This
work
utilizes
the
concept
of
curcumin
amorphization
to
improve
drawbacks
currently
found
if
it
is
used
as
a
pharmaceutical
ingredient,
such
low
solubility,
limited
bioavailability,
and
absorption,
by
anchoring
with
silica
nanoparticles
(SiO2NP).
Curcumin
loading
was
determined
following
kinetic
adsorption
parameters,
resulting
in
more
than
70%
being
loaded
onto
after
180
min.
The
adjusted
data
resulted
Langmuir
BET
best-fit
coefficient
relating
favorable
multilayer
mechanism.
With
reduction
particle
area
loading,
increased
SiO2NP
size.
Due
curcumin,
FTIR
presented
free
unbounded
vibration
SiO2NP,
disappearing
favor
chemical
reaction.
XRD
pattern
showed
complete
drug
release
under
ethanol
up
41%
30
days.
To
this,
photodegradation
on
performed,
showing
vast
improvement
antioxidant
activity
(ABTS
DPPH)
72
h,
related
degradation
products
that
were
hydrophilic
but
still
lower
pure
demonstrating
protection
effect
SiO2NP.
These
led
an
increase
antimicrobial
potential
against
fungus
Gram-negative
Gram-positive
bacteria
when
anchored
photodegraded,
their
depolymerization.
Docking
studies
conducted
assess
antibacterial
effect,
revealing
conjugated
double
bond,
common
region
for
photolysis,
remains
prominent,
even
anchored.
Interestingly,
nanosilica
enhances
efficacy,
potentially
attributed
its
ability.
By
performing
posterior
enhanced
benefits
achieved
providing
support
degraded
act
targeted
applications
cancer
can
promote
stable
release.
Antioxidants,
Journal Year:
2024,
Volume and Issue:
13(3), P. 331 - 331
Published: March 8, 2024
Curcumin,
a
natural
polyphenolic
component
from
Curcuma
longa
roots,
is
the
main
bioactive
of
turmeric
spice
and
has
gained
increasing
interest
due
to
its
proposed
anti-cancer,
anti-obesity,
anti-inflammatory,
antioxidant,
lipid-lowering
effects,
in
addition
thermogenic
capacity.
While
intake
dietary
sources
such
as
curry
may
be
sufficient
affect
intestinal
microbiome
thus
act
indirectly,
intact
curcumin
body
too
low
(<1
microM)
not
signaling
gene
expression,
observed
vitro
with
cultured
cells
(10–20
microM).
Several
strategies
can
envisioned
increase
levels
body,
decreasing
metabolism
or
absorption
through
formation
nanoparticles.
However,
since
high
could
also
lead
undesired
regulatory
effects
on
cellular
studies
need
carefully
monitored.
Here,
we
review
bioavailability
what
extent
using
nanoformulations
bioactivity
metabolites.
This
enhancement
potentially
amplify
disease-preventing
curcumin,
often
by
leveraging
robust
antioxidant
properties.
PubMed,
Journal Year:
2024,
Volume and Issue:
23, P. 212 - 263
Published: Jan. 1, 2024
Niosomes
are
drug
delivery
systems
with
widespread
applications
in
pharmaceutical
research
and
the
cosmetic
industry.
vesicles
of
one
or
more
bilayers
made
non-ionic
surfactants,
cholesterol,
charge
inducers.
Because
their
bilayer
characteristics,
similar
to
liposomes,
niosomes
can
be
loaded
lipophilic
hydrophilic
cargos.
Therefore,
they
stable
cheaper
preparation
than
liposomes.
They
classified
into
four
categories
according
sizes
structures,
namely
small
unilamellar
(SUVs),
large
(LUVs,),
multilamellar
(MLVs),
multivesicular
(MVVs).
There
many
methods
for
niosome
preparation,
such
as
thin-film
hydration,
solvent
injection,
heating
method.
The
current
study
focuses
on
pharmacological
effects
natural
chemical
anti-inflammatory
compounds
kinds
literature
during
past
decade.
We
found
that
most
was
carried
out
load
agents
like
non-steroidal
drugs
(NSAIDs)
vesicles.
studies
revealed
could
improve
agents'
physicochemical
properties,
including
solubility,
cellular
uptake,
stability,
encapsulation,
release
liberation,
efficiency,
oral
bioavailability
topical
absorption.
See
also
graphical
abstract(Fig.
1).
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(5), P. 2911 - 2911
Published: March 2, 2024
This
paper
delves
into
the
diverse
and
significant
roles
of
curcumin,
a
polyphenolic
compound
from
Curcuma
longa
plant,
in
context
cancer
inflammatory
diseases.
Distinguished
by
its
unique
molecular
structure,
curcumin
exhibits
potent
biological
activities
including
anti-inflammatory,
antioxidant,
potential
anticancer
effects.
The
research
comprehensively
investigates
curcumin’s
interactions
with
key
proteins
involved
progression
response,
primarily
through
docking
studies.
In
cancer,
effectiveness
is
determined
examining
interaction
pivotal
like
CDK2,
CK2α,
GSK3β,
DYRK2,
EGFR,
among
others.
These
suggest
role
impeding
cell
proliferation
survival.
Additionally,
highlights
impact
on
inflammation
influence
such
as
COX-2,
CRP,
PDE4,
MD-2,
which
are
central
to
pathway.
vitro
clinical
studies
extensively
reviewed,
shedding
light
binding
mechanisms,
pharmacological
impacts,
therapeutic
application
various
cancers
conditions.
understanding
functionality
agent.
Conclusively,
this
review
emphasizes
promise
treating
wide
range
health
issues,
attributed
complex
chemistry
broad
properties.
points
towards
growing
importance
multi-faceted
natural
medical
scientific
community.
Journal of the mechanical behavior of biomedical materials/Journal of mechanical behavior of biomedical materials,
Journal Year:
2024,
Volume and Issue:
160, P. 106769 - 106769
Journal of Translational Medicine,
Journal Year:
2025,
Volume and Issue:
23(1)
Published: Jan. 12, 2025
Rotator
cuff
injury
(RCI),
characterized
by
shoulder
pain
and
restricted
mobility,
represents
a
subset
of
tendon-bone
insertion
injuries
(TBI).
In
the
majority
cases,
surgical
reconstruction
affected
tendons
or
ligaments
is
required
to
address
damage.
However,
numerous
clinical
failures
have
underscored
suboptimal
outcomes
associated
with
such
procedures.
Further
investigations
revealed
that
these
are
largely
attributable
delayed
healing
at
interface,
excessive
formation
vascularized
scar
tissue,
inadequate
integration
tendon
grafts
within
bone
tunnels.
As
result,
process
rotator
faces
significant
challenges.Bone
marrow-derived
mesenchymal
stem
cell
exosomes
(BMSC-exos)
emerged
as
prominent
focus
research
field
bioengineering,
owing
their
remarkable
potential
regulate
cellular
proliferation
differentiation,
modulate
immune
responses,
facilitate
tissue
repair
regeneration
following
this
review,
we
explore
anti-inflammatory,
angiogenic,
anti-scarring,
metabolism-modulating
effects
BMSC-exos
in
context
injury.
Additionally,
limitations
ongoing
challenges
current
research,
offering
insights
could
guide
application
treatment
future.
