Sumatriptan Mitigates Bleomycin-induced Lung Fibrosis in Male Rats: Involvement of Inflammation, Oxidative Stress and α-SMA

Tissue and Cell, Journal Year: 2024, Volume and Issue: 88, P. 102349 - 102349

Published: March 12, 2024

Language: Английский

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Integrating Metabolomics and Network Analyses to Explore Mechanisms of Geum japonicum var. chinense Against Pulmonary Fibrosis: Involvement of Arachidonic Acid Metabolic Pathway

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(4), P. 1462 - 1462

Published: Feb. 10, 2025

Pulmonary fibrosis (PF) emerges as a significant pulmonary sequelae in the convalescent phase of coronavirus disease 2019 (COVID-19), with current strategies neither specifically preventive nor therapeutic. Geum japonicum var. chinense (GJC) is used traditional Chinese medicine to effectively treat various respiratory conditions. However, protective effects GJC against PF remains unclear. In present study, anti-PF effect aqueous extract was studied using mouse model induced by bleomycin (BLM). To characterize metabolite changes related and reveal therapeutic targets for extract, we performed metabolomic network analysis on mice lungs. Finally, key were then validated Western blotting. alleviated onset progression lung inhibiting inflammatory responses regulating oxidative stress levels. Integrating serum metabolomics analyses showed arachidonic acid (AA) pathway be most important metabolic PF. Further validation AA protein levels rise ALOX5, PTGS2, CYP2C9, PLA2G2A treatment regulated above programming. conclusion, promising botanical drug delay mice. The primary mechanism action associated comprehensive regulation metabolites expression pathway.

Language: Английский

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Plant Polyphenol‐Based Injectable Hydrogels: Advances and Biomedical Applications

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 27, 2025

Plant polyphenol-based hydrogels, known for their biocompatibility and adhesive properties, have emerged as promising materials in biomedical applications. These hydrogels leverage the catechol group's ability to form stable bonds moist environments, similar mussel proteins. This review provides a comprehensive overview of synthesis, adhesion mechanisms, applications, particularly wound healing, tissue regeneration, drug delivery. However, challenges related vivo stability long-term remain critical barriers clinical translation. Future research should focus on enhancing bioactivity, biocompatibility, scalability these while addressing concerns toxicity, immune responses, large-scale manufacturing. Advances artificial intelligence-assisted screening 3D/4D bioprinting are expected accelerate development Furthermore, integration biomimetic designs responsive functionalities, such pH or temperature sensitivity, holds promise further improving therapeutic efficacy. In conclusion, multifunctional plant represents frontier advancing personalized medicine minimally invasive treatments.

Language: Английский

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Bioactivity of autotrophic and mixotrophic Tetraselmis chuii (CCAP 66/21B) extracts against H2O2-mediated stress in A549 cells.

Process Biochemistry, Journal Year: 2025, Volume and Issue: unknown

Published: May 1, 2025

Language: Английский

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