Probiotics, prebiotics, and postbiotics in health and disease

MedComm, Journal Year: 2023, Volume and Issue: 4(6)

Published: Nov. 4, 2023

The gut microbiota and its homeostasis play a crucial role in human health. However, for some diseases related to the microbiota, current traditional medicines can only relieve symptoms, it is difficult solve root causes or even cause side effects like disturbances microbiota. Increasing clinical studies evidences have demonstrated that probiotics, prebiotics, postbiotics prevent treat various diseases, but currently they be used as dietary supplements rather than medicines, which restricts application of probiotics field medicine. Here, this review analyzes importance health problems systematically summarizes effectiveness mechanisms maintaining treating based on animal models trials. And research outcomes development trends field, challenges prospects their health, alleviating are analyzed. It hoped promote disease treatment open up new frontiers probiotic research.

Language: Английский

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A Comprehensive Review of Bioactive Compounds from Lactic Acid Bacteria: Potential Functions as Functional Food in Dietetics and the Food Industry

Foods, Journal Year: 2023, Volume and Issue: 12(15), P. 2850 - 2850

Published: July 27, 2023

Lactic acid bacteria (LAB) are beneficial microbes known for their health-promoting properties. LAB well ability to produce substantial amounts of bioactive compounds during fermentation. Peptides, exopolysaccharides (EPS), bacteriocins, some amylase, protease, lipase enzymes, and lactic the most important generated by activity Additionally, product produced is dependent on type fermentation used. derived from genera Lactobacillus Enterococcus popular probiotics at present. Consuming fermented foods has been previously connected a number benefits such as antibacterial immune system modulation. Furthermore, functional food implementations lead application in therapeutic nutrition prebiotic, immunomodulatory, antioxidant, anti-tumor, blood glucose lowering actions. Understanding characteristics diverse sources its potential crucial applications. This review presents an overview knowledge regarding interactions between isolated dairy products (dairy LAB) foods, prospect functioning human health. Finally, health advantages emphasized.

Language: Английский

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Roles of Short-Chain Fatty Acids in Inflammatory Bowel Disease

Nutrients, Journal Year: 2023, Volume and Issue: 15(20), P. 4466 - 4466

Published: Oct. 21, 2023

The gut microbiome is a diverse bacterial community in the human gastrointestinal tract that plays important roles variety of biological processes. Short-chain fatty acids (SCFA) are produced through fermentation dietary fiber. Certain microbes responsible for producing SCFAs such as acetate, propionate and butyrate. An imbalance diversity can lead to metabolic disorders inflammation-related diseases. Changes SCFA levels associated microbiota were observed IBD, suggesting an association between disease. affect reactive oxygen species (ROS) with IBD. Gut closely related it study them further.

Language: Английский

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Unveiling the role of functional foods with emphasis on prebiotics and probiotics in human health: A review

Journal of Functional Foods, Journal Year: 2024, Volume and Issue: 119, P. 106337 - 106337

Published: July 6, 2024

Functional foods particularly prebiotics and probiotics have attracted a lot of attention due to their ability alter gut microbiota an impact on number health disease-related factors, in relation human recent years. are that provide benefits beyond simple sustenance. They contain biologically active ingredients offer additional when consumed regular basis as part balanced diet. Prebiotics, which indigestible fibers specifically promote the growth activity beneficial bacteria, probiotics, live microorganisms upon consumption sufficient amount, shown great promise modifying composition function microbiota. The identified review problem involves clarifying precise impacts immune system function, composition, metabolic health, disease prevention. This emphasizes numerous advantages preserving balance microbiota, boosting immunity, enhancing parameters, reducing risk diseases. also insight advances formulation functional mitigating conditions synergy between prebiotics.

Language: Английский

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A review on probiotics and dietary bioactives: Insights on metabolic well-being, gut microbiota, and inflammatory responses

Food Chemistry Advances, Journal Year: 2025, Volume and Issue: 6, P. 100919 - 100919

Published: Feb. 11, 2025

Language: Английский

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Lactic acid bacteria: Nature, Characterization, Mode of action, Products and Applications

Process Biochemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

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Accounting for the health risk of probiotics

Heliyon, Journal Year: 2024, Volume and Issue: 10(6), P. e27908 - e27908

Published: March 1, 2024

Probiotics have long been associated with a myriad of health benefits, so much that their adverse effects whether mild or severe, are often neglected overshadowed by the enormous volume articles describing beneficial in current literature. Recent evidence has demonstrated several risks probiotics warrant serious reconsideration applications and further investigations. This review aims to highlight studies report on how might cause opportunistic systemic local infections, detrimental immunological effects, metabolic disturbance, allergic reactions, facilitating spread antimicrobial resistance. To offer recent account literature, within last five years were prioritized. The narration these was based nature following order preference: clinical human samples, vivo animal models, situ, vitro and/or silico. We hope this will inform consumers, food scientists, medical practitioners, risks, while also encouraging research focus clarify probiotics.

