Environmental Research, Journal Year: 2024, Volume and Issue: unknown, P. 120002 - 120002
Published: Sept. 1, 2024
Language: Английский
The Egyptian Journal of Aquatic Research, Journal Year: 2024, Volume and Issue: 50(2), P. 225 - 233
Published: April 7, 2024
Language: Английский
Citations
32
Microchemical Journal, Journal Year: 2024, Volume and Issue: unknown, P. 111687 - 111687
Published: Sept. 1, 2024
Language: Английский
Citations
9
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(18), P. 10167 - 10167
Published: Sept. 22, 2024
Male factors may be present in up to 50–70% of infertile couples and the prevalence male infertility accounts for 20–30% cases. Understanding mechanisms causes behind remains a challenge, but new diagnostic tools such as DNA fragmentation might aid cases where routine semen analysis is insufficient. fragmentation, which refers damages or breaks genetic material spermatozoa, considered one main due impaired functional capability sperm. The aim narrative review investigate enlighten potential correlation between parameters seminal profile reproductive outcomes. Comprehensive research PubMed/Medline Scopus databases was conducted 28 studies were included review. Fourteen provided data regarding impact showed significantly lower sperm count, concentration, motility, abnormal morphology with an increased index (DFI). Similarly, 15 DFI on Two higher aneuploidy rates values, seven pregnancy live birth values. Ultimately, this highlight, collectively, importance measuring assessment infertility. Further are needed explore effectiveness interventions aiming reduce levels.
Language: Английский
Citations
9
Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15
Published: March 8, 2024
Background Obesity and metabolic syndrome pose significant health challenges in the United States (US), with connections to disruptions sex hormone regulation. The increasing prevalence of obesity might be associated exposure phthalates (PAEs). Further exploration impact PAEs on is crucial, particularly from a perspective. Methods A total 7780 adult participants National Health Nutrition Examination Survey (NHANES) 2013 2016 were included study. Principal component analysis (PCA) coupled multinomial logistic regression was employed elucidate association between urinary metabolite concentrations likelihood obesity. Weighted quartiles sum (WQS) utilized consolidate mixed levels (total testosterone (TT), estradiol hormone-binding globulin (SHBG)). We also delved into machine learning models accurately discern status identify key variables contributing most these models. Results Component 1 (PC1), characterized by mono(2-ethyl-5-carboxypentyl) phthalate (MECPP), mono(2-ethyl-5-hydroxyhexyl) (MEHHP), mono(2-ethyl-5-oxohexyl) (MEOHP) as major contributors, exhibited negative Conversely, PC2, monocarboxyononyl (MCNP), monocarboxyoctyl (MCOP), mono(3-carboxypropyl) (MCPP) showed positive Mixed decreased TT increased SHBG. During interrelations among obesity, hormones, PAEs, based Random Forest (RF) eXtreme Gradient Boosting (XGBoost) algorithms demonstrated best classification efficacy. In both models, hormones highest variable importance, certain metabolites made contributions model’s performance. Conclusions Individuals exhibit lower SHBG, accompanied elevated levels. Exposure disrupts levels, an risk US adults. interrelationships three factors, RF XGBoost algorithm superior performance, displaying higher importance.
Language: Английский
Citations
6
Reproductive Biology and Endocrinology, Journal Year: 2025, Volume and Issue: 23(1)
Published: Jan. 25, 2025
Endocrine-disrupting chemicals (EDCs) interfere with the endocrine system and negatively impact reproductive health. Biochanin A (BCA), an isoflavone anti-inflammatory estrogen-like properties, has been identified as one such EDC. This study investigates effects of BCA on transcription, metabolism, hormone regulation in primary human granulosa cells (GCs), a specific focus activation bitter taste receptors (TAS2Rs). Primary GCs from 60 participants were treated 10 µM BCA, selective antagonists used to block TAS2R activation. The assessed expression TAS2R14 TAS2R43, analyzed StAR CYP17A1 gene expression. Intracellular calcium levels, lipid droplet size, mitochondrial network complexity measured evaluate cellular metabolism energy dynamics. treatment significantly upregulated TAS2R43 expression, leading 70% increase mRNA levels twofold (p < 0.05). These reversed by antagonists. Additionally, decreased intracellular Ca2+ 0.01) reduced size 0.001), both which counteracted Enhanced 0.001) was also observed, suggesting increased fusion improved findings indicate that modulates transcriptional metabolic processes through TAS2Rs, highlighting their role regulation. statistically significant results emphasize relevance further exploring EDCs like Collaborative research efforts are essential address mitigate adverse impacts fertility.
