Two-dimensional nanomaterials-based optical biosensors empowered by machine learning for intelligent diagnosis DOI

Rongshuang Tang,

Jianyu Yang,

Changzhuan Shao

et al.

TrAC Trends in Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 118162 - 118162

Published: Feb. 1, 2025

Language: Английский

Machine learning assisted multi-signal nanozyme sensor array for the antioxidant phenolic compounds intelligent recognition DOI

Jiahao Xu,

Yu Wang, Ziyuan Li

et al.

Food Chemistry, Journal Year: 2025, Volume and Issue: 471, P. 142826 - 142826

Published: Jan. 7, 2025

Language: Английский

Citations

3
Machine learning-assisted carbon dots synthesis and analysis: state of the art and future directions DOI
Fanyong Yan, Ruixue Bai, Juanru Huang

et al.

TrAC Trends in Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 118141 - 118141

Published: Jan. 1, 2025

Language: Английский

Citations

2
Machine learning in analytical chemistry: From synthesis of nanostructures to their applications in luminescence sensing DOI

Maryam Mousavizadegan,

Ali Firoozbakhtian, Morteza Hosseini

et al.

TrAC Trends in Analytical Chemistry, Journal Year: 2023, Volume and Issue: 167, P. 117216 - 117216

Published: Aug. 3, 2023

Language: Английский

Citations

42
Signal Amplification Strategy Design in Nanozyme‐Based Biosensors for Highly Sensitive Detection of Trace Biomarkers DOI
Mengting Wang, Hongxing Liu, Kelong Fan

et al.

Small Methods, Journal Year: 2023, Volume and Issue: 7(11)

Published: Oct. 10, 2023

Abstract Nanozymes show great promise in enhancing disease biomarker sensing by leveraging their physicochemical properties and enzymatic activities. These qualities facilitate signal amplification matrix effects reduction, thus boosting performance. In this review, recent studies from the last five years, concentrating on detection improvement through nanozyme‐based biosensing are examined. This enhancement primarily involves modulations of size, morphology, doping, modification, electromagnetic mechanisms, electron conduction efficiency, surface plasmon resonance nanozymes for increased sensitivity. addition, a comprehensive description synthesis tuning strategies employed has been provided. includes detailed elucidation catalytic mechanisms alignment with fundamental principles enhanced technology, accompanied presentation quantitatively analyzed results. Moreover, diverse applications strip sensing, colorimetric electrochemical surface‐enhanced Raman scattering have outlined. Additionally, limitations, challenges, corresponding recommendations concerning application summarized. Furthermore, insights offered into future development outlook biosensing. review aims to serve not only as reference sensitivity biosensors but also catalyst exploring nanozyme broader

Language: Английский

Citations

37
Dual enzyme induced colorimetric sensor for simultaneous identifying multiple pathogens DOI
Weiwei Chen, Ming Li, Zikang Chen

et al.

Biosensors and Bioelectronics, Journal Year: 2023, Volume and Issue: 234, P. 115344 - 115344

Published: April 23, 2023

Language: Английский

Citations

31
A bimetallic peroxidase-mimicking nanozyme with antifouling property for construction of sensor array to identify phosphoproteins and diagnose cancers DOI
Han Lv, Xinxin Ma, Guofang Zhang

et al.

Biosensors and Bioelectronics, Journal Year: 2024, Volume and Issue: 258, P. 116370 - 116370

Published: May 6, 2024

Language: Английский

Citations

17
Enhanced “Electronic Tongue” for Dental Bacterial Discrimination and Elimination Based on a DNA-Encoded Nanozyme Sensor Array DOI Creative Commons
Ling Zhang,

Zhengnan Qi,

Yichi Yang

et al.

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(9), P. 11228 - 11238

Published: Feb. 25, 2024

Bacterial infections are the second leading cause of death around world, especially those caused by delayed treatment and misdiagnosis. Therefore, rapid discrimination effective elimination multiple bacteria great importance for improving survival rate in clinic. Herein, a novel colorimetric sensor array bacterial is constructed using programmable DNA-encoded iron oxide nanoparticles (IONPs) as sensing elements. Utilizing differential interactions on IONPs, 11 kinds dental 6 proteins have been successfully identified linear discriminant analysis (LDA). Moreover, developed system also performs well quantitative determination individual identification mixtures. More importantly, practicability this strategy further verified precise differentiation blind artificial saliva samples. Furthermore, used efficiently killing bacteria, demonstrating potential clinical prophylaxis therapy.

Language: Английский

Citations

15
Cascade reaction triggered colorimetric array for identification of organophosphorus pesticides congeners DOI
Zikang Chen, Ming Li, Weiwei Chen

et al.

Biosensors and Bioelectronics, Journal Year: 2024, Volume and Issue: 253, P. 116143 - 116143

Published: Feb. 24, 2024

Language: Английский

Citations

14
Machine learning in nanozymes: from design to application DOI

Yubo Gao,

Zhicheng Zhu, Zhen Chen

et al.

Biomaterials Science, Journal Year: 2024, Volume and Issue: 12(9), P. 2229 - 2243

Published: Jan. 1, 2024

Nanozymes, a distinctive class of nanomaterials with enzyme-like activity and kinetics akin to enzyme-catalysed reactions, present several advantages over natural enzymes, including cost-effectiveness, heightened stability, adjustable activity.

Language: Английский

Citations

14
Nanozyme-Inhibited SERS Multichannel Paper-Based Sensor Array for the Quantification and Identification of Biothiols and Cancer Cells Based on Three Ag-Based Nanomaterials DOI
Linjie Wang, Yixin Chen,

Yang Ji

et al.

Analytical Chemistry, Journal Year: 2024, Volume and Issue: 96(28), P. 11353 - 11365

Published: July 6, 2024

Biothiols play essential roles in maintaining normal physiological functions, resisting oxidative stress, and protecting cell health. Establishing an effective reliable sensor array for the accurate quantification discrimination of diverse biothiols is extremely meaningful. In this work, Ag/Mn3O4, Ag3PO4, Ag3Cit with excellent oxidase-mimetic activity surface-enhanced Raman scattering (SERS)-enhanced features have been prepared loaded onto Whatman filter paper (WFP) to build SERS chips as three sensing channels, which can induce 3,3′,5,5′-tetramethylbenzidine (TMB) oxidation SERS-active reporters (TMBox) concurrently generate prominent signals. Nevertheless, addition suppress conversion from TMB TMBox, cause reduction signal TMBox. Interestingly, each channel different TMBox signals' variations due differences inhibition abilities exclusive properties chip, be plotted specific fingerprint patterns biothiol further translated into intuitive two-dimensional (2D) clustering profiles through linear discriminant analysis (LDA) hierarchical cluster (HCA) techniques precise identification these six minimum concentration 1 μM. More importantly, exploited intracellular glutathione (GSH), differentiate between cancer cells based on GSH contents even identify types tumor cells, demonstrating its powerful application prospects disease diagnosis.

Language: Английский

Citations

14