Language: Английский

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The Microbiota–Gut–Brain Axis and Neurological Disorders: A Comprehensive Review

Life, Journal Year: 2024, Volume and Issue: 14(10), P. 1234 - 1234

Published: Sept. 26, 2024

Microbes have inhabited the earth for hundreds of millions years longer than humans. The microbiota-gut-brain axis (MGBA) represents a bidirectional communication pathway. These communications occur between central nervous system (CNS), enteric (ENS), and emotional cognitive centres brain. field research on gut-brain has grown significantly during past two decades. Signalling occurs gut microbiota brain through neural, endocrine, immune, humoral pathways. A substantial body evidence indicates that MGBA plays pivotal role in various neurological diseases. include Alzheimer's disease (AD), autism spectrum disorder (ASD), Rett syndrome, attention deficit hyperactivity (ADHD), non-Alzheimer's neurodegeneration dementias, fronto-temporal lobe dementia (FTLD), Wilson-Konovalov (WD), multisystem atrophy (MSA), Huntington's chorea (HC), Parkinson's (PD), multiple sclerosis (MS), amyotrophic lateral (ALS), temporal epilepsy (TLE), depression, schizophrenia (SCZ). Furthermore, correlation therapeutics will be discussed. Conversely, mood delivery, exercise, psychotropic agents, stress, neurologic drugs can influence MGBA. By understanding MGBA, it may possible to facilitate into microbial-based interventions therapeutic strategies

Language: Английский

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Precision Psychobiotics for Gut–Brain Axis Health: Advancing the Discovery Pipelines to Deliver Mechanistic Pathways and Proven Health Efficacy

Microbial Biotechnology, Journal Year: 2025, Volume and Issue: 18(1)

Published: Jan. 1, 2025

ABSTRACT Advancing microbiome–gut–brain axis science requires systematic, rational and translational approaches to bridge the critical knowledge gaps currently preventing full exploitation of gut microbiome as a tractable therapeutic target for gastrointestinal, mental brain health. Current research is still marked by many open questions that undermine widespread application humans. For example, lack mechanistic understanding probiotic effects means it remains unclear why even apparently closely related strains exhibit different in vivo. live microbial psychobiotics, consensus on their adjunct treatments conventional neuromodulators, use unmedicated populations or at‐risk cohorts with sub‐clinical symptomatology warranted. This missing information both sides equation when treating central nervous system (CNS) conditions makes psychobiotic challenging, especially compared other pharmaceutical functional food approaches. Expediting transition from positive preclinical data proven benefits humans includes interpreting promises pitfalls animal behavioural assays, well navigating mechanism‐informed decision making select right microbe(s) job. In this review, we consider how these decisions can be supported light accrued range clinical studies across healthy, pathological study populations, where specific have been evaluated context gastrointestinal physiology, function behaviour. Examples successful, partial unsuccessful translation bench bedside are considered. We also discuss developments silico analyses enhanced our moved towards pinpointing host–microbe interactions most important optimal gut–brain function. Combining assays vitro ex vivo domains incorporating model organisms prime discovery pipelines promising rationally selected candidates.

Language: Английский

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Exploring Therapeutic Advances: A Comprehensive Review of Intestinal Microbiota Modulators

Antibiotics, Journal Year: 2024, Volume and Issue: 13(8), P. 720 - 720

Published: Aug. 1, 2024

The gut microbiota establishes a mutually beneficial relationship with the host starting from birth, impacting diverse metabolic and immunological processes. Dysbiosis, characterized by an imbalance of microorganisms, is linked to numerous medical conditions, including gastrointestinal disorders, cardiovascular diseases, autoimmune disorders. This promotes proliferation toxin-producing bacteria, disrupts host's equilibrium, initiates inflammation. Genetic factors, dietary choices, drug use can modify microbiota. However, there optimism. Several therapeutic approaches, such as probiotics, prebiotics, synbiotics, postbiotics, microbe-derived products, microbial substrates, aim alter microbiome. review thoroughly explores potential these modulators, analysing recent studies evaluate their efficacy limitations. It underscores promise microbiota-based therapies for treating dysbiosis-related conditions. article aims ensure practitioners feel well-informed up date on most influential methods in this evolving field providing comprehensive current research.

Language: Английский

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