Language: Английский
Citations
0
HORMONES, Journal Year: 2025, Volume and Issue: unknown
Published: March 4, 2025
Language: Английский
Citations
0
Early pregnancy, Journal Year: 2025, Volume and Issue: unknown, P. 70 - 80
Published: April 16, 2025
Citations
0
Human Reproduction, Journal Year: 2024, Volume and Issue: 39(5), P. 936 - 954
Published: March 4, 2024
Abstract STUDY QUESTION Is there a cumulative toxicity of disposables used in IVF procedures? SUMMARY ANSWER A may be detected when consumables are cumulatively, while no is the same and tested individually. WHAT IS KNOWN ALREADY Many components items laboratories impair human embryonic development. Consequently, it necessary to screen all reagents materials which could contact with gametes embryos. Toxicity tests, such as mouse embryo assay sperm motility (HSMA), by manufacturers quality control tools demonstrate safety their products. This evaluation currently individually performed for each single consumable. However, during an cycle, several devices sequentially, potentially creating exposure chemical contaminants, not consumables. DESIGN, SIZE, DURATION The objective this observational study conducted from March 2021 October 2022 was evaluate HSMA methodology if sequentially used. Fourteen categories routine procedures were studied, included oocyte collection (cups, condoms, aspiration needles), manipulation (flasks, tubes, tips, pipettes, transfer catheters, syringes, gloves), culture (dishes), storage (straws). PARTICIPANTS/MATERIALS, SETTING, METHODS After obtaining patient consent, surplus semen assessed having normal parameters according World Health Organization 2010 criteria perform HSMAs. First, consumable Then, associations three, four, five consumables, previously validated non-toxic individually, analyzed. HSMAs three times ensure reproducibility, defined threshold index (SMI) below 0.85 at least two tests. MAIN RESULTS AND THE ROLE OF CHANCE Thirty-six references first across 53 lots. Forty-nine (92%) demonstrated compliance. four (8%) revealed toxicity: one lot 1 ml lots cups, 25 cm2 flasks. These excluded procedures. total 48 combinations assessed, involving 41 32 that tested. Among evaluated combinations, 17 out (35%) exhibited SMI tests (n = 8) or 9). Notably, (18%) three-consumable associations, 16 (31%) four-consumable nine 15 (60%) five-consumable found compliant. did originate consumable, because only pre-validated but had origin. risk increased number association (Cochran–Mantel–Haenszel statistic, P 0.013). LIMITATIONS, REASONS FOR CAUTION high proportion non-compliant can attributed directly extreme rigorous extraction conditions employed deviate encountered clinical use. Also, (e.g. duration, concentrations, protein supplementation medium) influence sensitivity WIDER IMPLICATIONS FINDINGS highlights significance performing testing on before introducing them into practice. Disposables should detect immediate toxicities also combination. Our results advocate rationalizing procedure re-evaluating use glass FUNDING/COMPETING INTEREST(S) received fundings GCS Ramsay Santé pour l’Enseignement et la Recherche (Paris, France) Centre de Biologie Médicale BIOGROUP (Le Chesnay-Rocquencourt, France). authors declare they have conflict interest perceived prejudicing impartiality reported research. TRIAL REGISTRATION NUMBER N/A.
Language: Английский
Citations
3
Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(7), P. 2145 - 2145
Published: April 8, 2024
Recurrent implantation failure (RIF) poses a significant challenge in assisted reproductive technology (ART) outcomes. The endometrium plays crucial role embryo implantation, and its protein expression profile is integral determining receptivity. Proteomics has emerged as valuable tool unraveling the molecular intricacies underlying endometrial receptivity RIF. aim of present review to analyze contribution proteomics understanding women with RIF, based on results proteomic studies. Medline/Pubmed databases were searched using keywords pertaining combined terms related 15 studies included review. Several proteins have been found exbibit differential biopsies fluid samples between fertile RIF during receptive phase. varied significantly among Nevertheless, similar changes levels annexin-6, progesterone receptor, MMP-2, MMP-9 more than one study indicating that certain could potentially be effective biomarkers contributes analysis are promising for improving clinical management
Language: Английский
Citations
3
Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(12), P. 3361 - 3361
Published: June 7, 2024
Background: Recurrent pregnancy loss refers to the spontaneous demise of two or more pregnancies before 24 weeks gestation. In almost half cases recurrent miscarriages, causes remain unknown since there is no reliable way prognosis, early diagnosis, treatment. Recent research has detected differential expression certain miRNAs in reproductive system pathologies. Methods: The aim present review focus on microRNAs and their relationship with idiopathic miscarriages correlate miRNA miscarriage examine potential role as biomarkers. Pubmed/Medline Scopus databases were searched up 31st January 2024 terms related miRNAs. Results: total, 21 studies selected for review. A total 75 different identified, showing a statistically significant expression. Around 40 had increased expression, such miR-520, miR-184 miR-100-5p, decreased, let-7c, 14 either decreased depending study, miR-21. Conclusions: dysregulation strongly associated miscarriages. circulating peripheral blood miRNAs, miR-100-5p might be utilized biomarkers establish valuable non-invasive prognostic diagnostic tool future.
Language: Английский
Citations
3