PRILOZI,
Journal Year:
2023,
Volume and Issue:
44(1), P. 7 - 16
Published: March 1, 2023
Background:
COVID-19
is
a
disease
in
several
stages
starting
with
virus
replication
to
dysregulation
immune
system
response,
organ
failure
and
recovery/death.
Our
aim
was
determine
the
effect
of
Ganoderma
lucidum,
lycopene,
sulforaphane,
royal
jelly
resveratrol
extract
on
markers
oxidative
stress,
inflammation,
routine
laboratory
analyses
duration
symptoms
patients.
Methods:
The
stress
parameters
interleukines
6
8
(IL-6,
IL-8),
tumor
necrosis
factor
alpha
(TNF-α)
were
determined
order
estimate
antioxidant
anti-inflammatory
product
using
spectrophotometric
magnetic
bead-based
multiplex
assay
serum
30
patients
mild
form
COVID-19.
Results:
Statistically
significant
differences
obtained
for
all
investigated
between
treated
control
group.
Moreover,
observed
leukocytes,
neutrophil
leukocyte
ratio
iron.
average
9.4±0.487
days
versus
13.1±0.483
treatment
group,
respectively
(p=0.0003).
Conclusion:
results
demonstrated
promising
Ge132+NaturalTM
reducing
IL-6,
IL-8
TNF-α
levels,
evidence
presented
herein
suggest
that
combination
lucidum
extract,
could
be
used
as
potent
an
adjuvant
therapy
diseases
accompanied
by
increased
inflammation.
Molecules,
Journal Year:
2023,
Volume and Issue:
28(3), P. 1068 - 1068
Published: Jan. 20, 2023
Natural
extracts
have
been
and
continue
to
be
used
treat
a
wide
range
of
medical
conditions,
from
infectious
diseases
cancer,
based
on
their
convenience
therapeutic
potential.
products
derived
microbes,
plants,
animals
offer
broad
variety
molecules
chemical
compounds.
are
not
only
one
the
most
important
sources
for
innovative
drug
development
animal
human
health,
but
they
also
an
inspiration
synthetic
biology
chemistry
scientists
towards
discovery
new
bioactive
compounds
pharmaceuticals.
This
is
particularly
relevant
in
current
context,
where
antimicrobial
resistance
has
risen
as
global
health
problem.
Thus,
efforts
being
directed
toward
studying
natural
compounds’
composition
potential
generate
drugs
with
better
efficacy
lower
toxicity
than
existing
molecules.
Currently,
methodologies
analyze
vitro
activity
determine
suitability
agents.
Despite
traditional
technologies
employed,
technological
advances
contributed
implementation
methods
able
circumvent
issues
related
analysis
capacity,
time,
sensitivity,
reproducibility.
review
produces
updated
conventional
evaluate
Frontiers in Immunology,
Journal Year:
2025,
Volume and Issue:
16
Published: April 8, 2025
Chronic
inflammation
is
an
important
component
of
many
diseases,
including
autoimmune
intracellular
infections,
dysbiosis
and
degenerative
diseases.
An
element
this
state
the
mainly
positive
feedback
between
inflammatory
cytokines,
reactive
oxygen
species
(ROS),
nitric
oxide
(NO),
increased
calcium,
hypoxia-inducible
factor
1-alpha
(HIF-1α)
stabilisation
mitochondrial
oxidative
stress,
which,
under
normal
conditions,
enhance
response
against
pathogens.
Autophagy
nuclear
erythroid
2-related
2
(Nrf2)-mediated
antioxidant
are
negatively
coupled
with
above-mentioned
elements
to
maintain
defence
at
a
level
appropriate
severity
infection.
The
current
review
first
attempt
build
multidimensional
model
cellular
self-regulation
chronic
inflammation.
It
describes
feedbacks
involved
in
explains
possible
pathways
by
which
becomes
chronic.
multiplicity
suggests
that
symptomatic
treatment
should
focus
on
inhibiting
multiple
effectively
suppress
all
dysregulated
inflammation,
calcium
mito-stress
other
metabolic
disturbances.
Foods,
Journal Year:
2023,
Volume and Issue:
12(15), P. 2975 - 2975
Published: Aug. 7, 2023
has
served
as
a
valuable
food
supplement
and
medicinal
ingredient
with
outstanding
active
compounds
that
are
essential
for
human
protection
against
chronic
diseases.
Modern
pharmacology
studies
have
proven
Viruses,
Journal Year:
2025,
Volume and Issue:
17(4), P. 491 - 491
Published: March 28, 2025
The
SARS-CoV-2
proteases
Mpro
and
PLpro
are
critical
targets
for
antiviral
drug
development
the
treatment
of
COVID-19.
1,2,4-thiadiazole
functional
group
is
an
inhibitor
cysteine
proteases,
such
as
papain
cathepsins.
This
chemical
moiety
also
present
in
ceftaroline
fosamil
(CF),
FDA-approved
fifth-generation
cephalosporin
antibiotic.
study
investigates
interactions
between
CF,
its
primary
metabolites
(M1
dephosphorylated
CF
M2
opened
β-lactam
ring)
derivatives
(protonated
M1H
M2H),
open
rings
(open-M1H
open-M2H)
with
evaluates
CF’s
effects
on
vitro
viral
replication.
