Sex differences in externalizing and internalizing traits and ventral striatal responses to monetary loss DOI Creative Commons
Guangfei Li,

Yashuang Li,

Zhao Zhang

et al.

Research Square (Research Square), Journal Year: 2022, Volume and Issue: unknown

Published: Nov. 18, 2022

Abstract Ventral striatum (VS) processes rewarding and punishing stimuli. Women men vary in externalizing internalizing traits, which may influence neural responses to reward punishment. To investigate sex differences how individual traits VS punishment, we curated the data of Human Connectome Project identified 981 (473 men) subjects evaluated by Achenbach Adult Self-Report Syndrome Scales. We processed imaging with published routines extracted reactivity (β) win loss vs. baseline a gambling task for correlation symptom severity. Men women showed more severe symptoms higher response monetary losses (VS-loss β) but not wins. significant, positive between VS-loss β difference was confirmed slope test. The each VS-win differed significantly slope, confirming its specificity, men. Further, sex-specific relationship trait did extend activities during exposure negative emotion face matching task. conclude, their rather than severity young adults. findings highlight have implications psychological models behaviors

Language: Английский

Top-down circuitry from the anterior insular cortex to VTA dopamine neurons modulates reward-related memory DOI Creative Commons
Eduardo Hernández-Ortiz, Jorge Luis-Islas, Fatuel Tecuapetla

et al.

Cell Reports, Journal Year: 2023, Volume and Issue: 42(11), P. 113365 - 113365

Published: Nov. 1, 2023

The insular cortex (IC) has been linked to the processing of interoceptive and exteroceptive signals associated with addictive behavior. However, whether IC modulates acquisition drug-related affective states by direct top-down connectivity ventral tegmental area (VTA) dopamine neurons is unknown. We found that photostimulation VTA terminals anterior (aIC) induces rewarding contextual memory, activity, triggers release within VTA. Employing neuronal recordings neurochemical transsynaptic tagging techniques, we disclose functional organization aIC pre-synaptic bodies identifying recipient neurons. Furthermore, systemic administration amphetamine altered excitability modulated projection, where photoactivation enhances, whereas photoinhibition impairs, a Our study reveals key circuit involved in developing retaining drug reward-related providing insight into neurobiological basis behavior helping develop therapeutic addiction strategies.

Language: Английский

Citations

6
Appetitive and aversive cue reactivities differentiate neural subtypes of alcohol drinkers DOI Creative Commons
Yu Chen, Chiang‐Shan R. Li

Addiction Neuroscience, Journal Year: 2023, Volume and Issue: 7, P. 100089 - 100089

Published: April 8, 2023

Craving reflects the subjective urge to use drugs and can be triggered by both positive negative emotional states. No studies have systematically investigated relative roles of these mechanisms in pathophysiology substance misuse. Here, we performed meta-analyses drug cue-elicited reactivity win loss processing monetary incentive delay task identify distinct neural correlates appetitive aversive responses cues. We then characterized cue seventy-six alcohol drinkers performing a craving during fMRI. Imaging data were processed according published routines. The circuit involved medial cortical regions ventral striatum, insula, caudate mid-cingulate cortex. observed significant correlation activity (

Language: Английский

Citations

5
The differential neural substrates for reward choice under gain-loss contexts and risk in alcohol use disorder: Evidence from a voxel-based meta-analysis DOI
Jianguang Zeng,

Lantao You,

Haoxuan Sheng

et al.

Drug and Alcohol Dependence, Journal Year: 2023, Volume and Issue: 248, P. 109912 - 109912

Published: May 4, 2023

Language: Английский

Citations

5
Sex differences in externalizing and internalizing traits and ventral striatal responses to monetary loss DOI Creative Commons
Guangfei Li,

Yashuang Li,

Zhao Zhang

et al.

Journal of Psychiatric Research, Journal Year: 2023, Volume and Issue: 162, P. 11 - 20

Published: April 12, 2023

Language: Английский

Citations

4
Sex differences in dorsolateral prefrontal cortical and superior colliculus activities support the impact of alcohol use severity and sleep deficiency on two-back memory DOI Open Access
Guangfei Li,

Cao Yingjie,

Chunlan Yang

et al.

Quantitative Imaging in Medicine and Surgery, Journal Year: 2024, Volume and Issue: 14(7), P. 4972 - 4986

Published: June 29, 2024

Working memory refers to a process of temporary storage and manipulation information support planning, decision-making, action. Frequently comorbid alcohol misuse sleep deficiency have both been associated with working deficits. However, how interact impact remains unclear. In this study, we aim investigate the neural processes inter-relating misuse, memory.

