Vaccines,
Journal Year:
2022,
Volume and Issue:
10(12), P. 2100 - 2100
Published: Dec. 8, 2022
There
is
a
growing
risk
of
antimicrobial
resistance
(AMR)
having
an
adverse
effect
on
the
healthcare
system,
which
results
in
higher
costs,
failed
treatments
and
death
rate.
A
quick
diagnostic
test
that
can
spot
infections
resistant
to
antibiotics
essential
for
stewardship
so
physicians
other
professionals
begin
treatment
as
soon
possible.
Since
development
last
two
decades,
traditional,
standard
have
treat
healthcare-associated
(HAIs).
These
led
variety
cutting-edge
alternative
methods
combat
multidrug-resistant
pathogens
settings.
Here,
we
provide
overview
AMR
well
technologies
being
developed
prevent,
diagnose,
control
As
result
better
cleaning
hygiene
practices,
bacteria
be
reduced,
new,
quick,
accurate
instruments
diagnosing
HAIs
must
developed.
In
addition,
need
explore
new
therapeutic
approaches
diseases
caused
by
bacteria.
conclusion,
current
infection
will
crucial
managing
effectively.
vaccination,
antibiotic
usage
decrease
mechanisms
not
develop.
Chemical Society Reviews,
Journal Year:
2024,
Volume and Issue:
53(18), P. 8957 - 8979
Published: Jan. 1, 2024
Surface
enhanced
Raman
spectroscopy
(SERS)
is
meeting
the
requirements
in
biomedical
science
being
a
highly
sensitive
and
specific
analytical
tool.
By
employing
portable
systems
combination
with
customized
sample
pre-treatment,
point-of-care-testing
(POCT)
becomes
feasible.
Powerful
SERS-active
sensing
surfaces
high
stability
modification
layers
if
required
are
available
for
testing
application
complex
biological
matrices
such
as
body
fluids,
cells
or
tissues.
This
review
summarizes
current
state
collection
pretreatment
SERS
detection
protocols,
schemes,
ACS Sensors,
Journal Year:
2024,
Volume and Issue:
9(9), P. 4469 - 4494
Published: Sept. 9, 2024
Lung
cancer
remains
a
global
health
concern,
demanding
the
development
of
noninvasive,
prompt,
selective,
and
point-of-care
diagnostic
tools.
Correspondingly,
breath
analysis
using
nanobiosensors
has
emerged
as
promising
noninvasive
nose-on-chip
technique
for
early
detection
lung
through
monitoring
diversified
biomarkers
such
volatile
organic
compounds/gases
in
exhaled
breath.
This
comprehensive
review
summarizes
state-of-the-art
breath-based
diagnosis
employing
chemiresistive-module
supported
by
theoretical
findings.
It
unveils
fundamental
mechanisms
biological
basis
biomarker
generation
associated
with
cancer,
technological
advancements,
clinical
implementation
nanobiosensor-based
analysis.
explores
merits,
challenges,
potential
alternate
solutions
implementing
these
settings,
including
standardization,
biocompatibility/toxicity
analysis,
green
sustainable
technologies,
life-cycle
assessment,
scheming
regulatory
modalities.
highlights
nanobiosensors'
role
facilitating
precise,
real-time,
on-site
leading
to
improved
patient
outcomes,
enhanced
management,
remote
personalized
monitoring.
Additionally,
integrating
biosensors
artificial
intelligence,
machine
learning,
Internet-of-things,
bioinformatics,
omics
technologies
is
discussed,
providing
insights
into
prospects
intelligent
sniffing
nanobiosensors.
Overall,
this
consolidates
knowledge
on
breathomic
biosensor-based
screening,
shedding
light
its
significance
applications
advancing
medical
diagnostics
reduce
burden
hospitals
save
human
lives.
Biosensors,
Journal Year:
2023,
Volume and Issue:
13(3), P. 350 - 350
Published: March 6, 2023
There
are
various
pathogenic
bacteria
in
the
surrounding
living
environment,
which
not
only
pose
a
great
threat
to
human
health
but
also
bring
huge
losses
economic
development.
Conventional
methods
for
detection
usually
time-consuming,
complicated
and
labor-intensive,
cannot
meet
growing
demands
on-site
rapid
analyses.
Sensitive,
effective
necessary
environmental
monitoring,
food
safety
infectious
diagnosis.
Recently,
benefiting
from
its
advantages
of
rapidity
high
sensitivity,
surface-enhanced
Raman
spectroscopy
(SERS)
has
attracted
significant
attention
field
identification
as
well
drug
susceptibility
testing.
Here,
we
comprehensively
reviewed
latest
advances
SERS
technology
analysis.
Firstly,
mechanism
fabrication
substrate
were
briefly
introduced.
Secondly,
label-free
applied
species
was
summarized
detail.
Thirdly,
tags
high-sensitivity
discussed.
