Expert Opinion on Drug Delivery,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 3, 2024
Breast
cancer
is
one
of
the
main
causes
mortality
in
women
globally.
Early
and
accurate
diagnosis
represents
a
milestone
management.
Several
breast
diagnostic
agents
are
available.
Many
chemotherapeutic
conventional
dosage
forms
approved;
nevertheless,
they
lack
cell
specificity,
resulting
improper
treatment
undesirable
side
effects.
Recently,
nanotheranostics
has
emerged
as
new
paradigm
to
achieve
safe
effective
Pharmaceutics,
Journal Year:
2023,
Volume and Issue:
15(3), P. 831 - 831
Published: March 3, 2023
Despite
all
the
advances
seen
in
recent
years,
severe
adverse
effects
and
low
specificity
of
conventional
chemotherapy
are
still
challenging
problems
regarding
cancer
treatment.
Nanotechnology
has
helped
to
address
these
questions,
making
important
contributions
oncological
field.
The
use
nanoparticles
allowed
improvement
therapeutic
index
several
drugs
facilitates
tumoral
accumulation
intracellular
delivery
complex
biomolecules,
such
as
genetic
material.
Among
wide
range
nanotechnology-based
drug
systems
(nanoDDS),
solid
lipid
(SLNs)
have
emerged
promising
for
delivering
different
types
cargo.
Their
core,
at
room
body
temperature,
provides
SLNs
with
higher
stability
than
other
formulations.
Moreover,
offer
features,
namely
possibility
perform
active
targeting,
sustained
controlled
release,
multifunctional
therapy.
Furthermore,
biocompatible
physiologic
materials
easy
scale-up
low-cost
production
methods,
meet
principal
requirements
an
ideal
nanoDDS.
present
work
aims
summarize
main
aspects
related
SLNs,
including
composition,
administration
routes,
well
show
most
studies
about
Pharmaceutics,
Journal Year:
2023,
Volume and Issue:
15(3), P. 879 - 879
Published: March 8, 2023
Despite
recent
advances,
cancer
remains
the
primary
killer
on
a
global
scale.
Numerous
forms
of
research
have
been
conducted
to
discover
novel
and
efficient
anticancer
medications.
The
complexity
breast
is
major
challenge
which
coupled
with
patient-to-patient
variations
heterogeneity
between
cells
within
tumor.
Revolutionary
drug
delivery
expected
provide
solution
that
challenge.
Chitosan
nanoparticles
(CSNPs)
prospects
as
revolutionary
system
capable
enhancing
activity
reducing
negative
impacts
normal
cells.
use
smart
systems
(SDDs)
delivering
materials
improve
bioactivity
NPs
understand
intricacies
has
garnered
significant
interest.
There
are
many
reviews
about
CSNPs
present
various
points
view,
but
they
not
yet
described
series
in
therapy
from
cell
uptake
death.
With
this
description,
we
will
more
complete
picture
for
designing
preparations
SDDs.
This
review
describes
SDDSs,
targeting
stimulus
response
using
their
mechanism.
Multimodal
chitosan
SDDs
medication
therapeutic
results.
Molecules,
Journal Year:
2023,
Volume and Issue:
28(3), P. 1393 - 1393
Published: Feb. 1, 2023
DATS
(diallyl
trisulfide),
an
anti-oxidant
and
cytotoxic
chemical
derived
from
the
plant
garlic,
has
been
found
to
have
potential
therapeutic
activity
against
triple-negative
breast
cancer
(TNBC).
Its
hydrophobicity,
short
half-life,
lack
of
target
selectivity,
limited
bioavailability
at
tumor
site
limit
its
efficacy
in
treating
TNBC.
Overexpression
Folate
receptor
on
surface
TNBC
is
a
well-known
for
overcoming
off-targeting,
lipid
nanoparticles
solve
limitations
half-life.
In
order
overcome
these
constraints,
we
developed
folic
acid
(FA)-conjugated
DATS-SLNs
this
research.
