Chitosan nanoparticle delivery systems: An effective approach to enhancing efficacy and safety of anticancer drugs

Nano TransMed, Journal Year: 2024, Volume and Issue: 3, P. 100040 - 100040

Published: June 27, 2024

Currently, cancer is the leading cause of death globally. In absence specific treatment and early diagnosis, procedures like surgery, chemotherapy, radiation therapy are often used to manage disease. However, these approaches fail control due inefficacy, nonspecific distribution, side effects drugs. Anticancer drugs essential in reducing cell growth helping damage those cells. severe have limited bioavailability their distribution throughout body. Therefore, development intelligent drug release systems essential. Nanoparticle delivery promising strategies improve therapeutic efficacy safety, overcoming challenges. Among systems, a natural polysaccharide called chitosan, derivative chitin, has gained considerable attention as biocompatible, biodegradable, mucoadhesive material for creating nanoparticles. Chitosan nanoparticles provide several advantages, including improved stability, cellular uptake, solubility anticancer drugs, modulation kinetics, biodistribution. Additionally, chitosan can be modified on surface with ligands or stimuli-responsive moieties achieve targeted cells tissues. This review explores recent advances chitosan-based nanoparticle delivery, efficacy, applications therapy.

Language: Английский

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Nano revolution: Exploring the frontiers of nanomaterials in science, technology, and society

Nano-Structures & Nano-Objects, Journal Year: 2024, Volume and Issue: 39, P. 101299 - 101299

Published: Aug. 23, 2024

Language: Английский

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Co-biopolymer of chitosan/carboxymethyl cellulose hydrogel improved by zinc oxide and graphene quantum dots nanoparticles as pH-sensitive nanocomposite for quercetin delivery to brain cancer treatment

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 253, P. 127091 - 127091

Published: Sept. 25, 2023

Language: Английский

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Nanomaterials as an advanced nano-tool for the Doxorubicin delivery/ Co-Delivery—A Comprehensive Review

Journal of Drug Delivery Science and Technology, Journal Year: 2023, Volume and Issue: 83, P. 104432 - 104432

Published: April 6, 2023

Language: Английский

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Nanoscale drug delivery systems for cancer therapy using paclitaxel— A review of challenges and latest progressions

Journal of Drug Delivery Science and Technology, Journal Year: 2023, Volume and Issue: 84, P. 104494 - 104494

Published: May 16, 2023

Language: Английский

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Nanocomposite of chitosan/gelatin/carbon quantum dots as a biocompatible and efficient nanocarrier for improving the Curcumin delivery restrictions to treat brain cancer

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 242, P. 124986 - 124986

Published: May 24, 2023

Language: Английский

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Chitosan in Oral Drug Delivery Formulations: A Review

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(9), P. 2361 - 2361

Published: Sept. 21, 2023

Nanoformulations have become increasingly useful as drug delivery technologies in recent decades. As therapeutics, oral administration is the most common method, although it not always effective route because of challenges with swallowing, gastrointestinal discomfort, low solubility, and poor absorption. One significant barriers that medications must overcome to exert a therapeutic effect impact first hepatic transit. Studies shown controlled-release systems using nanoparticles composed biodegradable natural polymers significantly improve administration, which why these materials attracted attention. Chitosan possesses wide variety properties functions pharmaceutical well healthcare industries. Drug encapsulation transport within body are two its important features. Moreover, chitosan can enhance efficacy by facilitating interaction target cells. Based on physicochemical properties, potentially be synthesized into nanoparticles, this review summarizes advances applications orally delivered nanoparticle interventions.

Language: Английский

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Advances in the delivery of anticancer drugs by nanoparticles and chitosan-based nanoparticles

International Journal of Pharmaceutics X, Journal Year: 2024, Volume and Issue: 8, P. 100281 - 100281

Published: Aug. 28, 2024

Cancer is the leading cause of death globally, and conventional treatments have limited efficacy with severe side effects. The use nanotechnology has potential to reduce effects drugs by creating efficient controlled anticancer drug delivery systems. Nanoparticles (NPs) used as carriers offer several advantages, including enhanced protection, biodistribution, selectivity and, pharmacokinetics. Therefore, this review devoted various organic (lipid, polymeric) well inorganic nanoparticles based on different building units providing a wide range potent Within these nanoparticulate systems, chitosan (CS)-based NPs are discussed particular emphasis due unique properties CS its derivatives non-toxicity, biodegradability, mucoadhesivity, tunable physico-chemical biological allowing their alteration specifically target cancer cells. In context streamlining systems (DDS), innovative nanoplatform-based therapy pathways involving passive active targeting stimuli-responsive DDS enhancing overall orthogonality developed NP-DDS towards included. most up-to-date information delivering anti-cancer using modern dosage forms specifically, CSNPs, summarised evaluated concerning benefits, limitations, advanced applications.

Language: Английский

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Cyclodextrin nanocarriers in Coordination Chemistry: Enhancing encapsulation and targeted delivery of 5-Fluorouracil for cancer treatment

Results in Chemistry, Journal Year: 2024, Volume and Issue: 12, P. 101878 - 101878

Published: Oct. 30, 2024

Language: Английский

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Synthesis, characterization, and evaluation of the anticancer properties of pH‐responsive carvacrol‐zinc oxide quantum dots on breast cancer cell line (MDA‐MB‐231)

Cell Biochemistry and Function, Journal Year: 2024, Volume and Issue: 42(4)

Published: May 28, 2024

Abstract Since most solid tumors have a low pH value, pH‐responsive drug delivery system may offer broad method for tumor‐targeting treatment. The present study is used to analyze the anticancer activity of carvacrol‐zinc oxide quantum dots (CVC‐ZnO QDs) against breast cancer cells (MDA‐MB‐231). CVC‐ZnO QDs demonstrate responsive and are specifically released within acidic tumor microenvironment. This property enables targeted exclusively while minimizing impact on normal cells. To synthesized ZnO QDs, CVC was loaded then examined by X‐ray diffraction, ultraviolet‐visible, Fourier transform infrared spectrophotometer, scanning electron microscopy‐energy dispersive X‐ray, transmission microscopy. For up 20 h, release in different pH‐buffered solutions. results showed that carvacrol stable an solution. Further, cytotoxicity assay, antioxidant, lipid peroxidation activity, reactive oxygen species, mitochondrial membrane potential, nuclear damage, ability cause apoptosis were all examined. Apoptosis markers such as Bcl2, Bax, caspase‐3, caspase‐9, also studied. In conclusion, destabilized MDA‐MB‐231cells under its microenvironment regulated apoptosis.

Language: Английский

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