SIRT1 activation by 2,3,5,6-tetramethylpyrazine alleviates neuroinflammation via inhibiting M1 microglia polarization DOI Creative Commons
Yu Chen,

Fu Peng,

Chao Yang

et al.

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: Aug. 4, 2023

Background Neuroinflammation has been reported as a potential contributing factor to brain diseases, and is characterized by activated microglia with release of multiple inflammatory mediators. 2,3,5,6-Tetramethylpyrazine (TMP) an active alkaloid in Ligusticum chuanxiong Hort. various biological activities, including anti-inflammatory neuroprotection properties. However, the anti-neuroinflammatory activity TMP less studied its molecular mechanisms this field remain unclear. This study aimed investigate effects underlying neuroinflammation. Methods In vitro , lipopolysaccharide (LPS)-stimulated BV2 were used assess on cytokines well components SIRT1/NF-κB signaling pathway, which measured using ELISA, western blotting, qRT-qPCR immunofluorescence. Moreover, LPS-induced acute neuroinflammation model mice was performed detect whether could exert vivo EX527, SIRT1 inhibitor, given intraperitoneally every two days prior treatment. Serums spinal trigeminal nucleus (Sp5) tissues collected for ELISA assay, Sp5 HE staining, Nissl immunofluorescence, qRT-PCR blotting. Results treatment significantly reduced secretion pro-inflammatory cytokines, TNF-α IL-6, promoted protein expression inactivated NF-κB pathway Interestingly, pretreatment EX527 blocked therapeutic . Furthermore, levels chemokines, prevented from polarizing towards state through activating inhibiting activation mice. And reversed beneficial against LPS exposure Conclusion summary, unravels that mitigate via pathway.

Language: Английский

The mechanism of microglia-mediated immune inflammation in ischemic stroke and the role of natural botanical components in regulating microglia: A review DOI Creative Commons
Jinsong Zeng, Tingting Bao, Kailin Yang

et al.

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 13

Published: Feb. 2, 2023

Ischemic stroke (IS) is one of the most fatal diseases. Neuroimmunity, inflammation, and oxidative stress play important roles in various complex mechanisms IS. In particular, early proinflammatory response resulting from overactivation resident microglia infiltration circulating monocytes macrophages brain after cerebral ischemia leads to secondary injury. Microglia are innate immune cells that constantly monitor microenvironment under normal conditions. Once occurs, activated produce dual effects neurotoxicity neuroprotection, balance two determines fate damaged neurons. The activation defined as classical (M1 type) or alternative (M2 type). M1 type secrete pro-inflammatory cytokines neurotoxic mediators exacerbate neuronal damage, while M2 promote a repairing anti-inflammatory response. Fine regulation M1/M2 microglial minimize damage maximize protection has therapeutic value. This review focuses on interaction between other involved IS phenotypic characteristics, mechanism natural plant components regulating IS, providing novel candidate drugs for drug development.

Language: Английский

Citations

75
Unraveling the aroma profiling of Baijiu: Sensory characteristics of aroma compounds, analytical approaches, key odor-active compounds in different Baijiu, and their synthesis mechanisms DOI
Lianqing Wang,

Ping Tang,

Pengjie Zhang

et al.

Trends in Food Science & Technology, Journal Year: 2024, Volume and Issue: 146, P. 104376 - 104376

Published: Feb. 16, 2024

Language: Английский

Citations

35
Monomeric compounds from traditional Chinese medicine: New hopes for drug discovery in pulmonary fibrosis DOI Open Access
Qi Wang, Wenjun Li, Haibo Hu

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 159, P. 114226 - 114226

Published: Jan. 17, 2023

Pulmonary fibrosis (PF) is a chronic and irreversible pulmonary disease, can lead to decreased lung function, respiratory failure even death. The pathogenesis research treatment strategy of PF significantly lag behind the medical progress clinical needs. this disease remains thorny problem, effective therapeutic drugs are still limited. Monomeric compounds from traditional Chinese medicine own various biological activities high safety. They play broad part in treating diseases also candidate drug for preventing PF. In paper, we reviewed mechanism action potential value anti-PF monomeric medicine. These attenuate inflammatory response, oxidative stress, epithelial mesenchymal transformation other processes through many signaling pathways, inhibit activation differentiation fibroblasts, thus contributing This review provide new ideas development efficiency with low toxicity.

