Nanotechnology in ovarian cancer: Diagnosis and treatment

Life Sciences, Journal Year: 2020, Volume and Issue: 266, P. 118914 - 118914

Published: Dec. 16, 2020

Language: Английский

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Magnetic nanoparticles in developing electrochemical sensors for pharmaceutical and biomedical applications

Talanta, Journal Year: 2021, Volume and Issue: 226, P. 122108 - 122108

Published: Jan. 21, 2021

Language: Английский

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Current advance of nanotechnology in diagnosis and treatment for malignant tumors

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: Aug. 12, 2024

Cancer remains a significant risk to human health. Nanomedicine is new multidisciplinary field that garnering lot of interest and investigation. shows great potential for cancer diagnosis treatment. Specifically engineered nanoparticles can be employed as contrast agents in diagnostics enable high sensitivity high-resolution tumor detection by imaging examinations. Novel approaches labeling are also made possible the use nanoprobes nanobiosensors. The achievement targeted medication delivery therapy accomplished through rational design manufacture nanodrug carriers. Nanoparticles have capability effectively transport medications or gene fragments tissues via passive active targeting processes, thus enhancing treatment outcomes while minimizing harm healthy tissues. Simultaneously, context radiation sensitization photothermal enhance therapeutic efficacy malignant tumors. This review presents literature overview summary how nanotechnology used According oncological diseases originating from different systems body combining pathophysiological features cancers at sites, we most recent developments applications. Finally, briefly discuss prospects challenges cancer.

Language: Английский

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Recent Advances in Electrochemical Immunosensors with Nanomaterial Assistance for Signal Amplification

Biosensors, Journal Year: 2023, Volume and Issue: 13(1), P. 125 - 125

Published: Jan. 11, 2023

Electrochemical immunosensors have attracted immense attention due to the ease of mass electrode production and high compatibility miniature electric reader, which is beneficial for developing point-of-care diagnostic devices. can be divided into label-free label-based sensing strategies equipped with potentiometric, amperometric, voltammetric, or impedimetric detectors. Emerging nanomaterials are frequently used on electrochemical as a highly rough conductive interface electrodes nanocarriers immobilizing capture antibodies, electroactive mediators, catalyzers. Adopting increase immunosensor characteristics lower detection limits better sensitivity. Recent research has shown innovative immobilization procedures meet requirements different immunosensors. This review discusses past five years advances in (metal nanoparticles, metal nanostructures, carbon nanotubes, graphene) integrated immunosensor. Furthermore, new tendency endeavors nanomaterial-based discussed.

Language: Английский

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A novel metal–organic framework based electrochemical immunosensor for the rapid detection of Salmonella typhimurium detection in milk

Food Chemistry, Journal Year: 2024, Volume and Issue: 444, P. 138672 - 138672

Published: Feb. 5, 2024

Language: Английский

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Cascade signal amplifying strategy for ultrasensitive detection of tumor biomarker by DNAzyme cleaving mediated HCR

Sensors and Actuators B Chemical, Journal Year: 2024, Volume and Issue: 420, P. 136466 - 136466

Published: Aug. 14, 2024

Language: Английский

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Electrochemical protein biosensors for disease marker detection: progress and opportunities

Microsystems & Nanoengineering, Journal Year: 2024, Volume and Issue: 10(1)

Published: May 22, 2024

Abstract The development of artificial intelligence-enabled medical health care has created both opportunities and challenges for next-generation biosensor technology. Proteins are extensively used as biological macromolecular markers in disease diagnosis the analysis therapeutic effects. Electrochemical protein biosensors have achieved desirable specificity by using specific antibody–antigen binding principle immunology. However, active centers biomarkers surrounded a peptide matrix, which hinders charge transfer results insufficient sensor sensitivity. Therefore, electrode-modified materials transducer devices been designed to increase sensitivity improve practical application prospects electrochemical sensors. In this review, we summarize recent reports biomarker detection. We highlight latest research on detection cancer, viral infectious diseases, inflammation, other diseases. corresponding sensitive materials, structures, principles associated with such also addressed generally. Finally, present an outlook use marker next few years.

Language: Английский

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Development of a labeled-free and labeled electrochemical aptasensor for the detection of cancer antigen 125 by using magnetic g-C3N4/MoS2 nanocomposite

Sensors and Actuators Reports, Journal Year: 2024, Volume and Issue: 7, P. 100195 - 100195

Published: April 24, 2024

Efficient and timely detection of cancer biomarkers is pivotal for enhancing treatment outcomes mitigating patient mortality. This study addresses the pressing need a swift, accurate, non-invasive method to identify antigen 125 (CA125), vital biomarker in ovarian cancer. Leveraging growing prominence nano-biosensors their high selectivity sensitivity, we present development characterization an innovative electrochemical nano-biosensor. The sensor, featuring aptamer strands immobilized on glassy carbon electrode modified with graphitic nitrides, molybdenum disulfide, magnetic nanoparticles (g-C3N4/MoS2/Fe3O4), demonstrates superior sensitivity accuracy CA125 detection. Utilizing methylene blue labeled ferrocyanide label-free detection, our aptasensor achieves low limit (LOD) at 0.202 U.mL−1 0.215 U.mL−1, respectively, broad range from 2 10 U.mL−1. exhibits pronounced affinity CA125, demonstrating enhanced stability compared other biomolecules. Crucially, evaluation both normal serum samples underscores aptasensor's remarkable performance. These findings not only establish robust foundation future research diagnosis but also highlight potential clinical impact nano-biosensor advancing early methodologies.

Language: Английский

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Green synthesis of metal nanoparticles, characterization, and biosensing applications

Sensors International, Journal Year: 2024, Volume and Issue: 5, P. 100287 - 100287

Published: Jan. 1, 2024

This comprehensive review provides an in-depth overview of the green (biological) synthesis, characterization, and biosensor applications metal nanoparticles (NPs). Because their unique physical chemical properties, high surface area, nanoscale size, NPs have become crucial in various fields. The emphasizes several NPs, particularly silver (AgNPs), gold (AuNPs), platinum (PtNPs), copper (CuNPs), zinc oxide (ZnONPs), iron (FeONPs), palladium (PdNPs). Green synthesis methods, a truly innovative approach, utilize biological substances such as plant extracts, bacteria, fungi, yeast. These methods offer environmentally friendly biologically compatible alternatives to conventional techniques. details these sustainable approaches advantages over traditional methods. natural sources provide abundant, cost-effective, alternative for NP production. importance thorough characterization is also discussed, highlighting techniques transmission electron microscopy (TEM), scanning (SEM), X-ray photoelectron spectroscopy (XPS), Fourier-transform infrared (FTIR), diffraction (XRD), UV–Vis analyze shape, structural integrity, optical behavior NPs. highlights vast potential biosensors, which play critical role medical diagnostics, environmental monitoring, food safety. Incorporating electrochemical, optical, thermometric, piezoelectric biosensors significantly enhances sensitivity specificity, enabling rapid real-time detection analytes.

Language: Английский

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An electrochemical biosensor designed with entropy-driven autocatalytic DNA circuits for sensitive detection of ovarian cancer-derived exosomes

Biosensors and Bioelectronics, Journal Year: 2024, Volume and Issue: 250, P. 116060 - 116060

Published: Jan. 23, 2024

Language: Английский

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