The Impact of Physical Exercise on Oxidative and Nitrosative Stress: Balancing the Benefits and Risks

Published: April 11, 2024

This general review assesses the impact of physical exercise on oxidative and nitrosative stress counteractive role antioxidants, drawing from a systematic literature search up to March 2024 in databases like PubMed Web Science. The highlights studies effect production reactive oxygen species (ROS) nitrogen (RNS) antioxidant responses both human animal models based rigorous inclusion exclusion criteria. Due variety types participants' characteristics, narrative synthesis approach was adopted. findings indicate that moderate boosts defenses, known as hormesis, whereas excessive activity may increase damage. also explores complex effects supplementation, revealing while natural dietary antioxidants support health, high-dose supplements could potentially hinder positive adaptations exercise. Recommendations for athletes active population highlight importance balancing intake optimize health benefits. concludes with call more detailed research tailored nutrition plans dissect these intricate relationships further.

Language: Английский

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Combined effects of natural products and exercise on apoptosis pathways in obesity-related skeletal muscle dysfunction

APOPTOSIS, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 20, 2025

Language: Английский

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Research Progress on the Effect and Mechanism of Exercise Intervention on Sarcopenia Obesity

Clinical Interventions in Aging, Journal Year: 2024, Volume and Issue: Volume 19, P. 1407 - 1422

Published: Aug. 1, 2024

With the increasingly severe situation of obesity and population aging, there is growing concern about sarcopenia (SO). SO refers to coexistence sarcopenia, which imposes a heavier burden on individuals society compared or alone. Therefore, comprehending pathogenesis implementing effective clinical interventions are vital for its prevention treatment. This review uses comprehensive literature search analysis PubMed, Web Science, CNKI databases, with terms including "Sarcopenic obesity", "exercise", "cytokines", "inflammation", "mitochondrial quality control", "microRNA", covering relevant studies published up July 2024. The results indicate that complex, involving mechanisms like age-related changes in body composition, hormonal alterations, inflammation, mitochondrial dysfunction, genetic epigenetic factors. Regarding exercise SO, aerobic can reduce fat mass, resistance increase skeletal muscle mass strength, combined achieve both, making it optimal intervention SO. potential by may prevent treat include regulating cytokine secretion, inhibiting inflammatory pathways, improving quality, mediating microRNA expression. emphasizes effectiveness mitigating sarcopenic through multifactorial mechanistic insights into exercise's therapeutic effects. Understanding these informs targeted strategies aimed at alleviating societal individual burdens associated

Language: Английский

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MCC950 Ameliorates Diabetic Muscle Atrophy in Mice by Inhibition of Pyroptosis and Its Synergistic Effect with Aerobic Exercise

Molecules, Journal Year: 2024, Volume and Issue: 29(3), P. 712 - 712

Published: Feb. 4, 2024

Diabetic muscle atrophy is an inflammation-related complication of type-2 diabetes mellitus (T2DM). Even though regular exercise prevents further deterioration atrophic status, there no effective mediator available for treatment and the underlying cellular mechanisms are less explored. In this study, we investigated therapeutic potential MCC950, a specific, small-molecule inhibitor NLRP3, to treat pyroptosis diabetic in mice. Furthermore, used MCC950 intervene protective effects aerobic against Blood gastrocnemius (GAS) samples were collected after 12 weeks intervention state was assessed. We initially corroborated phenotype db/db mice (D) by comparison with control m/m (W) examining parameters such as fasting blood glucose (D vs. W: 24.47 ± 0.45 mmol L−1 4.26 0.6 L−1, p < 0.05), grip strength 166.87 15.19 g 191.76 14.13 g, time 1082.38 104.67 s 1716 168.55 s, 0.05) speed exhaustion 24.25 2.12 m min−1 34.75 2.66 min−1, GAS wet weight 0.07 0.01 0.13 ratio body 0.18 0.01% 0.54 0.02%, fiber cross-sectional area (FCSA) 1875 368.19 µm2 2747.83 406.44 µm2, 0.05). found that both (10 mg kg−1) improved had deteriorated mice, inhibited serum inflammatory markers significantly attenuated GAS. addition, combined (DEI) exhibited improvement uptake capacity performance. This also FCSA indicated Laminin immunofluorescence compared group alone (DI) (DEI DI: 2597 310.97 1974.67 326.15 or only (DE) DE: 2006.33 263.468 Intriguingly, combination reduced NLRP3-mediated factors cleaved-Caspase-1, GSDMD-N prevented apoptosis These findings first demonstrate targeting improves homeostasis function. report inhibiting can enhance beneficial on atrophy. Since T2DM age-related diseases, young current study do not seem fully reflect characteristics Considering fragile nature complete implementation intervention, relatively thoroughly confirmed. Taken together, comprehensively effect mass, performance, well synergistic therefore providing novel strategy disease.