Language: Английский

Citations

29
Copper exposure causes alteration in the intestinal microbiota and metabolites in Takifugu rubripes DOI Creative Commons
Pengfei Liu, Yan‐Yun Liu,

Jianxin Cheng

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 272, P. 116064 - 116064

Published: Feb. 10, 2024

Copper is an environmental pollutant, and copper in aquatic environments mainly comes from soil water. It enters the environment through atmospheric deposition, sewage discharge, industrial production, organisms, causing toxicity. Takifugu rubripes (T. rubripes) a marine fish with high economic value. Due to toxic effects of heavy metals on organisms such as fish, it can affect gut community metabolites fish. The important channel for communicate outside world necessary pathway metabolism nutrients substances body. Studies have shown that due changes global water emissions sensitivity environment, may pose greater potential hazards organisms. poses risk species than other metal/metal like pollutants (such cadmium, lead, mercury, arsenic, etc.) . In order elucidate exposure T. rubripes. this study, we exposed 0, 50, 100, or 500 μg/L three days, microbiota structure were investigated using 16 S rRNA gene metabolomics techniques. research results indicate increase concentration, intestinal tissue undergoes significant damage. sequencing show alters microbiota. 100 inhibited colonization bacterial gut, disrupted barrier, made susceptible pathogens. Liquid chromatography–mass spectrometry analysis showed regulated production L-histidine, arachidonic acid, L-glutamic which are related energy immunity. Microbiome–metabolome correlation Subdoligranulum, Family_XIII_AD3011_group, Clostridium_sensu_stricto_1 key bacteria ion intervention, they might up-regulate levels indole-3-acetic 3-indoleacrylic 5-hydroxyindole tryptophan pathway. summary, our has demonstrated cause pathological High concentrations ions intestine, damage fish's immune system, alter microbiota, lead metabolic dysfunction. providing reference evaluation biological toxicity metal elements environment. This study provides evaluating environments.

Language: Английский

Citations

12
Metabolites of traditional Chinese medicine targeting PI3K/AKT signaling pathway for hypoglycemic effect in type 2 diabetes DOI Creative Commons

Yuhan Feng,

Yan‐Fang Ren, Xia Zhang

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: May 10, 2024

Type 2 diabetes mellitus is a chronic metabolic disease characterized by insulin resistance, with high morbidity and mortality worldwide. Due to the tightly intertwined connection between resistance pathway PI3K/AKT signaling pathway, regulating its associated targets essential for hypoglycemia prevention of type mellitus. In recent years, metabolites isolated from traditional Chinese medicine has received more attention acceptance superior bioactivity, safety, fewer side effects. Meanwhile, numerous in vivo vitro studies have revealed that present possess better bioactivities balance glucose metabolism, ameliorating preventing via pathway. this article, we reviewed literature related improving IR possessing therapeutic potential targeting focusing on hypoglycemic mechanism elaborating significant role order provide reference clinical treatment

Language: Английский

Citations

12
High-Altitude Medicinal Plants as Promising Source of Phytochemical Antioxidants to Combat Lifestyle-Associated Oxidative Stress-Induced Disorders DOI Creative Commons

Mohammad Vikas Ashraf,

Sajid Aleem Khan,

Surya Misri

et al.

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(8), P. 975 - 975

Published: July 23, 2024

Oxidative stress, driven by reactive oxygen, nitrogen, and sulphur species (ROS, RNS, RSS), poses a significant threat to cellular integrity human health. Generated during mitochondrial respiration, inflammation, UV exposure pollution, these damage cells contribute pathologies like cardiovascular issues, neurodegeneration, cancer, metabolic syndromes. Lifestyle factors exert substantial influence on oxidative stress levels, with mitochondria emerging as pivotal players in ROS generation equilibrium. Phytochemicals, abundant plants, such carotenoids, ascorbic acid, tocopherols polyphenols, offer diverse antioxidant mechanisms. They scavenge free radicals, chelate metal ions, modulate signalling pathways mitigate damage. Furthermore, plants thriving high-altitude regions are adapted extreme conditions, synthesize secondary metabolites, flavonoids phenolic compounds bulk quantities, which act form robust defence against including radiation temperature fluctuations. These promising sources for drug development, offering innovative strategies manage stress-related ailments enhance Understanding harnessing the potential of phytochemicals from represent crucial steps combating stress-induced disorders promoting overall wellbeing. This study offers comprehensive summary production physio-pathological aspects lifestyle-induced explores antioxidants. Additionally, it presents an appraisal medicinal antioxidants, highlighting their development creation therapeutic approaches.

Language: Английский

Citations

12
Bibliometric analysis of research progress on tetramethylpyrazine and its effects on ischemia-reperfusion injury DOI

Ming-Zhu Qi,

Xiaohui Su, Zhuohang Li

et al.

