Exploring extracellular RNA as drivers of chemotherapy resistance in cancer

Molecular Biology Reports, Journal Year: 2025, Volume and Issue: 52(1)

Published: Jan. 21, 2025

Language: Английский

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Pharmacological, computational, and mechanistic insights into triptolide’s role in targeting drug-resistant cancers

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 25, 2025

Language: Английский

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Comprehensive Insights into Oral Squamous Cell Carcinoma: Diagnosis, Pathogenesis, and Therapeutic Advances

Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 261, P. 155489 - 155489

Published: July 27, 2024

Language: Английский

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GAS5 lncRNA: A biomarker and therapeutic target in breast cancer

Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 260, P. 155424 - 155424

Published: June 20, 2024

Language: Английский

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lncRNAs as prognostic markers and therapeutic targets in cuproptosis-mediated cancer

Clinical and Experimental Medicine, Journal Year: 2024, Volume and Issue: 24(1)

Published: Sept. 26, 2024

Abstract Long non-coding RNAs (lncRNAs) have emerged as crucial regulators in various cellular processes, including cancer progression and stress response. Recent studies demonstrated that copper accumulation induces a unique form of cell death known cuproptosis, with lncRNAs playing key role regulating cuproptosis-associated pathways. These may trigger cell-specific responses to stress, presenting new opportunities prognostic markers therapeutic targets. This paper delves into the cuproptosis-mediated cancer, underscoring their potential biomarkers targets for innovative strategies. A thorough review scientific literature was conducted, utilizing databases such PubMed, Google Scholar, ScienceDirect, search terms like 'lncRNAs,' 'cuproptosis,' 'cancer.' Studies were selected based on relevance lncRNA regulation cuproptosis pathways implications prognosis treatment. The highlights significant contribution cuproptosis-related genes pathways, impacting metabolism, mitochondrial responses, apoptotic signaling. Specific are breast, lung, liver, ovarian, pancreatic, gastric cancers. objective this article is explore cancers mediated by cuproptosis.

Language: Английский

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Recent advances in natural nanoclay for diagnosis and therapy of cancer: A review

Colloids and Surfaces B Biointerfaces, Journal Year: 2024, Volume and Issue: 235, P. 113768 - 113768

Published: Jan. 26, 2024

Language: Английский

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Investigating Novel Thiophene Carbaldehyde Based Thiazole Derivatives as Potential Hits for Diabetic Management: Synthesis, In Vitro and In Silico Approach

ChemistrySelect, Journal Year: 2024, Volume and Issue: 9(8)

Published: Feb. 21, 2024

Abstract This research work is based on synthesis of eleven novel thiazole derivatives (3 a‐k) thiophene carbaldehyde. All the synthesized compounds were successfully synthesized, characterized by 1 H‐NMR and EI‐MS spectroscopic techniques finally subjected for their in vitro α‐glucosidase inhibitory activity. Seven 3 i (IC 50 =10.21±1.84 μM) , b =11.14±0.99 f =13.21±2.76 h =14.21±0.31 k =15.21±1.02 e =16.21±1.32 μM), c =18.21±1.89 series displayed excellent potential better than standard acarbose. However, two g =33.21±1.99 d =42.31±2.12 showed significant activity while j a found less active with IC values 82.31±0.31 88.36±1.21 μM respectively. Additional revealed that are not exhibiting any cytotoxic effects. The molecular docking study these good binding site interactions scores.

Language: Английский

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Connecting the Dots: LncRNAs in the KRAS Pathway and Cancer

Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 262, P. 155570 - 155570

Published: Aug. 29, 2024

Language: Английский

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Boosting antitumor efficacy using docetaxel-loaded nanoplatforms: from cancer therapy to regenerative medicine approaches

Journal of Translational Medicine, Journal Year: 2024, Volume and Issue: 22(1)

Published: May 30, 2024

Abstract The intersection of nanotechnology and pharmacology has revolutionized the delivery efficacy chemotherapeutic agents, notably docetaxel, a key drug in cancer treatment. Traditionally limited by poor solubility significant side effects, docetaxel’s therapeutic potential been significantly enhanced through its incorporation into nanoplatforms, such as nanofibers nanoparticles. This advancement offers targeted delivery, controlled release, improved bioavailability, dramatically reducing systemic toxicity enhancing patient outcomes. Nanofibers provide versatile scaffold for release utilizing techniques like electrospinning to tailor profiles. Nanoparticles, on other hand, enable precise tumor cells, minimizing damage healthy tissues sophisticated encapsulation methods nanoprecipitation emulsion. These nanotechnologies not only improve pharmacokinetic properties docetaxel but also open new avenues regenerative medicine facilitating therapy cellular regeneration. narrative review highlights transformative impact docetaxel-loaded nanoplatforms oncology beyond, showcasing overcome limitations traditional chemotherapy pave way future innovations therapies. Through these advancements, promises era precision medicine, treatments while adverse effects. Graphical

Language: Английский

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Regulatory roles of N6-methyladenosine (m6A) methylation in RNA processing and non-communicable diseases

Cancer Gene Therapy, Journal Year: 2024, Volume and Issue: unknown

Published: June 5, 2024

Language: Английский

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