PLATELET-RICH PLASMA IN ANTI-AGING AND AESTHETIC MEDICINE DOI Creative Commons
Yuliya Fedorchenko

Anti-Aging Eastern Europe, Journal Year: 2024, Volume and Issue: 3(4), P. 168 - 174

Published: Dec. 28, 2024

Skin aging is a multifactorial process influenced by intrinsic and extrinsic factors, leading to structural functional deterioration, including wrinkles, laxity, pigmentation, barrier dysfunction. Platelet-Rich Plasma (PRP) has emerged as novel regenerative therapy in anti-aging aesthetic medicine due its ability stimulate collagen production, tissue repair, neo-angiogenesis through autologous growth factors. PRP demonstrated significant efficacy improving skin texture, tone, elasticity, particularly when combined with microneedling, dermal fillers, or fractional lasers. In addition facial rejuvenation, shows promise treating androgenetic alopecia (AGA), enhancing hair density thickness, reducing shedding minimal adverse effects. The treatment’s safety profile, versatility, shorter recovery periods make it an appealing alternative conventional therapies. Despite clinical potential, further research warranted standardize protocols, elucidate cellular mechanisms, optimize outcomes for widespread application dermatology.

Language: Английский

Engineered protein-based materials for tissue repair: A review DOI
Jiayin Feng, Fangyan Wang,

Yunyuan Shao

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 303, P. 140674 - 140674

Published: Feb. 3, 2025

Language: Английский

Citations

4
Effect of platelet-rich plasma on angiogenic and regenerative properties in patients with critical limb ischemia DOI Creative Commons
Hamid Tanzadehpanah, Sima Nobari,

A Hoseini

et al.

Regenerative Therapy, Journal Year: 2025, Volume and Issue: 28, P. 517 - 526

Published: Feb. 6, 2025

Language: Английский

Citations

1
Increasing the concentration of plasma molecules improves the biological activity of platelet-rich plasma for tissue regeneration DOI Creative Commons

Mikel Sánchez,

Jon Mercader Ruiz,

Daniel Marijuán Pinel

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Feb. 6, 2025

Language: Английский

Citations

0
Advances in regenerative medicine-based approaches for skin regeneration and rejuvenation DOI Creative Commons

Nathalia Silva Dutra Alves,

Gustavo Roncoli Reigado,

Mayara Santos

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 13

Published: Feb. 12, 2025

Significant progress has been made in regenerative medicine for skin repair and rejuvenation. This review examines core technologies including stem cell therapy, bioengineered substitutes, platelet-rich plasma (PRP), exosome-based therapies, gene editing techniques like CRISPR. These methods hold promise treating a range of conditions, from chronic wounds burns to age-related changes genetic disorders. Challenges remain optimizing these therapies broader accessibility ensuring long-term safety efficacy.

Language: Английский

Citations

0
Platelet-Based Injections for Knee Osteoarthritis DOI

Giulia Marcella Maryse Chiari Gaggia,

Pietro Conte, Giuseppe Anzillotti

et al.

Clinics in Sports Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

0
Pathophysiology and potential treatment modalities in women with recurrent urinary tract infection DOI Creative Commons
Wei Liao,

Yuan‐Hong Jiang,

Jia‐Fong Jhang

et al.

Tzu Chi Medical Journal, Journal Year: 2025, Volume and Issue: 37(2), P. 117 - 124

Published: April 1, 2025

A BSTRACT Urinary tract infection (UTI) of the urinary bladder is a common bacterial that predominantly affects women, with many experiencing recurrent episodes. Recurrent UTIs (rUTIs) are associated significant physical, psychological, and social difficulties. Further, they closely related to lower dysfunction (LUTD). LUTD function structure, thereby contributing urgency, frequency, incontinence, which, in turn, increases risk infections due impaired urothelial defense mechanisms. The current study explored pathophysiology women rUTIs. Potential treatments for rUTIs include long-term prophylactic antibiotics, probiotics, D-mannose, vaccines, small molecule inhibitors, stem cell therapy. Moreover, it evaluated use platelet-rich plasma (PRP) therapy as treatment modality LUTD. PRP has regenerative anti-inflammatory properties. Hence, can be promising option enhancing barrier integrity reducing recurrence. Repeated intravesical injections effective improving symptoms decreasing UTI recurrences by proliferative ability urothelium patients this review examined potential predictors successful outcomes such cytokine biomarker levels, which provided insights into patient selection individualized strategies. Identifying predictive biomarkers responsiveness essential optimizing improve clinical quality life rUTIs, future research should focus on refining PRP, exploring combination therapies, validating biomarkers.

Language: Английский

Citations

0
The Well-Forgotten Old: Platelet-Rich Plasma in Modern Anti-Aging Therapy DOI Creative Commons
Anna V. Gorodilova,

Chulpan B. Kharisova,

Maria N. Osinnikova

et al.

