The Pharmacological Efficacy of Baicalin in Inflammatory Diseases

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(11), P. 9317 - 9317

Published: May 26, 2023

Baicalin is one of the most abundant flavonoids found in dried roots Scutellaria baicalensis Georgi (SBG) belonging to genus Scutellaria. While baicalin demonstrated have anti-inflammatory, antiviral, antitumor, antibacterial, anticonvulsant, antioxidant, hepatoprotective, and neuroprotective effects, its low hydrophilicity lipophilicity limit bioavailability pharmacological functions. Therefore, an in-depth study baicalin’s pharmacokinetics contributes laying theoretical foundation for applied research disease treatment. In this view, physicochemical properties anti-inflammatory activity are summarized terms bioavailability, drug interaction, inflammatory conditions.

Language: Английский

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Current status and progress in research on dressing management for diabetic foot ulcer

Frontiers in Endocrinology, Journal Year: 2023, Volume and Issue: 14

Published: Aug. 17, 2023

Diabetic foot ulcer (DFU) is a major complication of diabetes and associated with high risk lower limb amputation mortality. During their lifetime, 19%–34% patients can develop DFU. It estimated that 61% DFU become infected 15% those require amputation. Furthermore, developing increases the mortality by 50%–68% at 5 years, higher than some cancers. Current standard management includes surgical debridement, use topical dressings wound decompression, vascular assessment, glycemic control. Among these methods, local treatment builds protective physical barrier, maintains moist environment, drains exudate from wounds. This review summarizes development, pathophysiology, healing mechanisms The latest research progress main application in laboratory clinical stage are also summarized. discussed this include traditional (gauze, oil yarn, Chinese medicine, others), basic (hydrogel, hydrocolloid, sponge, foam, film agents, bacteriostatic dressings, composite (collagen, nanomaterials, chitosan bioactive (scaffold stem cells, decellularized matrix, autologous platelet enrichment plasma, modern technology (3D bioprinting, photothermal effects, bioelectric microneedle smart bandages, orthopedic prosthetics regenerative medicine). dressing challenges limitations purpose to help readers understand pathogenesis mechanism DFU, physicians select correctly, provide an updated overview potential biomaterials devices management, ideas for further exploration development dressings. Proper promote healing, reduce cost treating patient pain.

Language: Английский

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Mesenchymal stem cell therapy for non-healing diabetic foot ulcer infection: New insight

Frontiers in Bioengineering and Biotechnology, Journal Year: 2023, Volume and Issue: 11

Published: April 13, 2023

Diabetic foot ulcer (DFU) is considered the most catastrophic complication of diabetes mellitus (DM), leading to repeated hospitalizations, infection, gangrene, and finally amputation limb. In patients suffering from mellitus, wound-healing process impaired due various factors such as endothelial dysfunction synthesis advanced glycation end-products, hence, conventional therapeutic interventions might not be effective. With increasing applications mesenchymal stem cells (MSCs) in recent years, their potential a method for improving has gained remarkable attention. this field, exert beneficial effects through immunomodulation, differentiation into essential at site ulcers, promoting angiogenesis, among others. article, we review cellular molecular pathways which cell therapy reinforces healing non-healing ulcers.

Language: Английский

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Thou shall not heal: Overcoming the non-healing behaviour of diabetic foot ulcers by engineering the inflammatory microenvironment

Advanced Drug Delivery Reviews, Journal Year: 2023, Volume and Issue: 203, P. 115120 - 115120

Published: Oct. 25, 2023

Diabetic foot ulcers (DFUs) are a devastating complication for diabetic patients that have debilitating effects and can ultimately lead to limb amputation. Healthy wounds progress through the phases of healing leading tissue regeneration restoration barrier function skin. In contrast, in dysregulation these leads chronic, non-healing wounds. particular, unresolved inflammation DFU microenvironment has been identified as key facet chronic hyperglyceamic patients, DFUs fail beyond inflammatory phase towards resolution. Thus, control over modulation response is promising therapeutic avenue treatment. This review discusses current state-of-the art regarding microenvironment, with specific focus on development biomaterials-based delivery strategies their cargos direct microenvironment.

