Emodin influence pyroptosis-related Caspase 1-GSDMD axis alleviated cerebral ischemia-reperfusion injury in rats DOI Creative Commons
Liang Tao, Guofang Zhang, Xiaolin Hu

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: March 20, 2025

Abstract Background Cerebrovascular disease encompasses a wide range of conditions characterized by cerebrovascular lesions or disruptions in blood flow. Ischemic stroke, among these conditions, is the most prevalent and known for its substantial morbidity, disability, mortality rates, making it leading cause global disability. Effective management ischemia-reperfusion injury holds paramount importance stroke treatment, regardless whether thrombolytic therapy administered. Previous studies have shown that Emodin exhibits anti-inflammatory neuroprotective properties, providing protection against various organs modulating pyroptosis. However, precise molecular mechanisms underlying effects cerebral remain poorly understood. Therefore, objective this study was to elucidate context ischemic stroke. Methods SD rats were randomly assigned different groups, including control group, sham operation model intervention group with varying dosages. Cerebral induced using middle artery occlusion (MCAO) method. Intraperitoneal injections 10mg/kg, 20mg/kg 40 mg/kg administered assess neurological changes rats. The modified Neurological Severity Score (mNSS) used evaluate deficits. infarct volume ratio determined through TTC staining, while HE staining employed observe pathomorphological changes. Using Western blotting (WB) technique immunofluorescence, we investigated expression levels cellular localization proteins associated cell pyroptosis, NLRP3, Caspase 1 GSDMD. Additionally, enzyme-linked immunosorbent assay (ELISA) measure IL-1β IL-18. whole animal approved Affiliated Hospital Zunyi Medical University (approval number KLLY(A)-2021-083) all methods are reported accordance ARRIVE guidelines. Results significant beneficial improving deficits caused injury. It effectively reduces volume, alleviates cytopathic damage suppresses pyroptosis-related proteins, Furthermore, decreases pro-inflammatory cytokines IL-18, thus attenuating inflammatory response. Conclusions upregulated after demonstrates rats, potentially mediated 1-GSDMD axis.

Language: Английский

Natural antioxidants from some fruits, seeds, foods, natural products, and associated health benefits: An update DOI Creative Commons
Md. Mizanur Rahaman, Rajib Hossain, Jesús Herrera‐Bravo

et al.

Food Science & Nutrition, Journal Year: 2023, Volume and Issue: 11(4), P. 1657 - 1670

Published: Jan. 13, 2023

Abstract Antioxidants are compounds that inhibit the oxidation of other molecules and protect body from effects free radicals, produced either by normal cell metabolism or as an effect pollution exposure to external factors responsible for premature aging play a role in cardiovascular disease. degenerative diseases such cataracts, Alzheimer's disease, cancer. While many antioxidants found nature, others obtained synthetic form reduce oxidative stress organisms. This review highlights pharmacological relevance fruits, plants, natural sources their beneficial on human health through analysis in‐depth discussion studies included phytochemistry effects. The information this was collected several scientific databases (ScienceDirect, TRIP database, PubMed/Medline, Scopus, Web Science), professional websites, traditional medicine books. Current evidence have shown various present some seeds, foods, products different health‐promoting Adopting functional foods with high antioxidant potential will improve effective affordable management radical while avoiding toxicities unwanted side caused conventional medication.

Language: Английский

Citations

191
Rosmarinic acid and its derivatives: Current insights on anticancer potential and other biomedical applications DOI Creative Commons

Shumaila Ijaz,

Javed Iqbal, Banzeer Ahsan Abbasi

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 162, P. 114687 - 114687

Published: April 14, 2023

Cancer is still the leading cause of death worldwide, burdening global medical system. Rosmarinic acid (RA) among first secondary metabolites discovered and it a bioactive compound identified in plants such as Boraginaceae Nepetoideae subfamilies Lamiaceae family, including Thymus masticmasti chinaythia koreana, Ocimum sanctum, Hyptis pectinate. This updated review to highlight chemopreventive chemotherapeutic effects RA its derivatives, thus providing valuable clues for potential development some complementary drugs treatment cancers. Relevant information about RA's derivatives were collected from electronic scientific databases, PubMed/Medline, Scopus, TRIP database, Web Science, Science Direct. The results studies showed numerous significant biological antiviral, antibacterial, anti-inflammatory, anti-tumour, antioxidant antiangiogenic effects. Most on anticancer with corresponding mechanisms are experimental preclinical stage missing evidence clinical trials support research. To open new therapeutic perspectives future must elucidate molecular targets action more detail, human toxic adverse

