Genes & Diseases,
Journal Year:
2023,
Volume and Issue:
11(4), P. 100987 - 100987
Published: June 22, 2023
Cancer
occurrence
and
development
are
closely
related
to
increased
lipid
production
glucose
consumption.
Lipids
the
basic
component
of
cell
membrane
play
a
significant
role
in
cancer
processes
such
as
cell-to-cell
recognition,
signal
transduction,
energy
supply,
which
vital
for
rapid
proliferation,
invasion,
metastasis.
Sterol
regulatory
element-binding
transcription
factor
1
(SREBP1)
is
key
regulating
expression
genes
cholesterol
biosynthesis,
homeostasis,
fatty
acid
synthesis.
In
addition,
SREBP1
its
upstream
or
downstream
target
implicated
various
metabolic
diseases,
particularly
cancer.
However,
no
review
biology
has
yet
been
published.
Herein,
we
summarized
roles
mechanisms
biological
cells,
including
modification,
metabolism
reprogramming,
mitochondrial
metabolism,
immunity,
tumor
microenvironment,
epithelial-mesenchymal
transition,
cycle,
apoptosis,
ferroptosis.
Additionally,
discussed
potential
prognosis,
drug
response
sensitivity
chemotherapy
radiotherapy,
drugs
targeting
corresponding
pathway,
elucidating
clinical
application
based
on
pathway.
Journal of Nanobiotechnology,
Journal Year:
2022,
Volume and Issue:
20(1)
Published: June 14, 2022
As
Traditional
Chinese
Medicine
(TCM)
drugs,
Huangqi
and
Danshen
are
always
applied
in
combination
for
spinal
cord
injury
(SCI)
treatment
based
on
the
compatibility
theory
of
TCM.
Astragalus
Polysaccharidesis
(APS)
Tanshinone
IIA
(TSIIA)
main
active
ingredients
Danshen,
they
both
possess
neuroprotective
effects
through
antioxidant
activities.
However,
low
solubility
poor
bioavailability
have
greatly
limited
their
application.
In
recent
years,
selenium
nanoparticles
(SeNPs)
drawn
enormous
attention
as
potential
delivery
carrier
drugs.In
this
study,
TCM
ingredients-based
SeNPs
surface
decorated
with
APS
loaded
TSIIA
(TSIIA@SeNPs-APS)
were
successfully
synthesized
under
guidance
Such
design
improved
benefits
high
stability,
efficient
highly
therapeutic
efficacy
SCI
illustrated
by
an
improvement
protective
TSIIA.
The
vivo
experiments
indicated
that
TSIIA@SeNPs-APS
displayed
efficiency
cellular
uptake
long
retention
time
PC12
cells.
Furthermore,
had
a
satisfactory
effect
against
oxidative
stress-induced
cytotoxicity
cells
inhibiting
excessive
reactive
oxygen
species
(ROS)
production,
so
to
alleviate
mitochondrial
dysfunction
reduce
cell
apoptosis
S
phase
cycle
arrest,
finally
promote
survival.
can
protect
neurons
rats
enhancing
GSH-Px
activity
decreasing
MDA
content,
which
was
possibly
via
metabolism
SeCys2
regulating
selenoproteins
resist
damage.TSIIA@SeNPs-APS
exhibited
promising
anti-oxidation
therapy
SCI,
paved
way
developing
synergistic
nanotechnology
improve
well
establishing
novel
treatments
stress-related
diseases
associated
Se
regulation.
Nutrients,
Journal Year:
2023,
Volume and Issue:
15(13), P. 3019 - 3019
Published: July 3, 2023
Dietary
plant
polysaccharides,
one
of
the
main
sources
natural
possess
significant
cancer
prevention
activity
and
potential
development
value
in
food
medicine
fields.
The
anti-tumor
mechanisms
polysaccharides
are
mainly
elaborated
from
three
perspectives:
enhancing
immunoregulation,
inhibiting
tumor
cell
growth
invasion
metastasis.
immune
system
plays
a
key
role
progression,
immunomodulation
is
considered
pathway
for
or
treatment.
Although
much
progress
has
been
made
revealing
relationship
between
huge
challenges
still
met
research
polysaccharides.
Results
suggest
that
certain
polysaccharide
types
glycosidic
linkage
forms
significantly
affect
biological
immunoregulation.
At
present,
vitro
effects
immunoregulation
dietary
widely
reported
articles;
however,
vivo
deserving
further
investigation.
In
this
paper,
aspects
behind
polysaccharides'
achieved
through
cells
mediatory
gut
microbiota
systematically
summarized,
with
aim
encouraging
future
on
use
prevention.
Molecules,
Journal Year:
2024,
Volume and Issue:
29(8), P. 1691 - 1691
Published: April 9, 2024
Astragali
radix
is
a
traditional
medicinal
herb
with
long
history
and
wide
application.
It
frequently
used
in
prescriptions
other
materials
to
replenish
Qi.
According
the
classics
of
Chinese
medicine,
attributed
properties
such
as
Qi
replenishing
surface
solidifying,
sore
healing
muscle
generating,
inducing
diuresis
reduce
edema.
Modern
pharmacological
studies
have
demonstrated
that
some
extracts
active
ingredients
function
antioxidants.
The
polysaccharides,
saponins,
flavonoids
offer
beneficial
effects
preventing
controlling
diseases
caused
by
oxidative
stress.
However,
there
still
lack
comprehensive
research
on
effective
components
molecular
mechanisms
through
which
exerts
antioxidant
activity.
In
this
paper,
we
review
radix;
summarize
content,
bioavailability,
mechanisms;
reference
for
clinical
application
Astragalus
future
development
novel