Pharmacology & Therapeutics, Journal Year: 2024, Volume and Issue: 259, P. 108656 - 108656

Published: May 10, 2024

Language: Английский

Citations

10
A Sustainable Retinal Drug Co‐Delivery for Boosting Therapeutic Efficacy in wAMD: Unveiling Multifaceted Evidence and Synergistic Mechanisms DOI
Congyan Liu, Wenting Su, Xi Jiang

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(14)

Published: Feb. 22, 2024

Abstract Sustainable retinal codelivery poses significant challenges technically, although it is imperative for synergistic treatment of wet age‐related macular degeneration (wAMD). Here, a microemulsion‐doped hydrogel (Bor/PT‐M@TRG) engineered as an intravitreal depot composing temperature‐responsive (TRG) and borneol‐decorated paeoniflorin (PF) & tetramethylpyrazine (TMP)‐coloaded microemulsions (Bor/PT‐M). Bor/PT‐M@TRG, functioning the “ammunition depot”, resides in vitreous continuously releases Bor/PT‐M therapeutic “bullet”, enabling deep penetration into retina 21 days. A single injection Bor/PT‐M@TRG yields substantial reductions choroidal neovascularization (CNV, hallmark feature wAMD) progression mitigates oxidative stress‐induced damage vivo. Combinational PF&TMP regulates “reactive oxygen species/nuclear factor erythroid‐2‐related 2/heme oxygenase‐1” pathway blocks “hypoxia inducible factor‐1α/vascular endothelial growth factor” signaling retina, synergistically cutting off loop CNV formation. Utilizing fluorescence resonance energy transfer liquid chromatography‐mass spectrometry techniques, they present compelling multifaceted evidence sustainable spanning formulations, ARPE‐19 cells, vivo eye balls, ex section/retina‐choroid complex cell levels. Such approach elucidated key driving force behind exceptional outcomes Bor/PT‐M@TRG. These findings highlight significance drug rational combination effective wAMD.

Language: Английский

Citations

9
Bioactive compounds from Chinese herbal plants for neurological health: mechanisms, pathways, and functional food applications DOI Creative Commons
Meng Wang, Chao Wang,

Zhao Kaiwei

et al.

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: Jan. 31, 2025

Neurological disorders pose significant global public health challenges, with a rising prevalence and complex pathophysiological mechanisms that impose substantial social economic burdens. Traditional Chinese Medicine (TCM), its holistic approach multi-target effects, has gained increasing attention in the treatment of neurological diseases. This review explores bioactive compounds derived from herbal plants, focusing on their action, underlying pathways, potential applications functional food development. The highlights neuroprotective properties flavonoids, alkaloids, polysaccharides, polyphenols found key TCM herbs such as Scutellaria baicalensis , Salvia miltiorrhiza Ligusticum chuanxiong Gastrodia elata . These have demonstrated anti-inflammatory, antioxidant, neurogenic making them promising candidates for prevention conditions, including Alzheimer’s disease (AD), Parkinson’s (PD), depression. Furthermore, synergistic effects formulations targeting multiple signaling pathways offer advantages over single-target therapies, especially combating neurodegenerative also discusses challenges future directions integrating these into foods dietary supplements, aiming to improve enhance clinical outcomes. Ultimately, this work aims provide valuable insights TCM-based interventions promoting well-being addressing burden disorders.

Language: Английский

Citations

1
Tetramethylpyrazine Confers Protection Against Oxidative Stress and NLRP3-Dependent Pyroptosis in Rats with Endometriosis DOI Creative Commons
Ke Xu, Mingzhe Zhang, Xiaofeng Zou

et al.

Organogenesis, Journal Year: 2025, Volume and Issue: 21(1)

Published: Feb. 18, 2025

Tetramethylpyrazine (TMP) has been confirmed to suppress inflammation in endometriosis (EMs). Herein, this study investigated whether and how TMP affected NLRP3 inflammasomes oxidative stress EMs. After establishment of an EMs rat model, rats were treated with different concentrations TMP. The size endometriotic lesions the latency frequency torsion recorded, followed by measurement relevant indicators (TNF-α, IL-6, IL-2, IL-10, MDA, SOD, GSH, CAT, ROS, NLRP3, ASC, GSDMD, caspase-1, Nrf2, HO-1). experimentally determined that treatment markedly decreased improved levels inflammatory proteins, markers, inflammasome, pyroptotic proteins elevated EMs, all which reversed upon treatment. Additionally, activities CAT lowered partly abrogated Furthermore, downregulation Nrf2 HO-1 was counteracted To sum up, represses excessive stress, inflammasome activation, pyroptosis may activate Nrf2/HO-1 pathway.

Language: Английский

Citations

1