Recent Advances in 3D Printing of Smart Scaffolds for Bone Tissue Engineering and Regeneration

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(34)

Published: June 11, 2024

The repair and functional reconstruction of bone defects resulting from severe trauma, surgical resection, degenerative disease, congenital malformation pose significant clinical challenges. Bone tissue engineering (BTE) holds immense potential in treating these defects, without incurring prevalent complications associated with conventional autologous or allogeneic grafts. 3D printing technology enables control over architectural structures at multiple length scales has been extensively employed to process biomimetic scaffolds for BTE. In contrast inert grafts, next-generation smart possess a remarkable ability mimic the dynamic nature native extracellular matrix (ECM), thereby facilitating regeneration. Additionally, they can generate tailored controllable therapeutic effects, such as antibacterial antitumor properties, response exogenous and/or endogenous stimuli. This review provides comprehensive assessment progress 3D-printed BTE applications. It begins an introduction physiology, followed by overview technologies utilized scaffolds. Notable advances various stimuli-responsive strategies, efficacy, applications are discussed. Finally, highlights existing challenges development implementation scaffolds, well emerging this field.

Language: Английский

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3D Bioprinting of Natural Materials and Their AI-Enhanced Printability: A Review

Bioprinting, Journal Year: 2025, Volume and Issue: unknown, P. e00385 - e00385

Published: Jan. 1, 2025

Language: Английский

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A review on microbes mediated resource recovery and bioplastic (polyhydroxyalkanoates) production from wastewater

Microbial Cell Factories, Journal Year: 2024, Volume and Issue: 23(1)

Published: July 1, 2024

Abstract Background Plastic is widely utilized in packaging, frameworks, and as coverings material. Its overconsumption slow degradation, pose threats to ecosystems due its toxic effects. While polyhydroxyalkanoates (PHA) offer a sustainable alternative petroleum-based plastics, their production costs present significant obstacles global adoption. On the other side, multitude of household industrial activities generate substantial volumes wastewater containing both organic inorganic contaminants. This not only poses threat but also presents opportunities get benefits from circular economy. Main body abstract Production bioplastics may be improved by using nutrients minerals feedstock for microbial fermentation. Strategies like feast-famine culture, mixed-consortia integrated processes have been developed PHA highly polluted with high loads. Various process parameters loading rate, content (volatile fatty acids), dissolved oxygen, operating pH, temperature critical roles accumulation biomass. Research advances are going on downstream recovery utilizing combination physical chemical (halogenated solvents, surfactants, green solvents) methods. review highlights recent developments upcycling resources into PHA, encompassing various strategies, processing methodologies, techno-economic analyses. Short conclusion Organic carbon nitrogen promising, cost-effective source producing bioplastic. Previous attempts focused enhancing productivity through optimizing culture systems growth conditions. However, despite technological progress, challenges persist, such low productivity, intricate processing, scalability issues, properties resulting PHA. Graphical

Language: Английский

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Bioplastic packaging for fresh meat and fish: Current status and future direction on mitigating food and packaging waste

Trends in Food Science & Technology, Journal Year: 2024, Volume and Issue: 152, P. 104660 - 104660

Published: Aug. 8, 2024

This work evaluates the preparedness of packaging industry towards more circular, sustainable solutions for fresh meat and fish. The term bioplastic is ill-defined, creating confusion between all stakeholders in value chain. implementation as food contact material will only occur when there are demonstrated that can equally or better protect fish from spoilage, compared to conventional plastic. Price, supply chain availability, machinability, safety also be key shift fossil bioplastic. application at its infancy. In this work, a multidisciplinary approach was employed highlight need holistic eco-design minimizes waste, due high environmental footprint meat. Although bioplastics positively perceived by end-users, including consumers, widespread their market implementation. Their sorting end-of-life major challenges. chains underdeveloped, terms costs, scale-up, sorting, recycling even most promising materials. Most still do not meet specified technological functionalities required substitute fossil-fuel counterparts. For appropriate eco-design, it important quantify using life cycle assessment considering material-food unit importantly, ensure safety, demonstrating absence migration harmful substances packaging, especially derived waste byproducts. development active intelligent increase shelf products add significant food-packaging unit.

Language: Английский

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PHA Microplastic Aging Decreases N₂O Sink Capacity: Released γ-Butyrolactone Decouples Denitrifying Electron Transfer and Oxidative Phosphorylation

Environmental Science & Technology, Journal Year: 2025, Volume and Issue: 59(2), P. 1298 - 1307

Published: Jan. 9, 2025

Bacterial denitrification is a main pathway for soil N2O sinks, which crucial assessing and controlling emissions. Biobased polyhydroxyalkanoate (PHA) microplastic particles (MPs) degrade slowly in conventional environments, remaining inert extended periods. However, the impacts of PHA aging on bacterial sink capacity before degradation remain poorly understood. Here, model strain Paracoccus denitrificans was exposed to 0.05-0.5% (w/w) virgin aged MPs. Although no significant changes molecular weights were observed, MPs hindered cell growth reduction rates, leading surge 1H NMR spectroscopy UPLC-QTOF-MS analysis identified γ-butyrolactone as key component released from Metabolic verifications at cellular level confirmed its inhibition ATP synthesis. The that protonated hydrolyzed spontaneously periplasm would compete protons with ATPase destroy coupling between denitrifying electron transfer oxidative phosphorylation. Consequently, energy-deficient cells reduced supply reduction, did not contribute energy conservation. This work unveils novel mechanism by impairs highlights need consider environmental risks posed biobased aging.

Language: Английский

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Exploiting Latent Microbial Potential for Producing Polyhydroxyalkanoates: A Holistic Approach

Environmental Research, Journal Year: 2025, Volume and Issue: unknown, P. 120895 - 120895

Published: Jan. 1, 2025

Language: Английский

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Microalgae to bioplastics – routes and challenges

Cleaner Engineering and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 100922 - 100922

Published: Feb. 1, 2025

Language: Английский

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Exploring biotechnology for plastic recycling, degradation and upcycling for a sustainable future

Biotechnology Advances, Journal Year: 2025, Volume and Issue: unknown, P. 108544 - 108544

Published: Feb. 1, 2025

Language: Английский

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Green Synthesis of Polyhydroxyalkanoates (PHAs): Agro-industrial Waste as Feedstock

Published: Jan. 1, 2025

Language: Английский

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Microplastics in the Marine Environment: Challenges and the Shift Towards Sustainable Plastics and Plasticizers

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: unknown, P. 137945 - 137945

Published: March 1, 2025

Language: Английский

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