The Role of Pyroptosis in Coronary Heart Disease

The Anatolian Journal of Cardiology, Journal Year: 2024, Volume and Issue: unknown, P. 318 - 328

Published: Jan. 1, 2024

The incidence and mortality of cardiovascular diseases, which coronary heart disease (CHD) is a significant burden, are on the rise. Pyroptosis as an incipient programmed cell death mediated by inflammasomes can sense cytoplasmic contamination or interference typically marked intracellular swelling, plasma membrane blistering intense inflammatory cytokine release. As research pyroptosis continues to progress, there mounting evidence that vital participant in pathophysiological basis CHD. Atherosclerosis major CHD involves endothelial cells, macrophages, vascular smooth muscle other immune often association with release pro-inflammatory factors. When cardiomyocytes damaged, it will eventually lead failure. Previous studies have covered plays critical role In this review, we describe properties pyroptosis, summarize its contribution related targets diseases involving angina pectoris, myocardial infarction, ischemia perfusion injury failure, highlight potential drugs for different diseases.

Language: Английский

---

Shikonin mitigates cyclophosphamide-induced cardiotoxicity in mice: the role of sirtuin-1, NLRP3 inflammasome, autophagy, and apoptosis

Journal of Pharmacy and Pharmacology, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 22, 2024

The aim of this study was to elucidate the protective potential shikonin (SHK) on cyclophosphamide (CP)-induced cardiotoxicity in Swiss albino mice.

Language: Английский

---

Exploring the Mechanism of Chuanxiong Rhizoma against Thrombosis Based on Network Pharmacology, Molecular Docking and Experimental Verification

Molecules, Journal Year: 2023, Volume and Issue: 28(18), P. 6702 - 6702

Published: Sept. 19, 2023

Chuanxiong rhizoma (CX) has been utilized for centuries as a traditional herb to treat blood stasis syndromes. However, the pharmacological mechanisms are still not completely revealed. This research was aimed at exploring molecular of CX treatment thrombosis. Network pharmacology used predict potential anti-thrombosis mechanism after correlating targets active components with Furthermore, we verified using thrombosis via docking and in vitro experiments. results showed that total 18 ingredients 65 were collected, including 8 core compounds 6 targets. We revealed first time tissue factor (TF) had close relationship most TF is primary coagulation physiological hemostasis pathological have strong affinity according analysis. The experiments indicated Ligustilide (LIG), representative component CX, could inhibit procoagulant activity, mRNA protein over-expression dose-dependent manner EA.hy926 cells through PI3K/Akt/NF-κB signaling pathway. work demonstrated or one important biological processes also might be central target when treating inhibition novel

Language: Английский

---

Cinnamaldehyde protects cardiomyocytes from oxygen‐glucose deprivation/reoxygenation‐induced lipid peroxidation and DNA damage via activating the Nrf2 pathway

Chemical Biology & Drug Design, Journal Year: 2024, Volume and Issue: 103(2)

Published: Feb. 1, 2024

Abstract Rapid restoration of perfusion in ischemic myocardium is the most direct and effective treatment for coronary heart disease but may cause myocardial ischemia/reperfusion injury (MIRI). Cinnamaldehyde (CA, C9H8O), a key component well‐known Chinese medicine cinnamomum cassia, has cardioprotective effects against MIRI. This study aimed to observe therapeutic effect CA on MIRI elucidate its potential mechanism. H9C2 rat cardiomyocytes were pretreated with solution at 0, 10, 100 μM, respectively subjected oxygen‐glucose deprivation/reoxygenation (OGD/R). Then cell viability, NF‐κB caspase3 gene levels, reduced glutathione (GSH)/oxidized (GSSG) ratio, superoxide dismutase (SOD) level, reactive oxygen species (ROS) generation, 4‐hydroxynonenal (4‐HNE), malondialdehyde (MDA) detected. The severity DNA damage was assessed by tail moment (TM) values using alkaline comet assay. Besides, damage‐related proteins Nrf2 pathway detected western blot. increased GHS/GSSG SOD PARP1, Nrf2, PPAR‐γ, HO‐1 protein levels cardiomyocytes, while reducing NF‐κB, caspase3, ROS 4‐HNE MDA content, γ‐H2AX TM values. Inhibition reversed viability apoptosis OGD/R induced cardiomyocytes. μM more than 10 CA. In OGD/R‐induced cardiomyocyte model, can protect from attenuating lipid peroxidation repairing damage. mechanism be related activation pathway.

