Nanoparticle-based therapeutic approaches for wound healing: a review of the state-of-the-art

Materials Today Chemistry, Journal Year: 2022, Volume and Issue: 27, P. 101319 - 101319

Published: Dec. 21, 2022

Language: Английский

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Applications of Various Types of Nanomaterials for the Treatment of Neurological Disorders

Nanomaterials, Journal Year: 2022, Volume and Issue: 12(13), P. 2140 - 2140

Published: June 22, 2022

Neurological disorders (NDs) are recognized as one of the major health concerns globally. According to World Health Organization (WHO), neurological main causes mortality worldwide. include Alzheimer’s disease, Parkinson′s Huntington′s Amyotrophic lateral sclerosis, Frontotemporal dementia, Prion Brain tumor, Spinal cord injury, and Stroke. These diseases considered incurable because no specific therapies available cross blood-brain barrier (BBB) reach brain in a significant amount for pharmacological effect brain. There is need development strategies that can improve efficacy drugs circumvent BBB. One promising approaches use different types nano-scale materials. nano-based have ability increase therapeutic effect, reduce toxicity, exhibit good stability, targeted delivery, drug loading capacity. Different shapes nanomaterials been widely used treatment disorders, including quantum dots, dendrimers, metallic nanoparticles, polymeric carbon nanotubes, liposomes, micelles. nanoparticles unique characteristics, sensitivity, selectivity, BBB when nano-sized particles, imaging studies NDs. In this review, we briefly summarized recent literature on various their mechanism action disorders.

Language: Английский

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Polymeric Nanoparticles as Tunable Nanocarriers for Targeted Delivery of Drugs to Skin Tissues for Treatment of Topical Skin Diseases

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(2), P. 657 - 657

Published: Feb. 15, 2023

The topical route is the most appropriate for targeted delivery of drugs to skin tissues treatment local diseases; however, stratum corneum (SC), foremost layer skin, acts as a major barrier. Numerous passive and active drug techniques have been exploited overcome this barrier; these modalities are associated with several detrimental effects which restrict their clinical applicability. Alternatively, nanotechnology-aided interventions extensively investigated administration wide range therapeutics. In review, we mainly focused on biopharmaceutical significance polymeric nanoparticles (PNPs) (made from natural polymers) various diseases such psoriasis, atopic dermatitis (AD), infection, cancer, acute-to-chronic wounds, acne. encapsulation drug(s) into inner core or adsorption onto shell PNPs has shown marked improvement in physicochemical properties, avoiding premature degradation controlling release kinetics, permeation through SC, retention layers. Furthermore, functionalization PEGylation, conjugation targeting ligand, pH/thermo-responsiveness further success optimizing therapeutic efficacy diseases. Despite enormous progress development PNPs, translation still lacking, could be potential future perspective researchers working field.

Language: Английский

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Progress in Wound-Healing Products Based on Natural Compounds, Stem Cells, and MicroRNA-Based Biopolymers in the European, USA, and Asian Markets: Opportunities, Barriers, and Regulatory Issues

Polymers, Journal Year: 2024, Volume and Issue: 16(9), P. 1280 - 1280

Published: May 3, 2024

Wounds are breaks in the continuity of skin and underlying tissues, resulting from external causes such as cuts, blows, impacts, or surgical interventions. Countless individuals suffer minor to severe injuries, with unfortunate cases even leading death. In today’s scenario, several commercial products available facilitate healing process wounds, although chronic wounds still present more challenges than acute wounds. Nevertheless, huge demand for wound-care within healthcare sector has given rise a rapidly growing market, fostering continuous research development endeavors innovative wound-healing solutions. Today, there many commercially including those based on natural biopolymers, stem cells, microRNAs that promote This article explores recent breakthroughs harness potential microRNAs. A comprehensive exploration is undertaken, covering not only but also phase. Additionally, we provide thorough examination opportunities, obstacles, regulatory considerations influencing commercialization across diverse markets Europe, America, Asia.

Language: Английский

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Advance and Challenges in the Treatment of Skin Diseases with the Transdermal Drug Delivery System

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(8), P. 2165 - 2165

Published: Aug. 21, 2023

Skin diseases are among the most prevalent non-fatal conditions worldwide. The transdermal drug delivery system (TDDS) has emerged as a promising approach for treating skin diseases, owing to its numerous advantages such high bioavailability, low systemic toxicity, and improved patient compliance. However, effectiveness of TDDS is hindered by several factors, including barrier properties stratum corneum, nature carrier, conditions. In this paper, we provide an overview development from first-generation fourth-generation systems, highlighting characteristics each carrier in terms mechanism composition, penetration method, action, recent preclinical studies. We further investigated significant challenges encountered crucial significance clinical trials.

Language: Английский

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Multifunctional lipid-based nanoparticles for wound healing and antibacterial applications: A review

Advances in Colloid and Interface Science, Journal Year: 2023, Volume and Issue: 321, P. 103002 - 103002

Published: Sept. 27, 2023

Wound healing primarily involves preventing severe infections, accelerating healing, and reducing pain scarring. Therefore, the multifunctional application of lipid-based nanoparticles (LBNs) has received considerable attention in drug discovery due to their solid or liquid lipid core, which increases ability provide prolonged release, reduce treatment costs, improve patient compliance. LBNs have also been used medical cosmetic practices formulated for various products based on skin type, disease conditions, administration product efficiency, stability, toxicity; therefore, understanding interaction with biological systems is very important. it necessary perform an in-depth analysis results from a comprehensive characterization process produce delivery desired properties. This review will detailed information different types LBNs, formulation methods, characterisation, antimicrobial activity, wound models (both vitro vivo studies). Also, clinical commercial applications are summarized.

