Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease,
Journal Year:
2025,
Volume and Issue:
1871(3), P. 167640 - 167640
Published: Jan. 5, 2025
Diabetes
is
an
extremely
costly
disease,
one-third
of
which
are
attributed
to
the
management
diabetic
foot
disease
including
chronic,
non-healing,
ulcers
(DFUs).
Therefore,
much
effort
needed
understand
pathogenesis
DFUs
and
novel
therapeutics.
We
utilized
exosome
staining
confirm
interaction
between
fibroblast-derived
exosomes
macrophages.
Subsequently,
we
employed
public
data
qPCR
screen
for
upregulated
miRNAs
in
DFUs.
The
relationship
was
validate
miR-93-5
ATG16L1
through
prediction
dual-luciferase
reporter
assays.
A
variety
molecular
biology
experiments
were
used
subsequent
pathway
validation.
Additionally,
established
Atg16l1
Nano-Micro Letters,
Journal Year:
2023,
Volume and Issue:
16(1)
Published: Dec. 12, 2023
In
vivo
monitoring
of
animal
physiological
information
plays
a
crucial
role
in
promptly
alerting
humans
to
potential
diseases
animals
and
aiding
the
exploration
mechanisms
underlying
human
diseases.
Currently,
implantable
electrochemical
microsensors
have
emerged
as
prominent
area
research.
These
not
only
fulfill
technical
requirements
for
but
also
offer
an
ideal
platform
integration.
They
been
extensively
studied
their
ability
monitor
minimally
invasive
manner,
characterized
by
bloodless,
painless
features,
exceptional
performance.
The
development
has
witnessed
significant
scientific
technological
advancements
through
dedicated
efforts.
This
review
commenced
with
comprehensive
discussion
construction
microsensors,
including
materials
utilized
methods
employed
fabrication.
Following
this,
we
proceeded
explore
various
implantation
technologies
microsensors.
addition,
overview
was
provided
applications
specifically
investigation
disease
mechanisms.
Lastly,
concise
conclusion
conducted
on
recent
obstacles
pertaining
practical
implementation
Materials Advances,
Journal Year:
2023,
Volume and Issue:
4(15), P. 3091 - 3113
Published: Jan. 1, 2023
This
review
aims
to
provide
an
overview
of
nanoparticles
for
diabetes
mellitus
therapy.
It
explores
the
properties,
synthesis
and/or
functionalization,
mechanistic
aspects,
and
therapeutics
its
complications.
ChemistrySelect,
Journal Year:
2023,
Volume and Issue:
8(5)
Published: Feb. 2, 2023
Abstract
Aldose
reductase
(AR,
ALR2;
EC
1.1.1.21),
an
enzyme
that
converts
glucose
to
fructose
on
the
polyol
pathway,
is
important
member
of
Aldo‐keto
superfamily.
ALR2
part
rate‐limiting
step,
which
associated
with
diabetic
complications
in
this
process,
and
plays
a
role
regulating
reactive
oxygen
species
induced
by
growth
factors
cytokines.
Despite
fact
sulfides
sulfones
have
been
discovered
variety
other
biological
functions,
current
study,
we
assessed
inhibitory
potential
derivatives
bis‐sulfide
(
5
–
i
)
bis‐sulfone
6
order
further
our
interest
designing
discovering
powerful
inhibitors.
The
results
investigations
showed
all
exhibit
activity
against
ALR2,
K
I
values
ranging
from
0.53±0.03
4.20±0.06
μM.
Among
these
agents,
2,6‐bis((4‐chlorophenyl)(phenylthio)methyl)cyclohexan‐1‐one
h
),
2,6‐bis((3‐nitrophenyl)(phenylthio)methyl)cyclohexan‐1‐one
c
2,6‐bis((3‐chlorophenyl)(phenylthio)methyl)cyclohexan‐1‐one
g
exhibited
prominent
constants
μM,
0.65±0.04
0.71±0.05
respectively,
were
found
be
more
potent
than
epalrestat
=0.79±0.01
μM)
currently,
only
inhibitor
(ALR2I)
utilized
treatment.
Additionally,
silico
molecular
docking
experiments
carried
out
explain
how
bis‐sulfides
bis‐sulfones
interacted
target
ALR2′s
binding
site.
According
ADME‐Tox
compounds
are
predicted
ALR2Is
appropriate
drug‐like
characteristics.
study‘s
findings
could
exploited
create
innovative
therapeutics
prevent
diabetes
complications.
Foods,
Journal Year:
2024,
Volume and Issue:
13(23), P. 3882 - 3882
Published: Nov. 30, 2024
Natural
plant
polysaccharides
are
renowned
for
their
broad
spectrum
of
biological
activities,
making
them
invaluable
in
both
the
pharmaceutical
and
food
industries.
Their
safety,
characterized
by
low
toxicity
minimal
side
effects,
coupled
with
potential
therapeutic
properties,
positions
as
crucial
elements
health-related
applications.
The
functional
effectiveness
these
is
deeply
connected
to
structural
attributes,
including
molecular
weight,
monosaccharide
components,
types
glycosidic
bonds.
These
influence
how
interact
gut
microbiota,
potentially
alleviating
various
metabolic
inflammatory
disorders
such
bowel
disease,
diabetes,
liver-associated
pathologies,
obesity,
kidney
diseases.
operate
through
a
range
mechanisms.