Language: Английский

Citations

63
Podophyllotoxin and its derivatives: Potential anticancer agents of natural origin in cancer chemotherapy DOI Creative Commons
Sara Motyka,

Karolina Jafernik,

Halina Ekiert

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2022, Volume and Issue: 158, P. 114145 - 114145

Published: Dec. 29, 2022

The use of plant secondary metabolites has gained considerable attention among clinicians in the prevention and treatment cancer. A metabolite isolated mainly from roots rhizomes Podophyllum species (Berberidaceae) is aryltetralin lignan - podophyllotoxin (PTOX). purpose this review to discuss therapeutic properties PTOX as an important anticancer compound natural origin. relevant information regarding antitumor mechanisms its derivatives were collected analyzed scientific databases. results analysis showed exhibits potent cytotoxic activity; however, it cannot be used pure form due toxicity generation many side effects. Therefore, practically remains clinically unusable. Currently, high effort focused on attempts synthesize analogs that have better for e.g. etoposide (VP-16), teniposide, etopophos. are drugs which showing additional immunosuppressive, antiviral, antioxidant, hypolipemic, anti-inflammatory In review, paid potential usefulness vitro cultures P. peltatum can a valuable source lignans, including PTOX. conclusion, preclinical pharmacological studies vivo confirm chemotherapeutic derivatives. future, clinical human subjects needed certify effects certified more detail validate experimental studies.

Language: Английский

Citations

69
Multi-Target Mechanisms of Phytochemicals in Alzheimer’s Disease: Effects on Oxidative Stress, Neuroinflammation and Protein Aggregation DOI Open Access
Javad Sharifi‐Rad, Simona Rapposelli, Simona Sestito

et al.

Journal of Personalized Medicine, Journal Year: 2022, Volume and Issue: 12(9), P. 1515 - 1515

Published: Sept. 15, 2022

Alzheimer's disease (AD) is a neurodegenerative characterized by tangle-shaped accumulation of beta-amyloid peptide fragments and Tau protein in brain neurons. The pathophysiological mechanism involves the presence Aβ-amyloid peptide, protein, oxidative stress, an exacerbated neuro-inflammatory response. This review aims to offer updated compendium most recent promising advances AD treatment through administration phytochemicals. literature survey was carried out electronic search following specialized databases PubMed/Medline, Embase, TRIP database, Google Scholar, Wiley, Web Science regarding published works that included molecular mechanisms signaling pathways targeted phytochemicals various experimental models vitro vivo. results studies showed use against has gained relevance due their antioxidant, anti-neuroinflammatory, anti-amyloid, anti-hyperphosphorylation properties protein. Some bioactive compounds from plants have been shown ability prevent stop progression Alzheimer's.

Language: Английский

Citations

46
Cucurbitacins as potential anticancer agents: new insights on molecular mechanisms DOI Creative Commons
Carla Varela, Catarina Melim, Beatriz Guapo Neves

et al.

Journal of Translational Medicine, Journal Year: 2022, Volume and Issue: 20(1)

Published: Dec. 31, 2022

Abstract Since ancient times, plants have been an extensive reservoir of bioactive compounds with therapeutic interest for new drug development and clinical application. Cucurbitacins are a compelling example these leads, primarily present in the plant kingdom, especially Cucurbitaceae family. However, natural also known several genera within other families. Beyond family, they families, as well some fungi one shell-less marine mollusc. Despite abundance cucurbitacins different species, their obtaining isolation is limited, result, increase chemical synthesis has developed by researchers. Data on anticancer activities were collected from databases such PubMed/MedLine, TRIP database, Web Science, Google Scholar, ScienceDirect information was arranged sequentially better understanding antitumor potential. The results studies showed that significant biological activities, anti-inflammatory, antioxidant, antimalarial, antimicrobial, hepatoprotective In conclusion, there studies, both vitro vivo reporting this important anticancer/chemopreventive potential; hence comprehensive review topic recommended future research.

