A systematic review of spatial and temporal epidemiological approaches, focus on lung cancer risk associated with particulate matter DOI Creative Commons
Basanta Kumar Neupane, Bipin Kumar Acharya, Chunxiang Cao

et al.

BMC Public Health, Journal Year: 2024, Volume and Issue: 24(1)

Published: Oct. 24, 2024

Particulate matter (PM), including the major risk factor for lung cancer (LC), greatly impacts human health. Although numerous studies have highlighted spatiotemporal patterns and PM-LC associations, these not been well-reviewed. Thus, we examined epidemiological linked with provided concise, up-to-date data. We used certain keywords to review articles published in PubMed, Web of Science, Scopus, Google Scholar until 30th June 2024 identified 1474 research articles. then filtered based on our criteria ultimately dropped down 30 this review. Out thirty reviewed relation, twenty-four focused PM2.5, four PM10, two both, indicating that approximately 80% respondents were inclined toward fine particles their health impacts. The study revealed 22 visualization, 12 exploration, 15 modeling methods. A strong positive relationship was reported between LC ranging from 1.04 1.60 (95% CI) a 10 µg/m3 increase PM2.5 exposure. However, compared PM10 found significantly less association. Very few advanced methods examine association PM. Advanced analysis techniques should be employed explore specific geographical locations. Further utilize approaches link PM cancer.

Language: Английский

The emerging potential of green-synthesized nanoparticles as colorimetric sensors for ammonia detection DOI
Mohammad Amin Rashidi, Rezvan Zendehdel,

Shahab Falahi

et al.

Microchemical Journal, Journal Year: 2023, Volume and Issue: 196, P. 109646 - 109646

Published: Nov. 14, 2023

Language: Английский

Citations

5
Rutin encapsulated Decellularized earthworm granulation hydrogel promotes angiogenesis in wound healing of diabetic rabbit model by inhibiting TRAF1/NF-κB pathway DOI Creative Commons
Sofi Imtiyaz Ali, Ahmed M. E. Elkhalifa, Showkat Ul Nabi

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 97, P. 105803 - 105803

Published: May 23, 2024

Diabetic micro-vasculopathy is induced by accumulation of Reactive Oxygen Species (ROS) which results in delayed wound healing under hyperglycemic conditions. The classical practice treating diabetic includes surgical debridement, hyperbaric oxygen therapy and use antibiotics to control infection. therapeutic interventions based on these practices have been found ineffective management vasculopathy. Henceforth, engineered biomaterials with anti-oxidant activity become research hotspots for their high biological activity, due sustained release active principles weak immunogenicity. Based postulates, current study was conducted evaluate potential Rutin encapsulated decellularized earthworm granulation tissue (RdECM) special reference angiogenesis. angiogenetic RdECM evaluated cell line conditions we significant decline ROS Deoxyribonucleic acid (DNA) damage inhibition Nuclear factor kappa B (NF-Kβ) pathway subsequent aggregation cells tubular structure. Application resulted accelerated healing, reduction DNA down regulation TNF receptor associated 1 (TRAF1). These changes TRAF1-mediated NF-κB signal activation subsequently angiogenesis wound. findings support utility as agent its against healing.

Language: Английский

Citations

1
The research progress of crosstalk mechanism of autophagy and apoptosis in diabetic vascular endothelial injury DOI Creative Commons
Hanyu Liu, Qiyuan Yao, Xueru Wang

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 170, P. 116072 - 116072

Published: Dec. 25, 2023

In recent years, the widespread prevalence of diabetes has become a major killer that threatens health people worldwide. Of particular concern is hyperglycemia-induced vascular endothelial injury, which one factors aggravate diabetic disease. During process apoptosis an important pathological manifestation and autophagy key regulatory mechanism. Autophagy interact with each other. Hence, crosstalk mechanism between two processes means regulating injury. This article reviews research progress in context injury discusses its role this The purpose to guide prevention treatment future.

