Review Article: Anabolic‐Androgenic Steroids, Violence, and Crime: Two Cases and Literature Review DOI
Harrison G. Pope, Gen Kanayama, James I. Hudson

et al.

American Journal on Addictions, Journal Year: 2021, Volume and Issue: 30(5), P. 423 - 432

Published: April 19, 2021

Background and Objectives Anabolic‐androgenic steroid (AAS) use has become a major worldwide substance disorder, affecting tens of millions individuals. Importantly, it is now increasingly recognized that some individuals develop uncharacteristically violent or criminal behaviors when using AAS. We sought to summarize available information on this topic. Methods reviewed the published literature AAS‐induced behavioral effects augmented with extensive observations from our clinical forensic experience. Results It generally accepted AAS users while taking these drugs. Although may partially reflect premorbid psychopathology, sociocultural factors, expectational effects, accumulating evidence suggests they are also attributable biological themselves. The mechanism remains speculative, but preliminary data suggest possible role for brain regions involved in emotional reactivity, such as amygdala cognitive control, including frontal cortex. For unknown reasons, appear idiosyncratic; most display few minority develops severe effects. Conclusion Scientific Significance Professionals encountering settings should be alert possibility violence criminality employ strategies assess whether indeed contributory factor given case. Further research needed elucidate explain why only subset appears vulnerable (Am J Addict 2021;00:00–00)

Language: Английский

Obsessive–compulsive disorder DOI
Dan J. Stein, Daniel L. Costa, Christine Löchner

et al.

Nature Reviews Disease Primers, Journal Year: 2019, Volume and Issue: 5(1)

Published: Aug. 1, 2019

Language: Английский

Citations

585

Obsessive-Compulsive Disorder: Puzzles and Prospects DOI Creative Commons
Trevor W. Robbins, Matilde M. Vaghi, Paula Banca

et al.

Neuron, Journal Year: 2019, Volume and Issue: 102(1), P. 27 - 47

Published: April 1, 2019

Language: Английский

Citations

445

Validity and utility of Hierarchical Taxonomy of Psychopathology (HiTOP): III. Emotional dysfunction superspectrum DOI

David Watson,

Holly Frances Levin-Aspenson, Monika A. Waszczuk

et al.

World Psychiatry, Journal Year: 2022, Volume and Issue: 21(1), P. 26 - 54

Published: Jan. 11, 2022

The Hierarchical Taxonomy of Psychopathology (HiTOP) is a quantitative nosological system that addresses shortcomings traditional mental disorder diagnoses, including arbitrary boundaries between psychopathology and normality, frequent co‐occurrence, substantial heterogeneity within disorders, diagnostic unreliability over time across clinicians. This paper reviews evidence on the validity utility internalizing somatoform spectra HiTOP, which together provide support for an emotional dysfunction superspectrum. These are composed homogeneous symptom maladaptive trait dimensions currently subsumed multiple classes, depressive, anxiety, trauma‐related, eating, bipolar, somatic as well sexual aspects personality disorders. Dimensions falling superspectrum broadly linked to individual differences in negative affect/neuroticism. Extensive establishes share genetic diatheses, environmental risk factors, cognitive affective difficulties, neural substrates biomarkers, childhood temperamental antecedents, treatment response. structure these validators mirrors superspectrum, with some correlates more specific or conditions, others common both, thereby underlining hierarchical domain. Compared demonstrated substantially improved utility: greater reliability, larger explanatory predictive power, clinical applicability. Validated measures available implement HiTOP practice, can make classification useful, both research clinic.

Language: Английский

Citations

189

Toward a neurocircuit-based taxonomy to guide treatment of obsessive–compulsive disorder DOI
Elizabeth Shephard, Emily Stern, Odile A. van den Heuvel

et al.

