Journal of Biochemical and Molecular Toxicology,
Journal Year:
2025,
Volume and Issue:
39(4)
Published: April 1, 2025
ABSTRACT
Enhanced
macrophage
M2
polarization
and
CD8
+
T
cell
dysfunction
contribute
to
the
pathophysiology
of
non‐small
lung
cancer
(NSCLC).
Motor
neuron
pancreatic
homeobox
1
(MNX1)
has
emerged
as
a
potential
tumor‐promoting
player.
Here,
we
clarified
activity
MNX1
in
NSCLC.
PMA‐induced
THP‐1
M0‐like
macrophages
or
cells
were
co‐cultured
with
NSCLC
cells.
Cell
colony
formation,
migration,
proliferation,
apoptosis,
invasiveness
assessed
by
wound
healing,
CCK‐8,
flow
cytometry,
transwell
assays,
respectively.
The
ratio
CD206
was
analyzed
cytometry.
Ki‐67
expression
tested
immunofluorescence.
ChIP
luciferase
assays
used
evaluate
relationship
between
MYCN
MNX1.
highly
expressed
NSCLC,
its
loss‐of‐function
suppressed
growth,
motility,
depletion
also
diminished
apoptosis.
Mechanistically,
increased
at
transcriptional
level.
increase
reversed
impact
on
malignant
behaviors,
polarization,
viability.
vivo
growth
A549
subcutaneous
xenografts.
Additionally,
counteracted
Wnt/β‐catenin
pathway.
Our
findings
elucidate
oncogenic
role
MYCN/MNX1/Wnt/β‐catenin
pathway
driving
diminishing
study
thus
uncovers
novel
mechanism
underlying
development
highlights
targets
for
combating
Experimental Gerontology,
Journal Year:
2024,
Volume and Issue:
188, P. 112389 - 112389
Published: March 8, 2024
Aging-related
diseases
(ARDs)
are
a
major
global
health
concern,
and
the
development
of
effective
therapies
is
urgently
needed.
Kaempferol,
flavonoid
found
in
several
plants,
has
emerged
as
promising
candidate
for
ameliorating
ARDs.
This
comprehensive
review
examines
Kaempferol's
chemical
properties,
safety
profile,
pharmacokinetics,
highlights
its
potential
therapeutic
utility
against
underpinned
by
distinctive
structure,
which
confers
antioxidative
anti-inflammatory
properties.
Kaempferol
counteracts
reactive
oxygen
species
(ROS)
modulates
crucial
cellular
pathways,
thereby
combating
oxidative
stress
inflammation,
hallmarks
low
toxicity
wide
margins,
demonstrated
preclinical
clinical
studies,
further
substantiate
potential.
Compelling
evidence
supports
substantial
addressing
ARDs
through
mechanisms,
notably
anti-inflammatory,
antioxidant,
anti-apoptotic
actions.
exhibits
versatile
neuroprotective
effect
modulating
various
proinflammatory
signaling
including
NF-kB,
p38MAPK,
AKT,
β-catenin
cascade.
Additionally,
it
hinders
formation
aggregation
beta-amyloid
protein
regulates
brain-derived
neurotrophic
factors.
In
terms
anticancer
potential,
kaempferol
acts
diverse
inducing
apoptosis,
arresting
cell
cycle
at
G2/M
phase,
suppressing
epithelial-mesenchymal
transition
(EMT)-related
markers,
affecting
phosphoinositide
3-kinase/protein
kinase
B
pathways.
Subsequent
studies
should
focus
on
refining
dosage
regimens,
exploring
innovative
delivery
systems,
conducting
trials
to
translate
these
findings
into
applications.
PubMed,
Journal Year:
2024,
Volume and Issue:
23, P. 34 - 52
Published: Jan. 1, 2024
This
review
delves
into
the
pivotal
role
of
long
non-coding
RNA
NEAT1
in
cancer
biology,
particularly
lung
(LC).
It
emphasizes
NEAT1's
unique
subcellular
localization
and
active
involvement
gene
regulation
chromatin
remodeling.
The
highlights
impact
on
LC
development
progression,
including
cell
processes
such
as
proliferation,
migration,
invasion,
resistance
to
therapy,
positioning
it
a
potential
diagnostic
marker
therapeutic
target.
complex
web
regulatory
interactions
with
proteins
microRNAs
is
explored,
alongside
challenges
targeting
therapeutically.
concludes
optimistically,
suggesting
future
avenues
for
research
personalized
therapies,
shedding
light
crucial
LC.
See
also
Graphical
abstract(Fig.
1).
Parkinson's
disease
(PD)
is
a
degenerative
neurological
condition
marked
by
the
gradual
loss
of
dopaminergic
neurons
in
substantia
nigra
pars
compacta.
The
precise
etiology
PD
remains
unclear,
but
emerging
evidence
suggests
significant
role
for
disrupted
autophagy-a
crucial
cellular
process
maintaining
protein
and
organelle
integrity.