Language: Английский

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Glucose-responsive, antioxidative HA-PBA-FA/EN106 hydrogel enhanced diabetic wound healing through modulation of FEM1b-FNIP1 axis and promoting angiogenesis

Bioactive Materials, Journal Year: 2023, Volume and Issue: 30, P. 29 - 45

Published: July 22, 2023

The diabetic wounds remain to be unsettled clinically, with chronic characterized by drug-resistant bacterial infections, compromised angiogenesis and oxidative damage the microenvironment. To ameliorate stress applying antioxidant treatment in wound site, we explore function of folliculin-interacting protein 1 (FNIP1), a mitochondrial gatekeeper works alter morphology, reduce phosphorylation protect cells from unwarranted ROS accumulation. And our vitro experiments showed effects FNIP1 ameliorating rescued impaired HUVECs high glucose environment. realize drug delivery local regulation sites, novel designed glucose-responsive HA-PBA-FA/EN106 hydrogel is introduced for improving healing. Due dynamic phenylboronate ester structure phenylboronic acid group between hyaluronic (HA) (PBA), able release drugs. Fulvic (FA) added hydrogel, which not only severs as crosslinking agent but also provides antibacterial anti-inflammatory abilities. Moreover, FEM1b-FNIP1 axis inhibitor EN106 ameliorated stimulated through regulation. These vivo results demonstrated that accelerated repair use may provide promising strategy repair.

Language: Английский

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Characterization of the microenvironment of diabetic foot ulcers and potential drug identification based on scRNA-seq

Frontiers in Endocrinology, Journal Year: 2023, Volume and Issue: 13

Published: Jan. 4, 2023

Background Diabetes foot ulcers (DFUs) are a type of infection, ulcer, and/or deep tissue destruction caused by neuropathy and vascular disease in the distal extremities diabetic patients. Its pathogenesis its microenvironment not entirely understood. Methods Initially, GSE165816 data set from GEO database was utilized for single cell analysis to reveal functional status DFUs. The GSE199939 RNA-seq external validation. On basis logistic regression machine learning algorithm (OCLR), pseudo time series analysis, dryness index drug target gene were then performed. By constructing drug-gene gene-gene networks, we can locate most recent DFUs treatments. Finally, immunofluorescence technology used detect cell-related markers microenvironment, qPCR expression targets Results Firstly, Cell Maker obtain information about human cells related markers, manually reviewed total 45 kinds maker that may appear which divided into 17 clusters after annotation. Subsequently, counted proportions DM different types cells, results showed macrophages, white blood monocytes higher patients with DFUs, while pluripotent stem stromal DM. Pseudo-time differentiation pathways immune mesenchymal similar three states, other distributed stages. At level cell, scores both multipotential hematopoietic significantly lower DFU healing non-healing than Additionally, highly expressed genes chosen as targets. We identified seven potential discovered twenty drugs high significance. colocalization relationship between CD19, ITGAM, HLA-DR macrophages skin healthy subjects analyzed laser confocal microscopy triple labeling method. expressions those subjects, co-localization significant Conclusion This study serve resource treatment

Language: Английский

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Advances in the treatment of type 2 diabetes mellitus by natural plant polysaccharides through regulation of gut microbiota and metabolism: A review

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 274, P. 133466 - 133466

Published: June 26, 2024

Language: Английский

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Comprehensive review on recent trends and perspectives of natural exo-polysaccharides: Pioneering nano-biotechnological tools

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 265, P. 130747 - 130747

Published: March 12, 2024

Language: Английский

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A novel pH/ROS dual responsive engineering hydrogels based on poly(tannic acid)-assisted surface deposition of nano-enzymes with efficient antibacterial and antioxidant activity for diabetic wound healing

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 496, P. 153370 - 153370

Published: June 20, 2024

Language: Английский

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Endothelial FOXM1 and Dab2 promote diabetic wound healing

JCI Insight, Journal Year: 2025, Volume and Issue: 10(2)

Published: Jan. 22, 2025

Diabetes mellitus can cause impaired and delayed wound healing, leading to lower extremity amputations; however, the mechanisms underlying regulation of vascular endothelial growth factor-dependent (VEGF-dependent) angiogenesis remain unclear. In our study, molecular underpinnings dysfunction in diabetes are investigated, focusing on roles disabled-2 (Dab2) Forkhead box M1 (FOXM1) VEGF receptor 2 (VEGFR2) signaling cell function. Bulk RNA-sequencing analysis identified significant downregulation Dab2 high-glucose-treated primary mouse skin cells. diabetic mice with deficiency Dab2, vivo vitro healing were reduced when compared wild-type mice. Restoration expression by injected mRNA-containing, LyP-1-conjugated lipid nanoparticles rescued Furthermore, FOXM1 was downregulated cells under high-glucose conditions as determined analysis. found bind promoter, regulating its influencing VEGFR2 signaling. The inhibitor FDI-6 phosphorylation VEGFR2. Our study provides evidence crucial establishes targeted delivery a promising treatment for complications.

Language: Английский

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