Research Progress in Iron-Based Nanozymes: Catalytic Mechanisms, Classification, and Biomedical Applications

Analytical Chemistry, Journal Year: 2023, Volume and Issue: 95(29), P. 10844 - 10858

Published: July 12, 2023

Natural enzymes are crucial in biological systems and widely used biology medicine, but their disadvantages, such as insufficient stability high-cost, have limited wide application. Since Fe3O4 nanoparticles were found to show peroxidase-like activity, researchers designed developed a growing number of nanozymes that mimic the activity natural enzymes. Nanozymes can compensate for defects higher with lower cost. Iron, nontoxic low-cost transition metal, has been synthesize variety iron-based unique structural physicochemical properties obtain different mimicking catalytic properties. In this perspective, mechanisms, modulation, recent research progress sensing, tumor therapy, antibacterial anti-inflammatory applications systematically presented. The challenges perspectives on development also analyzed discussed.

Language: Английский

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Nanozymes towards Personalized Diagnostics: A Recent Progress in Biosensing

Biosensors, Journal Year: 2023, Volume and Issue: 13(4), P. 461 - 461

Published: April 5, 2023

This review highlights the recent advancements in field of nanozymes and their applications development point-of-care biosensors. The use as enzyme-mimicking components biosensing systems has led to improved performance miniaturization these sensors. unique properties nanozymes, such high stability, robustness, surface tunability, make them an attractive alternative traditional enzymes applications. Researchers have explored a wide range nanomaterials, including metals, metal oxides, metal–organic frameworks, for nanozyme-based Different sensing strategies, colorimetric, fluorescent, electrochemical SERS, been implemented using signal-producing components. Despite numerous advantages, there are also challenges associated with biosensors, stability specificity, which need be addressed wider future biosensors looks promising, potential bring paradigm shift biomolecular sensing. highly specific, multi-enzyme mimicking could lead creation sensitive low-biofouling Integration into diagnostics promises revolutionize healthcare by improving patient outcomes reducing costs while enhancing accuracy sensitivity diagnostic tools.

Language: Английский

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Breaking the pH Limitation of Nanozymes: Mechanisms, Methods, and Applications

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(31)

Published: April 14, 2024

Although nanozymes have drawn great attention over the past decade, activities of peroxidase-like, oxidase-like, and catalase-like are often pH dependent with elusive mechanism, which largely restricts their application. Therefore, a systematical discussion on pH-related catalytic mechanisms together methods to overcome this limitation is in need. In review, various exhibiting pH-dependent collected root causes for dependence comprehensively analyzed. Subsequently, regulatory concepts including environment reconstruction direct activity improvement break restriction summarized. Moreover, applications pH-independent sensing, disease therapy, pollutant degradation overviewed. Finally, current challenges future opportunities development suggested. It anticipated that review will promote further design broaden application range higher efficiency.

Language: Английский

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Nanohybrid SERS substrates intended for food supply chain safety

Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 494, P. 215349 - 215349

Published: July 28, 2023

Language: Английский

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Novel nanozyme Ag/Fe3O4@h-BN with peroxidase-mimicking and oxidase-mimicking activities for dye degradation, As(V) removal and detection

Chemical Engineering Journal, Journal Year: 2023, Volume and Issue: 461, P. 141589 - 141589

Published: Feb. 11, 2023

Language: Английский

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Label‐free surface‐enhanced Raman spectroscopy coupled with machine learning algorithms in pathogenic microbial identification: Current trends, challenges, and perspectives

Deleted Journal, Journal Year: 2024, Volume and Issue: 2(3)

Published: March 5, 2024

Abstract Infectious diseases caused by microbial pathogens remain a primary contributor to global health burdens. Prompt control and effective prevention of these are critical for public medical diagnostics. Conventional detection methods suffer from high complexity, low sensitivity, poor selectivity. Therefore, developing rapid reliable pathogen has become imperative. Surface‐enhanced Raman Spectroscopy (SERS), as an innovative non‐invasive diagnostic technique, holds significant promise in pathogenic microorganism due its rapid, reliable, cost‐effective advantages. This review comprehensively outlines the fundamental theories (RS) with focus on label‐free SERS strategy, reporting latest advancements technique detecting bacteria, viruses, fungi clinical settings. Furthermore, we emphasize application machine learning algorithms spectral analysis. Finally, challenges faced probed, prospective development is discussed.

Language: Английский

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Rational Design of Nanozymes for Engineered Cascade Catalytic Cancer Therapy

Chemical Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 27, 2025

Nanozymes have shown significant potential in cancer catalytic therapy by strategically catalyzing tumor-associated substances and metabolites into toxic reactive oxygen species (ROS) situ, thereby inducing oxidative stress promoting cell death. However, within the complex tumor microenvironment (TME), rational design of nanozymes factors like activity, reaction substrates, TME itself significantly influence efficiency ROS generation. To address these limitations, recent research has focused on exploring that affect activity developing nanozyme-based cascade systems, which can trigger two or more processes tumors, producing therapeutic achieving efficient stable with minimal side effects. This area remarkable progress. Perspective provides a comprehensive overview nanozymes, covering their classification fundamentals. The regulation nanozyme strategies are discussed detail. Furthermore, representative paradigms for successful construction systems treatment summarized focus revealing underlying mechanisms. Finally, we current challenges future prospects development biomedical applications.

Language: Английский

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Advances and Future Trends in Nanozyme-Based SERS Sensors for Food Safety, Environmental and Biomedical Applications

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(2), P. 709 - 709

Published: Jan. 15, 2025

Nanozymes, a kind of nanoparticles with enzyme-mimicking activities, have attracted considerable attention due to their robust catalytic properties, ease preparation, and resistance harsh conditions. By combining nanozymes surface-enhanced Raman spectroscopy (SERS) technology, highly sensitive selective sensors been developed. These are capable detecting wide range analytes, such as foodborne toxins, environmental pollutants, biomedical markers. This review provides an overview recent advancements in the synthesis surface modification nanozymes, highlighting ability mimic multiple enzymes enhance performance. In addition, we explore development applications nanozyme-based SERS food contaminants, The concludes perspectives challenges facing field, involving need for deeper understanding nanozyme principles mechanisms, standardized systems characterization, engineering tailored properties specific applications. Finally, discuss potential integrating various techniques create multi-modal detection platforms, paving way next generation analytical tools fields safety, monitoring, diagnostics.

Language: Английский

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Heterojunction MnO₂-nanosheet-decorated Ag nanowires with enhanced oxidase-like activity for the sensitive dual-mode detection of glutathione

Nanoscale, Journal Year: 2022, Volume and Issue: 14(41), P. 15340 - 15347

Published: Jan. 1, 2022

The biocatalytic design of nanomaterials with enzyme-like activity is considered a reliable and promising toolkit for the generation diagnostic agents in complex biological microenvironments.

Language: Английский

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Interfacial deposition of Ag nanozyme on metal-polyphenol nanosphere for SERS detection of cellular glutathione

Biosensors and Bioelectronics, Journal Year: 2023, Volume and Issue: 228, P. 115200 - 115200

Published: March 9, 2023

Language: Английский

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