, a lipid-soluble orange-reddish-colored carotenoid pigment, is one most investigated pigments. Natural astaxanthin mainly produced from microalgae, it shows much stronger antioxidant properties than its synthetic counterpart. This paper aims to summarize discuss important aspects findings associated with possible use crustacean byproducts source astaxanthin. last five years research on crustaceans their natural astaxanthin, there are many new regarding content different species green extraction protocols extraction. However, lack information amounts currently obtained well cost-effectiveness production byproducts. Improvement these areas would certainly contribute reduction waste reuse processing industry. Successful exploitation recovery this valuable compound both environmental social benefits. Finally, astaxanthin’s strong biological activity prominent health benefits been discussed paper.

Language: Английский

Citations

63
Role of Phytochemicals in Skin Photoprotection via Regulation of Nrf2 DOI Creative Commons
Anyamanee Chaiprasongsuk, Uraiwan Panich

Frontiers in Pharmacology, Journal Year: 2022, Volume and Issue: 13

Published: May 12, 2022

Ethnopharmacological studies have become increasingly valuable in the development of botanical products and their bioactive phytochemicals as novel effective preventive therapeutic strategies for various diseases including skin photoaging photodamage-related problems abnormal pigmentation inflammation. Exploring roles mitigating ultraviolet radiation (UVR)-induced damage is thus importance to offer insights into medicinal ethnopharmacological potential photoprotective agents. UVR plays a role premature aging (or photoaging) or impaired integrity function through triggering biological responses cells apoptosis, oxidative stress, DNA In addition, melanin produced by epidermal melanocytes play protective against UVR-induced therefore hyperpigmentation mediated UV irradiation could reflect sign defensive response stress. However, alteration synthesis may be implicated damage, particularly individuals with fair skin. Oxidative stress induced contributes process inflammation activation related signaling pathways such mitogen-activated protein kinase (MAPK)/activator protein-1 (AP-1), phosphatidylinositol 3-kinase (PI3K)/protein B (Akt), nuclear factor kappa (NF-κB) signal transducer activator transcription (STAT) keratinocytes dermal fibroblasts. ROS formation also regulation melanogenesis via modulating MAPK, PI3K/Akt melanocortin 1 receptor (MC1R)-microphthalmia-associated (MITF) cascades. Additionally, erythroid 2-related 2 (Nrf2)-regulated antioxidant defenses can affect major involved photoaging, associated barrier dysfunction melanogenesis. This review highlights potentially acting Nrf2 inducers improving cellular homeostasis function. Taken together, understanding targeting photoprotection provide an insight natural promising strategy delay improve conditions.

Language: Английский

Citations

51
Preparation of high internal phase Pickering emulsion by centrifugation for 3D printing and astaxanthin delivery DOI

Jia Song,

Yuanda Sun,

Haitao Wang

et al.

Food Hydrocolloids, Journal Year: 2023, Volume and Issue: 142, P. 108840 - 108840

Published: April 29, 2023

Language: Английский

Citations

36
Natural Compounds and Glutathione: Beyond Mere Antioxidants DOI Creative Commons
C. Di Giacomo, Giuseppe Antonio Malfa, Barbara Tomasello

et al.

Antioxidants, Journal Year: 2023, Volume and Issue: 12(7), P. 1445 - 1445

Published: July 18, 2023

The tripeptide glutathione plays important roles in many cell processes, including differentiation, proliferation, and apoptosis; fact, disorders homeostasis are involved both the etiology progression of several human diseases, cancer. Natural compounds have been found to modulate levels function beyond their role as mere antioxidants. For example, certain can upregulate expression glutathione-related enzymes, increase availability cysteine, limiting amino acid for synthesis, or directly interact with its function. These may therapeutic potential a variety disease states where dysregulation is contributing factor. On other hand, flavonoids’ deplete could be significant cancer treatment. Overall, while natural and/or preventive properties able levels, more research needed fully understand mechanisms action benefits prevention treatment diseases. In this review, particular emphasis will placed on phytochemical belonging class polyphenols, terpenoids, glucosinolates that an impact physiological pathological conditions. classes secondary metabolites represent most food-derived bioactive intensively explored studied last few decades.

Language: Английский

Citations

29
Astaxanthin ameliorates inflammation, oxidative stress, and reproductive outcomes in endometriosis patients undergoing assisted reproduction: A randomized, triple-blind placebo-controlled clinical trial DOI Creative Commons

Sahar Rostami,

Ashraf Alyasin,

Mojtaba Saedi

et al.