In
silico
analyses
(molecular
docking
molecular
dynamics
(MD)
simulations)
demonstrated
that
potential
inhibitors
Mpro.
Docking
analysis
indicated
majority
ligands
were
more
stable
than
PLpro;
however,
biochemical
preferred
target
CF.
inhibited
replication
human
Calu-3
cell
model
at
submicromolar
concentrations
when
added
to
culture
medium
12
h.
Our
results
suggest
should
be
evaluated
a
repurposing
agent
COVID-19,
considering
not
only
but
other
relevant
cellular
pathways.
Additionally,
reactivity
sulfur
warrants
further
exploration
protease
inhibitors.
International journal of medicinal mushrooms,
Journal Year:
2023,
Volume and Issue:
25(5), P. 1 - 15
Published: Jan. 1, 2023
Coronavirus
disease
2019
(COVID-19)
caused
by
SARS-CoV-2
is
characterized
acute
respiratory
distress
syndrome
(ARDS)
facilitated
cytokine
storm
and
other
risk
factors
that
increase
susceptibility
complications
leading
to
death.
Emerging
as
a
major
global
public
health
challenge,
the
has
claimed
more
than
6
million
lives
catastrophic
economic
disruptions.
However,
there
are
concerns
about
safety
well
efficacy
of
drugs
vaccines
presently
used
control
pandemic,
therefore
necessitating
intense
search
for
safe
natural
products
can
effectively
safely
combat
it.
This
work
reviews
studies
on
lingzhi
or
reishi
medicinal
mushroom,
<i>Ganoderma
lucidum</i>
its
properties
may
potentially
infection
co-morbidities.
Available
evidence
suggests
<i>Ganoderma</i>
mushroom
co-morbidities
aggravate
severity
disease.
Preclinical
clinical
evaluation
establish
dose,
efficacy,
potential
toxicity
possible
use
in
management
COVID-19
recommended.
New Zealand Journal of Botany,
Journal Year:
2024,
Volume and Issue:
unknown, P. 1 - 59
Published: Aug. 8, 2024
The
global
COVID-19
pandemic,
caused
by
SARS-CoV-2,
has
created
an
urgent
need
for
novel
antiviral
agents,
as
it
led
to
a
devastating
loss
of
lives
worldwide.
In
response,
numerous
vaccines
were
developed
in
2022,
with
ongoing
efforts
more
candidates.
Despite
significant
progress,
reports
vaccine-related
issues
and
side
effects
have
emerged.
effectiveness
been
challenged
new
viral
variants,
lack
well-designed
vivo
experiments,
randomised
controlled
trials.
Currently,
no
clinically
approved
medications
exist
treating
COVID-19.
However,
few
broad-spectrum
drugs
shown
promising
outcomes
clinical
studies.
Many
scientists
believe
that
natural
compounds
derived
from
herbal
medicines
mushrooms
could
offer
substantial
benefits
patients.
Ganoderma,
known
its
traditional
use
promoting
health
longevity,
rich
history
therapeutic
applications
dietary
supplementation.
Numerous
epidemiological
studies
demonstrated
Ganoderma
derivatives
can
enhance
innate
adaptive
immune
responses
against
various
pathogens,
including
viruses,
laboratory
settings
living
organisms.
Therefore,
the
secondary
metabolites
such
triterpenoids,
polysaccharides,
glycoproteins,
hold
potential
developing
drugs.
These
mechanisms,
inhibition
replication,
modulation
responses,
direct
virucidal
effects.
Given
search
effective
treatments
COVID-19,
bioactive
stand
out
candidates
further
research
development.
Their
multifaceted
mechanisms
make
them
suitable
exploration
agents
potentially
contributing
enhancing
existing
treatments.
Environmental Toxicology,
Journal Year:
2024,
Volume and Issue:
39(12), P. 5238 - 5249
Published: Aug. 17, 2024
ABSTRACT
Integrins,
the
receptors
of
extracellular
matrix,
are
critical
in
proliferation
and
metastasis
cancer
cells.
GMI,
a
Ganoderma
microsporum
immunomodulatory
protein,
possesses
anticancer
antivirus
abilities.
The
object
this
study
is
to
investigate
role
GMI
integrins
signaling
pathway
lung
cells
that
harbor
EGFR
L858R/T790M
double
mutation
osimertinib‐resistance.
Liquid
chromatography‐mass
spectrometry
western
blot
assay
were
used
effect
on
inhibiting
protein
expressions
H1975
migration
ability
xenograft
tumor
growth
suppressed
by
GMI.
To
elucidate
integrin
family
resistant
osimertinib
(AZD‐9291,
Tagrisso),
establish
osimertinib‐resistant
cells,
named
H1975/TR
Integrin
αV
stemness
markers
much
higher
than
cell
viability,
spheroid
growth,
β1
Furthermore,
formation
spheres
via
blocking
cascade.
This
first
reveal
novel
function
constraining
stem
abolishing
αV‐related
EGFR‐mutated
