Gut microbiota in post-acute COVID-19 syndrome: not the end of the story DOI Creative Commons

Yaping An,

Linlin He,

Xin Xu

et al.

Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 24, 2024

The coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), has led to major global health concern. However, the focus on immediate effects was assumed as tip of iceberg due symptoms following infection, which defined post-acute COVID-19 (PACS). Gut microbiota alterations even after resolution and gastrointestinal are key features PACS. derived metabolites disorders may play a crucial role in inflammatory immune response SARS-CoV-2 infection through gut-lung axis. Diet is one modifiable factors closely related gut COVID-19. In this review, we described reciprocal crosstalk between lung, highlighting participation diet destroying barrier, perturbing metabolism regulating system. Therefore, bolstering beneficial species dietary supplements, probiotics or prebiotics fecal transplantation (FMT) be novel avenue for PACS prevention. This review provides better understanding association long-term consequences COVID-19, indicates modulating dysbiosis potentiality addressing multifaceted condition.

Language: Английский

Polysaccharides as Protective Agents against Heavy Metal Toxicity DOI Creative Commons
Lukman Iddrisu, Felix Danso, Kit‐Leong Cheong

et al.

Foods, Journal Year: 2024, Volume and Issue: 13(6), P. 853 - 853

Published: March 11, 2024

Polysaccharides are functional foods or drugs that can be used to alleviate heavy metal poisoning by cadmium, lead, mercury, and arsenic. Industries generate substantial quantities of toxic wastes, such as wastewater discharges, paints, electronic waste, batteries, pigments, plastics, into the environment pose a risk human health. Therefore, it is imperative eliminate accumulated ions from body environment. Heavy toxicity lead decreased energy levels impair functioning vital organs, brain, lungs, kidneys, liver, blood. Prolonged exposure result in progressive physical, muscular, neurological degeneration resembles conditions multiple sclerosis, Parkinson’s disease, Alzheimer’s muscular dystrophy. operate through mechanisms chelation, antioxidant defense, immunomodulation, tissue repair. involved removal include methionine cysteine, together with N-acetylcysteine, an acetylated form S-adenosylmethionine, metabolite methionine, α-lipoic acid, tripeptide glutathione (GSH). These compounds effectively bind harmful metals create stable complex defend biological targets ions, thus decreasing their effects causing them excreted body. This review also highlights importance polysaccharides’ ability mitigate oxidative stress, enhance immune responses, support repair processes. ubiquitous nature take part diverse processes, making potential natural therapies for metal-related diseases. discusses effectiveness polysaccharides allow have inherent features enable function pharmacological agents regulate response.

Language: Английский

Citations

12
Prebiotic characteristics of added-value polysaccharides from jackfruit peel waste during in vitro digestion and fecal fermentation DOI Creative Commons
Yunfeng Li, Bin Wu, Jianping Chen

et al.

LWT, Journal Year: 2023, Volume and Issue: 187, P. 115330 - 115330

Published: Sept. 1, 2023

Food waste can be used more efficiently to increase food sustainability. Polysaccharides from jackfruit peel (PJP)1 are derived agricultural waste, and little is known about their in vitro digestion fermentation characteristics. This study aimed elucidate PJP structural properties, the dynamic changes during simulated salivary gastrointestinal fecal fermentation, its effects on human intestinal microbiota. Structural analysis showed a typical polysaccharide structure with high stability an amorphous heteropolysaccharide. The monosaccharides of glucose, mannose, galactose, arabinose, rhamnose. In models, that reach colon intact. degradation by microbiota being releasing free oligosaccharides, producing short-chain fatty acids, particularly acetic acid, modulating composition microbes. promoted growth beneficial flora Weissella, Enterococcus, Bifidobacterium, Lactococcus Prevotella process. These findings could improve usage create possibilities for use as potential prebiotic.

Language: Английский

Citations

14
Maternal infection of SARS-CoV-2 during the first and second trimesters leads to newborn telomere shortening DOI Creative Commons
Lina Wang, Junfeng Zhang, Fangfei Liu

et al.