The
design
experiment
(DoE)
method
was
employed
optimize
FA-DATS-SLNs’
nanoformulation,
which
resulted
particle
size
168.2
±
3.78
nm
entrapment
71.91
6.27%.
similarity
index
between
MCF-7
MDA-MB-231
cell
lines
demonstrates
that
FA-DATS-SLNs
are
more
therapeutically
efficacious
treatment
aggravating
Higher
cellular
internalization
efficient
Bcl2
protein
downregulation
support
hypothesis
functionalization
FA
improves
anticancer
when
compared
with
DATS-SLNs.
FA-functionalized
demonstrated
be
promising
strategy
management.
International Journal of Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
651, P. 123763 - 123763
Published: Jan. 2, 2024
Nanomaterials'
application
in
cancer
therapy
has
been
driven
by
their
ability
to
encapsulate
chemotherapeutic
drugs
as
well
reach
the
tumor
site.
Nevertheless,
nanomedicines'
translation
limited
due
lack
of
specificity
towards
cells.
Although
nanomaterials'
surface
can
be
coated
with
targeting
ligands,
such
mostly
achieved
through
non-covalent
functionalization
strategies
that
are
prone
premature
detachment.
Notwithstanding,
cells
often
establish
resistance
mechanisms
impair
effect
loaded
drugs.
This
bottleneck
may
addressed
using
near-infrared
(NIR)-light
responsive
nanomaterials.
The
NIR-light
triggered
hyperthermic
generated
these
nanomaterials
cause
irreversible
damage
or
sensitize
them
chemotherapeutics'
action.
Herein,
a
novel
covalently
functionalized
targeted
NIR-absorbing
nanomaterial
for
chemo-photothermal
was
developed.
For
such,
dopamine-reduced
graphene
oxide
were
bonded
hyaluronic
acid,
and
then
doxorubicin
(DOX/HA-DOPA-rGO).
produced
showed
suitable
physicochemical
properties,
high
encapsulation
efficiency,
photothermal
capacity.
vitro
studies
revealed
cytocompatible
display
an
improved
uptake
CD44-overexpressing
breast
Importantly,
combination
DOX/HA-DOPA-rGO
NIR
light
reduced
cells'
viability
just
23
%,
showcasing
potential
therapy.
Biomedicine & Pharmacotherapy,
Journal Year:
2023,
Volume and Issue:
166, P. 115331 - 115331
Published: Aug. 18, 2023
Elemene
(ELE)
is
a
group
of
broad-spectrum
anticancer
active
ingredients
with
low
toxicity
extracted
from
traditional
Chinese
medicines
(TCMs),
such
as
Curcumae
Rhizoma
and
Curcuma
Radix,
which
can
exert
antitumour
activities
by
regulating
various
signal
pathways
targets.
However,
the
strong
hydrophobicity,
short
half-life,
bioavailability
weak
in
vivo
targeting
ability
ELE
restrict
its
use.
Targeted
drug
delivery
systems
based
on
nanomaterials
are
among
most
viable
methods
to
overcome
these
shortcomings.
In
this
review,
we
first
summarize
recent
studies
clinical
uses
an
adjunct
drug.
ELE-based
combination
strategies
have
great
promise
for
enhancing
efficacy,
reducing
adverse
reactions,
improving
patients'
quality
life
immune
function.
Second,
mechanisms
strategies.
The
potential
include
inducing
pyroptosis
ferroptosis,
promoting
senescence,
METTL3-mediated
m6A
modification,
suppressing
Warburg
effect,
apoptosis
cell
cycle
arrest.
Most
importantly,
comprehensively
targeted
ELE,
including
passively
actively
systems,
stimuli-responsive
codelivery
combined
other
therapies,
bioavailability,
increasing
ability,
controlling
release,
effects
reversing
MDR.
Our
summary
will
provide
reference
TCMs
advanced
future.