Molecular Psychiatry, Journal Year: 2021, Volume and Issue: 26(9), P. 4583 - 4604

Published: Jan. 7, 2021

Language: Английский

Citations

163

Persistent enhancement of basolateral amygdala-dorsomedial striatum synapses causes compulsive-like behaviors in mice DOI Creative Commons
In Bum Lee, Eugene Lee,

Nicholas A Han

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Jan. 8, 2024

Abstract Compulsive behaviors are observed in a range of psychiatric disorders, however the neural substrates underlying not clearly defined. Here we show that basolateral amygdala-dorsomedial striatum (BLA-DMS) circuit activation leads to manifestation compulsive-like behaviors. We revealed BLA neurons projecting DMS, mainly onto dopamine D1 receptor-expressing neurons, largely overlap with neuronal population responds aversive predator stress, widely used anxiogenic stressor. Specific optogenetic BLA-DMS induced strong anxiety response followed by compulsive grooming. Furthermore, developed mouse model for compulsivity displaying wide spectrum chronically activating circuit. In these mice, persistent molecular changes at synapses were causally related phenotypes. Together, our study demonstrates involvement emergence enduring via its synaptic changes.

Language: Английский

Citations

20

Error Processing and Inhibitory Control in Obsessive-Compulsive Disorder: A Meta-analysis Using Statistical Parametric Maps DOI

Luke Norman,

Stephan F. Taylor, Yanni Liu

et al.

Biological Psychiatry, Journal Year: 2018, Volume and Issue: 85(9), P. 713 - 725

Published: Nov. 29, 2018

Language: Английский

Citations

153

A Unified Functional Network Target for Deep Brain Stimulation in Obsessive-Compulsive Disorder DOI
Ningfei Li, Barbara Hollunder, Juan Carlos Baldermann

et al.

Biological Psychiatry, Journal Year: 2021, Volume and Issue: 90(10), P. 701 - 713

Published: April 20, 2021

Language: Английский

Citations

64

Abnormal resting-state functional connectivity in patients with obsessive-compulsive disorder: A systematic review and meta-analysis DOI
Jing Liu, Lingxiao Cao, Hailong Li

et al.

Neuroscience & Biobehavioral Reviews, Journal Year: 2022, Volume and Issue: 135, P. 104574 - 104574

Published: Feb. 10, 2022

Language: Английский

Citations

64

Fear conditioning and extinction in obsessive-compulsive disorder: A systematic review DOI Creative Commons
Samuel E. Cooper, Joseph E. Dunsmoor

Neuroscience & Biobehavioral Reviews, Journal Year: 2021, Volume and Issue: 129, P. 75 - 94

Published: July 24, 2021

Language: Английский

Citations

58

An overview of the first 5 years of the ENIGMA obsessive–compulsive disorder working group: The power of worldwide collaboration DOI Creative Commons
Odile A. van den Heuvel,

Premika S.W. Boedhoe,

Sara Bertolín

et al.

Human Brain Mapping, Journal Year: 2020, Volume and Issue: 43(1), P. 23 - 36

Published: March 10, 2020

Abstract Neuroimaging has played an important part in advancing our understanding of the neurobiology obsessive–compulsive disorder (OCD). At same time, neuroimaging studies OCD have had notable limitations, including reliance on relatively small samples. International collaborative efforts to increase statistical power by combining samples from across sites been bolstered ENIGMA consortium; this provides specific technical expertise for conducting multi‐site analyses, as well access a community scientists. In article, we outline background to, development of, and initial findings ENIGMA's working group, which currently consists 47 34 institutes 15 countries 5 continents, with total sample 2,323 patients 2,325 healthy controls. Initial work focused cortical thickness subcortical volumes, structural connectivity, brain lateralization children, adolescents adults OCD, also study commonalities distinctions different neurodevelopment disorders. Additional is ongoing, employing machine learning techniques. Findings date contributed neurobiological models provided model global scientific collaboration, number clinical implications. Importantly, shed new light questions about whether functional alterations found reflect neurodevelopmental changes, effects disease process, or medication impacts. We conclude summary ongoing ENIGMA‐OCD, consideration future directions research within beyond ENIGMA.

Language: Английский

Citations

70