Frontiers in Pharmacology,
Journal Year:
2024,
Volume and Issue:
15
Published: Dec. 11, 2024
Objective
The
objective
of
this
study
was
to
analyze
the
impact
nanotechnology
on
treatment
and
recovery
spinal
cord
injury
(SCI),
a
condition
that
has
profound
global
effects
physical
psychological
health.
Methods
We
utilized
Web
Science
Core
Collection
obtain
bibliometric
data.
With
tools
such
as
VOSviewer
CiteSpace,
we
conducted
comprehensive
review
422
relevant
publications
identify
research
trends
influential
works
in
field
applied
SCI.
Results
analysis
revealed
significant
contributions
from
both
China,
Sweden
United
States,
pinpointed
inflammation,
apoptosis,
nano-drug
delivery
primary
areas
focus
current
research,
with
emerging
evident
recent
literature.
Conclusion
Nanotechnology
hold
great
potential
revolutionize
SCI
through
targeted
therapeutics
modulation
pathological
processes.
This
provided
valuable
insights
into
evolving
landscape
underscoring
importance
continuous
innovation
interdisciplinary
collaboration.
Cell Death and Disease,
Journal Year:
2024,
Volume and Issue:
15(4)
Published: April 1, 2024
Abstract
Macrophages,
as
pivotal
cells
within
the
tumour
microenvironment,
significantly
influence
impact
of
and
reactions
to
treatments
for
solid
tumours.
The
rapid
evolution
bioengineering
technology
has
revealed
vast
potential
engineered
macrophages
in
immunotherapy,
disease
diagnosis,
tissue
engineering.
Given
this
landscape,
goal
harnessing
innovating
a
novel
strategy
immunotherapy
cannot
be
overstated.
diverse
strategies
realm
cancer
encompassing
macrophage
drug
delivery
systems,
chimeric
antigen
receptor
therapy,
synergistic
treatment
approaches
involving
bacterial
outer
membrane
vesicles
macrophages,
are
meticulously
examined
review.
These
methodologies
designed
enhance
therapeutic
efficacy
against
tumours,
particularly
those
that
drug-resistant
metastatic.
Collectively,
these
immunotherapies
poised
supplement
refine
current
paradigms,
thus
heralding
new
frontier
fight
malignant
Signal Transduction and Targeted Therapy,
Journal Year:
2025,
Volume and Issue:
10(1)
Published: March 7, 2025
Abstract
Macrophages
are
immune
cells
belonging
to
the
mononuclear
phagocyte
system.
They
play
crucial
roles
in
defense,
surveillance,
and
homeostasis.
This
review
systematically
discusses
types
of
hematopoietic
progenitors
that
give
rise
macrophages,
including
primitive
progenitors,
erythro-myeloid
stem
cells.
These
have
distinct
genetic
backgrounds
developmental
processes.
Accordingly,
macrophages
exhibit
complex
diverse
functions
body,
phagocytosis
clearance
cellular
debris,
antigen
presentation,
response,
regulation
inflammation
cytokine
production,
tissue
remodeling
repair,
multi-level
regulatory
signaling
pathways/crosstalk
involved
homeostasis
physiology.
Besides,
tumor-associated
a
key
component
TME,
exhibiting
both
anti-tumor
pro-tumor
properties.
Furthermore,
functional
status
is
closely
linked
development
various
diseases,
cancer,
autoimmune
disorders,
cardiovascular
disease,
neurodegenerative
metabolic
conditions,
trauma.
Targeting
has
emerged
as
promising
therapeutic
strategy
these
contexts.
Clinical
trials
macrophage-based
targeted
drugs,
immunotherapies,
nanoparticle-based
therapy
were
comprehensively
summarized.
Potential
challenges
future
directions
targeting
also
been
discussed.
Overall,
our
highlights
significance
this
versatile
cell
human
health
which
expected
inform
research
clinical
practice.
Journal of Materials Chemistry B,
Journal Year:
2024,
Volume and Issue:
12(29), P. 7001 - 7019
Published: Jan. 1, 2024
The
properties
of
nanomaterials
make
them
promising
and
advantageous
for
use
in
drug
delivery
systems,
but
challenges
arise
from
the
immune
system's
recognition
exogenous
nanoparticles,
leading
to
their
clearance
reduced
targeting
efficiency.