Moreover,
emphasized
application
prospects
microfluidic
chips
antimicrobial
testing
(AST).
In
end,
gave
an
outlook
on
future
development
trends
point-of-care
diagnoses
bacterial
infections.
Journal of Pharmaceutical Analysis,
Journal Year:
2023,
Volume and Issue:
13(12), P. 1429 - 1451
Published: Aug. 24, 2023
With
the
continuous
discovery
and
research
of
predictive
cancer-related
biomarkers,
liquid
biopsy
shows
great
potential
in
cancer
diagnosis.
Surface-enhanced
Raman
scattering
(SERS)
microfluidic
technology
have
received
much
attention
among
various
biomarker
detection
methods.
The
former
has
ultrahigh
sensitivity
can
provide
a
unique
fingerprint.
In
contrast,
latter
characteristics
miniaturization
integration,
which
realize
accurate
control
samples
high-throughput
through
design.
Both
for
point-of-care
testing
(POCT),
their
combination
(lab-on-a-chip
SERS
(LoC-SERS))
good
compatibility.
this
paper,
basic
situation
circulating
proteins,
tumor
cells,
exosomes,
DNA
(ctDNA),
microRNA
(miRNA)
diagnosis
cancers
is
reviewed,
these
biomarkers
by
LoC-SERS
platform
recent
years
described
detail.
At
same
time,
challenges
future
development
are
discussed
at
end
review.
Summarizing
current
expected
to
reference
scholars
engaged
related
work
interested
field.
Food Frontiers,
Journal Year:
2024,
Volume and Issue:
5(2), P. 392 - 419
Published: Jan. 10, 2024
Abstract
Raman
spectroscopy
is
a
nondestructive
and
highly
effective
technique
for
analyzing
biological
tissues
diagnosing
diseases
by
providing
detailed
spectral
information
about
the
specific
molecular
structures
of
substances.
Its
efficacy
in
these
applications
has
been
widely
recognized,
making
it
powerful
tool
field.
This
article
presents
comprehensive
overview
latest
developments
its
wide‐ranging
diagnosis
critical
diseases,
such
as
cancer,
infections,
neurodegenerative
predicting
surgical
outcomes.
It
highlights
significant
contributions
areas,
shedding
light
on
potential
valuable
diagnostic
tool.
delves
into
advancements
biomedical
sciences,
with
focus
state‐of‐the‐art
techniques
surface‐enhanced
spectroscopy,
resonance
tip‐enhanced
spectroscopy.
These
have
shown
great
various
within
The
explores
their
use
ex
vivo
medical
diagnosis,
covering
topics
sample
collection,
data
processing,
successful
establishment
correlations
between
spectra
biochemical
diseases.
Furthermore,
discusses
limitations
current
research
offers
insights
future
directions
further
exploration
field
sciences.
International Journal of Nanomedicine,
Journal Year:
2024,
Volume and Issue:
Volume 19, P. 389 - 401
Published: Jan. 1, 2024
Introduction:
Ultrasensitive
bacterial
detection
methods
are
crucial
to
ensuring
accurate
diagnosis
and
effective
clinical
monitoring,
given
the
significant
threat
infections
pose
human
health.
The
aim
of
this
study
is
develop
a
biosensor
with
capabilities
for
broad-spectrum
detection,
rapid
processing,
cost-effectiveness.
Methods:
A
magnetically-assisted
SERS
was
designed,
employing
wheat
germ
agglutinin
(WGA)
recognition
antibodies
specific
capture.
Gold
nanostars
(AuNSs)
were
sequentially
modified
Raman
reporter
molecules
WGA,
creating
versatile
tag
high
affinity
diverse
range
bacteria.
Staphylococcus
aureus
(
S.
)
Pseudomonas
aeruginosa
P.
antibody-modified
Fe
3
O
4
magnetic
gold
nanoparticles
(MGNPs)
served
as
capture
probes.
Target
bacteria
captured
by
MGNPs
combined
tags,
forming
"sandwich"
composite
structure
detection.
Results:
AuNSs,
core
size
65
nm,
exhibited
excellent
storage
stability
(RSD=5.6%)
demonstrated
superior
enhancement
compared
colloidal
nanoparticles.
Efficient
binding
resulted
in
efficiencies
89.13%
85.31%,
respectively.
Under
optimized
conditions,
developed
assay
achieved
limit
(LOD)
7
CFU/mL
5
.
concentration
(10–
10
6
CFU/mL)
showed
strong
linear
correlation
intensity
at
1331
cm
−
1
Additionally,
recoveries
(84.8%
-
118.0%)
low
RSD
(6.21%
11.42%)
observed
spiked
urine
samples.
Conclusion:
This
introduces
simple
innovative
sensitive
quantitative
or
,
utilizing
WGA
antibodies.
enhances
type
biosensor,
offering
novel
platform
timely
infections.
Keywords:
SERS,
pathogenic
bacteria,
dual-recognition