Journal of Translational Medicine, Journal Year: 2024, Volume and Issue: 22(1)

Published: Nov. 21, 2024

Abstract Background Initial telomere length (TL) in newborns is the major determinant for TL later life while newborn/early-life predicts long-term health and lifespan. It important to identify key factors that affect homeostasis throughout embryonic development precision interventions maintain optimal fetus/prenatal infants. SARS-CoV-2 has caused a widespread global pandemic of COVID-19, but it remains unclear whether maternal infection impairs prenatal homeostasis. Methods We recruited 413 normally delivered whose mothers were either non-infected or infected with during different trimesters pregnancy (otherwise healthy). Telomere cord blood (CB) was assessed using qPCR. CB analyzed cytokine levels. Placental senescence determined senescence-associated β-galactosidase staining. Results Control (non-infected maternal) newborn significantly longer than from (1.568 ± 0.340 vs 1.390 0.350, P = 0.005). Such shorter observed only if occurred first second (1.261 1.346 0.353, < 0.0001 0.001, respectively). There no differences between controls at third trimester 1.565 0.329, > 0.05). Across trimester, there positive correlation gestational weeks infection, suggesting earlier occurs, worse effect taken on fetal coupled downregulated expression telomerase reverse transcriptase more frequent trimester. IL-6, C reactive protein other levels serum placentas. Conclusions Maternal leads causes much severe damage. The infection-mediated cell histopathological abnormalities result defective placental function through which impaired. Thus, vaccination against COVID-19 should be done advance women who plan pregnancy.

Language: Английский

Citations

2
COVID-19 and Gastrointestinal Tract: From Pathophysiology to Clinical Manifestations DOI Creative Commons
Filippo Vernia, Hassan Ashktorab,

Nicola Cesaro

et al.

Medicina, Journal Year: 2023, Volume and Issue: 59(10), P. 1709 - 1709

Published: Sept. 24, 2023

Background: Since its first report in Wuhan, China, December 2019, COVID-19 has become a pandemic, affecting millions of people worldwide. Although the virus primarily affects respiratory tract, gastrointestinal symptoms are also common. The aim this narrative review is to provide an overview pathophysiology and clinical manifestations COVID-19. Methods: We conducted systematic electronic search English literature up January 2023 using Medline, Scopus, Cochrane Library, focusing on papers that analyzed role SARS-CoV-2 tract. Results: Our highlights directly infects tract can cause such as diarrhea, nausea/vomiting, abdominal pain, anorexia, loss taste, increased liver enzymes. These result from mucosal barrier damage, inflammation, changes microbiota composition. exact mechanism how overcomes acid gastric environment leads intestinal damage still being studied. Conclusions: vaccination prevalence less severe symptoms, long-term interaction with remains concern. Understanding interplay between essential for future management virus.

Language: Английский

Citations

4
Exploring Physical Activity, Sleep, and Nutrition’s Role in Fatigue Among Post-COVID-19 Patients DOI Open Access
Isabell Pink, Miriam Wiestler, Lea Pueschel

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(23), P. 4056 - 4056

Published: Nov. 26, 2024

Background/Objectives: A significant number of patients experience prolonged symptoms following COVID-19 in particular cases fatigue. Yet, pathomechanisms COVID-19-related fatigue remain unclear. Methods: This study investigated after confirmed SARS-CoV-2 infection (PC) with relevant according to the Fatigue Assessment Scale (≥22 points) rule out malnutrition as a driving factor for and evaluate daily activity sleep characteristics. Dietary behavior was recorded through food diaries physical by self-reported (questionnaires) objective (activity tracker) outcomes. Data were collected over 7-day period compared healthy control group (HC). subgroup analysis severe fatigue, well sex-specific analysis, included. Results: No differences dietary intake observed, but an indication toward healthier Mediterranean diet PC median Diet Score 4 (IQR 3, 5) HC vs. 5 6) (p = 0.24). There also no activity, either or subjective measures. However, duration 49 min longer 0.003). Conclusions: In conclusion, did not significantly contribute yet showed increased duration. As characteristics play crucial role mental wellbeing, association sleep, should be evaluated further studies.

Language: Английский

Citations

0
Towards natural polymers and nanoparticles as nanotherapies to combat COVID-19 DOI

Clarity Ropafadzo Mapengo

Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 297 - 315

Published: Nov. 29, 2024

Language: Английский

Citations

0
Gut microbiota in post-acute COVID-19 syndrome: not the end of the story DOI Creative Commons

Yaping An,

Linlin He,

Xin Xu

et al.

Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 24, 2024

The coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), has led to major global health concern. However, the focus on immediate effects was assumed as tip of iceberg due symptoms following infection, which defined post-acute COVID-19 (PACS). Gut microbiota alterations even after resolution and gastrointestinal are key features PACS. derived metabolites disorders may play a crucial role in inflammatory immune response SARS-CoV-2 infection through gut-lung axis. Diet is one modifiable factors closely related gut COVID-19. In this review, we described reciprocal crosstalk between lung, highlighting participation diet destroying barrier, perturbing metabolism regulating system. Therefore, bolstering beneficial species dietary supplements, probiotics or prebiotics fecal transplantation (FMT) be novel avenue for PACS prevention. This review provides better understanding association long-term consequences COVID-19, indicates modulating dysbiosis potentiality addressing multifaceted condition.

Language: Английский

Citations

0