International Journal of Nanomedicine,
Journal Year:
2024,
Volume and Issue:
Volume 19, P. 9175 - 9193
Published: Sept. 1, 2024
Ischemic
stroke
is
a
refractory
disease
wherein
the
reperfusion
injury
caused
by
sudden
restoration
of
blood
supply
main
cause
increased
mortality
and
disability.
However,
current
therapeutic
strategies
for
inflammatory
response
induced
cerebral
ischemia-reperfusion
(I/R)
are
unsatisfactory.
This
study
aimed
to
develop
functional
nanoparticle
(MM/ANPs)
comprising
apelin-13
(APNs)
encapsulated
in
macrophage
membranes
(MM)
modified
with
distearoyl
phosphatidylethanolamine-polyethylene
glycol-RVG29
(DSPE-PEG-RVG29)
achieve
targeted
therapy
against
ischemic
stroke.
Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 9, 2024
Spinal
cord
injury
(SCI)
is
a
common
nerve
caused
by
external
force,
resulting
in
sensory
and
motor
impairments.
Previous
studies
demonstrated
that
inhibiting
the
neuroinflammation
promoted
SCI
repair.
However,
these
approaches
are
low
efficient,
lack
targeting
specificity,
even
require
repeated
high
doses
of
systemic
administration.
To
address
such
issues,
present
study,
chitosan-modified
hydrogel
microspheres
encapsulating
with
zinc-doped
bioactive
glasses
(CS-MG@Zn/BGs)
constructed
for
targeted
repair
SCI.
In
vitro,
CS-MG@Zn/BGs
effectively
inhibited
acute
inflammatory
response
initiated
microglia
angiogenic
activities.
vivo,
injured
site,
attenuated
infiltration
modulating
polarization
toward
M2
type.
Furthermore,
it
facilitated
vascular
reconstruction,
neuronal
differentiation,
axonal
regeneration
remyelination
at
thereby
function
recovery
mice.
The
vitro
vivo
results
implied
may
be
promising
alternative
rehabilitation
Abstract
Spinal
cord
injury
(SCI)
triggers
an
immediate
influx
of
immune
cells
that
secrete
pro‐inflammatory
cytokines
and
reactive
oxygen
species
cause
tissue
damage
is
secondary
to
the
initial
physical
trauma.
We
aim
reprogram
these
promote
a
less
inflammatory
more
pro‐regenerative
environment.
Herein,
we
investigated
window
in
time
during
which
poly(lactide‐co‐glycolide)
nanoparticles
(NPs)
administration
can
successfully
modulate
response
functional
sparing.
The
dynamics
cell
infiltration
were
studied
following
injection
NPs
intravenously
every
24
h
for
7
days
injury,
with
first
starting
at
2,
4,
or
hours
post‐injury
(hpi).
At
(dpi),
early
NP
intervention
decreased
number
infiltrating
macrophages
neutrophils,
but
delaying
treatment
until
hpi
increased
neutrophils
above
control.
All
mice
received
had
greater
neuronal
sparing
contralateral
timepoints
neuromuscular
junction
innervation
motor
endplate
neurons
neural
circuits
2
group
corresponded
function,
as
measured
by
ladder
beam
test.
Collectively,
results
suggest
preserve
function
SCI.
Materials Today Bio,
Journal Year:
2025,
Volume and Issue:
31, P. 101556 - 101556
Published: Feb. 4, 2025
Spinal
cord
injury
(SCI)
presents
a
formidable
challenge
in
clinical
settings,
resulting
sensory
and
motor
function
loss
imposing
significant
personal
societal
burdens.
However,
owning
to
the
adverse
microenvironment
limited
regenerative
capacity,
achieving
complete
functional
recovery
after
SCI
remains
elusive.
Additionally,
traditional
interventions
including
surgery
medication
have
series
of
limitations
that
restrict
effectiveness
treatment.
Recently,
tissue
engineering
(TE)
has
emerged
as
promising
approach
for
promoting
neural
regeneration
SCI,
which
can
effectively
delivery
drugs
into
site
cells
improve
survival
differential.
Here,
we
outline
main
pathophysiology
events
post
injury,
further
discuss
materials
common
assembly
strategies
used
scaffolds
treatment,
expound
on
latest
advancements
treatment
methods
based
drug
cell
detail,
propose
future
directions
repair
with
TE
highlight
potential
applications.