They
enhance
formation
short-chain
fatty
acids,
which
pivotal
keeping
intestinal
health
balance.
Additionally,
they
strengthen
mucosal
barrier,
deterring
ingress
pathogens
toxins
into
host
system.
By
modulating
immune
responses
within
gut,
help
managing
immune-mediated
disorders,
role
activating
specific
cellular
signaling
pathways
further
underscores
potential.
review
delves
intricate
structure-activity
relationships
natural
interactions
flora.
understanding
relationships,
scientific
community
can
develop
targeted
strategies
use
therapeutics,
leading
innovative
treatments
Furthermore,
insights
gained
drive
advancement
research
polysaccharide
applications,
providing
direction
novel
dietary
supplements
foods
designed
support
overall
well-being.
Critical Reviews in Food Science and Nutrition,
Journal Year:
2022,
Volume and Issue:
64(4), P. 1177 - 1210
Published: Aug. 29, 2022
Non-starch
polysaccharides
(NSPs)
have
been
reported
to
exert
therapeutic
potential
on
managing
type
2
diabetes
mellitus
(T2DM).
Various
mechanisms
proposed;
however,
several
studies
not
considered
the
correlations
between
anti-T2DM
activity
of
NSPs
and
their
molecular
structure.
Moreover,
current
understanding
role
in
T2DM
treatment
is
mainly
based
vitro
vivo
data,
more
human
clinical
trials
are
required
verify
actual
efficacy
treating
T2DM.
The
related
NSPs,
including
regulating
insulin
action,
promoting
glucose
metabolism
postprandial
blood
level,
anti-inflammatory
gut
microbiota
(GM),
reviewed.
structure-function
relationships
summarized,
structure
from
highlighted.
development
medication
or
dietary
supplements
could
be
promoted
with
an
in-depth
multiple
regulatory
effects
treatment/intervention
Frontiers in Bioengineering and Biotechnology,
Journal Year:
2023,
Volume and Issue:
11
Published: June 27, 2023
As
nanotechnology
develops
in
the
fields
of
mechanical
engineering,
electrical
information
and
communication,
medical
care,
it
has
shown
great
promises.
In
recent
years,
nanorobots
have
made
significant
progress
terms
selection
materials,
fabrication
methods,
driving
force
sources,
clinical
applications,
such
as
nanomedicine.
It
involves
bypassing
biological
tissues
delivering
drugs
directly
to
lesions
target
cells
using
nanorobots,
thus
increasing
concentration.
also
proved
useful
for
monitoring
disease
progression,
complementary
diagnosis,
minimally
invasive
surgery.
Also,
we
examine
development
nanomedicine
its
applications
medicine,
focusing
on
use
treatment
various
major
diseases,
including
how
they
are
generalized
modified.
The
purpose
this
review
is
provide
a
summary
discussion
current
research
future
Endocrine Reviews,
Journal Year:
2024,
Volume and Issue:
45(4), P. 437 - 459
Published: Jan. 31, 2024
Abstract
The
treatment
of
polycystic
ovary
syndrome
(PCOS)
faces
challenges
as
all
known
treatments
are
merely
symptomatic.
US
Food
and
Drug
Administration
has
not
approved
any
drug
specifically
for
treating
PCOS.
As
the
significance
genetics
epigenetics
rises
in
development,
their
pivotal
insights
have
greatly
enhanced
efficacy
success
target
discovery
validation,
offering
promise
guiding
advancement
PCOS
treatments.
In
this
context,
we
outline
genetic
epigenetic
PCOS,
which
provide
novel
into
pathogenesis
complex
disease.
We
also
delve
prospective
method
harnessing
strategies
to
identify
potential
targets
ensure
safety.
Additionally,
shed
light
on
preliminary
evidence
distinctive
associated
with
gene
therapies
context
Journal of Orthopaedic Translation,
Journal Year:
2024,
Volume and Issue:
45, P. 107 - 119
Published: March 1, 2024
Diabetic
foot
is
a
major
complication
of
diabetes.
The
bone
transverse
transport
method
could
be
applied
in
clinics
for
treatment,
which
improve
the
metabolism
tissues
via
lasting
distraction
forces.
However,
process'
specific
regulating
mechanism
still
unknown.
Journal of Diabetes Science and Technology,
Journal Year:
2024,
Volume and Issue:
unknown
Published: March 20, 2024
Background:
Glucose
is
vital
for
biological
processes,
requiring
blood
sugar
levels
to
be
maintained
between
3.88
and
6.1
mmol/L,
especially
during
fasting.
Elevated
signal
diabetes,
a
global
concern
affecting
537
million
people,
necessitating
effective
glucose-monitoring
devices.
Method:
Enzyme-based
sensors,
though
selective,
are
sensitive
environmental
factors.
Nonenzymatic
those
with
nanoparticles,
offer
stability,
high
surface
area,
cost-effectiveness.
Existing
literature
supports
their
immediate
glucose
oxidation,
showcasing
exceptional
sensitivity.
Results:
This
review
details
nonenzymatic
highlighting
materials,
detection
limits,
the
promise
of
nanoparticle-based
designs,
which
exhibit
enhanced
sensitivity
selectivity
in
detection.
Conclusion:
Nanoparticle-based
as
reviewed,
show
potential
monitoring,
overcoming
enzyme-based
limitations.
The
conclusion
suggests
future
directions
advancing
these
emphasizing
ongoing
innovation
this
critical
research
area.