Cells, Journal Year: 2024, Volume and Issue: 13(21), P. 1755 - 1755

Published: Oct. 23, 2024

Currently, approaches to personalized medicine are actively developing. For example, the use of platelet-rich plasma (PRP) is growing every year. As a result activation, platelets release wide range growth factors, cytokines, chemokines, and angiogenic after which these molecules regulate chemotaxis, inflammation, vasomotor function play crucial role in restoring integrity damaged vascular walls, angiogenesis, tissue regeneration. Due characteristics, PRP has potential regenerative gerontology. products used not only esthetic but also stimulate regeneration relieve chronic inflammation. therapy number advantages, controversial results clinical studies, lack standardization sample preparation material, insufficient objective data on evaluation efficacy do allow us unambiguously look at for therapeutic purposes. In this review, we will examine current PRP-based analyze contribution diseases associated with aging.

Language: Английский

Citations

2
Regenerative Inflammation: The Mechanism Explained from the Perspective of Buffy-Coat Protagonism and Macrophage Polarization DOI Open Access
Rubens Andrade Martins, Fábio Ramos Costa, Luyddy Pires

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(20), P. 11329 - 11329

Published: Oct. 21, 2024

The buffy-coat, a layer of leukocytes and platelets obtained from peripheral blood centrifugation, plays crucial role in tissue regeneration the modulation inflammatory responses. This article explores mechanisms regenerative inflammation, highlighting critical buffy-coat influencing macrophage polarization its therapeutic potential. Macrophage into M1 M2 subtypes is pivotal balancing inflammation repair, with macrophages driving pro-inflammatory responses promoting healing regeneration. buffy-coat's rich composition progenitor cells, cytokines, growth factors-such as interleukin-10, transforming factor-β, monocyte colony-stimulating factor-supports transition to macrophages, enhancing repair resolution inflammation. dynamic interaction between components opens new avenues for strategies aimed at improving managing conditions, particularly musculoskeletal diseases such osteoarthritis. Furthermore, use buffy-coat-derived therapies conjunction other modalities, platelet-rich plasma, holds promise more effective clinical outcomes.

Language: Английский

Citations

2
Efficacy and safety of allogeneic platelet-rich plasma in chronic wound treatment: a meta-analysis of randomized controlled trials DOI Creative Commons
Yalong Li, Xingtong Wang, Yucong Li

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Oct. 24, 2024

Abstract Allogeneic platelet-rich plasma (al-PRP) is gaining attention in clinical practice for treating chronic refractory wounds, though research results remain controversial. To assess the efficacy of al-PRP wounds. Databases including PubMed, Cochrane Library, Embase, CNKI, SinoMed, VIP, and WFPD were searched randomized controlled trials comparing with conventional treatments up to October 2023. Two researchers independently screened studies, extracted data, assessed quality. Statistical analysis was conducted using RevMan 5.4, potential publication bias corrected funnel plots Egger’s test. Twelve studies 717 cases included. Meta-analysis showed significantly improved outcomes compared non-al-PRP treatments: increased healing rate (RR 2.72, 95% CI 1.77–4.19, p < 0.00001), shortened time (SMD − 1.03, -1.31 -0.75, 1.19, 1.10–1.28, wound shrinkage (MD 35.65%, 21.65–49.64, reduced hospital stays -2.62, -4.35 -0.90, = 0.003). Al-PRP a feasible, effective, safe biological therapy Trial registration : PROSPERO Identifier CRD42022374920.

Language: Английский

Citations

1
A Comprehensive Guide of Cellular Blood-Derived and Mesenchymal Stem Cell-Based Autologous Biological Preparations for Tissue Repair, Regeneration, and Wound Healing DOI
Peter A. Everts,

Luga Podesta,

Robert W. Alexander

et al.

IntechOpen eBooks, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 12, 2024

The use of autologous biological preparations (ABPs) and their combinations fills a void in health care treatment options that exists between surgical procedures current pharmaceutical treatments. There is wide range ABPs can safely effectively be prepared at point using tissues from the patient such as peripheral blood, bone marrow, adipose tissue to treat clinical conditions. blood-derived mesenchymal stem cell cellular plays important roles modulation repair processes complex settings. Biological products derived are advantageous because nature safety profiles. include platelet-rich plasma (PRP), marrow concentrates (BMCs), (ATC) with its unique stromal vascular fractions (SVFs). In addition, combined create more diverse possess high degree regenerative activity potential. Likewise, concentrated acellular proteins generate temporary fibrin matrix interact bioactive molecules various ABPs. Practitioners reason application mimic classical healing angiogenesis cascades initiate repair, regeneration, wound during non-surgical interventions, aiming restore integrity function damaged tissues.

Language: Английский

Citations

0