Language: Английский

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The Application of Nanogels as Efficient Drug Delivery Platforms for Dermal/Transdermal Delivery

Gels, Journal Year: 2023, Volume and Issue: 9(9), P. 753 - 753

Published: Sept. 15, 2023

The delivery of active molecules via the skin seems to be an efficient technology, given various disadvantages oral drug administration. Skin, which is largest human organ body, has important role acting as a barrier for pathogens and other including drugs; in fact, it serves primary defense system blocking any particle from entering body. Therefore, overcome barriers poor permeability, researchers implement novel carriers can effectively carry out transdermal molecules. Another significant issue medical society tries solve effective dermal especially topical wound delivery. application nanogels only one available approaches offering promising results both administration routes. Nanogels are polymer-based networks nanoscale dimensions have been explored potent poorly soluble drugs, genes vaccines. present unique physicochemical properties, i.e., high surface area, biocompatibility, etc., and, importantly, improve solubility. In this review, authors aimed summarize applications possible vehicles pharmaceutical ingredients discuss their future manufacturing field.

Language: Английский

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Curcumin‐based nanoformulations alleviate wounds and related disorders: A comprehensive review

BioFactors, Journal Year: 2023, Volume and Issue: 49(4), P. 736 - 781

Published: March 24, 2023

Abstract Despite numerous advantages, curcumin's (CUR) low solubility and bioavailability limit its employment as a free drug. CUR‐incorporated nanoformulation enhances the angiogenesis, collagen deposition, fibroblast proliferation, reepithelization, synthesis, neovascularization, granulation tissue formation in different wounds. Designing nanoformulations with controlled‐release properties ensure presence of CUR defective area during treatment. Different encompassing nanofibers, nanoparticles (NPs), nanospray, nanoemulsion, nanosuspension, nanoliposome, nanovesicle, nanomicelle were described present study comprehensively. Moreover, for some other systems which contain nano‐CUR or nanoformulations, including films, composites, scaffolds, gel, hydrogels seems CUR‐loaded NPs incorporation has better control sustained release, thereby, until final stages wound healing is more possible. Incorporating chitosan into nanofiber increased release time, while 80% was released 240 h (10 days). Therefore, this system can guarantee entire period. Furthermore, porous structures such sponges, aerogels, hydrogels, scaffolds disclosed promising performance. These architectures interconnected pores mimic native extracellular matrix, thereby facilitating attachment infiltration cells at site, besides maintaining flow nutrients oxygen within three‐dimensional structure essential rapid proper healing, well enhancing mechanical strength.

Language: Английский

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Functionalization of curcumin nanomedicines: a recent promising adaptation to maximize pharmacokinetic profile, specific cell internalization and anticancer efficacy against breast cancer

Journal of Nanobiotechnology, Journal Year: 2023, Volume and Issue: 21(1)

Published: March 25, 2023

Abstract Owing to its diverse heterogeneity, aggressive nature, enormous metastatic potential, and high remission rate, the breast cancer (BC) is among most prevalent types of associated with mortality. Curcumin (Cur) a potent phytoconstituent that has gained remarkable recognition due exceptional biomedical viability against wide range ailments including BC. Despite exhibiting strong anticancer clinical translation Cur restricted intrinsic physicochemical properties such as low aqueous solubility, chemical instability, bioavailability, short plasma half-life. To overcome these shortcomings, nanotechnology-aided developments have been extensively deployed. The implication nanotechnology pointedly improved properties, pharmacokinetic profile, cell internalization, efficacy Cur; however, majority Cur-nanomedicines are still facing grandeur challenges. advent various functionalization strategies PEGylation, surface decoration different moieties, stimuli-responsiveness (i.e., pH, light, temperature, heat, etc.), tethering specific targeting ligand(s) based on biochemical targets (e.g., folic acid receptors, transferrin CD44, multifunctionalization (multiple functionalities) revolutionized fate Cur-nanomedicines. This study ponders significance adaptable functionalizations for amplifying cytotoxicity via induction apoptosis, passive active tumor microenvironment (TME), while reversing multidrug resistance (MDR) reoccurrence in Nevertheless, therapeutic outcomes BC remarkably after adaptation functionalizations; this evolving strategy demands extensive research scalable translation. Graphical

Language: Английский

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Progress in Topical and Transdermal Drug Delivery Research—Focus on Nanoformulations

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(6), P. 817 - 817

Published: June 16, 2024

Skin is the largest organ and a multifunctional interface between body its environment. It acts as barrier against cold, heat, injuries, infections, chemicals, radiations or other exogeneous factors, it also known mirror of soul. The skin involved in temperature regulation by storage fat water. an interesting tissue regard to local transdermal application active ingredients for prevention treatment pathological conditions. Topical delivery emerging route drug cosmetic administration. beneficial avoiding side effects rapid metabolism. Many pharmaceutical, technological innovations have been described patented recently field. In this review, main features morphology physiology are presented being followed description classical novel nanoparticulate dermal formulations. biophysical aspects penetration drugs cosmetics into across their investigation diffusion chambers, skin-on-a-chip devices, high-throughput measuring systems with advanced analytical techniques shown. current knowledge about mathematical modeling future perspectives briefly discussed end, all involving nanoparticulated systems.

Language: Английский

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