Biosensors and Bioelectronics, Journal Year: 2024, Volume and Issue: 267, P. 116805 - 116805
Published: Sept. 20, 2024
Language: Английский
Sensors, Journal Year: 2024, Volume and Issue: 24(16), P. 5143 - 5143
Published: Aug. 8, 2024
This comprehensive review delves into the forefront of biosensor technologies and their critical roles in disease biomarker detection therapeutic drug monitoring. It provides an in-depth analysis various types applications, including enzymatic sensors, immunosensors, DNA elucidating mechanisms specific healthcare applications. The highlights recent innovations such as integrating nanotechnology, developing wearable devices, trends miniaturisation, showcasing transformative potential healthcare. In addition, it addresses significant sensitivity, specificity, reproducibility, data security challenges, proposing strategic solutions to overcome these obstacles. is envisaged that will inform decision-making, drive technological innovation, enhance global outcomes by synthesising multidisciplinary insights.
Language: Английский
Citations
22
Chemical Reviews, Journal Year: 2024, Volume and Issue: 124(20), P. 11242 - 11347
Published: Oct. 9, 2024
Biopsy, including tissue and liquid biopsy, offers comprehensive real-time physiological pathological information for disease detection, diagnosis, monitoring. Fluorescent probes are frequently selected to obtain adequate on processes in a rapid minimally invasive manner based their advantages biopsy. However, conventional fluorescent have been found show aggregation-caused quenching (ACQ) properties, impeding greater progresses this area. Since the discovery of aggregation-induced emission luminogen (AIEgen) promoted advancements molecular bionanomaterials owing unique high quantum yield (QY) signal-to-noise ratio (SNR),
Language: Английский
Citations
18
TrAC Trends in Analytical Chemistry, Journal Year: 2023, Volume and Issue: 167, P. 117252 - 117252
Published: Aug. 25, 2023
Fluorescent biosensors are powerful analytical tools that have been widely employed in a range of vitro and vivo biomedical applications. However, traditional fluorophores exhibit aggregation-caused quenching (ACQs) effects hinder their use the development more advanced fluorescent biosensors. The discovery by Prof. Ben Zhong Tang aggregation-induced emission (AIE) luminogen (AIEgen) opposite to those impacted ACQ provides unique opportunities for design novel "turn-on" These AIEgens thus attracted extensive interest from researchers seeking leverage properties produce effective biosensing molecules, strategies, associated A wide array with structures, functional groups, optical properties, applications developed recent years. In present review, we provide comprehensive overview advances field AIEgen-based biosensor discuss future clinical prospects these molecules. Through discussions, hope strong evidence-based foundation further efforts aimed at producing increasingly
Language: Английский
Citations
26
Sensors, Journal Year: 2023, Volume and Issue: 23(15), P. 6808 - 6808
Published: July 30, 2023
As a new type of one-dimensional semiconductor nanometer material, silicon nanowires (SiNWs) possess good application prospects in the field biomedical sensing. SiNWs have excellent electronic properties for improving detection sensitivity biosensors. The combination and effect transistors (FETs) formed one special biosensor with high target selectivity real-time label-free. Recently, SiNW-FETs received more attention fields detection. Here, we give critical review progress SiNW-FETs, particular, about reversible surface modification methods. Moreover, summarized applications DNA, protein, microbial We also discuss related working principle technical approaches. Our provides an extensive discussion studying challenges future development SiNW-FETs.
Language: Английский
Citations
24
Chem, Journal Year: 2024, Volume and Issue: 10(7), P. 2031 - 2073
Published: July 1, 2024
Language: Английский
Citations
14
Chemical Communications, Journal Year: 2024, Volume and Issue: 60(22), P. 2994 - 3007
Published: Jan. 1, 2024
Mitochondria, as essential organelles in cells, play a crucial role cellular growth and apoptosis. Monitoring mitochondria is of great importance, mitochondrial dysfunction often considered hallmark event cell Traditional fluorescence probes used for imaging sensing are mostly intensity-based susceptible to factors such concentration, the probe environment, intensity. Probes based on resonance energy transfer (FRET) can effectively overcome external interference achieve high-contrast well quantitative monitoring microenvironments. This review focuses recent advances application FRET-based structure microenvironment sensing.
Language: Английский
Citations
8
Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 67(15), P. 12571 - 12600
Published: July 23, 2024
Targeting dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) has been verified to regulate the progression of tau pathology as a promising treatment for Alzheimer's disease (AD), while research progress on DYRK1A inhibitors seemed be in bottleneck period. In this work, we identified
Language: Английский
Citations
7
Biosensors and Bioelectronics, Journal Year: 2024, Volume and Issue: 250, P. 116082 - 116082
Published: Jan. 29, 2024
Language: Английский
Citations
6
ACS Sensors, Journal Year: 2024, Volume and Issue: 9(4), P. 1749 - 1755
Published: April 8, 2024
Aggregation-induced emission (AIE) has offered a promising approach for developing low-background fluorescent methods; however, its applications often suffer from complex probe synthesis and poor biocompatibility. Herein, novel AIE biosensing method kanamycin antibiotic assays was developed by utilizing DNA network nanostructure assembled an aptamer recognition reaction to capture large number of tetraphenylethylene fluorogen-labeled signal (DTPE) probes. Due the excellent hydrophilicity oligonucleotides, DTPE exhibited water solubility without obvious background emission. Based on ingenious nucleotide design, abundance G-quadruplex blocks neighboring captured were formed nanostructure. Because greatly restricted free motion this unique nanostructure, strong fluorescence response produced construct transduction strategy. Together with target recycling rolling circle amplification-based cascade nucleic acid amplification, wide linear range 75 fg mL–1 1 ng detection limit down 24 mL–1. The analytical performance effective manipulation improvement over previous approaches determine potential various applications.
Language: Английский
Citations
6
ACS Nano, Journal Year: 2024, Volume and Issue: 18(24), P. 15935 - 15949
Published: June 4, 2024
Monitoring T lymphocyte differentiation is essential for understanding cell fate regulation and advancing adoptive immunotherapy. However, current biomarker analysis methods necessitate lysis, leading to source depletion. Intracellular pH (pHi) can be affected by the presence of lactic acid (LA), a metabolic mediator activity such as glycolysis during activation; therefore, it potentially good state. In this work, dual emitting enhancement-based nanoprobe, namely, AIEgen@F127-AptCD8, was developed accurately detect pHi cells "read" process. The nanocore probe comprises pair AIE dyes, TPE-AMC (pH-sensitive moiety) TPE-TCF, that form donor–acceptor sensitive detection enhancement analysis. nanoprobe exhibits distinctly narrow range values (from 6.0 7.4) precisely distinguish differentiated lymphocytes from naïve ones based on their distinct profiles. Activated CD8+ demonstrate lower (6.49 ± 0.09) than (7.26 0.11); Jurkat exhibit (6.43 0.06) compared nonactivated (7.29 7 days post-activation. glycolytic product profiles in strongly correlate with profiles, ascertaining reliability probing predicting states. specificity dynamic capabilities make promising tool indirectly noninvasively monitoring activation
Language: Английский
Citations
6