Language: Английский

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Exploring the Metabolic Link Between Malnutrition and Sarcopenia in Gastrointestinal Malignancies

Annals of Nutrition and Metabolism, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 5

Published: Jan. 14, 2025

Dear Editor

Language: Английский

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Exercise Attenuates Skeletal Muscle Atrophy in Senescent SAMP8 Mice: Metabolic Insights from NMR-Based Metabolomics

Molecules, Journal Year: 2025, Volume and Issue: 30(9), P. 2003 - 2003

Published: April 30, 2025

Age-related skeletal muscle atrophy is a major health concern in the elderly, contributing to reduced mobility, increased risk of falls, and metabolic dysfunction. The senescence-accelerated prone 8 (SAMP8) mouse model, known for its rapid aging early cognitive decline, serves as an essential model studying age-related degeneration. While previous studies have shown that exercise attenuates by promoting regeneration improving strength, underlying mechanisms remain poorly understood. This study used SAMP8 evaluate effects on associated changes. Our results show promoted growth reducing body weight, increasing mass, decreasing fat accumulation. Furthermore, improved grip tone, fiber cross-sectional area, thereby preserving functionality. NMR-based metabolomic analysis identified key pathways modulated exercise, including glycine, serine, threonine metabolism; alanine, aspartate, glutamate pyruvate taurine hypotaurine metabolism. These findings underscore therapeutic potential combating wasting elucidate benefits.

Language: Английский

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Decoding the Impact of Theabrownin on Skeletal Muscle Function in Gestational Diabetic Offspring: Insights from Integrated Metabolome and Transcriptome Analysis

Journal of Agricultural and Food Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: May 6, 2025

Gestational diabetes mellitus (GDM) often leads to long-term metabolic issues, including skeletal muscle dysfunction in the offspring, with traditional managements focusing solely on blood glucose regulation and not addressing structural changes. Theabrownin (TB), a polyphenol derived from Pu-erh tea, has known antioxidant benefits, but its effects function GDM offspring remain unclear. In this study, model was induced mice, their were treated by TB. Transcriptomic metabolomic analyses identified key genes metabolites involved lipid metabolism, oxidative stress, inflammation. TB treatment significantly improved reduced alleviated inflammation of offspring. Key (Fabp3, Acot1, Acot4) (Palmitic acid, Oleic acid) regulated Pathway analysis revealed that mitigates GDM-induced through modulation biosynthesis unsaturated fatty acids. These findings highlight potential theabrownin (TB) as therapeutic agent for improving metabolism. Further investigation is needed elucidate mechanisms evaluate effects.

Language: Английский

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Evolutionary edge: NOD-like receptors in immunity

Biomedical Journal, Journal Year: 2024, Volume and Issue: 47(1), P. 100702 - 100702

Published: Jan. 30, 2024

This issue of the Biomedical Journal delves into multifaceted roles NOD-like receptors (NLRs) in immunity, examining their subfamilies and functions within innate adaptive autoimmune inflammatory conditions, mitophagy regulation. In this dynamics mRNA vaccines are explored, as well synergistic effects a ketogenic diet with anti-tumor therapies, curcumin RANKL osteoclastogenesis, validation rapid diagnostic test for an oral cancer biomarker. Additionally, advancements ocular care highlighted, featuring novel prodrug targeting corneal neovascularization, discussing efficacy dexamethasone implants against macular edema. Concluding, further insights impact sweetened foods on child development given.

Language: Английский

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Fat loss and muscle gain: The possible role of cortical glutamate in determining the efficacy of physical exercise

Obesity Research & Clinical Practice, Journal Year: 2024, Volume and Issue: 18(3), P. 163 - 170

Published: May 1, 2024

Language: Английский

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Identifying threshold of CT-defined muscle loss after radiotherapy for survival in oral cavity cancer using machine learning

European Radiology, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 20, 2024

Language: Английский

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