Co‐development of attention deficit hyperactivity disorder and autistic trait trajectories from childhood to early adulthood DOI Creative Commons
Amy Shakeshaft, Jon Heron, Rachel Blakey

et al.

Journal of Child Psychology and Psychiatry, Journal Year: 2023, Volume and Issue: 64(11), P. 1596 - 1607

Published: June 22, 2023

Background Attention deficit hyperactivity disorder (ADHD) and autism, defined as traits or disorders, commonly co‐occur. Developmental trajectories of ADHD autistic both show heterogeneity in onset course, but little is known about how symptom co‐develop into adulthood. Methods Using data from a population cohort, the Avon Longitudinal Study Parents Children, we examined correlations between across development, using Social Communication Disorders Checklist subscale Strengths Difficulties Questionnaire. We modelled joint developmental parent‐reported 4 25 years, then characterised trajectory classes based on sociodemographic, perinatal, psychopathology, cognition social functioning variables tested for associations with neurodevelopmental/psychiatric polygenic scores (PGS). Results Three were identified; typically developing majority low‐stable ADHD‐autistic (87%), male‐predominant subgroup child/adolescent‐declining (6%) late‐emerging (6%). trait greatest young adulthood two nontypically classes. There higher rates emotional conduct problems, low IQ, childhood seizures poor declining compared to class. Emotional, peer problems more prevalent during childhood/adolescent‐declining class other classes, Neurodevelopmental/psychiatric PGS also differed: showed elevated group, group additionally schizophrenia decreased executive function PGS, whereas broad depression PGS. Conclusions Distinct patterns ADHD‐autism co‐development are present development general population, each different characterising factors genetic signatures indexed by

Language: Английский

The role of prefrontal cortex in cognitive control and executive function DOI Creative Commons
Naomi P. Friedman, Trevor W. Robbins

Neuropsychopharmacology, Journal Year: 2021, Volume and Issue: 47(1), P. 72 - 89

Published: Aug. 18, 2021

Concepts of cognitive control (CC) and executive function (EF) are defined in terms their relationships with goal-directed behavior versus habits controlled automatic processing, related to the functions prefrontal cortex (PFC) regions networks. A psychometric approach shows unity diversity CC constructs, 3 components most commonly studied constructs: general or common specific mental set shifting working memory updating. These constructs considered against cellular systems neurobiology PFC what is known its functional neuroanatomical network organization based on lesioning, neurochemical, neuroimaging approaches across species. also context motivation, as "cool" "hot" forms. Its Common component shown be distinct from intelligence (g) closely response inhibition. Impairments possible causes psychiatric symptoms consequences disorders. The factor psychopathology (p) dimensional such impulsivity large scale developmental adult populations considered, well implications for genetic studies RDoC classification.

Language: Английский

Citations

888
Multivariate genome-wide association meta-analysis of over 1 million subjects identifies loci underlying multiple substance use disorders DOI Open Access
Alexander S. Hatoum, Sarah M. C. Colbert, Emma C. Johnson

et al.

Nature Mental Health, Journal Year: 2023, Volume and Issue: 1(3), P. 210 - 223

Published: March 22, 2023

Language: Английский

Citations

130
Cortical gene expression architecture links healthy neurodevelopment to the imaging, transcriptomics and genetics of autism and schizophrenia DOI Creative Commons
Richard Dear, Konrad Wagstyl, Jakob Seidlitz

et al.

Nature Neuroscience, Journal Year: 2024, Volume and Issue: 27(6), P. 1075 - 1086

Published: April 22, 2024

Abstract Human brain organization involves the coordinated expression of thousands genes. For example, first principal component (C1) cortical transcription identifies a hierarchy from sensorimotor to association regions. In this study, optimized processing Allen Brain Atlas revealed two new components gene architecture, C2 and C3, which are distinctively enriched for neuronal, metabolic immune processes, specific cell types cytoarchitectonics, genetic variants associated with intelligence. Using additional datasets (PsychENCODE, Cell BrainSpan), we found that C1–C3 represent generalizable transcriptional programs within cells differentially phased during fetal postnatal development. Autism spectrum disorder schizophrenia were specifically C1/C2 respectively, across neuroimaging, differential genome-wide studies. Evidence converged especially in support C3 as normative program adolescent development, can lead atypical supragranular connectivity people at high risk schizophrenia.

Language: Английский

Citations

20
Twin studies to GWAS: there and back again DOI Creative Commons
Naomi P. Friedman, Marie T. Banich, Matthew C. Keller

et al.

Trends in Cognitive Sciences, Journal Year: 2021, Volume and Issue: 25(10), P. 855 - 869

Published: July 24, 2021

Language: Английский

Citations

66
Multi-ancestral genome-wide association study of clinically defined nicotine dependence reveals strong genetic correlations with other substance use disorders and health-related traits. DOI Creative Commons
Emma C. Johnson, Dongbing Lai, Alex P. Miller

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 31, 2025

ABSTRACT Genetic research on nicotine dependence has utilized multiple assessments that are in weak agreement. We conducted a genome-wide association study of defined using the Diagnostic and Statistical Manual Mental Disorders (DSM-NicDep) 61,861 individuals (47,884 European ancestry, 10,231 African 3,746 East Asian ancestry) compared results to other nicotine-related phenotypes. replicated well-known at CHRNA5 locus (lead SNP: rs147144681, p =1.27E-11 ancestry; lead SNP = rs2036527, 6.49e-13 cross-ancestry analysis). DSM-NicDep showed strong positive genetic correlations with cannabis use disorder, opioid problematic alcohol use, lung cancer, material deprivation, several psychiatric disorders, negative respiratory function educational attainment. A polygenic score predicted DSM-5 tobacco disorder 6 11 individual diagnostic criteria, but none Fagerström Test for Nicotine Dependence (FTND) items, independent NESARC-III sample. In genomic structural equation models, loaded more strongly previously identified factor general addiction liability than did “problematic use” (a combination cigarettes per day by FTND). Finally, was genetically correlated GWAS as electronic health records, suggesting combining wide availability EHR data nuanced criterion-level analyses DSM may produce new insights into genetics this disorder.