Language: Английский

Citations

1
Functional networks of reward and punishment processing and their molecular profiles predicting the severity of young adult drinking DOI Creative Commons

Yashuang Li,

Lin Yang, Dongmei Hao

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Feb. 7, 2024

ABSTRACT Background Alcohol misuse is associated with altered punishment and reward processing. Here, we investigated neural network responses to the molecular profiles of connectivity features predicting alcohol use severity in young adults. Methods We curated Human Connectome Project data employed connectome-based predictive modeling (CPM) examine how functional (FC) during wins losses 981 was quantified by first principal component analysis all drinking measures Semi-Structured Assessment for Genetics Alcoholism. combined CPM findings JuSpace toolbox characterize severity. Results The connectomics appeared specific, comprising less than 0.12% features. These connectivities featured medial frontal, motor/sensory, cerebellum/brainstem networks processing fronto-parietal, motor/sensory Spatial correlation analyses showed that these were predominantly serotonergic GABAa signaling. Conclusions A distinct pattern predicted adult drinkers. “neural fingerprints” help elucidating impact on brain providing evidence new targets future intervention.

Language: Английский

Citations

0
Hypothalamic connectivities and self-evaluated aggression in young adults DOI Creative Commons

Yuxing Jared Yao,

Yu Chen, Chiang‐Shan R. Li

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 27, 2024

Abstract Introduction The hypothalamus plays a pivotal role in supporting motivated behavior, including aggression. Previous work suggested differential roles of the medial (MH) and lateral (LH) aggressive behaviors, but little is known about how their resting-state functional connectivity (rsFC) may relate to aggression humans. Methods We employed data from Human Connectome Project (HCP) examined rsFC’s LH MH 745 young adults (393 women). also explored sex differences rsFC’s. processed imaging with published routines evaluated results voxel-wise regression on score, as obtained Achenbach Adult Self Report, corrected threshold. Results analysis revealed significant rsFC between clusters middle temporal occipital gyri across all subjects thalamus for men, both negative correlation score. Slope test confirmed LH-thalamus No was observed MH. Conclusions These findings suggest rsFCs manifestation highlight need further research into sex-specific neural pathways other related behavioral traits importance mental health.

Language: Английский

Citations

0
Impulsivity Impacts Suicidality in Patients with Alcohol Use Disorder with and without Comorbid Depression DOI Creative Commons

Vincent Xi-Yu Wang,

Ding‐Lieh Liao, En‐Liang Wu

et al.

Taiwanese Journal of Psychiatry, Journal Year: 2024, Volume and Issue: 38(4), P. 171 - 176

Published: Oct. 1, 2024

Abstract Objective: The independent rôle of impulsivity in alcoholism patient’s suicidality is less elucidated. In this study, we intended to investigate how and depression contribute patients with alcohol use disorder (AUD). Methods: We recruited 27 adult AUD major depressive (AUD MDD) 33 only without MDD). assessed suicidality, severity, impulsivity, other psychiatric comorbidities. Suicidality was quantified for the frequency previous history suicide attempts current intent/tendency. Impulsivity measured using Barratt Impulsiveness Scale (BIS). addressed contributed both indices multiple ordinal regressions. Results: Patients MDD versus those showed significantly higher ( p < 0.001), more severe 0.01), polysubstance 0.05), anxiety comorbidities BIS scores 0.001). a better-fitting final model regression stepwise elimination, total score independently associated tendency 0.05) 0.01). contrast, Hamilton Depression Rating Scale-17 suicidal tendencies but not attempts. Conclusion: Depressed relative nondepressed individuals severity use. Across groups, found predict suicidality. suggest that prevention efforts may include assessment patients.

Language: Английский

Citations

0
The effects of cocaine use severity and abstinence on behavioral performance and neural processes of response inhibition DOI
Guangfei Li, Zhao Zhang, Yihe Zhang

et al.

Psychiatry Research Neuroimaging, Journal Year: 2023, Volume and Issue: 336, P. 111734 - 111734

Published: Oct. 20, 2023

Language: Английский

Citations

0
Appetitive and aversive cue reactivities differentiate biotypes of alcohol drinkers DOI Creative Commons
Yu Chen, Chiang‐Shan R. Li

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2022, Volume and Issue: unknown

Published: Aug. 2, 2022

Abstract Craving reflects the subjective urge to use drugs and can be triggered by both positive negative emotional states. However, no studies have systematically investigated relative roles of these mechanisms in pathophysiology substance misuse or distinguished individual vulnerability disorders. In current study, we performed meta-analyses drug cue-elicited reactivity win loss processing monetary incentive delay task identify distinct neural correlates appetitive aversive responses during cue exposure. We then characterized seventy-six alcohol drinkers performing a craving fMRI. Imaging data were processed according published routines. The circuit involved medial cortical regions ventral striatum, insula, caudate mid-cingulate cortex. observed significant correlation β estimates activity circuit. individuals varied responses. From regression (y) vs. (x) , identified participants top 1/3 each those with (n = 15) 11) residuals as “approach” “avoidance” biotype, others “mixed” biotype 50). For clinical characteristics, avoidance showed higher sensitivity punishment. contrast, approach levels sensation seeking expectancy for social physical pressure. findings highlighted underpinnings components substantiated importance biotyping misuse.

Language: Английский

Citations

0