Today,
air
pollution
is
the
greatest
threat
to
organismal
healthspan.
The
environment
of
our
planet
earth,
habitat
over
eight
billion
humans
and
estimated
twenty
billions
other
animals,
contaminated
with
a
wide
variety
pollutants.
Unfortunately,
humans,
out
living
organisms
on
are
solely
responsible
for
polluting
through
emitting
pollutants
like
particulate
matter
from
industry,
fuel
engine
vehicles,
biomass
combustion,
toxic
fumes
blasting,
wildfire.
In
modern
world,
human-caused
induce
massive
oxidative
stress
inflammation,
major
contributors
in
initiation
progression
many
diseases
including
pulmonary,
cardiovascular,
renal,
hepatic,
reproductive,
neurological,
mental,
accelerated
biological
aging.
provocative
question
following:
how
can
we
solve
this
human-created
problem?
As
it
not
realistic
clean
at
once
pollution,
initiatives
have
been
undertaken
develop
novel
therapeutic
approaches
control
air-pollutant-induced
inflammation
protect
pollution-induced
devastating
diseases.
article,
I
discuss
key
findings
numerous
recent
preclinical
studies
documenting
first,
role
pollutant
PM2.5
augmentation
stress,
associated
diseases;
second,
efficacies
different
natural
synthetic
compounds
amelioration
PM2.5-induced
pyroptosis,
pathologies.
Nutrients,
Journal Year:
2024,
Volume and Issue:
16(2), P. 259 - 259
Published: Jan. 15, 2024
Chronic
inflammation
is
the
result
of
an
acute
inflammatory
response
that
fails
to
eliminate
pathogenic
agent
or
heal
tissue
injury.
The
consequence
this
failure
lays
foundations
onset
several
chronic
ailments,
including
skin
disorders,
respiratory
and
neurodegenerative
diseases,
metabolic
syndrome,
and,
eventually,
cancer.
In
context,
long-term
use
synthetic
anti-inflammatory
drugs
treat
illnesses
cannot
be
tolerated
by
patients
owing
severe
side
effects.
Based
on
this,
need
for
novel
agents
endowed
with
effects
prompted
search
potential
candidates
also
within
plant
kingdom,
being
recognized
as
a
source
molecules
currently
employed
in
therapeutical
areas.
Indeed,
ever-growing
evidence
properties
dietary
polyphenols
traced
route
towards
study
flavonoid-rich
sources,
such
Citrus
bergamia
(bergamot)
its
derivatives.
Interestingly,
recent
paradigm
circular
economy
has
promoted
valorization
fruit
waste
regard
bergamot,
it
brought
light
new
corroborating
bergamot
byproducts,
thus
increasing
scientific
knowledge
field.
Therefore,
review
aims
gather
latest
literature
supporting
beneficial
role
both
derivatives
products
different
models
inflammatory-based
highlighting
great
potentiality
re-evaluation
perspective.
Journal of Asthma and Allergy,
Journal Year:
2024,
Volume and Issue:
Volume 17, P. 717 - 731
Published: Aug. 1, 2024
Accumulating
evidence
indicates
that
oxidative
stress
and
inflammation
are
the
pathological
basis
of
allergic
diseases.
Inhibition
NOD-like
receptor
family
pyrin
domain-containing
3
(NLRP3)
inflammasome
could
ameliorate
rhinitis
(AR).
Here,
we
explored
effects
mechanisms
underlie
NLRP3
inhibition
on
in
AR.
Ecotoxicology and Environmental Safety,
Journal Year:
2025,
Volume and Issue:
295, P. 118140 - 118140
Published: April 1, 2025
Numerous
studies
have
demonstrated
a
positive
correlation
between
the
frequency
and
severity
of
allergic
rhinitis
(AR)
with
fine
particulate
matter
(PM2.5)
exposure,
although
exact
mechanisms
remain
poorly
understood.
This
study
aimed
to
investigate
role
gut
microbiota
disorder
NLRP3
pathway
activation
in
PM2.5-induced
nasal
epithelial
barrier
damage
AR
mice.
The
results
indicated
that
PM2.5
could
exacerbate
symptoms
mucosa.
pathway-related
proteins
including
NLRP3,
Caspase-1,
GSDMD,
IL-1β
were
elevated.
Additionally,
mucosa
injury
was
significantly
worsen
mice
disorder.
Gut
Microbiomic
Ileibacterium
Alistipes
are
associated
exacerbation.
Metabolomic
analysis
suggested
bile
acid
metabolism
is
potential
contributor
aggravate
damage.
revealed
positively
Alistipes,
Ileibacterium,
cholic
PC
(15:0/15:0).
correlated
LPE18:2
negatively
zonula
occludens-1
(ZO-1)
Claudin-1
proteins.
In
summary,
may
cause
abnormal
inflammasome
activation,
which
participate
exposure-induced
exacerbation
supplied
new
insight
targets
for
prevention
treatment
AR.
