The Role of Small Extracellular Vesicles Derived from Glial Cells in the Central Nervous System under both Normal and Pathological Conditions DOI
Sajad Sahab Negah, Hamid Reza Moradi, Fatemeh Forouzanfar

et al.

Neurochemical Research, Journal Year: 2025, Volume and Issue: 50(2)

Published: Jan. 30, 2025

Language: Английский

Engineered exosomes and composite biomaterials for tissue regeneration DOI Creative Commons
Weikang Hu, Wang Wang, Zesheng Chen

et al.

Theranostics, Journal Year: 2024, Volume and Issue: 14(5), P. 2099 - 2126

Published: Jan. 1, 2024

Exosomes, which are small vesicles enclosed by a lipid bilayer and released many cell types, widely dispersed have garnered increased attention in the field of regenerative medicine due to their ability serve as indicators diseases agents with therapeutic potential. Exosomes play crucial role mediating intercellular communication through transfer biomolecules, including proteins, lipids, RNA, other molecular constituents, between cells. The targeted transport proteins nucleic acids specific cells has potential enhance or impair biological functions. applications, they can be used alone combination approaches. examination unique attributes functions these factors emerged prominent study realm biomedical research. This manuscript summarizes origins properties exosomes, structural, biological, physical, chemical aspects. paper offers complete recent progress tissue repair medicine, emphasizing possible implications methods forthcoming regeneration attempts.

Language: Английский

Citations

20
Environmental pollutants and exosomes: A new paradigm in environmental health and disease DOI
Afsaneh Javdani-Mallak,

Iman Salahshoori

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 925, P. 171774 - 171774

Published: March 18, 2024

Language: Английский

Citations

14
Profound Properties of Protein-Rich, Platelet-Rich Plasma Matrices as Novel, Multi-Purpose Biological Platforms in Tissue Repair, Regeneration, and Wound Healing DOI Open Access
Peter A. Everts, José Fábio Lana,

Robert W. Alexander

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(14), P. 7914 - 7914

Published: July 19, 2024

Autologous platelet-rich plasma (PRP) preparations are prepared at the point of care. Centrifugation cellular density separation sequesters a fresh unit blood into three main fractions: platelet-poor (PPP) fraction, stratum rich in platelets (platelet concentrate), and variable leukocyte bioformulation erythrocyte fractions. The employment autologous platelet concentrates facilitates biological potential to accelerate support numerous activities that can lead tissue repair, regeneration, wound healing, and, ultimately, functional structural repair. Normally, after PRP preparation, PPP fraction is discarded. One less well-known but equally important features particular growth factors (GFs) not abundantly present PRP, as they reside outside alpha granules. Precisely, insulin-like factor-1 (IGF-1) hepatocyte factor (HGF) mainly fraction. In addition their roles angiogenesis activators, these plasma-based GFs also known inhibit inflammation fibrosis, promote keratinocyte migration repair healing. Additionally, for presence exosomes other macrovesicles, exerting cell-cell communication cell signaling. Newly developed ultrafiltration technologies incorporate processing methods by eliminating, fast efficient manner, water, cytokines, molecules, proteins with molecular mass (weight) than pore size fibers. Consequently, viable viscous protein concentrate total proteins, like fibrinogen, albumin, alpha-2-macroglobulin created. Consolidating small volume high highly concentrated protein-rich creates protein-rich, (PR-PRP) preparation. After activation PR-PRP matrix retains interactions between invading resident cells, macrophages, fibroblast, mesenchymal stem cells (MSCs), well embedded molecules. administered biologic will ultimately undergo fibrinolysis, leading sustained release molecules have been retained until dissolved. We discuss unique reparative regenerative properties matrix.

Language: Английский

Citations

14
Exosome-Based Macromolecular neurotherapeutic drug delivery approaches in overcoming the Blood-Brain barrier for treating brain disorders DOI
Krishna Yadav,

R. Vijayalakshmi,

Kantrol Kumar Sahu

et al.

European Journal of Pharmaceutics and Biopharmaceutics, Journal Year: 2024, Volume and Issue: 199, P. 114298 - 114298

Published: April 18, 2024

Language: Английский

Citations

12
CAR-based immunotherapy for breast cancer: peculiarities, ongoing investigations, and future strategies DOI Creative Commons

Zhipu Niu,

Jingyuan Wu, Qiancheng Zhao

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: April 12, 2024

Surgery, chemotherapy, and endocrine therapy have improved the overall survival postoperative recurrence rates of Luminal A, B, HER2-positive breast cancers but treatment modalities for triple-negative cancer (TNBC) with poor prognosis remain limited. The effective application rapidly developing chimeric antigen receptor (CAR)-T cell in hematological tumors provides new ideas cancer. Choosing suitable specific targets is crucial applying CAR-T treatment. In this paper, we summarize therapy’s potential different subtypes based on existing research progress, especially TNBC. CAR-based immunotherapy has resulted advancements CAR-macrophages, CAR-NK cells, CAR-mesenchymal stem cells (MSCs) may be more safer treating solid tumors, such as However, tumor microenvironment (TME) side effects pose challenges to immunotherapy. cells-derived exosomes are advantageous therapy. Exosomes carrying CAR immense value provide a modality good effects. review, an overview development discuss progress CAR-expressing We elaborate TNBC prospects using CAR-MSCs

Language: Английский

Citations

10
Exosome may be the next generation of promising cell-free vaccines DOI Creative Commons

Zelan Dai,

Ruiru Cai,

Hong Zeng

et al.

Human Vaccines & Immunotherapeutics, Journal Year: 2024, Volume and Issue: 20(1)

Published: May 7, 2024

Traditional vaccines have limits against some persistent infections and pathogens. The development of novel vaccine technologies is particularly critical for the future. Exosomes play an important role in physiological pathological processes. present many advantages, such as inherent capacity being biocompatible, non-toxic, which make them a more desirable candidate vaccines. However, research on exosomes are their infancy barriers low yield, purity, weak targeting limit applications Accordingly, further exploration necessary to improve these problems subsequently facilitate functional studies exosomes. In this study, we reviewed origin, classification, functions, modifications, separation purification, characterization methods Meanwhile, focused mechanism cancer COVID-19

Language: Английский

Citations

8
Insights into tumor-derived exosome inhibition in cancer therapy DOI
Ziwei Tang, Cheng Chen, Chen Zhou

et al.

European Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: 285, P. 117278 - 117278

Published: Jan. 13, 2025

Language: Английский

Citations

1
Recent advances and future prospects of engineered exosomes as advanced drug and gene delivery systems DOI
Waleed Y. Rizg, Majed Alghamdi, Sherif El Saadany

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: 106, P. 106696 - 106696

Published: Feb. 6, 2025

Language: Английский

Citations

1
Exploring the immuno-nano nexus: A paradigm shift in tumor vaccines DOI Open Access
Yuanyuan Li, Yuxing Xu,

Wenwen Su

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2025, Volume and Issue: 184, P. 117897 - 117897

Published: Feb. 7, 2025

Language: Английский

Citations

1
Exosomes as Therapeutic and Diagnostic Tools: Advances, Challenges, and Future Directions DOI

Tejas C. Jangam,

Sharav Desai, Vipul P. Patel

et al.

Cell Biochemistry and Biophysics, Journal Year: 2025, Volume and Issue: unknown

Published: March 24, 2025

Language: Английский

Citations

1