Duguetia furfuracea (A.ST. Hil.) Saff.: Neuroprotective Effect on Chemically Induced Amnesia, Anxiolytic Effects and Preclinical Safety Evaluation in Mice DOI Creative Commons

Maiara Fava de Souza,

J. M. dos Santos, Sidney Mariano dos Santos

et al.

Biology, Journal Year: 2024, Volume and Issue: 13(12), P. 981 - 981

Published: Nov. 27, 2024

Duguetia furfuracea, “araticum-seco”, is known to contain several bioactive compounds that can mitigate oxidative stress and act on the central nervous system (CNS). This effect partly attributed its potent antioxidant acetylcholinesterase (AChE) inhibitors. In this study, effects were explored of methanolic extract (MEDF) alkaloid fraction (AFDF) D. furfuracea (leaves) cognitive behaviors in male mice with scopolamine (Scop)-induced impairment biochemical parameters. Additionally, anxiolytic behavior, subacute toxicity, molecular docking activity reported. MEDF (30, 100 or 300 mg/kg) AFDF (30 orally administered for 16 days Scop (intraperitoneally, i.p.) between 11 16. The behavior (open field test marble burying) healthy mice, Scop-induced memory (object recognition Morris water maze (MWM)) assessed, parameters (malondialdehyde (MDA) AChE levels) measured after euthanasia. toxicological impact was assessed female Swiss 28 days. available DPPH, ABTS β-carotene/linoleic acid models. results revealed exhibit significantly alleviated Sco-induced impairment, inhibited cortex (40%) MDA (51.51%) levels. Reticuline reported coupling involves link-type hydrogen bonds van der Waals interactions. exhibited capacity (DPPH, IC50 = 18.10 ± 1.70 µg/mL; ABTS, 10.41 1.69 µg/mL). did not reveal signs toxicity. conclusion, shows promise mitigating scopolamine-induced deficits, potentially because it inhibits activity, reduces levels, enhances activities.

Language: Английский

Alkaloids Unveiled: A Comprehensive Analysis of Novel Therapeutic Properties, Mechanisms, and Plant-Based Innovations DOI Creative Commons

L Sarvananda,

Hewa D.T. Madhuranga,

M.B.L.N. Kaushalya

et al.

Intelligent Pharmacy, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 1, 2024

Language: Английский

Citations

9
Penifuranone A: A Novel Alkaloid from the Mangrove Endophytic Fungus Penicillium crustosum SCNU-F0006 DOI Open Access
Hao Jia, Li Wu,

Rongrong Liu

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(9), P. 5032 - 5032

Published: May 5, 2024

One previously undescribed alkaloid, named penifuranone A (1), and three known compounds (2–4) were isolated from the mangrove endophytic fungus Penicillium crustosum SCNU-F0006. The structure of new alkaloid (1) was elucidated based on extensive spectroscopic data analysis single-crystal X-ray diffraction analysis. Four natural isolates one synthetic derivative A, compound 1a, screened for their antimicrobial, antioxidant, anti-inflammatory activities. Bioassays revealed that exhibited strong activity in vitro by inhibiting nitric oxide (NO) production lipopolysaccharide-activated RAW264.7 cells with an IC50 value 42.2 μM. docking study 1 ideal fit within active site murine inducible synthase (iNOS), establishing characteristic hydrogen bonds.

Language: Английский

Citations

7
Current View on Major Natural Compounds Endowed with Antibacterial and Antiviral Effects DOI Creative Commons
Roberto Arrigoni, Andrea Ballini, Emilio Jirillo

et al.

Antibiotics, Journal Year: 2024, Volume and Issue: 13(7), P. 603 - 603

Published: June 28, 2024

Nowadays, infectious diseases of bacterial and viral origins represent a serious medical problem worldwide. In fact, the development antibiotic resistance is responsible for emergence strains that are refractory even to new classes antibiotics. Furthermore, recent COVID-19 pandemic suggests viruses can emerge spread all over world. The increase in depends on multiple factors, including malnutrition, massive migration population from developing industrialized areas, alteration human microbiota. Alternative treatments conventional antibiotics antiviral drugs have intensively been explored. this regard, plants marine organisms an immense source products, such as polyphenols, alkaloids, lanthipeptides, terpenoids, which possess antibacterial activities. Their main mechanisms action involve modifications cell membranes, with formation pores, release cellular content, inhibition adherence host cells, well efflux pump. Natural antivirals interfere replication spreading, protecting enhanced production interferon. Of note, these not free side effects, their administration humans needs more research terms safety. Preclinical natural compounds confirms effects against bacteria viruses, but there still only few clinical trials. Therefore, full exploitation intensive studies next steps be pursued area medicine.

Language: Английский

Citations

5
Alkaloids in Chelidonium majus L: a review of its phytochemistry, pharmacology and toxicology DOI Creative Commons
Xinlan Li, Yanping Sun, Meng Wang

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Aug. 22, 2024

Chelidonium majus L. ( C. majus) , commonly known as “Bai Qu Cai” in China, belongs to the genus of Papaveraceae family. It has rich medicinal value, such alleviating coughs, asthma, spasms and pain. Recent studies have demonstrated that is abundant various alkaloids, which are primary components a range pharmacological effects, including anti-microbial, anti-inflammatory, anti-viral, anti-tumor effects. So far, 94 alkaloids been isolated from benzophenanthridine, protoberberine, aporphine, protopine other types alkaloids. This paper aims review research progress phytochemistry, pharmacology toxicology order provide theoretical basis for application field chemistry afford reference further development efforts.

Language: Английский

Citations

5
Electrochemically Driven Chalcogenative Cyclization of 2-Alkynyl Aryl Oxime: Access to Functionalized Isoquinolines DOI
Jiajun Hu, Bo Li,

Feng Xiong

et al.

The Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 7, 2025

A transition-metal-free electrochemical chalcogenative cyclization of 2-alkynyl aryl oxime with dichalcogenides has been established to assemble valuable 4-organochalcogen isoquinolines concisely. This protocol proceeds via constant electrolysis in a user-friendly undivided cell setup. It circumvents the necessity transition metal catalysts, chemical oxidants, and harsh reaction conditions. The practical utilities current were illustrated by excellent functional group tolerance, remarkable regio-selectivity, easy scalability, mild conditions, transformable isoquinoline products.

Language: Английский

Citations

0
Multicomponent Tf2O-Triggered Dearomative Triazinylmethylation of Isoquinolines Using Acetonitrile DOI

Huazheng Wang,

Yixin Chen, Shiqi Liu

et al.

The Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 13, 2025

A Tf2O-triggered dearomative triazinylmethylation of isoquinolines and other azaarenes utilizing acetonitrile as the nucleophile has been developed through a formal five-component reaction. This method showcases broad substrate scope exceptional functional group compatibility, presenting mild expedient synthetic approach. Kinetic studies, including kinetic isotope effect (KIE) Hammett analysis, indicate that activation by Tf2O constitutes rate-limiting step.

Language: Английский

Citations

0
Unveiling the therapeutic potential of medicinal plants in zebrafish caudal fin regeneration and wound healing: a systematic review DOI
Zakariyya Muhammad Bello, Rosy Iara Maciel de Azambuja Ribeiro, Hélio Batista dos Santos

et al.

Fish Physiology and Biochemistry, Journal Year: 2025, Volume and Issue: 51(2)

Published: April 1, 2025

Language: Английский

Citations

0
A comparative study of alkaloid and phenolic compounds in different organs and tissues of Berberis integerrima DOI Creative Commons

Nastaran Zhaleh,

Mohsen Sharifi,

Elaheh Samari

et al.

PLoS ONE, Journal Year: 2025, Volume and Issue: 20(5), P. e0321255 - e0321255

Published: May 19, 2025

Berberis integerrima Bunge is a valuable plant of the Berberidaceae family used in medicine and industry. The properties different parts this vary depend on distribution its secondary metabolites, including alkaloids phenolic compounds. Here, we aimed to evaluate compare phenolics organs tissues B. . Our results showed that highest content compounds was found fruit leaf, while total alkaloid level higher root. In fruit, leaf stem, main acids were caffeic acid, cinnamic acid gallic respectively. contrast, levels ferulic catechin, resveratrol luteolin detected berberine, one most important barberry, root, especially bark tissue. Further experiments aerial root , respectively, are likely responsible for antioxidant capacity these organs. Given high berberine (6.26 mg g -1 Dry Weight), after trying find simple yet effective method extract it 80% ethanol containing 2% acetic at 25 °C with 72 h maceration gave yield. Overall, accumulation patterns metabolites lead their applications.

Language: Английский

Citations

0
Vibrational spectra, molecular structure, electronic, pharmaceutical and bonding nature of (4S)-4-(3,4-dihydroxyphenyl)-1,2,3,4-tetrahydroisoquinoline-7,8-diol - anti hypertension agent DOI Creative Commons

J.D. Marlin Leena,

S. Stella Mary,

P. Sangeetha

et al.

Chemical Physics Impact, Journal Year: 2024, Volume and Issue: 8, P. 100532 - 100532

Published: Feb. 8, 2024

Several factors, including environment, behaviours, and heredity, influence the development of hypertension. The title compound dopamine D1 receptor agonist named (4S)-4-(3,4-dihydroxyphenyl)-1,2,3,4-tetrahydroisoquinoline-7,8-diol (4S4D4T) is one most important neurotransmitters associated with numerous neural disorders. Using DFT quantum chemical simulations, vibrational, electrical, structural possessions heading were predicted. To carry out computational investigations, a highly compatible method entitled B3LYP basis set was adopted. Vibrational Modes functional groups PED values calculated using VEDA software to compute geometric dimensions assign fundamental vibrations. gas solvent phases, MEP differentiates between nucleophilic electrophilic sites creates distribution for charge molecules. observed wavelength (TDSCF) UV-Vis spectra various solvents phases compared. NBO approach provides an understanding electron delocalization that results from hyperconjugation. FUKUI analysis used determine area site reaction. Electron density's topological carried QTAIM theory. ADME (Absorption, Distribution, Metabolism, Excretion) profiles are produced Swiss online tool. In summary, this dissertation offers thorough examination evaluates impact particular pharmaceuticals on solvation enzyme efficiency combination spectral quantitative computing methodologies. Therefore, plans further research can profit immensely by information gathered. protein-ligand docking Auto Dock proteins suggest molecule has pharmaceutical properties against receptors.

Language: Английский

Citations

3
Antibacterial and Antibiofilm Potential of Ethanolic Extracts of Duguetia vallicola (Annonaceae) against in-Hospital Isolates of Pseudomonas aeruginosa DOI Creative Commons
Orfa Inés Contreras Martínez,

Daniela Sierra-Quiroz,

Alberto Angulo Ortíz

et al.

Plants, Journal Year: 2024, Volume and Issue: 13(10), P. 1412 - 1412

Published: May 18, 2024

is an opportunistic pathogen that especially dominant in people with cystic fibrosis; the drug resistance expressed by this and its capacity for adaptation poses a significant challenge to treatment control, thereby increasing morbidity mortality rates globally. In sense, search new alternatives imminent today, products of plant origin being excellent alternative use. The objective research was evaluate antibacterial antibiofilm potential explore possible effect ethanolic extracts from wood bark

Language: Английский

Citations

1