Language: Английский

Citations

1
A brain DNA co‐methylation network analysis of psychosis in Alzheimer's disease DOI Creative Commons
Morteza Kouhsar, Luke Weymouth, Adam R. Smith

et al.

Alzheimer s & Dementia, Journal Year: 2025, Volume and Issue: 21(2)

Published: Feb. 1, 2025

Abstract INTRODUCTION The presence of psychosis in Alzheimer's disease (AD) is suggested to be associated with distinct molecular and neuropathological profiles the brain. METHODS We assessed brain DNA methylation AD donors (AD+P) without (AD−P) using EPIC array. Weighted gene correlation network analysis identified modules co‐methylated genes a discovery cohort (PITT‐ADRC: N = 113 AD+P, 40 AD−P), validation an independent (BDR: 79 117 Gene Ontology cell‐type enrichment analysis. Genetic data were integrated identify quantitative trait loci (mQTLs), which co‐localized GWAS for related traits. RESULTS replicated one AD+P module, was enriched synaptic pathways excitatory inhibitory neurons. mQTLs this module variants schizophrenia educational attainment. DISCUSSION This represents largest epigenetic study date, identifying pleiotropic relationships between Highlights prefrontal cortex subjects AD−P. WGCNA six cohort. One mapping

Language: Английский

Citations

1
New Research Perspectives on the Interplay Between Genes and Environment on Executive Function Development DOI Creative Commons
Patrícia Maidana Miguel, Michael J. Meaney, Patrícia Pelufo Silveira

et al.

Biological Psychiatry, Journal Year: 2023, Volume and Issue: 94(2), P. 131 - 141

Published: Jan. 17, 2023

Language: Английский

Citations

16
Better together: novel methods for measuring and modeling development of executive function diversity while accounting for unity DOI Creative Commons
Jessica Wise Younger,

Kristine D. O’Laughlin,

Joaquin A. Anguera

et al.

Frontiers in Human Neuroscience, Journal Year: 2023, Volume and Issue: 17

Published: July 24, 2023

Executive functions (EFs) are linked to positive outcomes across the lifespan. Yet, methodological challenges have prevented precise understanding of developmental trajectory their organization.We introduce novel methods address for both measuring and modeling EFs using an accelerated longitudinal design with a large, diverse sample students in middle childhood (N = 1,286; ages 8 14). We used eight adaptive assessments hypothesized measure three EFs, working memory, context monitoring, interference resolution. deployed equate EF challenge data-driven, network analytic approach reveal evolving diversity while simultaneously accounting unity.Using this paradigm shift brought new precision clarity development these showing tasks organized into stable components by age 10, but refinement composition continues through at least 14.

Language: Английский

Citations

16
Decreased GABA levels of the anterior and posterior cingulate cortex are associated with executive dysfunction in mild cognitive impairment DOI Creative Commons

Xiao-Na Fu,

Mengting Qin,

Xiaoming Liu

et al.

Frontiers in Neuroscience, Journal Year: 2023, Volume and Issue: 17

Published: Aug. 11, 2023

Background and purpose Executive function impairment, a slight but noticeable cognitive deficit in mild impairment (MCI) patients, is influenced by gamma-aminobutyric acid (GABA) levels. Reduced accompanied thinning of the cerebral cortex, which has higher GABA levels than white matter. However, relationships among levels, cortical thickness, executive MCI patients have not yet been elucidated. We investigated patients. Methods In this study, total 36 sex-, age-, education-matched healthy controls (HC) were recruited. But 33 35 HC included because head motion or poor data quality for three one HC. The plus relative to creatine (GABA+/Cr) glutamate-glutamine (Glx/Cr) anterior cingulate cortex (ACC) posterior (PCC) measured using Meshcher-Garwood point resolved spectroscopy (MEGA-PRESS) sequence. Metabolite ratios, their interrelationships determined groups. Results Patients with showed lower GABA+/Cr ACC PCC. Combined GABA+ Glx PCC good diagnostic efficacy (AUC: 0.82). no differences thickness found between two group, level was correlated worse performance on digit span test backward, shape trail test-B. associated Conclusion These results implied that decreased had critical role early diagnosis impaired MCI. Therefore, could be potential marker decline

Language: Английский

Citations

16
De novo variants in GABRA4 are associated with a neurological phenotype including developmental delay, behavioral abnormalities and epilepsy DOI Creative Commons
Samin A. Sajan, Ralph Gradisch, Florian Vogel

et al.

European Journal of Human Genetics, Journal Year: 2024, Volume and Issue: 32(8), P. 912 - 919

Published: April 2, 2024

Nine out of 19 genes encoding GABA

Language: Английский

Citations

6