Frontiers in Endocrinology, Journal Year: 2023, Volume and Issue: 14

Published: March 20, 2023

In a randomized, triple-blind, placebo-controlled clinical trial (RCT) including 50 infertile women with endometriosis candidate for assisted reproductive techniques (ART), we studied the effect of Astaxanthin (AST) on pro-inflammatory cytokines, oxidative stress (OS) markers, and early pregnancy outcomes.Before after 12 weeks AST treatment (6 mg per day), blood serum follicular fluid (FF) samples were collected from stage III/IV undergoing ART. Pro-inflammatory cytokines (IL-1β, IL-6, TNF-α) OS markers (malondialdehyde [MDA], superoxide dismutase [SOD], catalase [CAT], total antioxidant capacity [TAC]) measured in FF. ART outcomes also compared between groups.Increased levels TAC (398.661 ± 57.686 vs. 364.746 51.569; P = 0.004) SOD (13.458 7.276 9.040 5.155; 0.010) observed therapy group. Furthermore, MDA (14.619 2.505 15.939 1.512; 0.031) decreased significantly following treatment. addition, lower IL-1β (4.515 0.907 6.8760 0.8478; 0.000), IL-6 (5.516 0.646 5.0543 0.709; 0.024) TNF-α (2.520 0.525 2.968 0.548; 0.038) supplementation led to an improved number oocytes retrieved (14.60 7.79 9.84 6.44; 0.043), mature (MII) (10.48 6.665 6.72 4.3; 0.041), high-quality embryos (4.52 2.41 2.72 2.40; 0.024).AST pretreatment can modulate inflammation endometriosis-induced patients. therapy. Our results suggest that be potential therapeutic target patients

Language: Английский

Citations

25
More Than Pigments: The Potential of Astaxanthin and Bacterioruberin-Based Nanomedicines DOI Creative Commons
María José Morilla,

Kajal Ghosal,

Eder Lilia Romero

et al.

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(7), P. 1828 - 1828

Published: June 26, 2023

Carotenoids are natural products regulated by the food sector, currently used as feed dyes and antioxidants in dietary supplements composing functional foods for human consumption. Of nearly one thousand carotenoids described to date, only retinoids, derived from beta carotene, have status of a drug pharmaceutical sector. In this review, we address novel field: transformation xanthophylls, particularly highly marketed astaxanthin practically unknown bacterioruberin, therapeutic agents altering their pharmacokinetics, biodistribution, pharmacodynamics through formulation nanomedicines. The antioxidant activity xanthophylls is mediated routes different those classical oral anti-inflammatory drugs such corticosteroids non-steroidal (NSAIDs): remarkably, lack but also toxicity. Formulated nanomedicines, gain mechanisms other than increased bioavailability. Loaded into ad hoc tailored nanoparticles protect structure throughout storage during gastrointestinal transit or skin penetration, can be targeted delivered selected inflamed cell groups, achieving massive intracellular concentration after endocytosis small doses formulation. Most first reports showing activities topical xanthophyll-based nanomedicines against chronic diseases inflammatory bowel disease, psoriasis, atopic dermatitis, dry eye disease emerged between 2020 2023. Here discuss detail preclinical performance, mostly vesicular polymeric nanoparticles, on cellular models vivo. results, although preliminary, auspicious enough speculate upon potential use administration treatment diseases.

Language: Английский

Citations

23
Extraction and Separation of Natural Products from Microalgae and Other Natural Sources Using Liquefied Dimethyl Ether, a Green Solvent: A Review DOI Creative Commons
Tao Wang, Li Zhu,

Li Mei

et al.

Foods, Journal Year: 2024, Volume and Issue: 13(2), P. 352 - 352

Published: Jan. 22, 2024

Microalgae are a sustainable source for the production of biofuels and bioactive compounds. This review discusses significant research on innovative extraction techniques using dimethyl ether (DME) as green subcritical fluid. DME, which is characterized by its low boiling point safety an organic solvent, exhibits remarkable properties that enable high rates various active compounds, including lipids from high-water-content microalgae without need drying. In this review, superiority liquefied DME technology over conventional methods discussed in detail. addition, we elucidate mechanism address human health environment. also covers aspects related to equipment, applications different processes, estimation trend analysis Hansen solubility parameters. anticipate promising trajectory expansion resources.

Language: Английский

Citations

12