Foods,
Journal Year:
2025,
Volume and Issue:
14(6), P. 965 - 965
Published: March 12, 2025
Stingless
bee
propolis
has
emerged
globally
as
a
new
source
of
bioactive
molecules
that
can
advance
human
health.
However,
limited
research
been
conducted
on
Australian
stingless
propolis.
This
study
investigated
the
chemical
composition
and
biological
activity
produced
by
bees
Tetragonula
carbonaria
from
Gibberagee,
distinct
region
New
South
Wales
state
in
Australia.
Using
bioassay-guided
fractionation,
twelve
compounds
were
isolated,
including
six
A-ring
methylated
flavonoids.
Nine
these
demonstrated
strong
scavenging
against
2,2-diphenyl-1-picrylhydrazyl
radicals,
with
five
exhibiting
greater
potency
than
vitamin
C.
Chemical
structures
seven
additional
minor
flavonoids
determined
through
an
intensive
MS/MS
data
analysis.
In
silico
screening
19
revealed
all,
except
for
gallic
acid,
displayed
higher
binding
affinity
to
α-glucosidase
antidiabetic
drug,
voglibose.
showed
Gibberagee
is
promising
nutraceutical
cosmeceutical
applications
owing
its
antioxidant
properties.
The
unique
profile
C-methylated
potentially
provides
valuable
insights
into
botanical
origin.
Beni-Suef University Journal of Basic and Applied Sciences,
Journal Year:
2023,
Volume and Issue:
12(1)
Published: May 15, 2023
Abstract
Background
Flavonols
are
phytoconstituents
of
biological
and
medicinal
importance.
In
addition
to
functioning
as
antioxidants,
flavonols
may
play
a
role
in
antagonizing
diabetes,
cancer,
cardiovascular
disease,
viral
bacterial
diseases.
Quercetin,
myricetin,
kaempferol,
fisetin
the
major
dietary
flavonols.
Quercetin
is
potent
scavenger
free
radicals,
providing
protection
from
radical
damage
oxidation-associated
Main
body
abstract
An
extensive
literature
review
specific
databases
(e.g.,
Pubmed,
google
scholar,
science
direct)
were
conducted
using
keywords
“flavonol,”
“quercetin,”
“antidiabetic,”
“antiviral,”
“anticancer,”
“myricetin.”
Some
studies
concluded
that
quercetin
promising
antioxidant
agent
while
kaempferol
could
be
effective
against
human
gastric
cancer.
addition,
prevents
apoptosis
pancreatic
beta-cells
via
boosting
function
survival
rate
beta-cells,
leading
increased
insulin
secretion.
also
show
potential
alternatives
conventional
antibiotics,
restricting
infection
by
envelope
proteins
block
entry.
Short
conclusion
There
substantial
scientific
evidence
high
consumption
associated
with
reduced
risk
cancer
coronary
diseases,
alleviation,
tumor
growth
prevention,
secretion
improvement,
among
other
diverse
health
benefits.
Nevertheless,
more
required
determine
appropriate
concentration,
dose,
type
flavonol
for
particular
condition
prevent
any
adverse
side
effects.
Pharmacological Research - Natural Products,
Journal Year:
2024,
Volume and Issue:
3, P. 100046 - 100046
Published: April 19, 2024
Despite
the
quantities
and
diversity
of
chemical
compounds
such
as
flavonoids
discovered
in
lemongrass
(Cymbopogon
citratus
DC.),
available
data
are
fragmentary.
Their
variation
depending
on
type
extract
origin
plant
their
effect
biological
activities
not
deeply
discussed.
Therefore,
this
paper
provides
a
critical
discussion
bioactive
including
flavonoid
content
extracts
Cymbopogon
citratus,
associated
properties.
Recorded
showed
that
recent
studies
have
addressed
qualitatively
quantitatively
various
C.
citratus.
Existing
literature
clarified
significant
chemicals
used
parts
plants.
However,
effects
climate
change
other
environmental
quantity
quality
yet
available.
On
hand,
recorded
were
with
wide
range
pharmacological
properties
antioxidant,
anti-inflammation,
anti-microbial,
anti-diabetic
effects,
which
variable
types
flavonoids.
Other
anticancer,
analgesic,
diuretic
investigated
extracted
from
plant,
thus
more
advanced
needed
to
optimize
extraction
biomolecules
counting
flavonoids,
then
apply
them
most
devastating
diseases
pathogens.
Cells,
Journal Year:
2024,
Volume and Issue:
13(5), P. 390 - 390
Published: Feb. 24, 2024
Aging
populations
worldwide
are
placing
age-related
diseases
at
the
forefront
of
research
agenda.
The
therapeutic
potential
natural
substances,
especially
propolis
and
its
components,
has
led
to
these
products
being
promising
agents
for
alleviating
several
cellular
molecular-level
changes
associated
with
diseases.
With
this
in
mind,
scientists
have
introduced
a
contextual
framework
guide
future
aging
research,
called
hallmarks
aging.
This
encompasses
various
mechanisms
including
genomic
instability,
epigenetic
changes,
mitochondrial
dysfunction,
inflammation,
impaired
nutrient
sensing,
altered
intercellular
communication.
Propolis,
rich
array
bioactive
compounds,
functions
as
potent
functional
food,
modulating
metabolism,
gut
microbiota,
immune
response,
offering
significant
health
benefits.
Studies
emphasize
propolis'
properties,
such
antitumor,
cardioprotective,
neuroprotective
effects,
well
ability
mitigate
oxidative
stress,
DNA
damage,
pathogenic
bacteria
growth.
article
underscores
current
scientific
evidence
supporting
role
controlling
molecular
characteristics
linked
hallmarks,
hypothesizing
geroscience
research.
aim
is
discover
novel
strategies
improve
quality
life
older
individuals,
addressing
existing
deficits
perspectives
area.
Food & Function,
Journal Year:
2024,
Volume and Issue:
15(9), P. 4983 - 4999
Published: Jan. 1, 2024
Propolis
is
a
resinous
mixture
produced
by
honeybees
which
has
been
used
since
ancient
times
for
its
useful
properties.
However,
chemical
composition
and
bioactivity
may
vary,
depending
on
the
geographical
area
of
origin
type
tree
bees
use
collecting
pollen.
In
this
context,
research
aimed
to
investigate
total
phenolic
content
(using
Folin-Ciocalteu
assay)
antioxidant
capacity
FRAP,
DPPH,
ABTS
assays)
three
black
poplar
(Populus
nigra
L.)
propolis
(BPP)
solutions
(S1,
S2,
S3),
as
well
(HPLC-ESI-MSn)
biological
activities
(effect
cell
viability,
genotoxic/antigenotoxic
properties,
anti-inflammatory
activity,
effect
ROS
production)
one
showed
highest
activity
(S1).
The
hydroalcoholic
BPP
solution
S1
was
prototype
an
innovative,
research-type
product
Italian
nutraceutical
manufacturer.
contrast,
S2
S3
were
conventional
products
purchased
from
local
pharmacy
stores.
For
extracts,
50
compounds,
encompassing
acids
flavonoids,
identified.
summary,
results
interesting
profile
remarkable
antioxidant,
antigenotoxic,
ROS-modulating
innovative
extract
S1,
paving
way
future
research.
vivo
investigations
will
be
possible
line
take,
help
corroborate
hypothesis
potential
health
benefits
product,
even
stimulate
further
ameliorations
new
prototype.