Language: Английский

---

Hawthorn pectin plays a protective role in myocardial ischaemia by regulating intestinal flora and short chain fatty acids

Current Research in Food Science, Journal Year: 2024, Volume and Issue: 9, P. 100863 - 100863

Published: Jan. 1, 2024

Language: Английский

---

Hesperetin ameliorates ischemia/hypoxia‐induced myocardium injury via inhibition of oxidative stress, apoptosis, and regulation of Ca²⁺ homeostasis

Phytotherapy Research, Journal Year: 2022, Volume and Issue: 37(5), P. 1787 - 1805

Published: Nov. 27, 2022

Ischemia/hypoxia (I/H)-induced myocardial injury has a large burden worldwide. Hesperetin (HSP) cardioprotective effect, but the molecular mechanism underlying this is not clearly established. Here, we focused on protective mechanisms of HSP against I/H-induced myocardium injury. H9c2 cardiomyocytes were challenged with CoCl2 for 22 h to imitate hypoxia after treatment groups received 4 h. The viability was evaluated, and cardiac function indices, reactive oxygen species, apoptosis, mitochondrial membrane potential (MMP), intracellular Ca2+ concentration ([Ca2+ ]i ) measured. L-type current (ICa-L ), contraction, transients in isolated ventricular myocytes also recorded. We found that significantly increased cell viability, MMP while decreasing impairment, oxidative stress, [Ca2+ caused by . Furthermore, markedly attenuated ICa-L , concentration-dependent manner. Our findings suggest restoring balance, inhibiting improving function, reducing influx via channels (LTCCs). These data provide new direction applied research as LTCC inhibitor

Language: Английский

---

Effect and mechanism of Tangzhiqing in improving cardiac function in mice with hyperlipidaemia complicated with myocardial ischaemia

Heliyon, Journal Year: 2023, Volume and Issue: 9(5), P. e15645 - e15645

Published: April 20, 2023

Tangzhiqing formula (TZQ) is a traditional Chinese medicine prescribed to treat lipid metabolism disorders, atherosclerosis, diabetes and diabetic cardiomyopathy. However, some challenges hurdles remain. TZQ showed promising results in treating hyperlipidaemia. its effect on mechanism of action hyperlipidaemia complicated with myocardial ischaemia (HL-MI) remain unknown.In this study, network pharmacology-based strategy integrating target prediction was adopted predict the targets relevant treatment HL-MI further explore involved pharmacological mechanisms.A total 104 potential therapeutic were obtained, including MMP9, Bcl-2, Bax, which may be related apoptosis PI3K/AKT signalling pathways. Then, we confirmed these pathways animal experimentation. reduced levels, increased expression levels decreased caspase-3 caspase-9 activated pathway.In conclusion, study provides new insights into protective mechanisms against through pharmacology approaches.

Language: Английский

---

Protective effect of cinnamon extract against cobalt-induced multiple organ damage in rats

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: May 9, 2024

Background The role of oxidative stress and inflammation in cobalt (Co) toxicity has been the focus previous studies. Cinnamon its main components have reported to protective effects various tissues with antioxidant anti-inflammatory effects. Aims In this study, effect cinnamon extract (CE) against possible Co-induced heart, kidney, liver damage rats was investigated biochemically. Methods Eighteen albino Wistar -type male were categorized into three groups ( n = 6 per group): control (CG), CoCL 2 -administered (CoCL ), CE + (CE Co) groups. group administered (100 mg/kg), CG distilled water orally by gavage. One hour after administration, Co (150 mg/kg) This procedure repeated once daily for 7 days. Then, biochemical markers studied excised tissues. Results increased oxidants proinflammatory cytokines decreased antioxidants Heart, tissue affected damage. treatment suppressed -induced increase decrease shown attenuate cardiac reducing serum troponin I (TpI) creatine kinase-MB (CK-MB), renal creatinine blood urea nitrogen (BUN), alanine aminotransferase (ALT) aspartate (AST). Conclusion induced production parameters depletion rats. Our experimental results show that protects inflammatory changes CoCLl .

Language: Английский

---

Unravelling pharmacological mechanisms and effects of Tianma Siwu Decoction-derived compounds on ischemic stroke by multidimensional network pharmacological analysis

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: unknown, P. 118979 - 118979

Published: Oct. 1, 2024

Language: Английский

---

Preclinical anti-apoptotic properties of salidroside for hypoxic-ischemic cerebral damage: a systematic review and meta-analysis

Digital Chinese Medicine, Journal Year: 2023, Volume and Issue: 6(2), P. 121 - 135

Published: June 1, 2023

As the main active ingredient of Tibetan medicine Hongjingtian (Rhodiolae Crenulatae Radix et Rhizoma), salidroside (Sal) has a good anti-apoptotic potential. Currently, there are some conflicting results on mechanisms Sal. Here we conducted systematic review and meta-analysis to provide preclinical evidence its properties in preventing treating hypoxic-ischemic cerebral damage (HICD). The literature potential Sal treatment HICD from January 1, 1980 November 9, 2021 was searched online using Chinese databases including National Knowledge Infrastructure (CNKI), China Science Technology Journal Database (VIP), Wanfang Database, English PubMed Web Science. quality included articles evaluated by Cochrane Collaboration network bias risk assessment criteria, performed RevMan 5.3 software. A total 40 were finally included. Among articles, 30 about vivo animal experiments 17 vitro cell experiments, 7 them both experiments. After analysis, it found that had significant effects disease-related indicators (P < 0.05), such as infarctsize brain water content. studies, mainly affects expressions apoptotic factors through anti-inflammation, anti-oxidation, activation complement pathway, regulation signal transduction autophagy, thus exerting HICD. While for plays role models reduction Ca2+ overload, mitochondrial function, transduction, C3 complement. can take prevent treat enhanced membrane potential, overload.

Language: Английский

---