Language: Английский

Citations

44
Anticancer properties of bromelain: State-of-the-art and recent trends DOI Creative Commons
Raffaele Pezzani,

Manuel Jiménez-Garcia,

Xavier Capó

et al.

Frontiers in Oncology, Journal Year: 2023, Volume and Issue: 12

Published: Jan. 9, 2023

Bromelain is a key enzyme found in pineapple ( Ananas comosus (L.) Merr .); proteolytic substance with multiple beneficial effects for human health such as anti-inflammatory, immunomodulatory, antioxidant and anticarcinogenic, traditionally used many countries its potential therapeutic value. The aim of this updated comprehensive review focuses on the anticancer benefits bromelain, analyzing cytotoxic, apoptotic, necrotic, autophagic, immunomodulating, anti-inflammatory cancer cells animal models. Detailed information about at cellular, molecular signaling levels were collected from online databases PubMed/MedLine, TRIP database, GeenMedical, Scopus, Web Science Google Scholar. results analyzed studies showed that possesses corroborated pharmacological activities, anticancer, anti-edema, anti-microbial, anti-coagulant, anti-osteoarthritis, anti-trauma pain, anti-diarrhea, wound repair. Nonetheless, bromelain clinical are scarce still more research needed to validate scientific value diseases.

Language: Английский

Citations

35
Chinese herbal medicines: The modulator of nonalcoholic fatty liver disease targeting oxidative stress DOI
Pin Gong, Hui Long, Yuxi Guo

et al.

Journal of Ethnopharmacology, Journal Year: 2023, Volume and Issue: 318, P. 116927 - 116927

Published: July 31, 2023

Language: Английский

Citations

32
Recent advances in the discovery of plant-derived antimicrobial natural products to combat antimicrobial resistant pathogens: insights from 2018–2022 DOI
Sunmin Woo, Lewis Marquez, William J. Crandall

et al.

Natural Product Reports, Journal Year: 2023, Volume and Issue: 40(7), P. 1271 - 1290

Published: Jan. 1, 2023

Plants produce a wide array of secondary metabolites capable inhibiting pathways crucial for microbial survival and pathogenicity.

Language: Английский

Citations

25
Advanced application of nanotechnology in active constituents of Traditional Chinese Medicines DOI Creative Commons
Chong Qiu,

Jun Zhe Zhang,

Bo Wu

et al.

Journal of Nanobiotechnology, Journal Year: 2023, Volume and Issue: 21(1)

Published: Nov. 29, 2023

Abstract Traditional Chinese Medicines (TCMs) have been used for centuries the treatment and management of various diseases. However, their effective delivery to targeted sites may be a major challenge due poor water solubility, low bioavailability, potential toxicity. Nanocarriers, such as liposomes, polymeric nanoparticles, inorganic nanoparticles organic/inorganic nanohybrids based on active constituents from TCMs extensively studied promising strategy improve achieve higher therapeutic effect with fewer side effects compared conventional formulations. This review summarizes recent advances in nanocarrier-based systems types TCMs, including terpenoids, polyphenols, alkaloids, flavonoids, quinones, different natural sources. covers design preparation nanocarriers, characterization, vitro/vivo evaluations. Additionally, this highlights challenges opportunities field suggests future directions research. Nanocarrier-based shown great improving efficacy serve comprehensive resource researchers field. Graphical abstract

Language: Английский

Citations

25
An updated overview of anticancer effects of alternariol and its derivatives: underlying molecular mechanisms DOI Creative Commons
Muhammad Torequl Islam, Miquel Martorell, Carlos González-Contreras

et al.

Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 14

Published: March 23, 2023

Alternariol is a toxic metabolite of Alternaria fungi and studies have shown multiple potential pharmacological effects. To outline the anticancer effects mechanisms alternariol its derivatives based on database reports, an updated search PubMed/MedLine, ScienceDirect, Web Science, Scopus databases was performed with relevant keywords for published articles. The found to suggest that this mycotoxin and/or in many preclinical test systems. Scientific reports indicate exhibit through several pathways, including cytotoxic, reactive oxygen species leading oxidative stress mitochondrial dysfunction-linked cytotoxic effect, anti-inflammatory, cell cycle arrest, apoptotic death, genotoxic mutagenic, anti-proliferative, autophagy, estrogenic clastogenic mechanisms. In light these results, may be one hopeful chemotherapeutic agents.

Language: Английский

Citations

16