Language: Английский

Citations

3
Cytogenotoxicity assessment of diesel and petrol automobile exhaust soot nanoparticles in erythrocytes of Channa punctatus fish DOI Creative Commons

Sakshi Goswami,

Meenu Singh,

Parul Arya

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: March 1, 2024

Abstract Nanoparticles derived from automobile exhaust may tend to travel hundreds of miles their source emissions and have an adverse impact on environmental health. Numerous studies reported that the aquatic environment is known be a natural recipient contaminants soil air, which makes organisms vulnerable contamination by ultrafine particles/nanoparticles. The present report aimed investigate cytogenotoxic potential sublethal concentrations (0.05 ppm) diesel petrol soot nanoparticles (DAESNPs PAESNPs) in erythrocytes freshwater fish Channa punctatus. Morphological alterations (macrocytes, microcytes, kidney shaped, dacrocytes, notched, burr, sickle shaped flask shaped), nuclear (bean lobbed, bud blebbed condensed), MNs, oxidative stress, DNA damage apoptosis were assessed. Increased frequencies morphological ( average 7.12 ± 0.71, 7.24 0.84 DAESNP- PAESNP- treated fish, respectively), 10.60 ±1.97, 11.99 1.24 respectively) MNs (13.83 0.16, 11.83 1.58 found. Similarly, compared with control group, level malondialdehyde, byproduct lipid peroxidation was significantly greater, while reduced glutathione lower exposed fish. comet analysis parameters revealed both DAESNPs PAESNPs induced damage. In addition, Annexin-V FITC/PI assay data demonstrated led induction apoptosis. Our suggested experimental occur response genotoxic stress PAESNPs. Nonetheless, provoked due

Language: Английский

Citations

0
Evaluation of the Toxicological Efficacy of Protein Hydrolysates From Camel Milk β-Casein Against Different Types of Cancer Cell Lines in Vitro DOI Open Access
Sharaf Ali Hadi Al-Shaikh,

Kifah Saed Doosh

IOP Conference Series Earth and Environmental Science, Journal Year: 2024, Volume and Issue: 1371(6), P. 062027 - 062027

Published: July 1, 2024

Abstract This study aimed to isolate and purify the β-CN protein from camel milk using ion exchange chromatography gel filtration techniques verify its purity polyacrylamide electrophoresis (PAGE), Then prepare hydrolyzates of isolated by enzymatic hydrolysis enzyme pepsin trypsin their mixture in a ratio (1:1). The cytotoxicity degraders was studied conducting an MTT test determine toxic effect ability inhibit growth cancer cells represented HepG2 liver cells, PC3 prostate MCF-7 breast comparing them with normal HdFn vitro. results showed presence two peaks for on DEAE-Cellulose one peak Sephadex G-100 column appearance clear pure band gel. highest decomposition rate due synergistic action at 1:1 amounted 52.32%. also that have effective inhibitory cell concentration 400µg/mL, as inhibition reached (45.9, 59.5 63.3%) types, respectively. Based test, line chosen it is most affected under study. Cytotoxicity evaluated performing HCS detect some changes may occur measuring cellular indicators, including Viable Cell Count (VCC), total Nuclear Intensity (TNI), Membrane Permeability (CMP), Mitochondrial Potential (MMP), Cytochrome C releasing (CC) level. indicated decrease number (VCC) especially concentrations 100 200 µg/mL, 31.53 47.58%, respectively, increase significantly significance level (P≤0.05), 39.10 51.91%, there (MMP) 20.47 27.39%, significant release 16.16 25.84%, It can be concluded above high activity against

Language: Английский

Citations

0
Multimodal synergistic ferroptosis cancer therapy DOI
Nem Singh, Dahee Kim, Sunhong Min

et al.

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 522, P. 216236 - 216236

Published: Sept. 25, 2024

Language: Английский

Citations

0
A systematic review of spatial and temporal epidemiological approaches, focus on lung cancer risk associated with particulate matter DOI Creative Commons
Basanta Kumar Neupane, Bipin Kumar Acharya, Chunxiang Cao

et al.

BMC Public Health, Journal Year: 2024, Volume and Issue: 24(1)

Published: Oct. 24, 2024

Particulate matter (PM), including the major risk factor for lung cancer (LC), greatly impacts human health. Although numerous studies have highlighted spatiotemporal patterns and PM-LC associations, these not been well-reviewed. Thus, we examined epidemiological linked with provided concise, up-to-date data. We used certain keywords to review articles published in PubMed, Web of Science, Scopus, Google Scholar until 30th June 2024 identified 1474 research articles. then filtered based on our criteria ultimately dropped down 30 this review. Out thirty reviewed relation, twenty-four focused PM2.5, four PM10, two both, indicating that approximately 80% respondents were inclined toward fine particles their health impacts. The study revealed 22 visualization, 12 exploration, 15 modeling methods. A strong positive relationship was reported between LC ranging from 1.04 1.60 (95% CI) a 10 µg/m3 increase PM2.5 exposure. However, compared PM10 found significantly less association. Very few advanced methods examine association PM. Advanced analysis techniques should be employed explore specific geographical locations. Further utilize approaches link PM cancer.

Language: Английский

Citations

0